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regulator in Medical News

New role discovered for molecule important in development of the pancreas

... Institute for Diabetes, Obesity, and Metabolism at Penn. Pdx1 is a key regulator of pancreatic development and adult beta-cell function. For example, loss ... of these mutant mice led the team to conclude that Pdx1 is a master regulator of the development of endocrine cell precursors. Pdx1 binds directly to ...

Vaporized viral vector shows promise in anti-cancer gene therapy

... the Akt signaling pathway, which has been shown to be an important regulator of cell proliferation and cancer progression. A recent report found that ... genetic changes. They transfected the lentiviral vector with a negative regulator of Akt signaling, carboxyl-terminal modulator protein (CTMP), which would ...

Recent developments at Burnham Institute for Medical Research, May 2009

... controlled. The Komatsu laboratory previously demonstrated that the R-ras regulator of cell signaling keeps blood vessel growth in check. When the R-ras gene ... of Biological Chemistry , the Komatsu group found that an important regulator called GABP increases the activity of the R-ras gene. This discovery ...

JCI online early table of contents: May 1, 2009

... for some cases of MSUD. TITLE: Protein phosphatase 2Cm is a critical regulator of branched chain-amino acid catabolism in mice and cultured cells ... for the protein Fog2 in the adult heart The protein Fog2, which is a regulator of gene expression, is essential for embryonic development of both the ...

Low Cost Oxygen Regulator: Pay Less For Quality

... safety relief valve - Sintered filter for additional safety and longer regulator life Product Features: - Inlet connection: CGA-870 - Maximum inlet ... Number: MLC-115 (Flows: 0.5,1.0,2.0,3,4,5,6,8,10,12,15 LPM) MLC Mini regulator is the durable and affordable choice for your continuous flow oxygen ...

UCSF Researchers Use New Tools to Move in on Cancer Susceptibility Genes

... the researchers identified the Vitamin D Receptor as a candidate master regulator for skin cancer in the mice. Vitamin D levels in the blood have long ... is expressed in stem cells of the skin and intestine is a candidate master regulator for the development of hair follicles. In the context of skin cancer, hair ...

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regulator in Medical Technology

Clinical Trial Results on the Sleep-Promoting Effects of Vanda Pharmaceuticals' Circadian Regulator Tasimelteon (VEC-162) Published in The Lancet

... demonstrate the sleep-promoting effects of tasimelteon, a novel circadian regulator that acts by resetting the body clock. The internal body clock is a ... alone is estimated to exceed $65 billion. The novel circadian regulator tasimelteon holds promise for the treatment of patients with misalignments ...

Early Data Presented at ASCO Show Potential of RAD001 to Enhance Efficacy of, and Overcome Resistance to, Breast Cancer Treatments

... to cancer treatment by continuously inhibiting the mTOR protein, a central regulator of tumor cell division and blood vessel growth in cancer cells. "The ... In cancer cells, RAD001 inhibits mTOR, a protein that acts as a central regulator of tumor cell division, cell metabolism and blood vessel growth. RAD001 is ...

Everolimus (RAD001) Significantly Extends Progression-Free Survival in Advanced Kidney Cancer Patients After Failure of Other Targeted Therapy

... new approach to cancer treatment by inhibiting the mTOR protein, a central regulator of tumor cell division and blood vessel growth in cancer cells. The ... cancer cells, everolimus inhibits mTOR, a protein that acts as a central regulator of tumor cell division, cell metabolism and blood vessel growth. ...

Debiopharm Group and Mercury Therapeutics, Inc. Sign an Exclusive License Agreement for the Development and Commercialisation of Debio 0930

... platform is based on a proprietary technology that enables the discovery and development of novel compounds that directly activate AMPK, a key regulator of whole body energy metabolism, cholesterol and fatty acid production, and cell division. For more information on Mercury Therapeutics please ...

Amgen Announces Positive Top-Line Results for Denosumab in Trial for Delay of Skeletal Related Events in Bone Metastases Patients Compared to Zometa(R)

... Denosumab is the first fully human monoclonal antibody in late stage clinical development that specifically targets RANK Ligand, the essential regulator of osteoclasts (the cells that break down bone). With more than 19,000 patients in trials across indications worldwide, the denosumab development ...

Telik Announces Publication of Positive Phase 1 Results of a Multicenter Study of Ezatiostat Hydrochloride (TELINTRA(R), TLK199) Tablets In Patients With Myelodysplastic Syndrome

... of action that inhibits a target enzyme called glutathione S- transferase P1-1 which in turn facilitates the activation of JNK kinase, a key regulator of cellular growth and differentiation of blood. TELINTRA has been shown to stimulate normal multilineage differentiation of blood stem cell ...

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regulator in Medical Products

Tag-It Cystic Fibrosis ASPE Mix

Description:... CLIA approved laboratories for detection of up to 70 mutations and 6 variants (polymorphisms) in the cystic fibrosis transmembrane conductance regulator (CFTR) ....
Company:Tm Bioscience Corporation

Tag-It Cystic Fibrosis ASPE Mix B

Description:... CLIA approved laboratories for detection of up to 70 mutations and 6 variants (polymorphisms) in the cystic fibrosis transmembrane conductance regulator (CFTR) ....
Company:Tm Bioscience Corporation

Tag-It Cystic Fibrosis PCR Mix B

Description:... CLIA approved laboratories for detection of up to 70 mutations and 6 variants (polymorphisms) in the cystic fibrosis transmembrane conductance regulator (CFTR) ....
Company:Tm Bioscience Corporation

Tag-It Cystic Fibrosis PCR Mix

Description:... CLIA approved laboratories for detection of up to 70 mutations and 6 variants (polymorphisms) in the cystic fibrosis transmembrane conductance regulator (CFTR) ....
Company:Tm Bioscience Corporation

PYY, Total ELISA Test

Description:... Peptide YY (PYY) was first identified in 1980 (1) and has only recently been appreciated as a hormonal regulator of appetite (2). PYY is produced by the gut and released into the circulation after food intake, and is found to decrease appetite. The main form of ...
Company:Diagnostic Systems Laboratories, Inc.

Leptin Soluble Receptor ELISA Test

Description:... this is a unique binding protein or represents a form of the leptin receptor remains unclear. However, this carrier protein may be an important regulator and may explain rapid changes in serum leptin levels that occur as a result of starvation or forced feeding. Leptin may also play a role in other ...
Company:Diagnostic Systems Laboratories, Inc.

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regulator in Medical Definition

Autoimmune regulator

... Autoimmune regulator Identifiers Symbol AIRE Alt. Symbols AIRE1, APECED, APS1, APSI, PGA1 Entrez 326 HUGO 360 ...
regulator in Medical Dictionary

Chloride

... edriophthalmous; edrophonium; edrophonium chloride ; ... It is caused by a genetic abnormality in the CF trans membrane conductance regulator (CFTR) gene that results in the disruption of chloride transfer across cell membrane s. Diphenhydramine hydro chloride , 25 mg to 50 mg ...
regulator in Biological News

New diagnostic advance seen for head, throat cancer

... today announced the discovery of a genetic regulator that is expressed at higher levels in the most ... research has been demonstrated to be a master regulator that has important roles in many biological ... to this type of cancer." That this genetic regulator could be involved in both skin development and ...

UC Davis researchers discover a key to aggressive breast cancer

... itself is the culprit. By shutting down its own regulator gene, HER2 creates a permissive environment for ... Building on recent research showing that the regulator labeled LRIG1 and commonly called "Lig-1" ... that, when compared to healthy breast tissue, the regulator is significantly suppressed. "This suppression ...

Mayo Clinic researchers discover and manipulate molecular interplay that moves cancer cells

... cells and found that movement was blocked. PKD1 is therefore a negative regulator of directed cell migration, and if PKD1 is not expressed in tumor cells, ... and so the cell cannot move. "Now that we have identified PKD1 as key regulator in processes regulating actin-based directed tumor cell movement, we can ...

Female embryonic sexual development driven by universal factor

... into testis or ovary. This molecule, beta-catenin, is an important regulator of cell proliferation and differentiation. When it functions as a ... "That tells us very conclusively that beta-catenin is an internal regulator of this pathway," Yao said. To see how the absence of beta-catenin ...

Relationship between environmental stress and cancer elucidated

... such as oxidative stress, recruit a protein called SENP1 that cuts a regulator called SUMO1 away from the enzyme SIRT1 so its activity level drops, says ... apoptosis, becomes more active. SIRT1, found throughout the body, is a regulator of protein function through a process called acetylation. MCG researchers ...

Scientists track impact of DNA damage in the developing brain

... said those reports sparked new interest in single-strand DNA repair. This study focused on Xrcc1, a protein long recognized as the master regulator of a pathway essential for single-strand DNA repair in the nervous system. The brain is thought to be particularly susceptible to such damage because ...

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regulator in Biological Technology

BioMarin Licenses Technology From Leading Cystic Fibrosis Research Laboratory at the University of California, San Francisco

... demonstrated to improve cystic fibrosis transmembrane conductance regulator (CFTR) protein functionality. BioMarin expects the lead compounds to ... caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. With an incidence of approximately 1/3,500 births, cystic ...

Amgen to Participate in Reproductive Health Drugs Advisory Committee Meeting in August

... Denosumab is the first fully human monoclonal antibody in late stage clinical development that specifically targets RANK Ligand, an essential regulator of osteoclasts (the cells that break down bone). Denosumab is being investigated for its potential to inhibit all stages of osteoclast activity ...

PeriCor Therapeutics Reports Positive Preclinical Results of GP531 at the European Heart Failure Congress in Nice

... metabolite" that targets multiple pathways of cellular stress and myocardial injury to counter net ATP catabolism and, as such, acts as a key regulator of cellular energetics. Endogenous adenosine protects cells from multiple pathways of injury such as inflammation, apoptosis and necrosis. Endogenous ...

MIT reels in RNA surprise with microbial ocean catch

... samples, she found that much of the novel RNA they expected to be protein-coding was actually small RNA (or sRNA), which can serve as a catalyst or regulator for metabolic pathways in microbes. "What's surprising to me is the abundance of novel sRNA candidates in our data sets," said Shi. "When I looked ...

EntreMed ENMD-2076 Phase 1 Data to Be Presented at ASCO Annual Meeting

... currently in Phase 1 studies in advanced cancers and multiple myeloma. The Company's other therapeutic candidates include MKC-1, an oral cell-cycle regulator with activity against the mTOR pathway currently in multiple Phase 2 clinical trials for cancer, and ENMD-1198, a novel antimitotic agent currently ...

Tigris Pharmaceuticals Presents Results of Breast Cancer Research at AACR Annual Meeting

... mechanism of action of AF is believed to be that treatment with AF results in translocation of the arylhydrocarbon receptor (AhR; a transcriptional regulator of CYP1A1) from the cytoplasm to the nucleus, and its subsequent interaction with the xenobiotic-response element (XRE) sequence on the CYP1A1 ...

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regulator in Biological Products

Rabbit Anti-IFRD2 Polyclonal Antibody, Unconjugated from Proteintech Group, Inc.

Description:... interferon-related developmental regulator ...
Company:Proteintech Group, Inc.

Supercritical fluid chromatography and extraction systems (SFC/SFE) from JASCO

Description:... for supercritical fluid chromatography and extraction procedures using carbon dioxide as the mobile phase. - The BP-1580-81 automatic back pressure regulator to maintain the pressure of the mobile phase above its critical ....
Company:JASCO

Tubing Prep Station, 100-120 V from Bio-Rad

Description:... discharge with the Helios gene gun. The station includes a tubing support cylinder, power cord, O-rings, tubing prep unit, 12 foot Nalgene nitrogen regulator hose, two 0.1875 inch barb-to-male Luer-Lok fittings, nitrogen flowmeter fitting, 2.125 inch barb-to-male Luer-Lok fitting, one 0.078125 Allen ...
Company:Bio-Rad

Perfusion Pressure Kit - 8 channel from AutoMate Scientific, Inc

Description:... 0-10 psi precision pressure regulator and pressurized syringe holder for any researcher who needs: Faster liquid-switching Steady flow rate Microinjecting Fine microliter delivery ...
Company:AutoMate Scientific, Inc

Rabbit Anti-Human COP9 signalosome complex subunit 2 Polyclonal Antibody, Unconjugated from Aviva Systems Biology

Description:... component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes. The complex is also ...
Company:Aviva Systems Biology

Rabbit Anti-Human Regulator of g-protein signaling 2 Polyclonal Antibody, Unconjugated from Lifespan Biosciences

Description: Immunogen: Synthetic peptide corresponding to amino acids 22-37 SGHKSEEKREKMKRTL Antigen Family: Regulator of G-protein signalling; Antigen Subfamily: not assigned-Regulator of G-protein signalling Recommended Storage: Long term: -70C; Short term: ...
Company:Lifespan Biosciences

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regulator in Biological Definition

Homeobox

... . The diagram to the right is a structural model of the Rattus norvegicus Pit-1 homeobox-containing protein (purple) bound to DNA. Pit-1 is a regulator of growth hormone gene transcription. Pit-1 is a member of the POU DNA-binding domain family of transcription factors so it can bind to DNA using ...

Homeostasis

... is essential to living things as the lack of it harms the genetic material. With regard to any parameter , an organism may be a conformer or a regulator . Regulators try to maintain the parameter at a constant level, regardless of what is happening in its environment. Conformers allow the ...

Lac repressor

... various types of proteins. But human cells need a way to select the appropriate recipes for the current ambient conditions. For this humans need regulator molecules that act like factory foremen. They monitor the environment and use the information to signal to the cell. An enhancer tells the cell to ...

Thermoregulation

... of heat. And in such animals as the dog, who do not perspire easily by the skin, respiration becomes far more important. But for man the great heat regulator is undoubtedly the skin, which regulates heat loss by its vasomotor mechanism, and also by the nervous mechanism of perspiration. Dilatation of the ...

Unsolved problems in biology

... the proteome proteins expressed by a cell or organ at a particular time and under specific conditions? What is the complete function of the regulator genes ? The building block of life may be a precursor to a generation of electronic devices and computers , but what are the electronic properties ...

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regulator in Biological Dictionary

Telomere

... of diabetic nephropathy in patients with type 1 diabetes. ... Telomere dysfunction provokes regional amplification and deletion ... Negative regulator of telomere length (telomerase-dependent pathway) ... Tankyrase-mediated ADP-ribosylation of TRF1 inhibits binding to telomere repeats ... ...

Secondary metabolite

... products ... Secondary metabolites can be classified by their chemical structure or physical ... WARF Technology Summary P02379US: A Global regulator of Secondary Metabolite Biosynthesis in Fungi ... Secondary metabolites display a broad range of ... Prkofiles of secondary metabolites ...

Regulatory sequence

... for the detection of regulatory signals in non-coding sequences . ... Regulatory sequences . Synonym(s) genetic regulatory element. regulator regions, nucleic acid ... A DNA base sequence that controls gene expression. ... What is regulatory sequence ? Meaning of regulatory ...

Gastrin

... Produced. Peptide Ligand. Health and beauty. Health and fitness. Gastric Inhibitory Peptide ... INTRODUCTION Gastrin is the major hormonal regulator of gastric acid secretion 1 ... GASTRIN PHYSIOLOGY. Transgenic and gene deletion animal models. Causes of ... The European ...

Copy number control

... with a utility's NUC symbol and control number , ... Transcription initiation of the copy - number control and better-than-random ... as a regulator of plasmid genes for copy - number control and stable inheritance. ... 2 votes. Sociobiological Control of Plasmid copy number . Mukta ...

Centrosome

... cell biology, the centrosome is an organelle that serves as the main microtubule organizing center (MTOC) of the animal cell as well as a regulator of cell-cycle progression. It was discovered by Edouard Van Beneden in 1883 and was described and named in 1888 ... centrosome ( ) n. A small ...

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