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Relapse in Medical News

FDA Approves INVEGA(R) SUSTENNA(TM) for the Acute and Maintenance Treatment of Schizophrenia

... for schizophrenia, the symptoms and the risk of relapse (an exacerbation of symptoms) can be managed in ... with schizophrenia experience at least one relapse within five years of diagnosis(2), and the risk for relapse in patients can substantially increase as a ...

Subclinical markers predict relapse in juvenile idiopathic arthritis post methotrexate withdrawal

... Protein (MRP*) 8/14 predict an increased risk of relapse following withdrawal of methotrexate (MTX) ... has been proposed by researchers.1 The risk of relapse in JIA patients, once MTX is discontinued, is ... not differentiate between patients at-risk for relapse and those without this risk. However, MRP8/14 ...

Breast-feeding OK for Most Moms with MS

... but worry it might cause their disease to relapse may be reassured by a new study that discovered ... not taking MS medications did not experience a relapse of their disease while they were breast-feeding. ... two months were five times less likely to have a relapse than those who didn't breast-feed at all. The ...

First 10-year follow-up shows that treatment with AVONEX leads to long-term benefits in early multiple sclerosis patients

... beginning shortly after symptom-onset reduces relapse rates and may reduce disease progression for up ... had an EDSS of less than 3; and the annualized relapse rate for patients with up to 10 years of care was only 0.25, suggesting a relapse rate of only ...

First ten-year follow-up shows that treatment with AVONEX leads to long-term benefits in early multiple sclerosis patients

... beginning shortly after symptom-onset reduces relapse rates and may reduce disease progression for up ... had an EDSS of less than 3; and the annualized relapse rate for patients with up to 10 years of care was only 0.25, suggesting a relapse rate of only ...

New pill to treat MS

... can dramatically reduce the chances of a relapse or a deterioration of the condition, according to ... a few times a year can reduce the chances of a relapse by well over 50 per cent. And patients who took ... were over 55 per cent less likely to suffer a relapse and 30 per cent less likely to suffer worsening ...

Poniard Announces Publication of Results of Picoplatin Phase 2 Study in Journal of Clinical Oncology

... small cell lung cancer due to the rapid relapse of the disease and the slim chance that patients ... in patients with other solid tumors who relapse or are refractory to first-line platinums, such ... the efficacy and safety of picoplatin after relapse in SCLC patients. The primary efficacy endpoint ...

Hard-to-Treat Leukemia Cell Subtype Identified

... three-quarters of those with ETP-ALL suffered a relapse within a decade, compared with only 10 percent of ... 57 percent of ETP-ALL patients had a relapse within two years, compared with only 14 percent ... "The high risk of remission failure or subsequent relapse for patients with ETP-ALL, if treated with ...

Childhood Leukemia Subtype Resists Treatment

... Those with rare gene have disease relapse often within 5 years of apparent remission ... with ALL, those with this gene tended to have relapse of the disease, often within five years of ... unclassified strains of the disease in which relapse is frequent. Being able to pinpoint this ...

Gene abnormality found to predict childhood leukemia relapse

... in a gene that predict a high likelihood of relapse in children with acute lymphoblastic leukemia ... only 30 percent of children who experience a relapse of ALL will survive five years. Determining the risk of relapse faced by an individual patient would help ...

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Relapse in Medical Technology

Video: FDA Approves INVEGA(R) SUSTENNA(TM) for the Acute and Maintenance Treatment of Schizophrenia

... for schizophrenia, the symptoms and the risk of relapse (an exacerbation of symptoms) can be managed in ... with schizophrenia experience at least one relapse within five years of diagnosis(2), and the risk for relapse in patients can substantially increase as a ...

Acute Lymphoblastic Leukemia, the Most Common Childhood Cancer, Is Curable Without Preventive Cranial Radiation

... use, and only patients at highest risk for relapse have received cranial radiation. Now, St. ... identified many important risk factors for CNS relapse and optimized chemotherapy treatment, leading to ... Worth, Texas, between 2000 and 2007. The risk of relapse was determined by measurement of residual ...

Afinitor(R) Phase II Data Show Positive Results for Patients With Multiple Types of Lymphoma, Leading to Phase III Trial

... to explore potential of Afinitor to prevent relapse in patients with the most common type of ... However, NHL patients have a high risk of relapse after initial therapy and no treatments are ... for a Phase III study of Afinitor to prevent relapse in patients with diffuse large B-cell lymphoma, ...

RISPERDAL(R) CONSTA(R) (Risperidone) Long-Acting Treatment Delayed the Time to Relapse in Patients with Bipolar I Disorder

... (RLAT) significantly delayed the time to relapse compared to placebo in patients with Bipolar I ... placebo group. The primary endpoint was time to relapse of any mood episode (depression, mania, or mixed). Time to relapse was significantly longer in patients receiving ...

Two-Year Phase III Data Presented at AAN 61st Annual Meeting Show Positive Outcome of Cladribine Tablets in Patients With Multiple Sclerosis

... Endpoint met With a Significant Reduction in relapse Rate - Secondary Endpoints met Including MRI ... a 58% relative reduction in annualized relapse rates with respect to placebo (0.14 versus 0.33 ... a 55% relative reduction in annualized relapse rates with respect to placebo (0.15 versus 0.33; ...

Schering-Plough Highlights Hepatitis C Clinical Data Presentations at the European Association for the Study of the Liver (EASL) Annual Meeting

... the primary endpoint of the study. relapse rates between these two arms also were not ... duration or a reduced PEGINTRON dose on SVR and relapse rates among treatment-naive G2/3 patients in an ... (129/228). Neither co-primary endpoint was met. relapse rates were lower with 24 weeks compared to 16 ...

Gene Abnormality Found to Predict Childhood Leukemia Relapse

... in a gene that predict a high likelihood of relapse in children with acute lymphoblastic leukemia ... only 30 percent of children who experience a relapse of ALL will survive five years. Determining the risk of relapse faced by an individual patient would help ...

St. Jude Identifies Genomic Causes of a Certain Type of Leukemia Relapse

... the majority of acute lymphoblastic leukemia relapse cases arise from a cell already present at the ... offers a pathway to designing treatments for ALL relapse in children and, ultimately, in adults. ... more than 80 percent of ALL cases are cured, relapse is a significant problem, with only 30 percent of ...

European CHMP Issues Positive Opinion on Cymbalta for the Treatment of Generalised Anxiety Disorder

... double-blind placebo-controlled studies and a relapse prevention study -- involving more than 2,000 ... significantly decreased the likelihood of relapse in those patients who initially responded ... (7) Davidson JRT, et al. Duloxetine treatment for relapse prevention in adults with generalized anxiety ...

Patients Treated with Risperidone Long-Acting Injection had a Significantly Longer Time to Relapse Compared to Quetiapine in International Clinical Study

... their medication treatment, which can result in a relapse of symptoms (1,2). Today, data from a new ... had a significantly longer time to relapse (3) compared to patients treated with an oral ... Furthermore, over the 24-month treatment period, relapse occurred in 16.5 percent of patients treated with ...

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Relapse in Medical Dictionary

Relapse

... relapse : The return of signs and symptoms of a disease ... a patient has enjoyed a remission . Whether relapse d or refractory, tune in to learn about ... non-Hodgkin's lymphoma . Children who relapse 3 or more years after achieving a first ...

Marrow

... been approved by the U.S. Food and Drug Administration. Marrow relapse Very Early relapse ( Intermediate ... Bone marrow transplant ation is also sometimes ...

Remission

... activity is minimal or absent ( remission ) and when it is active ( relapse or flare). A child whose leukemia has gone into remission (meaning ... abnormal cells have disappeared) must be watched carefully for signs of relapse , particularly within the first year after the drugs are stopped. ...

Acute lymphocytic leukemia

... chromosome . Additional phase I/II trials have begun to evaluate the efficacy of annamycin in the treatment of patients with refractory or relapse d acute myelogenous leukemia (AML), acute lymphocytic leukemia (ALL), ... ...

Addiction

... depression was only a symptom of use, not a potential cause, and it was left untreated. Research now shows that this leads to increased risk of relapse . There is some risk of dependency and addiction with these drugs, but concerns about this are probably overemphasized. If you have panic ...

Alcohol withdrawal

... alcohol withdrawal . How to stop drinking alcohol If you have stopped drinking, seek help if you feel the need to drink again. This may help prevent relapse s. May drink shortly after waking to reduce feelings of alcohol withdrawal Develop a reduced capacity to control how often and how much they use ...

Aplastic

... paraplasm; par aplastic ; ... Indication: treatment of adult patients with refractory an aplastic astrocytoma, i.e., patients at first relapse who have experienced disease progression on a drug regimen containing a nitrosourea and procarbazine. Conditions that can decrease WBC ...

Borderline Personality Disorder

... , and borderline personality disorder , can make treatment of bulimia more difficult. Recovery from bulimia can take a long time and relapse is common. Personality Disorder - Borderline ( Borderline Personality Disorder ) Personality Disorder - Dependent (Dependent Personality ...

Bovine

... oral preparation of bovine myelin , has recently been tested in clinical trials for its effectiveness in reducing the frequency and severity of relapse s. Preliminary data indicate no difference between it and placebo . Alternative treatment ... Most insulin being used today is 'human ...

Chronic Pain

... pain Patients suffering from chronic pain may do well visiting a reputable health spa according to new research. Chronic pain : Prevent relapse s Man aging chronic pain isn't something that's achieved overnight. Lessen the effects of occasional setbacks by developing strategies to help ...

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Relapse in Biological News

St. Jude identifies genomic causes of a certain type of leukemia relapse

... offers a pathway to designing treatments for ALL relapse in children and, ultimately, in adults. The ... more than 80 percent of ALL cases are cured, relapse is a significant problem, with only 30 percent of ... "Examining the new changes that are arising at relapse tells us a lot about the individual genetic ...

Brain-nourishing molecule may predict schizophrenia relapse

... medicines as prescribed is a big reason patients relapse but science has already shown that BDNF levels ... the drug is becoming less effective and a relapse is imminent, the researchers say. Decreased ... levels may be even lower in patients when they relapse and go up, at least for a while, with treatment. ...

Cancer immunotherapy shows long-term promise in lung cancer

... for lung cancer patients, reduces the risk of relapse after surgery -- to the same extent as ... but after complete resection about 50% will relapse and die from their cancer," says Prof. ... the reduction in risk of postoperative cancer relapse is similar to the one obtained with postoperative ...

'Erasing' drug-associated memories may stop drug addiction relapses

... be altered or erased during the process called reconsolidation. Because relapse by drug abusers is often prompted when they recall drug-associated ... the effects of those memories in the future and help individuals resist relapse and maintain their abstinence." Dr Amy Milton, a co-author, said, "This ...

JCI table of contents: Aug. 16, 2007

... which targets BCR-ABL in a different way. However, patients that relapse after treatment with dasatinib, because BCR-ABL mutants emerge that are ... of the cancer returning, or at the very least increase the time before a relapse occurs In the study, which appears online on August 16 in advance of ...

New drug shows promise in treating drug-resistant prostate cancer

... men who initially received benefit from the drug but then relapsed, and their PSA levels came back up. We want to understand the mechanism of that relapse and to try to develop drugs that prevent that renewed resistance." For years, no treatment was available for CRPC; recently paclitaxel a ...

New medications show promise in treating drug-resistant prostate cancer

... men who initially received benefit from the drug, but then relapsed, and their PSA levels came back up. We want to understand the mechanism of that relapse and to try to develop drugs that prevent that renewed resistance," he said. ...

New tumor markers determine therapy intensity

... frequent malignant brain tumor in childhood, indicate precisely how aggressively the tumor will continue to spread and what the chances of disease relapse are. Researchers at the Center for Pediatric and Adolescent Medicine at the Heidelberg University Hospital and the German Cancer Research Center have ...

Positive results in Phase 2 trial of treatment of C-difficile-associated diarrhea

... said Donna Ambrosino, MD, Executive Director of the MBL and Professor of Pediatrics at UMMS. "The demonstration of significant protection from relapse indicates that treatment with monoclonal antibodies against the toxins could reduce this significant and costly public health problem." "These ...

U of MN study shows link between gene variations and cancer survival

... the disease. A research study led by Brian Van Ness, Ph.D., has successfully identified combinations of genes associated with early clinical relapse of multiple myeloma, a cancer of the white blood cells that produce antibodies. These results raise the possibility that a patient's genetic ...

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Relapse in Biological Technology

Valeant Pharmaceuticals Reports Encouraging Final Results With Taribavirin Phase IIb Study

... lower levels of anemia. In addition, relapse rates in the 25 mg/kg and 30 mg/kg arms were ... ribavirin, low doses are associated with a high relapse rate and, except for the lowest dose with taribavirin, relapse rates are also comparable to ribavirin. The ...

Sunesis Pharmaceuticals Provides Year-End Clinical Update on Voreloxin

... has now enrolled eight patients with AML in first relapse at the Schedule A MTD and complete remissions ... strategies in either newly diagnosed or first relapse AML populations." Phase 2 Trial of ... high. Treatment options remain limited following relapse and overall long-term survival has not changed ...

Study Suggests Risperidone Long-Acting Injection Combined with Standard Treatment Helped Delay Time to Relapse in Patients with Bipolar Disorder

... had a significant delay in the time to an initial relapse when risperidone long-acting injection (RLAI) was ... with placebo (p=0.004) and the relative risk of relapse was 2.4 times higher with placebo. The relapse rates were 47.8% with placebo and 22.2% with ....

The Pittsburgh Life Sciences Greenhouse Starts 2009 With Investment Momentum

... a proprietary monitoring and crisis alert service for managing the risk of relapse in 3 million patients with schizophrenia. Chronic Health Metrics' ... changes -- i.e., variability -- in the individual patient that signal relapse before serious symptoms develop. Clinical trials are underway in Erie, ...

BioCryst Reports Third Quarter 2008 Financial Results and Provides Corporate Update

... the study included evaluation of viral shedding, mortality, clinical relapse and time to resumption of usual activities. In the primary efficacy ... change from baseline in viral titer, zero mortality, no clinical relapse and a median of 10.8 days of time to resumption of usual activities. ...

BioCryst Reports Results From the First-Ever Completed Active-Controlled Phase 2 Study in Hospitalized Influenza

... of the study included evaluation of viral shedding, mortality, clinical relapse and time to resumption of usual activities. In the primary efficacy ... weighted change from baseline in viral titer, zero mortality, no clinical relapse and a median of 10.8 days of time to resumption of usual activities. There ...

Positive SPA Reply From the FDA for TopoTarget's Pivotal Trial With Belinostat in PTCL

... and are associated with a poor prognosis. Most patients with PTCL relapse after initial treatment with cytotoxic agents, and 5-year survival is less ... of extranodal NK/T-cell lymphoma. The majority of patients with PTCL will relapse after primary therapy. A number of chemotherapy regimens are used for ...

ARIUS presents new findings showing therapeutic antibody inhibits human leukemic cancer stem cells

... survival expectation for patients with AML is poor due to disease relapse and resistance to chemotherapy. CD9 appears to be an important driver for ... may provide a more effective means for increasing survival and decreasing relapse in AML and possibly other forms of leukemia." "ARIUS is very pleased to ...

Phase 2 Data Show Daclizumab Significantly Reduced Multiple Sclerosis Lesions in Patients Receiving Interferon Beta Therapy

... significance. Based on data up to week 24, analysis of the relapse rate, which was a secondary endpoint, indicates that both daclizumab regimens revealed a trend in reducing the annualized relapse rate compared to placebo (an approximately 35% reduction), but these ...

Sunesis Reports Financial Results for the Second Quarter 2009

... compares favorably relative to expected remission rates in this AML population of approximately 10 to 15 percent. In the Bolus Schedule, both first relapse and primary refractory patients are currently being enrolled in Phase 2. Updated clinical data from the Phase 2 study of single agent ...
Relapse in Biological Products

Human Cathepsin D from Calbiochem

Description:... protease in mammalian cells produced as a 52 kDa proenzyme. Overexpression of cathepsin D in human breast cancers is associated with higher risk of relapse and metastasis. Cathepsin D degrades extracellular matrix and releases growth factors bound to the matrix. Specific activity: ≥300 units/mg ...
Company:Calbiochem
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