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Recombination in Medical News

NYU School of Medicine pathology researchers solve another mystery in B lymphocyte development

... in the nucleus at stages that coincide with V(D)J recombination of the heavy and light chain (Igh and Igk) loci. ... and helps ensure that only one allele undergoes recombination at a time (a process known as allelic exclusion). In "RAG-1 and ATM Coordinate Monoallelic recombination and Nuclear Positioning of Immunoglobulin Loci," ...

Geneticists at the American Museum of Natural History trace the evolution of St. Louis encephalitis

... Flavivirus. Previous research had found that recombination (the cutting and pasting of strands of genetic ... in the coding for an envelope protein rather than recombination most likely caused changes that made the virus pathogenic to humans. recombination is important for disease; it makes novel proteins ...

Penn researchers identify first sex chromosome gene involved in meiosis and male infertility

... homologous chromosomes undergo pairing, synapsis, recombination and faithful segregation. Meiosis allows the ... appears to be a novel constituent of the meiotic recombination machinery. The team genetically engineered male ... of spermatocytes at later stages in the genetic recombination process and, ultimately, male infertility. ...

New genetic lineage of Ebola virus discovered in great apes

... are capable of exchanging genetic material by recombination processes. This process is currently well known ... derived from this research put the time of the recombination events at between 1996 and 2001. The events would ... of Congo between 2001 and 2003. Now if genetic recombination mechanisms are indeed part of the arsenal of the ...

Researchers crack the code of the common cold

... when many different strains of rhinovirus may be causing infections, recombination could rapidly produce new strains. Multiple mutations (as many as 800) ... a large number of patients, it is likely that hotspots for mutation or recombination will become apparent, and other regions resistant to mutational change may ...

Genetic Code of Common Cold Cracked

... genetic material from two separate strains infecting the same person. Such recombination had not been thought possible for rhinoviruses. That recombination is one reason why a vaccine against the common cold appears to be ...

Inverted DNA turns quiet developmental gene into a potent driver of t-cell lymphoma

... to create new combinations of proteins to respond to disease threats. This recombination process allows B cells to generate antibodies and T cells to generate T ... mice exhibited the inversion in 15 of 15 tumors they examined. Genetic recombination is a frequent component of T-cell malignancies, but it is startling to see ...

American Chemical Society's weekly PressPac -- Jan. 23, 2008

... may help increase the accuracy and efficiency of the homologous recombination of genes a process responsible for DNA repair, evolution, and genetic diversity. The new findings thus may shed light on ways to avoid recombination errors, which underpin cancer, aging, and other health problems. In the ...

BRIT1 allows DNA repair teams access to damaged sites

... damage site. The team showed that normal BRIT1 aids repair of double-stranded DNA breaks by allowing access to two repair pathways: homologous recombination (HR) and non-homologous end-joining (NHEC). DNA repair efficiency dropped by between 40 and 60 percent in cells with BRIT1 knocked down that were ...

Research suggests new cellular targets for HIV drug development

... is because macrophages multiply as a result of an inflammatory response, the researchers said. "The study points to macrophages as a site of recombination in active disease," said neurobiologist Kenneth C. Williams, Ph.D., a Boston College associate professor and AIDS expert who was not involved in the ...

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Recombination in Medical Technology

deCODE and SGENE Consortium Discover Deletions in the Human Genome Linked to Risk of Schizophrenia

... human genome that confer risk of schizophrenia. Such deletions are gaps in the normal sequence of the genome that can arise spontaneously during the recombination or reshuffling of the genome that takes place in the creation of sperm and eggs. The deletions reported in today's study are located on chromosomes ...

Sunesis Pharmaceuticals to Present Non-Clinical Data at the Annual Meeting of the American Association for Cancer Research

... San Diego Convention Center -- Sensitivity to SNS-595 is related to activation of double strand DNA break repair pathways including homologous recombination Session: Stress Responses Abstract #1859 8:00 a.m. - 12:00 p.m. Exhibit Hall B-F, San Diego Convention Center -- Ex vivo activity of ...

AVI BioPharma Reports Positive Pre-Clinical Influenza Data

... the H5N1 subtype. It is thought that co-infection of humans or certain animals (such as pigs) with both H1N1 and H5N1 can lead to a reassortment or recombination of viral particles, resulting in the emergence of a virus with dangerous public health properties, namely one to which the human population has no ...
Recombination in Biological News

Forced evolution: Can we mutate viruses to death?

... wanted to focus more attention on the roles that recombination and horizontal gene transfer play in the ... what we're doing here," he said. "If you know the recombination rate, mutation rate and fitness function, our ... the properties of the system. So, if you have recombination at a certain frequency, I can say exactly how ...

The structure of the Mre11 protein bound to DNA

... door to the predetermined control of homologous recombination for cancer therapeutics and gene targeting." The power of homologous recombination Homologous recombination is important not only for error-free repair of ...

Viral recombination another way HIV fools the immune system

... been released online. "The implication that recombination events are selected by immune responses ... had developed, possibly in response to a second recombination of viral sequences. "The first Gag recombination event facilitated escape from the primary immune ...

Zooming in on genetic shuffling

... UK, present the most precise map of genetic recombination yet. The study sheds light on fundamental ... exchange of larger fragments, but both types of recombination can increase genetic diversity and explain why ... same species differ in many ways. Both types of recombination can also act to separate the transmission of ...

Estimation of isolation times in the Drosophila simulans complex

... patterns of genes in regions of low and higher recombination can be reconciled by allowing a modestly larger ... those in parts of the genome characterized by low recombination appear to have become isolated more recently than ... rest of the genome. This could mean that the low recombination genes were able to move between species after ...

Centromeres cross over, a lot

... recombination at centromeres is higher than anywhere else on ... of the Journal of Cell Biology . Centromeric recombination has been hard to study because the DNA at ... only one chromatid would show a signal if no recombination had occurred. Instead, the authors found that ...

'Telepathic' genes recognize similarities in each other

... other in order to begin the process of homologous recombination whereby two double-helix DNA molecules come ... and then close themselves up again. recombination is an important process which plays a key role in ... for similar genes to begin the complex process of recombination without the help of proteins or other biological ...

Enhanced DNA-repair mechanism can cause breast cancer

... BRCA1 itself promotes DNA repair through recombination and the conventional view is that loss of BRCA1 ... cells that lack BRCA1 overcome the defects in recombination caused by loss of BRCA1," Bishop said, "but the recombination that occurs in this situation may be abnormal and ...

Is this the beginning of the end of plant breeding?

... division; co-segregation of sister chromatids at the first division; and recombination that occurs during the first divisiona swapping over process that adds ... this gene with two other previously described mutationsone that eliminates recombination and another that modifies chromosome segregationthe authors have created a ...

NYU College of Dentistry awarded $1.9 million NIH grant for HIV research

... recombination. "Previous work from my laboratory demonstrated that recombination between viruses occurs frequently, and our most recent study reveals that recombination is likely to be even more frequent than was previously thought. "This ...

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Recombination in Biological Technology

deCODE Discovers Gene Variants that May Help to Distribute the Work of Evolution between Men and Women

... that occurs in the formation of eggs and sperm. recombination is largely responsible for generating human ... the versions of the SNPs that increase recombination in men decrease it in women, and vice versa. This ... for approximately 22% of paternal variability in recombination and 6.5% of maternal variability. Little is known ...

Consortium publishes Phase II map of human genetic variation

... In their overview paper, researchers report that recombination rates vary more than six-fold among different gene classes. The highest rates of recombination were found among genes involved in the bodys ... such as signaling, were found to be more prone to recombination than those that code for proteins internal to ...

J. Craig Venter Institute Researchers Publish Significant Advance in Genome Assembly Technology

... creating the synthetic bacterial genome using a method called homologous recombination (a process that cells naturally use to repair chromosome damage). ... into yeast cells in one step and through the mechanism of homologous recombination were assembled into the synthetic M. genitalium genome. Several ...

Nanowires may boost solar cell efficiency, UC San Diego engineers say

... path from the p-n junction to the electrode a situation which increases recombination between holes and electrons and reduces efficiency in converting sunlight ... connected to an electrode. Thus, they do not minimize electron-hole recombination by providing electrons with a direct path from the p-n junction to the ...

Scientists create colorful 'brainbow' images of the nervous system

... proteins that cause cells to glow, Brainbow uses a well-known genetic recombination system known as Cre/lox in a new way, to shuffle genes encoding green, ... and inserted it into neuronal DNA. As they predicted, the cut-and-paste recombination occurred totally at random, in the process assigning scores of different ...

R-Tech Ueno Notifies R&D Items

... macular degeneration. 3. Development code RU-10 (eye diseases) Dry eye is targeted for development of the drug that contains gene recombination human serum albumin as an effective ingredient. Though the clinical study is currently interrupted, we intend to look for overseas affiliation soon ...

Frost & Sullivan Awards Precision Biosciences for Technology Innovation and Molecular Design Process in the Genomics Market

... of a genome can be combined with the introduction of synthesized sequence elements or DNA segments of interest," notes Dr. Basu. "The process of DNA recombination can then result in the production of transformed DNA elements, thereby modifying targeted genomes." Such modifications have wide-ranging ...

Chromosome breakpoints contribute to genetic variation

... and inversions can cause subtle or dramatic changes in how the genes function. Scientists once hypothesized that chromosomal breakage and recombination occurred randomly along the chromosomes during evolution. But in 2003, a team from the University of California at San Diego and the Lewin laboratory ...

Cellectis and Regeneron Sign an Agreement Over the use of Homologous Recombination Technology

... than October 30, 2008. About the licensed patents: The agreement relates to Institut Pasteur's patents covering certain uses of homologous recombination (US patents #6 528 313, 6 638 768 and 6 528 314, Japanese patents #3059481, #3298842 and #3298864 and European patents EP #419 621 and #682 112). As ...

Cellectis Sues Precision BioSciences for Infringement of its Patents Concerning Meganuclease Technology

... pending patent applications. Most of these patents are based on Cellectis' fully integrated genome engineering system referred to as its Meganuclease recombination Systems (MRSs). These systems offer natural, efficient, precise and flexible genome surgery with several applications, among others, in the ...

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Recombination in Biological Products

* Quick & Easy E. coli Gene Deletion Kit from Gene Bridges GmbH

Description:... or alter genes on the E.coli chromosome in less than one week. Red/ET recombination allows the exchange of genetic information in a base pair precise, ... kit which can be used to replace a gene on the E.coli chromosome. Red/ET recombination can replace fragments as large as 30kb from the E.coli chromosome. The ...
Company:Gene Bridges GmbH

BacMagic™ DNA Kit from Novagen

Description:... in a compatible transfer plasmid, such as the pBAC™or pTriEx™ vectors, is cotransfected with BacMagic DNA into insect cells. Homologous recombination within the cells restores the function of the virus ORF1629 while the target coding sequence replaces the BAC sequence. Only the recombinant ...
Company:Novagen

* Quick & Easy Conditional Knock Out Kit - loxP from Gene Bridges GmbH

Description:... E.coli with a eukaryotic promoter (PGK) for expression of neomycin resistance in mammalian cells. The included 706-Cre expression plasmid allows Cre recombination in E.coli . This kit can also be used to work on bacterial artificial chromosomes (BACs). The generation of targeting constructs is achieved ...
Company:Gene Bridges GmbH

loxP flanked, Pro and Euk. Neomycin Selection Cassette (loxP-PGK-gb2-neo-loxP) from Gene Bridges GmbH

Description:... by adding the corresponding sequence in the PCR primer. The template can easily be used to generate targeting constructs mediated by a single Red/ET recombination step. The loxP-PGK-gb2-neo-loxP template is not linear but plasmid based (3446bp in size). Due to its R6K origin it can not replicate in most E.coli ...
Company:Gene Bridges GmbH

FRT flanked, Pro and Euk. Neomycin Selection Cassette (FRT-PGK-gb2-neo-FRT) from Gene Bridges GmbH

Description:... by adding the corresponding sequence in the PCR primer. The template can easily be used to generate targeting constructs mediated by a single Red/ET recombination step. The FRT-PGK-gb2-neo-FRT template is not linear but plasmid based (3446bp in size). Due to its R6K origin it can not replicate in most E. coli ...
Company:Gene Bridges GmbH

Mut S from USB Corp.

Description:... role in proofreading the nascent strands in DNA replication, in transcription-coupled nucleotide excision repair and in preventing chromosomal recombination between different species of bacteria. Mut S binds to DNA specifically at base pair mismatches and small (<4 nt) insertions and ....
Company:USB Corp.
Recombination in Biological Definition

Genetic recombination

... Genetic recombination is the process by which the combination of ... genetics . However, in molecular biology , recombination generally refers to the molecular process by ... the structure of genes. One mechanism leading to recombination is chromosomal crossing over . In analog ...

Recombination

... recombination usually denotes a genetic event that occurs ... In biology , the process of Genetic recombination and meiosis , as summarized above. In ... the Ionosphere . In evolutionary computing recombination is another name for crossover. ...

Gene therapy

... the cell, but also to be incorporated into the chromosomes by genetic recombination . Somatic gene therapy can be broadly split in to two categories: ex ... in vivo are especially uncommon, because for most DNA constructs recombination is a very low probability event. Ex vivo The ex vivo approach was ...

Lambda phage

... P-O-P'. The integration itself is a sequential exchange (see genetic recombination ) via a Holliday structure and requires both the phage protein int ... and built an intrasome , a DNA-protein-complex designed for site-specific recombination of the phage and host DNA. The original BOB' secuanes is changed by the ...

Meiosis

... complex dissasembles (homologous chromoses are kept together by recombination nodules ), there is cellular growth and genetic transcription (and so ... and the establishment of new ones. See also Mitosis Genetic recombination Chromosome Diploid Haploid Sperm Ovum ...

Antibody

... Brooks/Cole. ISBN 0534421741 External links Lymphomation: Immunoglobulins How Lymphocytes Produce Antibody PLOS primer: V(D)J recombination and the Evolution of the Adaptive Immune System ...

Bacterial conjugation

... one must not. The F-plasmid (also called F-factor) is an episome (a plasmid that can integrate itself into the bacterial chromosome by genetic recombination ) of about 100 kb (kilo base pairs ) length. It carries its own origin of replication , called oriV . There can only be one copy of the F-plasmid ...

Cell growth

... . Notice that when meiosis starts, the two copies of chromosome number 2 are adjacent to each other. During this time, there can be genetic recombination events. Parts of the chromosome 2 DNA that you got from your mother (red) will swap over to the chromosome 2 DNA molecule that you got from your ...

Chromosomal crossover

... The physical basis of crossing over was first demonstrated by Harriet Creighton and Barbara McClintock in 1931 . See also Genetic recombination Recombinant frequency ...

DNA

... so that another double-stranded segment can pass through. Unknotting is required for the replication of circular DNA as well as for various types of recombination in linear DNA. Great length versus tiny breadth The narrow breadth of the double helix makes it impossible to detect by conventional ...

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Recombination in Biological Dictionary

Site-specific recombination

... Site - specific recombination , also known as conservative site - specific recombination , is a type of genetic recombination in which DNA strand exchange takes place ...

Recombination nodules

... Synaptonemal complex and recombination nodules in wild-type Drosophila melanogaster females. ... Gene conversion, recombination nodules , and the initiation of ... Synaptonemal complex and recombination nodules in wild-type Drosophila melanogaster ...

Recombination frequency

... (Redirected from recombination frequency ) Jump to: navigation, search ... The greater the frequency of recombination (segregation) between two genetic ... Genetic recombination is the process by which a strand of genetic ...

Recombination

... Genetic recombination is the process by which a strand of genetic ... to a different DNA molecule. In eukaryotes recombination occurs in mitosis as a common mechanism of DNA repair and ... Genetic recombination , the process by which genetic material is ...

LOD score

... ... 3 LOD score method for estimating recombination frequency. 4 recombination frequency ... Lod Score Method of ... lod score there is one free parameter, the recombination ... BioInfoBank Library :: Lod Score :: ...

Intragenic

... , inter ... analysis : detection of intragenic recombination or gene. conversion. ... Two methods are ...... Nevertheless, it appears that intragenic recombination alone is insufficient to ... If intragenic recombination is sufficiently frequent, it may be the ...

Homologous recombination

... Homologous recombination , also known as general recombination , is a type of genetic recombination in which genetic material is exchanged between ...

Heteroduplex Dna

... of nucleic acid originated through the genetic recombination of single complementary strands derived from ... summaries, ... Heteroduplex DNA in Meiotic recombination in Drosophila mei-9 Mutants ... Heteroduplex DNA in Meiotic recombination in Drosophila mei-9 Mutants summary ... HighBeam ...

Heteroduplex

... of nucleic acid originated through the genetic recombination of single complementary strands derived from ... at Britannica. Assorted References general recombination ( in nucleic acid (chemical compound): General recombination ) It is important to note that the initial ...

Genetic recombination

... Genetic recombination is the process by which a strand of genetic ... to a different DNA molecule. In eukaryotes recombination occurs in mitosis as a common mechanism of DNA repair and ... Genetic recombination . From CreationWiki, the encyclopedia of creation ...

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