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Radioisotope in Medical News

Personalizing medicine: New research shows potential of targeted therapies for cancer

... The excessive blood-pool activity masks the radioisotope uptake in tumor lesions, thereby lowering the ... to the imaging of tumors using a combination of radioisotope and antibody or RAII," said Otto Boerman, ... from the long antibody delivery process, radioisotope uptake in the tumor is significantly higher than ...

Einstein scientists treat cancer as an infectious disease -- with promising results

... home in on a specific protein targetand the radioisotope warhead destroys the cell to which the protein is ... Then the blast of radiation emitted by the radioisotope would destroy the live tumor cells nearby. ... in mice, the Einstein researchers attached the radioisotope rhenium-18 to monoclonal antibodies made against ...

Ongoing worldwide shortage of medical isotopes could threaten patient care, says expert

... are carried out each year using Tc-99m. Around 80 per cent of clinical nuclear medicine work is dependent on the routine availability of the radioisotope molybdenum-99 (Mo-99), from which Tc-99m is derived, which has a half-life of three days and cannot therefore be stockpiled. Ninety-five per cent ...

SNM expresses serious concerns as isotope shortage looms

... supply of medical isotopes in the United States. Reactor outages, coupled with recent efforts to curtail the use of highly-enriched uranium (HEU) in radioisotope production as a non-proliferation strategy and to deter terrorism, now pose a significant threat to Mo-99 availability within the United States. ...

New therapy shows promise for fighting treatment-resistant cancer cells

... symporter (hNIS) in the cancer cells. This gene would simultaneously track the cancer cells and treat them by allowing them to absorb iodine and radioisotope more easily. To improve imaging of the cancer cells even further, researchers also engineered the reporter gene to turn fluorescent when it ...

Combined radiation seed, chemotherapy wafer implants show promise in treating cancerous brain tumors

... low-activity iodine-125 seeds following the surgical removal of the tumor. The seeds, housed in a titanium casing filled with iodine-125 (a radioisotope of iodine) are the size of grains of rice. The seeds are left in the brain cavity permanently, and radiation is delivered for six months. Other ...

DRAXIS Names GE Healthcare as Exclusive Distributor of DRAXIMAGE(R) Sestamibi in USA

... medicine imaging to show how well the heart muscle (myocardium) is supplied with blood (perfused) both at rest and during strenuous activity. The radioisotope Technetium-99m is attached to the sestamibi molecule forming Tc-99m Sestamibi. When injected into the bloodstream this radiopharmaceutical agent is ...

Breast Cancer Imaging Study Indicates Breast-Specific Gamma Imaging (BSGI) Is a Strong Adjunct Imaging Modality to Mammography and Ultrasound

... in breast diagnostics that is performed with a high-resolution small field-of-view gamma camera and Tc-Sestamibi. According to Dr. Weigert, the radioisotope is taken up by cells with increased metabolic activity, such as the rapidly dividing cells in breast cancers; and areas of concern present at highly ...

Bradmer Medical Isotope Supply For Phase III Trial Secure

... on the situation as it relates to Bradmer. We made decisions earlier this year that ensured both the clinical and commercial supplies of the radioisotope for our product candidate, Neurabiab," said Alan M. Ezrin, Ph.D., President and Chief Executive Officer of Bradmer. "Our formulation work, completed ...

A fresh look at existing therapies: Researchers explore ways to teach approved drugs new tricks

... she said. Both veltuzumab and milatuzumab are naked antibodies − monoclonal antibodies that are not bound to a therapeutic drug or radioisotope − but each latches on to different receptors on the surface of lymphoma cells. Milatuzumab binds to the CD74 receptor and is then rapidly ...
Radioisotope in Medical Technology

Data To Be Presented at ASCO Supports Potential of Peregrine's Cotara(R) for the Treatment of Brain Cancer

... to brain tumors at high concentrations with minimal radiation exposure to other organs. Cotara is a targeted monoclonal antibody linked to a radioisotope being developed as a potential new treatment for glioblastoma multiforme (GBM), a deadly form of brain cancer. Cotara specifically targets cells at ...

Siemens Preclinical Imaging System Helps The Methodist Hospital in Houston Further Its Research Mission

... graphical user interface, offering both convenience and flexibility. On a larger scale, The Eclipse family of PET cyclotrons is Siemens solution for radioisotope production. The Eclipse cyclotron is an 11 MeV, negative ion, single particle accelerator designed for clinical and commercial production and ...
Radioisotope in Medical Definition

Nuclear medicine

... with the most common names being the nuclear medicine department and the radioisotope department. Contents 1 Diagnostic Testing 2 ... Fast Reactor • Nuclear propulsion • Nuclear thermal rocket • radioisotope thermoelectric generator Nuclear medicine PET • Radiation ...
Radioisotope in Medical Dictionary

Radioisotope

... radioisotope therapy involves having an injection or swallowing the radioisotope (eg radioactive iodine, Iodine-131). This ... circulating the body in the blood stream. radioisotope stent by Iso Stent Iso Stent is working in ...

Biliary system

... Cholescintigraphy: A diagnostic test in which a two-dimensional picture of a radiation source in the biliary system is obtained by the use of radioisotope s. A procedure called endoscopic retrograde cholangiopancreatoscopy ( ERCP ) allows the removal of some bile duct stones through the mouth, ...

Bone scan

... the spinal cord. X-ray s usually miss small skeletal trauma s such as stress fractures . Sometimes the doctor may advise a bone scan . radioisotope therapy is widely used in the treatment of thyroid disease and is also used in diagnostic procedures such as bone scan s. Bone Mineral ...

Chest X-ray

... a four-hour airline flight will expose you to the same amount of radiation (from cosmic rays) as from a simple chest X-ray . Because the radioisotope used in a PET scan is short-lived, the amount of radiation exposure the patient receives is about the same as two chest X-ray s. The ...

Chest X

... a four-hour airline flight will expose you to the same amount of radiation (from cosmic rays) as from a simple chest X -ray . Because the radioisotope used in a PET scan is short-lived, the amount of radiation exposure the patient receives is about the same as two chest X -ray s. The ...

Popliteal

... with water. PREVIOUS NEXT: When to seek medical advice ... Intra Coil ( femoral and popliteal ) INX stent (neuro vascular ) Iso Stent ( radioisotope stent ) Jo stent coronary stent graft (a.k.a. Jomed Jo stent ) Megalink biliary stent Memotherm colorectal stent Memotherm biliary stent ...

Radiology

... resonance im aging ) to diagnose or treat disease . radionuclide scanning ... Nuclear radiology is a sub-specialty of radiology in which radioisotope s (compounds containing radioactive forms of atoms) are introduced into the body for the purpose of im aging , evaluating organ function, or ...

Renal scan

... Renal scan Definition: A renal scan is a nuclear medicine examination that uses small amounts of radioactive materials ( radioisotope s) to measure the function of the kidney s. A renal scan is similar to (and in fact, may be a continuation of) a renal perfusion scintiscan. ...

Thyroid disease

... management. JAMA, 291(2): 228"238. Fish SA, Mandel SJ (2004). Hypothyroidism . In RE Rakel, ET Bope, eds., Conn's Current Therapy, pp. 689"692. radioisotope therapy is widely used in the treatment of thyroid disease and is also used in diagnostic procedures such as bone scan s. Thyroid disease ...

X-Ray

... cancer cells and shrink tumor s. Radiation may come from a machine outside the body (external-beam radiation therapy ) or from materials called radioisotope s. X-ray s - these can reveal any damage to the joints caused by arthritis and are most useful when confirming osteoarthritis . In the early ...

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Radioisotope in Biological News

Experts tackle shipment issues for beneficial radiation sources

... a recent six-month period indicate more delays than denials are taking place. Denials block shipments entirely, and delays can virtually render a radioisotope useless because of its short radioactive half-life. Between September 2007 and March 2008, a total of 69 reports of delays and denials of ...

The top 5 ways medical physics has changed health care

... medicine were developed by physicists who imported technologies such as X rays, nuclear magnetic resonance, ultrasound, particle accelerators and radioisotope tagging and detection techniques into the medical domain. There they became magnetic resonance imaging (MRI), computerized tomography (CT) scanning, ...

November GEOLOGY and GSA TODAY Media Highlights

... been carried out to characterize gas hydrate occurrence and related geological phenomena. Tomaru et al. measured the concentration of a long-lived radioisotope of iodine (129I) in pore waters from the eastern Nankai Trough, offshore the main island of Japan, in order to determine the potential age of iodine ...

Einstein researchers demonstrate a novel approach to treating AIDS

... onto antibodies. Once these precision-made molecules are injected into the body, the antibodies home in on a specific protein target…and the radioisotope "warhead" destroys the cell to which that protein is attached. Radioimmunotherapy is an accepted treatment for several types of cancer including ...

Report calls for improved monoclonal antibodies against solid tumors

... are available for optimization including size, charge, and valence; constant region type and glycosylation pattern; presence or absence of a radioisotope or a toxic moiety; dose, route, and schedule of administration; and use of a traditional or of a pre-targeting strategy.?They conclude the framework ...

Smoking damages key regulatory enzyme in the lung

... She added, "It's important that the public know about the benefits derived from the DOE's long-term investments in basic science--especially in radioisotope and radiotracer chemistry and imaging physics--that have played such an important role in introducing new nuclear medicine procedures into the ...

Alzheimer's cognitive decline slowed

... rates of decline followed the MMSE findings. Post-operative PET scans in four subjects showed significant increases in the brain's absorption of a radioisotope called 18-fluorodeoxyglucose, an indicator of increased metabolic activity in the brain. The researchers noted that the increase was observed in most ...
Radioisotope in Biological Technology

Data Presented at Society of Nuclear Medicine 2009 Annual Meeting Supports Potential of Peregrine's Cotara(R) for the Treatment of Brain Cancer

... to brain tumors at high concentrations with minimal radiation exposure to other organs. Cotara is a targeted monoclonal antibody linked to a radioisotope being developed as a potential new treatment for glioblastoma multiforme (GBM), a deadly form of brain cancer. The results reported today from an ...

Digirad Corporation Reports Financial Results for 2007 Fourth Quarter and Twelve Months

... to $4.5 million for the quarter, principally due to decreased DIS profitability attributable to greater than normal seasonality and the disruption in radioisotope supplies announced previously. Gross margin was 24 percent of revenues in the fourth quarter of 2007, compared to 28 percent of revenues in 2006. ...

Delivering Molecular Imaging Solutions Across Clinical Specialties: Siemens Showcases New Technologies at RSNA 2007

... of products for efficient preparation of radiolabeled PET compounds. On a larger scale, the Eclipse family of PET cyclotrons is Siemens' solution for radioisotope production of 18-fluoride-based radiotracers, as well as production N-13, 0-15 and C-11 isotopes. Tying it all together, Siemens Molecular Imaging ...

NorthStar signs exclusive agreement with Illinois foundation

... with offices in Madison and Naperville, Ill., develops and markets novel radioisotope production and purification technologies. Some contend that molecules that ... short-lived radiopharmaceuticals to be effective. Since each dose of the radioisotope is produced with nearly identical chemical and radioactive properties, the ...

Cerenkov Counting Performance on the TopCountTM Microplate Scintillation and Luminescence Counter

... TopSeal-A, a self-adhesive sealer. 32 P-ATP (Amersham #PB.10204) was the radioisotope used in all experiments. A stock solution containing 49,000 DPM/μL ... Instrument Company. 4. TopCount Topics TCA-018, Counting radioisotope and Luminescent Labels on Filters and Membranes with the FlexiFilterTM ...

NorthStar finds cancer-fighting use for nuclear fuel

... alpha particle-emitting radionuclide carried by targeting agents such as monoclonal antibodies. The targeting agent attaches to cancer cells and the radioisotope kills them, ideally minimizing collateral damage to normal cells. The agreement gives NorthStar the exclusive right to use MATT for the life of ...

Kodak in vivo imaging system: precise coregistration of molecular imaging with anatomical X-ray imaging in animals

... in Kodak MI 4.0 software and merged in Adobe Photoshop . The image in Figure 4 demonstrates the combination of radioisotope 18 F imaging (typically used in positron emission tomography (PET) imaging) with X-ray imaging. The mouse was injected with [ ...
Radioisotope in Biological Products

Fujifilm FLA-8000 from FUJIFILM Life Science

Description:... The Fujifilm Life Science FLA-8000 Fluorescent Image Analyzer features fluorescent and radioisotope image detection in a single laser imaging system. This powerful new research tool captures images of samples labeled with fluorescent dyes or ...
Company:FUJIFILM Life Science

Fujifilm FLA-5100 from FUJIFILM Life Science

Description:... for genomics. Fuji s FLA-5100 includes four imaging solutions in a single system. While optimized for fluorescence, the system also excels at radioisotope (RI) detection using the Imaging Plate method. Additional imaging methodologies include digitization using fluorescence board and chemiluminescence ...
Company:FUJIFILM Life Science

Fujifilm FLA-7000 from FUJIFILM Life Science

Description:... without any compromise to sensitivity. Fujis unique and reliable technology offers an increased homogeneity and sensitivity of the detection method. radioisotope images, fluorescent images including near-IR images, and digitized images (gel documentation images) can be captured on the unit by choosing among ...
Company:FUJIFILM Life Science

Custom Protein Kinase Substrate (PKS) Peptide Microarray from LC Sciences

Description:... negative controls as well as a universal highly phosphate-specific fluorescent dye staining reagent ensure quantitative results. There is no need for radioisotope labeling and potential signal bias due to antibody sequence specificity is eliminated. Test sequence signals can be directly compared to ...
Company:LC Sciences

Protein Kinase Substrate (PKS) Peptide Microarray - Comprehensive Service from LC Sciences

Description:... negative controls as well as a universal highly phosphate-specific fluorescent dye staining reagent ensure quantitative results. There is no need for radioisotope labeling and potential signal bias due to antibody sequence specificity is eliminated. Test sequence signals can be directly compared to ...
Company:LC Sciences

Standard Protein Kinase Substrate (PKS) Peptide Microarray from LC Sciences

Description:... negative controls as well as a universal highly phosphate-specific fluorescent dye staining reagent ensure quantitative results. There is no need for radioisotope labeling and potential signal bias due to antibody sequence specificity is eliminated. Test sequence signals can be directly compared to ...
Company:LC Sciences

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Radioisotope in Biological Definition

Monoclonal antibody

... specific antigen and induce an immunological response on the target cancer cell. Such mAb could also be modificated for delivery of a toxin , radioisotope , cytokine or other active conjugate; it is also possible to design bispecific antibodies that can bind with their Fab regions both to target ...
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