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Receptor in Medical News

Ferring Pharmaceuticals Announces Trade Name FIRMAGON(R) (degarelix for injection) for Advanced Prostate Cancer Treatment

... injectable gonadotropin-releasing hormone (GnRH) receptor antagonist indicated for patients with advanced ... injectable gonadotropin-releasing hormone (GnRH) receptor antagonist approved by the U.S. Food and Drug ... the treatment of advanced prostate cancer. As a receptor antagonist, FIRMAGON reversibly binds to the GnRH ...

Advanced targeted therapies effective as first-line treatment for lung cancer

... OUTCOMES OF PATIENTS WITH EPIDERMAL GROWTH FACTOR receptor (EGFR) MUTATIONS IN IPASS (IRESSATM PAN ASIA ... (ABSTRACT # B9.5) An epidermal growth factor receptor (EGFR) is a protein found on the surface of cells ... a protein called the epidermal growth factor receptor (EGFR). EGFR, which helps cells divide, is found ...

QuatRx Announces Further Positive Phase 3 Results For Ophena(TM) (Ospemifene Tablets) in Postmenopausal Vaginal Atrophy

... for Ophena(TM) , a new SERM (selective estrogen receptor modulator) for the treatment of the symptoms of ... program. Fispemifene is a new selective estrogen receptor antagonist that is in Phase 2 studies as an oral ... in men. Sobetirome, a novel, selective thyroid receptor beta agonist, is in Phase 1 as a potential ...

Colon capsule endoscopy diagnoses 64 percent of total polyps detected by conventional colonoscopy

... images per second. The pictures are recorded by a receptor which enables them to be downloaded subsequently ... passing through the intestine are recorded in the receptor which has to be attached to the patient that same ... That evening the person being examined takes the receptor to the medical services who download the images ...

Eliminating Cell Receptor Prevents Infections in Animal Study

... mice genetically engineered to lack a particular receptor in heart and pancreas cells, the study team ... process. In this case, we confirmed that this receptor really is involved in the disease." The ... , focused on the coxsackievirus and adenovirus receptor (CAR), which Bergelson discovered in 1997. He ...

Portola Pharmaceuticals Announces Several Scientific Presentations at International Society on Thrombosis and Haemostasis XII Congress

... antiplatelet drug elinogrel, a P2Y(12) ADP receptor antagonist currently in Phase II clinical ... & Co., Inc., and elinogrel, its P2Y(12) ADP receptor antagonist and potential competitor for Plavix* ... cancer and inflammatory diseases; a thromboxane receptor antagonist, which is an aspirin replacement ...

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Receptor in Medical Technology

Arena Pharmaceuticals Announces Lorcaserin Data Demonstrating Highly Significant Categorical and Absolute Weight Loss and Improvements in Secondary Endpoints Associated with Cardiovascular Risk

... first in a new class of selective serotonin 2C receptor agonists. The serotonin 2C receptor is located in areas of the brain involved in the ... such as the hypothalamus. Stimulation of this receptor is strongly associated with feeding behavior and ...

Medivation Announces Positive New Efficacy Data From Phase 1-2 Trial of MDV3100 in Advanced Prostate Cancer Patients

... evaluating MDV3100, a next-generation androgen receptor antagonist, in castration-resistant prostate ... to those achieved with first-generation androgen receptor antagonists." In vitro data recently ... of action is unlike that of the leading androgen receptor antagonist, bicalutamide. Specifically, MDV3100: ...

Arena Pharmaceuticals Announces the Presentation of Lorcaserin Phase 3 BLOOM Data at the American Diabetes Association's 69th Scientific Sessions

... first in a new class of selective serotonin 2C receptor agonists. The serotonin 2C receptor is located in areas of the brain involved in the ... such as the hypothalamus. Stimulation of this receptor is strongly associated with feeding behavior and ...

PROTECT-1 Phase II/III Induction-Stage Results for ChemoCentryx's Traficet-EN(TM) Presented in Oral Session at DDW 2009 Conference

... Efficacy of the Intestine-Specific Chemokine receptor Antagonist CCX282-B (Traficet-EN) in Treatment of ... disease. "Targeting the CCR9 chemokine receptor represents a new and highly specific approach to ... is an orally-active inhibitor of the chemokine receptor known as 'CCR9', which is selectively expressed ...

Scientists at The Karmanos Cancer Institute in Detroit Identify Potential New Target for Breast Cancer Therapy

... new therapeutic target for aggressive hormone receptor negative breast cancer tumors. (Logo: ... Karmanos scientists tested 84 cases of hormone receptor negative human breast carcinomas and discovered ... expressed in 74 percent of those cases. Hormone receptor negative breast carcinoma is considered an ...

Keryx Biopharmaceuticals Reports Single Agent Phase 2 Data of KRX-0401 (Perifosine) Further Demonstrating KRX-0401's Activity in the Treatment of Advanced Metastatic Renal Cell Cancer

... after Failing Treatment Either with a VEGF receptor Inhibitor or after Treatment with both a VEGF receptor Inhibitor and an mTOR Inhibitor NEW YORK, ... (PFS) in RCC patients who failed a prior VEGF receptor inhibitor (sunitinib or sorafenib). Safety of ...

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Receptor in Medical Products

Growth Hormone Binding Protein ELISA Test

Description:... extra-cellular domain of the Growth Hormone (GH) receptor and is an integral component of the growth ... it is either a cleavage product of the GH receptor or a splice variant of the GH receptor gene. Growth ...
Company:Diagnostic Systems Laboratories, Inc.

Leptin IRMA Test

Description:... sites in the hypothalamus to regulate appetite. Involvement of a leptin receptor or carrier protein in this kind of regulation has been suggested. Serum ... this is a separate protein or represents a circulating form of the leptin receptor remains to be investigated but this may be an important form of regulation ...
Company:Diagnostic Systems Laboratories, Inc.

Leptin ELISA Test

Description:... sites in the hypothalamus to regulate appetite. Involvement of a leptin receptor or carrier protein in this kind of regulation has been suggested. Serum ... this is a separate protein or represents a circulating form of the leptin receptor remains to be investigated but this may be an important form of regulation ...
Company:Diagnostic Systems Laboratories, Inc.

VerifyNow IIb/IIIa Assay

Description:... that induces the platelet to change the conformation of the GP IIb/IIIa receptor to a form that binds fibrinogen (Iso-TRAP). Additionally, the detection ... binding of the microbeads with activated platelets, since the GP IIb/IIIa receptor sites are blocked by the drug and cannot bind to the fibrinogen coated ...
Company:Accumetrics

IGF-II, w/ Extraction IRMA Test

Description:... by binding to target cell receptors. IGF-II binds with high affinity to the Type II IGF receptor, a monomeric protein which also serves as the receptor for mannose-6-phosphate [1]. However, it is believed that binding to the Type I IGF and insulin receptors may mediate the mitogenic actions of IGF-II ...
Company:Diagnostic Systems Laboratories, Inc.

IGF-II, w/ Extraction ELISA Test

Description:... by binding to target cell receptors. IGF-II binds with high affinity to the Type II IGF receptor, a monomeric protein which also serves as the receptor for mannose-6-phosphate [1]. However, it is believed that binding to the Type I IGF and insulin receptors may mediate the mitogenic actions of IGF-II ...
Company:Diagnostic Systems Laboratories, Inc.

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Receptor in Medical Definition

Depolarization-induced suppression of inhibition

... that DSI was dependent on the cannabinoid CB1 receptor function, there was no way of producing an in ... heavy involvement of the CB1 cannabinoid receptor in DSI, suggesting that the endocannabinoids ... mediators of DSI. They showed that cannabinoid receptor agonists, drugs that mimic the actions of ...

Thymocyte

... point, the beta chain of the T cell receptor rearranged by the thymocyte must retain the ... with gross defects introduced into the T cell receptor by gene rearrangement. In order to be ... Positive selection selects cells with a T cell receptor able to bind MHC class I/II or peptide ...

Central tolerance

... to self. [1] The process is required due to the random generation of receptor specificities that occurs during T cell and B cell differentiation, ... : Negative selection ( apoptosis ) Anergy (non-responsiveness) receptor editing (changing the specificity of the autoreactive cell) [4] ...

Neuropsychiatry

... maternal parenting/escapism/ unresolved feelings of homosexuality NMDA receptor activation in the human prefrontal cortex Ross et al (2006) Visual ... that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder. Molecular Psychiatry, ...
Receptor in Medical Dictionary

Estrogen

... used to decrease bone loss. Estrogen receptor positive. Breast cancer cells that have a ... s Ethinyl estradiol ... selective estrogen receptor modulator (SERM) New class of drug with ... produced primarily by the ovaries. Estrogen receptor assay (ER assay) A test that determines if ...

Histamine

... eating the offending food . Histamine H-2 receptor blockers stop the action of histamine on the ... Maxamine, formerly EpiLeukin) A phagocyte H2 receptor agonist intended for use in conjunction with ... of the action of histamine at histamine H2 receptor sites on the parietal cells. If this is not ...

Androgen

... sex hormone s, or by taking other drugs (antiandrogens). Androgen receptor gene variants have been examined in relation to both prostate cancer risk and disease progression. The androgen receptor is expressed during all stages of prostate carcinogen esis. Male ...

DIC

... ). MAURA DIC KLER, MD: HER2 stands for "human epidermal growth factor receptor type 2," and really it's a name of a receptor that sits on the surface of a breast cancer cell . The NKU DIC ...

Heart transplant

... Angiotensin Converting Enzyme -inhibitors (ACE-Inhibitors) Angiotensin II receptor antagonists (commonly called angiotensin II receptor blockers) ... A heart transplant is surgery in which a patient with ...

Intracellular

... others tend to be outside cells, or are extracellular. RET encodes a receptor tyrosine kinase with extracellular, trans membrane , and intracellular domains. Details of RET receptor and ligand interaction in this signalling pathway have been reviewed. ...

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Receptor in Biological News

Study reveals a reprogrammed role for the androgen receptor

... BOSTONThe androgen receptor a protein ignition switch for prostate cancer ... of adaptability. When drug therapy deprives the receptor of androgen hormones, thereby halting cell proliferation, the receptor manages to find an alternate growth route. A new ...

Scientists link immune system's natural killer cells to infant liver disease

... to halt disease progression by blocking the Nkg2d receptor and depleting NK cells at the time biliary ... they discovered that NK cells rely on the receptor gene, Nkg2d, to make contact with and attack bile ... damage. When researchers blocked the Nkg2d receptor and depleted the number of NK cells, it prevented ...

Dual role in breast tissue for a protein involved in leukemia

... to estrogen receptor-negative. When estrogen receptor levels were overexpressed, loss of Stat5a reduced ... type of preneoplasia. However, when estrogen receptor levels were normal, loss of Stat5a not only had ... was the same or different in cells with estrogen receptor overexpression. They found that Stat5a A is ...

Breakthrough in the treatment of bacterial meningitis

... that all three pathogens target the same receptor on human cerebrovascular endothelial cells the ... this interaction of bacterial adhesins with the receptor might offer unexpectedly broad protection against ... bacterial meningitis. Identification of the human receptor and bacterial ligands is like identifying a ...

Genetic study confirms the immune system's role in narcolepsy

... unique variants of the TCRA gene, which encodes a receptor protein on the surface of T cells. T cells are ... In concert with the HLA proteins, the T cell receptor enables T cells to recognize and attack foreign ... as bacteria and viruses. Changes to the T cell receptor could increase the likelihood that the cells will ...

Synthetic chemical offers solution for crops facing drought

... His lab then used pyrabactin to fish out a receptor for ABA a highly controversial topic involving ... of papers of questionable significance. A receptor is a protein molecule in a cell to which mobile ... "Scientists have been trying to solve the ABA receptor problem for more than 20 years, and claims for ...

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Receptor in Biological Technology

SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2009 FINANCIAL RESULTS

... property portfolio of proprietary taste receptor technologies. As of June 30, 2009, Senomyx is ... activity in the Company's proprietary sweet receptor screening assays. Recent efforts include the ... the protein Senomyx believes is the primary receptor responsible for human salt taste perception. ...

AEterna Zentaris: New Data Published on its Ghrelin Antagonist Compound, AEZS-123 (JMV2959), Supports its Use in Alcohol Addiction

... supporting the use of AEterna Zentaris' ghrelin receptor antagonist compound, AEZS-123 (JMV2959), for the ... the administration of AEZS-123, and a ghrelin receptor mouse knockout model, highlights the role of ... actions are blocked by administering ghrelin receptor antagonists such as AEZS-123, mice no longer show ...

AEterna Zentaris Presents Data Supporting Evaluation of AEZS-108 in Prostate Cancer at ASCO Meeting

... in male patients." Results LHRH receptor expression was demonstrated in more than 95% of ... majority of specimens showed moderate to strong receptor expression. Statistically, strong receptor expression correlated with higher pathologic ...

ChemoCentryx's Traficet-EN(TM) Phase II/III Induction Phase Data in Crohn's Disease to be Featured in Oral Presentation at 2009 Digestive Disease Week

... chemokine receptor. Targeting the CCR9 chemokine receptor represents a novel approach for the treatment of ... Efficacy of the Intestine-Specific Chemokine receptor Antagonist CCX282-B (Traficet-EN) in Treatment of ... receptor. In adults, CCR9 is a highly specific receptor expressed by T cells that migrate selectively to ...

SENOMYX ANNOUNCES FIRST QUARTER 2009 FINANCIAL RESULTS

... property portfolio of proprietary taste receptor technologies. As of March 31, 2009, Senomyx is ... Senomyx is using the Company's proprietary sweet receptor screening technology to identify enhancers of ... the protein Senomyx believes is the primary receptor responsible for human salt taste perception, the ...

Successful Phase I/II Clinical Trial Results From Cancer Patients Treated With Anti-Cancer Drug From Axelar AB

... AXL1717,an insulin-like growth factor-1 (IGF-1) receptor inhibitor which has no effects on the closely ... cancer patients in the future." The IGF-1 receptor is a promising target for the treatment of cancer, since the receptor is crucial for the survival and growth of ...

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Receptor in Biological Products

Rat Anti-Vitamin D Receptor Monoclonal Antibody, Unconjugated, Clone 9A7 from ABR-Affinity BioReagents

Description:... chicken intestinal cytoplasmic 1,25-(OH)2D3 receptor protein. MA1-710 detects vitamin D receptor (VDR) from human, rat, mouse, hamster, chicken, ... chicken intestinal cytoplasmic 1,25-(OH)2D3 receptor protein. This antibody recognizes an epitope ...
Company:ABR-Affinity BioReagents

PolarScreen Progesterone Receptor Competitor Assay Kit, Far Red from Molecular Probes (Invitrogen)

Description:... PolarScreen Progesterone receptor (PR) Competitor Assay Kits are ideal for studying or screening novel progesterone receptor binding compounds using fluorescence polarization ... the ligand binding domain of human progesterone receptor [PR-LBD(GST)] and a proprietary, fluorescently ...
Company:Molecular Probes (Invitrogen)

PR Competitor Assay Green from Invitrogen

Description:... Progesterone receptor (PR) Competitor Assay Kits are ideal for studying or screening novel progesterone receptor binding compounds using fluorescence polarization ... the ligand binding domain of human progesterone receptor [PR-LBD(GST)] and a proprietary, ...
Company:Invitrogen

Mouse Anti-67kD Laminin Receptor Prediluted Monoclonal Antibody, Unconjugated, SPM278 from GeneTex

Description:... with specific cell membrane receptors. Overexpression of Laminin receptor is reportedly an independent prognostic factor in breast cancer and correlates with the dissemination of the tumor cells in bone marrow. Laminin receptor appears to play an important role in tumor invasion and ....
Company:GeneTex

ER-beta Fluorescence polarization Assay Kit from Invitrogen

Description:... Estrogen receptor (ER) Competitor Assay Kits Green for Estrogen Receptors-alpha and -beta (ER-Alpha and ER-Beta) are ideal for screening novel estrogen receptor binding compounds and endocrine ....
Company:Invitrogen

Human, Bovine, Porcine, Rat VIP, aa 6-28 from Biotrend Chemikalien GmbH

Description:... (6-28) (human, bovine, porcine, rat) Vasoactive Intestinal Peptide (VIP) receptor antagonist. This carboxy-terminal VIP fragment was found to be twofold more potent than any previously described VIP receptor antagonists. Storage: Desiccate at -20 ...
Company:Biotrend Chemikalien GmbH

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Receptor in Biological Definition

Apoptosis

... neural tube: cells that receive Shh in a receptor in their membranes called Patched1 (Ptc1) survive ... absence of Shh, one of the ends of this same Ptc1 receptor (the carboxyl-terminal, inside the membrane) is ... These studies show how critical is the role of PS receptor (PSR) in the development of complex organisms ...

Immune system

... binds to a T "helper" cell's antigen receptor and to its CD28 receptor, which provides the ... / memory cell autoimmune disorders CD4 receptor /CD8 receptor / perforin / apoptosis /clonal selection ...

Ion channel

... Examples include the "nicotinic" Acetylcholine receptor , AMPA receptor and other neurotransmitter -gated channels. ... An example is the "muscarinic" Acetylcholine receptor Inward-rectifier K channels allow ...

Long-term potentiation

... one whose hippocampi were bathed in the NMDA receptor blocker APV , and the other acting as a control ... rats. This provided some evidence that the NMDA receptor — and thus LTP — was somehow involved ... learning. Doogie mice Enhanced NMDA receptor activity in the hippocampus has also been shown ...

Neurotransmitter

... It is important to appreciate that it is the receptor that dictates the neurotransmitter's effect. ... through neurotransmitter binding. Metabotropic receptor effects on ion channels are carried by second ... on whether an ionotropic or metabotropic receptor is the target of the molecule. Small molecule ...

Olfaction

... odor receptors. Humans have 347 functional odor receptor genes; the other genes have nonsense mutations . ... ), whereas some others cannot. Each olfactory receptor neuron in the nose expresses only one functional odor receptor. According to shape theory , each receptor detects a feature of the odor molecule . ...

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Receptor in Biological Dictionary

Transmembrane receptor

... Extracellular signaling molecules attach to the receptor , ... G protein-coupled receptors ... receptors, heptahelical receptors, serpentine receptor , and G protein-linked receptors (GPLR), comprise a large protein family ... receptor protein n. An intracellular protein or ...

Transferrin receptor

... Transferrin receptor (TfR) is a carrier protein for transferrin ... promote increased levels of transferrin receptor , to increase iron intake into the cell. Thus, transferrin receptor maintains cellular iron homeostasis. ...

Receptor

... In biochemistry, a receptor is a protein molecule, embedded in either the ... may attach. A molecule which binds to a receptor is called ... The androgen receptor (AR), also known as NR3C4, is a type of nuclear ...

Proto-oncogene

... cell. The RET proto - oncogene encodes a receptor tyrosine kinase for members of the glial cell ... ret proto - oncogene ( proto -ret) encodes a receptor type tyrosine kinase with ... Proto - ... MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The ...

Peroxisome

... ... Peroxisome proliferator-activated receptor alpha (PPAR-alpha), also known as NR1C1, is a nuclear receptor protein encoded by the PPARA gene. The ... targeting signal (PTS) that binds to a receptor ... Each has its own ...

Olfactory nerve

... cranial nerves. The specialized olfactory receptor neurons of the olfactory nerve are located in ... of the nasal cavity. ... An olfactory receptor neuron, also called an olfactory sensory ... transduction cell in the olfactory system. receptor neuron' target='_blank'>Full article >>> ...

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