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Purine in Medical News

Pharmasset Nominates PSI-938 as a New Nucleotide Analog Inhibitor of Hepatitis C for Preclinical Development

... a lead development candidate from two series of purine analogs for the treatment of chronic hepatitis C ... in clinical development in the future." purine nucleos(t)ide analogs have many of the benefits ... antivirals targeting HCV. In addition, these purine analogs are also active against the S282T ...

Enzyme complex could be key to new cancer treatments

... shows that these enzymes form a cluster prior to purine formation," said Erin Sheets, an assistant ... cells also can produce purines by recycling old purine material. Owing to this salvage process, cells ... for cell replication, the ability to halt purine synthesis could prove to be a valuable method for ...

BioCryst Pharmaceuticals Announces Presentation of Forodesine Data at the 45th Annual Meeting of the American Society of Clinical Oncology

... from May 29-June 2. Forodesine is a transition-state analog inhibitor of purine nucleoside phosphorylase (PNP), a purine salvage pathway enzyme that is essential for the proliferation of T-cells ...

BioCryst Reports Second Quarter 2009 Financial Results And Provides Corporate Update

... and autoimmune diseases. BioCryst has two product candidates in pivotal clinical trials; peramivir, an anti-viral for influenza, and forodesine, a purine nucleoside phosphorylase (PNP) inhibitor for cutaneous T-cell lymphoma (CTCL). Utilizing crystallography and structure-based drug design, BioCryst ...

Hard To Treat Diseases (HTDS) Slavica BioChem Update on Research Activities

... Field of Scientific and Technical Research (COST) organization. Dr. Pekovic also reported the scientific team has started some in vitro studies of purine nucleoside analogues (ribavirin, tiazofurin, the drugs we are investigating) effects on microglial cell culture (there is no current data in the ...

FDA approves ULORIC (febuxostat) for the chronic management of hyperuricemia in patients with gout

... About ULORIC (febuxostat) ULORIC works by blocking the enzyme xanthine oxidase. Xanthine oxidase is responsible for the breakdown of the purine base, hypoxanthine, to xanthine, and then to uric acid. By blocking this enzyme, ULORIC helps prevent uric acid production, thereby lowering elevated ...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

... stem cell antigen (PSCA); prostate-specific membrane antigen (PSMA); proteasome; protein kinase A type I (PKAI); protein kinase C (PKC); PKC-B; purine nucleoside phosphorylase (PNP); ras; R1 mRNA; R2 mRNA; Raf/B-Raf; Rad51; RET; ribonucleotide reductase (RNR); ribonucleotide reductase M2 ...

TREANDA New Drug Application for the Treatment of Chronic Lymphocytic Leukemia Granted Priority Review Status by FDA

... of marketing exclusivity in the United States, if the product is approved for this indication. About TREANDA TREANDA is a rationally designed purine analog/alkylator hybrid. Preclinical data demonstrate that this rationally designed hybrid acts in two ways to kill cancer cells. TREANDA damages the ...

Cephalon Submits New Drug Application for TREANDA for the Treatment of Chronic Lymphocytic Leukemia

... for CLL, the company will make a $15 million milestone payment to former shareholders of Salmedix. About TREANDA TREANDA is a rationally designed purine analog/alkylator hybrid. Preclinical data demonstrate that TREANDA induces rapid, sustained single- and double-strand DNA damage, which results in ...
Purine in Medical Technology

Cordex Signs European Development Partnership for ATPotent(TM) Sperm Motility Drug

... for the in vitro treatment of human and animal sperm, in which the active ingredient is adenosine 5'-triphosphate (ATP). ATP is a ubiquitous purine nucleotide found in every cell of the human body where it plays a critical role in cellular metabolism and constitutes the source of energy for all ...

Pharmasset Voluntarily Halts Clinical Studies with Clevudine in Hepatitis B Infected Patients

... to report the first antiviral data in the second half of 2009. In addition, we are collecting preclinical data from our research efforts to select a purine nucleos(t)ide for clinical development." Phase III QUASH Studies The QUASH studies are international, multi-center, randomized, double-blind ...

New Study Shows PCR and FCR Have Significant Activity in B-cell Chronic Lymphocytic Leukemia

... investigator and serves as co-chairman, and chairman for new protocol development, of US Oncology's National Lung Cancer Research Committee. purine analog-based regimens have emerged as highly active regimens in the treatment of chronic lymphocytic lymphoma (CLL). Promising results have been ...

TREANDA Demonstrates Substantial Efficacy in Patients with Relapsed Indolent Non-Hodgkin's Lymphoma

... at 11:00 am during the ASH meeting [Abstract #385]. About TREANDA (bendamustine HCl) TREANDA is a novel chemotherapeutic agent, a hybrid of a purine analog and an alkylator. Preclinical data demonstrate that TREANDA acts in two distinct ways to kill cancer cells. TREANDA damages the DNA in ...

TREANDA Significantly Improves Clinical Outcomes in Patients with Chronic Lymphocytic Leukemia Compared to Chlorambucil

... assessed by an Independent Data Monitoring Committee. About TREANDA (bendamustine HCl) TREANDA is a novel chemotherapeutic agent, a hybrid of a purine analog and an alkylator. Preclinical data demonstrate that TREANDA acts in two distinct ways to kill cancer cells. TREANDA damages the DNA in ...

Cephalon Announces Positive Results from Its Pivotal Study of TREANDA in Patients with Non-Hodgkin's Lymphoma

... patients with chronic lymphocytic leukemia (CLL), for which the FDA has granted orphan drug status. About TREANDA TREANDA is a rationally designed purine analog/alkylator hybrid. Preclinical data demonstrate that TREANDA acts in two ways to kill cancer cells. TREANDA damages the DNA in cancer cells, ...

BioCryst Initiates Enrollment in Pivotal Trial of Forodesine HCL in Patients with Cutaneous T-Cell Lymphoma (CTCL)

... Jon P. Stonehouse, President and Chief Executive Officer of BioCryst. Forodesine HCL is a transition-state analog inhibitor of the target enzyme purine nucleoside phosphorylase (PNP). In addition to CTCL, the drug is currently being studied in clinical trials for indications including T and B- cell ...
Purine in Medical Definition

Pathology

... of acid-base balance - H 2 O Dehydration / Hypervolemia - K + Hypokalemia / Hyperkalemia - Cl − Hyperchloremia / Hypochloremia purine and pyrimidine Hyperuricemia - Lesch-Nyhan syndrome - Xanthinuria Porphyrin Acute intermittent , Gunther's , Cutanea tarda , ...
Purine in Biological News

New computational technique allows comparison of whole genomes as easily as whole books

... Kim said. Since these genomes are very large, the researchers translated the genome sequences using a reduced, two-letter alphabet - R for the purine nucleic acids, adenine and guanine, and Y for the pyrimidine nucleic acids, thymine and cytosine - to reduce the complexity of calculation. Using an ...

Study of protein folds offers insight into metabolic evolution

... of metabolic networks (for an example, see the purine metabolism network in MANET). The result is a ... specifically the interconversion of the purine and pyrimidine nucleotides that compose the core ... see that all the enzymes that were involved in purine synthesis, for example, were very recent. Since ...

Switching to new anti-bacterial targets: Riboswitches

... and become resistant by acquiring mutations in their riboswitches. This work, in combination with the recently solved crystal structures of purine riboswitches, opens a path to the directed design of drugs targeting riboswitches for use as antibiotics. According to the researchers, it is ...
Purine in Biological Technology

BioCryst to Present Three Posters During the 50th American Society of Hematology Annual Meeting and Exposition

... Forodesine HCl and BCX-4208 are clinical-stage purine nucleoside phosphorylase (PNP) inhibitors. ... is as follows: BCX-4208 (RO5092888), a purine Nucleoside Phosphorylase ( PNP ) Inhibitor is a ... Time; Hall A A Phase II Study of the purine Nucleoside Phosphorylase (PNP) Inhibitor ...

Pharmasset Reports Fiscal Second Quarter 2009 Financial Results

... generation hepatitis C virus (HCV) product candidate, PSI-7851, and the purine series of compounds. Pharmasset reported a net loss of $15.5 million, ... Announce selection of candidate(s) from our purine series of nucleos(t)ide analog for HCV in second half of 2009; ...

BioCryst Reports Fourth Quarter and Year End 2008 Financial Results and Provides Corporate Update

... BCX-4208 A poster entitled, "A Phase 2 Study of the purine Nucleoside Phosphorylase (PNP) Inhibitor RO5092888 (BCX-4208) in Patients ... BioCryst also presented a poster at ASH entitled, "BCX-4208 (RO5092888), a purine Nucleoside Phosphorylase (PNP) Inhibitor is a Novel, Potent Orally Active ...

Alfacell's ONCONASE(R) and R-Amphinase Show Anti-Tumor Activity in Chronic Lymphocytic Leukemia and Acute Myeloblastic Leukemia Cells

... hours with either ONCONASE or R-Amph alone and in combination with the purine analogues cladribine (2-CdA) and fludarabine (FA), as well as with ... activity was seen in the combination of the endonuclease plus either purine analogue. The combination of doxorubicin with ONCONASE or R-Amph ...

Cephalon Submits New Drug Application for TREANDA for the Treatment of Patients with Relapsed Indolent Non-Hodgkin's Lymphoma

... About TREANDA TREANDA is a novel chemotherapeutic agent, a hybrid of a purine analog and an alkylator. Preclinical data demonstrate that TREANDA acts in ... (a disruption of normal cell division). The contribution of the purine analog to the antitumor effect of TREANDA is under investigation but has ...

BioCryst Pharmaceuticals to Announce Second Quarter 2009 Financial Results on July 30, 2009

... and autoimmune diseases. BioCryst has two product candidates in pivotal clinical trials; peramivir, an anti-viral for influenza, and forodesine, a purine nucleoside phosphorylase (PNP) inhibitor for cutaneous T-cell lymphoma (CTCL). Utilizing crystallography and structure-based drug design, BioCryst ...

FDA Approves ULORIC(R) (febuxostat) for the Chronic Management of Hyperuricemia in Patients with Gout

... About ULORIC (febuxostat) ULORIC works by blocking the enzyme xanthine oxidase. Xanthine oxidase is responsible for the breakdown of the purine base, hypoxanthine, to xanthine, and then to uric acid. By blocking this enzyme, ULORIC helps prevent uric acid production, thereby lowering elevated ...

BioCryst Reports Third Quarter 2008 Financial Results and Provides Corporate Update

... with moderate to severe plaque psoriasis were consistent with interim findings. BCX-4208, a potent, rationally designed, orally available purine nucleoside phosphorylase inhibitor, met its primary endpoint of safety and tolerability and displayed dose-dependant reductions in ...

Cephalon Submits New Drug Application for TREANDA for the Treatment of Chronic Lymphocytic Leukemia

... for CLL, the company will make a $15 million milestone payment to former shareholders of Salmedix. About TREANDA TREANDA is a rationally designed purine analog/alkylator hybrid. Preclinical data demonstrate that TREANDA induces rapid, sustained single- and double-strand DNA damage, which results in ...

FDA Grants Orphan Drug Designation to TREANDA, an Investigational Treatment for Chronic Lymphocytic Leukemia

... trioxide) injection and CEP-701 (lestaurtinib), which is in development. About TREANDA TREANDA is the first rationally designed purine analog / alkylator hybrid, combining the moieties of an antimetabolite and an alkylator. Preclinical data show that TREANDA induces rapid, sustained ...
Purine in Biological Products

Chicken Anti-DCTD (dCMP deaminase) Polyclonal Antibody, Unconjugated from GenWay Biotech, Inc.

Description:... Cell Car Protein Functions: Protein Byiosynthesis; Phosphotransferases; Pyrimidine Metabolism; One-Carbon Group Transferases; Dna Polymerase; purine Metabolism; Nucleotide Sugars Metabolism; Esterases; Glycosyltransferases; Cell Division; Ligases; Acid Anhydride Hydrolases; Nitrogen Tissues: ...
Company:GenWay Biotech, Inc.

Pyrophosphate Fluorometric (Blue) Assay Kit, EnzChek® from Molecular Probes (Invitrogen)

Description:... In the presence of inorganic phosphate (Pi ), the substrate 2-amino-6-mercapto-7-methylpurine ribonucleoside (MESG) is converted enzymatically by purine nucleoside phosphorylase (PNP) to ribose 1-phosphate and 2-amino-6-mercapto-7-methylpurine (Figure 1). Enzymatic conversion of MESG results in ...
Company:Molecular Probes (Invitrogen)
Purine in Biological Definition

Genetic code

... nucleotide bases grouped into 2 categories, purine and pyrimidine . The purine bases adenine ( A ) and guanine ( G ) are ... position. Since transition mutations (purine to purine or pyrimidine to pyrimidine mutations) are more ...

Genetic code

... nucleotide bases grouped into 2 categories, purine and pyrimidine . The purine bases adenine ( A ) and guanine ( G ) are ... position. Since transition mutations (purine to purine or pyrimidine to pyrimidine mutations) are more ...

Purine

... purine Chemical name purine Chemical formula C 5 H 4 N 4 ... SMILES C1(NC=N2)=C2C=NC=N1 purine is a heterocyclic aromatic organic compound ...

Pyrimidine

... these bases form hydrogen bonds with their complementary purines . purine pyrimidine A T G C In RNA , the complement of A is U instead of T: purine pyrimidine A U G C Thymine ...
Purine in Biological Dictionary

Transversion

... transversion refers to the substitution of a purine for a pyrimidine or vice versa . It can only ... transversion n. A point mutation in which a purine is replaced by a pyrimidine, or a pyrimidine ... ... transversion A mutation in which a purine is replaced by a ... transversion ... ...

Pyrimidine

... v • d • e ... Nucleotide metabolism: purine metabolism · Nucleotide salvage · Pyrimidine ... Pyrimidine Catabolism. De novo Synthesis of purine Nucleotides ... The purine and pyrimidine bases released are either ...

Purine

... purine (1) is a heterocyclic aromatic organic compound, ... of nitrogen-containing heterocycle in nature. purine ( ) n. A double-ringed, crystalline organic ... which is derived the nitrogen bases adenine purine a colorless crystalline nitrogen-containing ...

Guanine

... of a ... guanine ( ) n. ( Abbr. G ) A purine base, C 5 H 5 ON 5 , that is an essential ... molecule purine, and ... Guanine is a purine derivative, and in Watson-Crick base pairing ... - Thymine - Uracil - Guanine - Cytosine - purine - Pyrimidine ... Compare Cheap Prices for ...

Adenine

... ... Adenine is one of the two purine nucleobases used in forming nucleotides of the ... Vitamin B4. ... Adenine is one of the two purine nucleobases used in forming nucleotide s of ... differs among skeletal muscle ... purine bases are Adenine , Guanine and Hypoxanthine ...

Uric acid

... C 5 H 4 N 4 O 3 , that is a nitrogenous end product of protein and purine metabolism and is the chief nitrogenous High uric acid level — ... side effects uric acid diet ... Uric acid is the end product of purine degradation. ... High uric acid is a subtype of autism that ...

Ribonucleotides

... A ribonucleotide is a nucleotide in which a purine or pyrimidine base is linked to a ribose molecule. The base may be ... acid) is a polymer of ribonucleotides ... Surprisingly, the purine ribonucleotides are formed as such de novo, and the ... Dietary ...

Nitrogenous base

... pair of electrons of a nitrogen atom. Notable nitrogenous bases include purine bases. Pyrimidine and purine bases include the nucleobases : principally adenine, guanine, thymine, ...

Adenosine deaminase

... Adenosine deaminase is an enzyme (EC 3.5.4.4) involved in purine metabolism. It is needed for the breakdown of adenosine from food and ... ... A bstract: Adenosine deaminase (ADA) an enzyme involved in purine metabolism, ... adenosine deaminase alone to 55°C, for 5 minutes ...

Z-DNA

... Fratini & M. L. Kopka (1982) The anatomy of A-, B-, and Z-DNA . ... Left-handed Z-DNA can be formed by sequences containing alternating purine ... Under physiological conditions, Z-DNA formation is a dynamic process, largely ... Twenty years after visualizing a surprising left-handed ...

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