Personalizing medicine: New research shows potential of targeted therapies for cancer
... The excessive blood-pool activity masks the radioisotope uptake in tumor lesions, thereby lowering the ... to the imaging of tumors using a combination of radioisotope and antibody or RAII," said Otto Boerman, ... from the long antibody delivery process, radioisotope uptake in the tumor is significantly higher than ...Einstein scientists treat cancer as an infectious disease -- with promising results
... home in on a specific protein targetand the radioisotope warhead destroys the cell to which the protein is ... Then the blast of radiation emitted by the radioisotope would destroy the live tumor cells nearby. ... in mice, the Einstein researchers attached the radioisotope rhenium-18 to monoclonal antibodies made against ...Ongoing worldwide shortage of medical isotopes could threaten patient care, says expert
... are carried out each year using Tc-99m. Around 80 per cent of clinical nuclear medicine work is dependent on the routine availability of the radioisotope molybdenum-99 (Mo-99), from which Tc-99m is derived, which has a half-life of three days and cannot therefore be stockpiled. Ninety-five per cent ...SNM expresses serious concerns as isotope shortage looms
... supply of medical isotopes in the United States. Reactor outages, coupled with recent efforts to curtail the use of highly-enriched uranium (HEU) in radioisotope production as a non-proliferation strategy and to deter terrorism, now pose a significant threat to Mo-99 availability within the United States. ...New therapy shows promise for fighting treatment-resistant cancer cells
... symporter (hNIS) in the cancer cells. This gene would simultaneously track the cancer cells and treat them by allowing them to absorb iodine and radioisotope more easily. To improve imaging of the cancer cells even further, researchers also engineered the reporter gene to turn fluorescent when it ...Combined radiation seed, chemotherapy wafer implants show promise in treating cancerous brain tumors
... low-activity iodine-125 seeds following the surgical removal of the tumor. The seeds, housed in a titanium casing filled with iodine-125 (a radioisotope of iodine) are the size of grains of rice. The seeds are left in the brain cavity permanently, and radiation is delivered for six months. Other ...DRAXIS Names GE Healthcare as Exclusive Distributor of DRAXIMAGE(R) Sestamibi in USA
... medicine imaging to show how well the heart muscle (myocardium) is supplied with blood (perfused) both at rest and during strenuous activity. The radioisotope Technetium-99m is attached to the sestamibi molecule forming Tc-99m Sestamibi. When injected into the bloodstream this radiopharmaceutical agent is ...Bradmer Medical Isotope Supply For Phase III Trial Secure
... on the situation as it relates to Bradmer. We made decisions earlier this year that ensured both the clinical and commercial supplies of the radioisotope for our product candidate, Neurabiab," said Alan M. Ezrin, Ph.D., President and Chief Executive Officer of Bradmer. "Our formulation work, completed ...A fresh look at existing therapies: Researchers explore ways to teach approved drugs new tricks
... she said. Both veltuzumab and milatuzumab are naked antibodies − monoclonal antibodies that are not bound to a therapeutic drug or radioisotope − but each latches on to different receptors on the surface of lymphoma cells. Milatuzumab binds to the CD74 receptor and is then rapidly ...Experts tackle shipment issues for beneficial radiation sources
... a recent six-month period indicate more delays than denials are taking place. Denials block shipments entirely, and delays can virtually render a radioisotope useless because of its short radioactive half-life. Between September 2007 and March 2008, a total of 69 reports of delays and denials of ...The top 5 ways medical physics has changed health care
... medicine were developed by physicists who imported technologies such as X rays, nuclear magnetic resonance, ultrasound, particle accelerators and radioisotope tagging and detection techniques into the medical domain. There they became magnetic resonance imaging (MRI), computerized tomography (CT) scanning, ...November GEOLOGY and GSA TODAY Media Highlights
... been carried out to characterize gas hydrate occurrence and related geological phenomena. Tomaru et al. measured the concentration of a long-lived radioisotope of iodine (129I) in pore waters from the eastern Nankai Trough, offshore the main island of Japan, in order to determine the potential age of iodine ...Einstein researchers demonstrate a novel approach to treating AIDS
... onto antibodies. Once these precision-made molecules are injected into the body, the antibodies home in on a specific protein target…and the radioisotope "warhead" destroys the cell to which that protein is attached. Radioimmunotherapy is an accepted treatment for several types of cancer including ...Report calls for improved monoclonal antibodies against solid tumors
... are available for optimization including size, charge, and valence; constant region type and glycosylation pattern; presence or absence of a radioisotope or a toxic moiety; dose, route, and schedule of administration; and use of a traditional or of a pre-targeting strategy.?They conclude the framework ...Smoking damages key regulatory enzyme in the lung
... She added, "It's important that the public know about the benefits derived from the DOE's long-term investments in basic science--especially in radioisotope and radiotracer chemistry and imaging physics--that have played such an important role in introducing new nuclear medicine procedures into the ...Alzheimer's cognitive decline slowed
... rates of decline followed the MMSE findings. Post-operative PET scans in four subjects showed significant increases in the brain's absorption of a radioisotope called 18-fluorodeoxyglucose, an indicator of increased metabolic activity in the brain. The researchers noted that the increase was observed in most ...Digirad Corporation Reports Financial Results for 2007 Fourth Quarter and Twelve Months
... to $4.5 million for the quarter, principally due to decreased DIS profitability attributable to greater than normal seasonality and the disruption in radioisotope supplies announced previously. Gross margin was 24 percent of revenues in the fourth quarter of 2007, compared to 28 percent of revenues in 2006. ...NorthStar signs exclusive agreement with Illinois foundation
... with offices in Madison and Naperville, Ill., develops and markets novel radioisotope production and purification technologies. Some contend that molecules that ... short-lived radiopharmaceuticals to be effective. Since each dose of the radioisotope is produced with nearly identical chemical and radioactive properties, the ...Cerenkov Counting Performance on the TopCountTM Microplate Scintillation and Luminescence Counter
... TopSeal-A, a self-adhesive sealer. 32 P-ATP (Amersham #PB.10204) was the radioisotope used in all experiments. A stock solution containing 49,000 DPM/μL ... Instrument Company. 4. TopCount Topics TCA-018, Counting radioisotope and Luminescent Labels on Filters and Membranes with the FlexiFilterTM ...NorthStar finds cancer-fighting use for nuclear fuel
... alpha particle-emitting radionuclide carried by targeting agents such as monoclonal antibodies. The targeting agent attaches to cancer cells and the radioisotope kills them, ideally minimizing collateral damage to normal cells. The agreement gives NorthStar the exclusive right to use MATT for the life of ...Fujifilm FLA-8000 from FUJIFILM Life Science
Description:... The Fujifilm Life Science FLA-8000 Fluorescent Image Analyzer features fluorescent and radioisotope image detection in a single laser imaging system. This powerful new research tool captures images of samples labeled with fluorescent dyes or ...Fujifilm FLA-5100 from FUJIFILM Life Science
Description:... for genomics. Fuji s FLA-5100 includes four imaging solutions in a single system. While optimized for fluorescence, the system also excels at radioisotope (RI) detection using the Imaging Plate method. Additional imaging methodologies include digitization using fluorescence board and chemiluminescence ...Fujifilm FLA-7000 from FUJIFILM Life Science
Description:... without any compromise to sensitivity. Fujis unique and reliable technology offers an increased homogeneity and sensitivity of the detection method. radioisotope images, fluorescent images including near-IR images, and digitized images (gel documentation images) can be captured on the unit by choosing among ...Custom Protein Kinase Substrate (PKS) Peptide Microarray from LC Sciences
Description:... negative controls as well as a universal highly phosphate-specific fluorescent dye staining reagent ensure quantitative results. There is no need for radioisotope labeling and potential signal bias due to antibody sequence specificity is eliminated. Test sequence signals can be directly compared to ...Protein Kinase Substrate (PKS) Peptide Microarray - Comprehensive Service from LC Sciences
Description:... negative controls as well as a universal highly phosphate-specific fluorescent dye staining reagent ensure quantitative results. There is no need for radioisotope labeling and potential signal bias due to antibody sequence specificity is eliminated. Test sequence signals can be directly compared to ...Standard Protein Kinase Substrate (PKS) Peptide Microarray from LC Sciences
Description:... negative controls as well as a universal highly phosphate-specific fluorescent dye staining reagent ensure quantitative results. There is no need for radioisotope labeling and potential signal bias due to antibody sequence specificity is eliminated. Test sequence signals can be directly compared to ...