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Proteinuria in Medical News

Doctors See How Cancer Drug Can Damage Kidneys

... blood vessels. One side effect of Avastin is proteinuria -- excess protein in the urine, an indicator of ... problems. Various studies have found proteinuria in anywhere from 21 percent to 64 percent of ... of kidney damage," Quaggin said. "It is true that proteinuria is a very common finding, but it doesn't ...

Novel DNA vaccine leads to kidney damage prevention in systemic lupus erythematosus models

... and successfully targeting particular antibodies. Significant proteinuria (a urinary condition which can indicate kidney damage) (>1.5+) was less ... levels. Serum autoantibodies were tested by immunoprecipitation and ELISA. proteinuria (excessive protein in the urine) was assessed monthly using Multistix. ...

Receptor protein appears to be key in breakdown of kidney filtration

... with antibodies or small molecule compounds can prevent or decrease proteinuria in animals, which may represent a novel therapy for kidney diseases such ... in the uPAR-controlled pathway could reduce or prevent the development of proteinuria in mice. Such an agent is currently in phase II clinical trials for the ...

Questcor and Child Neurology Foundation Announce Creation of Infantile Spasms Awareness Week

... inflammatory component, including the treatment of exacerbations associated with multiple sclerosis (MS) and to induce a diuresis or a remission of proteinuria in the nephrotic syndrome without uremia of the idiopathic type or that due to lupus erythamatosus. Acthar is not approved for, but is used in ...

BioMarin and La Jolla Pharmaceutical Sign Worldwide (Excluding Asia Pacific) Development and Commercialization Agreement for Riquent

... is being evaluated in the international Phase 3 ASPEN trial designed to demonstrate that Riquent treatment delays the time to renal flare and reduces proteinuria in patients with lupus renal disease. The Riquent Phase 3 program is the subject of a special protocol assessment and has fast track designation from ...

Exjade(R) Benefits Chronically Transfused Patients by Significantly Reducing Toxic Iron That Can Damage Key Organs, According to Landmark Trial

... at a lower dose followed by gradual dose escalation, if the clinical benefit is expected to outweigh potential risks. Intermittent proteinuria (urine protein/creatinine ratio >0.6 mg/mg) occurred in 18.6% of EXJADE-treated patients, compared to 7.2% of deferoxamine-treated patients in ...

Halpin Foundation and the ASN announce recipient of Halpin Foundation-ASN research grant

... Syndrome and Other Mendelian Syndromes" will take place on Thursday, November 6 from 4:00 p.m. 6:00 p.m., and "New Insights into the Mechanisms of proteinuria and the Nephrotic Syndrome: Beyond the Slit Diaphragm" will occur on Friday, November 7 from 1:30 p.m. 3:30 p.m.. ...

Research May Help Predict Preeclampsia

... tricky. A woman may have a single blood pressure reading that is higher than normal before her pressure slips down again, or she may not exhibit proteinuria until later in her pregnancy. "Sometimes women present with this kind of vague feeling that they're just not feeling well," said Dr. B. Denise ...

MultiVu Video Feed: Study in the New England Journal of Medicine Shows High Blood Pressure Drug Tekturna(R) Reduces Key Marker of Kidney Disease

... of end-stage renal disease in developed countries, affecting more than 1.5 million people worldwide. In the AVOID (Aliskiren in the EValuation of proteinuria In Diabetes) study, Tekturna, when added to the maximum dose of losartan, reduced proteinuria by 20% compared to losartan alone in patients diagnosed ...

Study Showed ALIMTA(R) (pemetrexed for injection) Improved Survival in Certain Types of Non-Small Cell Lung Cancer

... 15, 64); nausea and vomiting (64 vs 58, 71); neutropenia (62 vs 18, 61); thrombocytopenia (47 vs 15, 36); pain (10 vs 7, 42); fever (30 vs 16, 38); proteinuria (10 vs 2, 32); constipation (10 vs 11, 31); diarrhea (24 vs 31, 30); rash (24 vs 13, 28); and bilirubin elevation (16 vs 25, 26). See complete ...
Proteinuria in Medical Technology

Exelixis Reports Top-Line Results of the Phase 2 Trial of XL784 in Patients With Proteinuria Associated With Diabetic Nephropathy

... with placebo in patients with proteinuria associated with diabetic nephropathy. Exelixis is ... phase 2 trial of XL784 in diabetic patients with proteinuria are scheduled for presentation on November 2, ... of the trial was a significant reduction in proteinuria compared with placebo. Secondary endpoints ...

Rigel's R788 Slows Progression of Murine Lupus in Preclinical Studies

... of the study, only 2 of the 29 mice in the 40 mg/kg group had elevated proteinuria compared to 21 of the 30 mice in the control group. All 29 (100%) of the ... the majority of the animals (~95%) given the 40 mg/kg dose had elevated proteinuria levels that decreased following the onset drug treatment. Systemic Lupus ...

Human Genome Sciences and GlaxoSmithKline Announce Positive Phase 3 Study Results for BENLYSTA(TM) in Systemic Lupus Erythematosus

... for the primary endpoint is based on intention-to-treat (ITT) and adjusted for baseline stratification factors, including SELENA SLEDAI score, proteinuria and race. In each of the two Phase 3 trials, patients were randomized to one of three treatment groups: 10 mg/kg belimumab (BLISS-52, ...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

... at a lower dose followed by gradual dose escalation, if the clinical benefit is expected to outweigh potential risks. Intermittent proteinuria (urine protein/creatinine ratio >0.6 mg/mg) occurred in 18.6% of Exjade-treated patients, compared to 7.2% of deferoxamine-treated patients in ...

Keryx Biopharmaceuticals Announces Termination of SUN-MACRO Phase 4 Trial

... which the Company would make a decision regarding whether the trial ought to be continued or terminated. Based on a review of the available proteinuria data, Sulonex did not appear to be different than placebo. The study was not terminated by the DSMC for a safety problem or safety signal. About ...

Powerful New Efficacy Data in Moderate and Severe Hypertensive Patients Supports FDA Approval of AVALIDE(R) (Irbesartan-Hydrochlorothiazide) as the First Combination Therapy for Initial Use in Patients Likely to Need Multiple Drugs to Achieve Their Blood

... with other antihypertensive agents. AVAPRO is also indicated for the treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (>300 mg/day) in patients with type 2 diabetes and hypertension. In this population, AVAPRO reduces the rate of progression of nephropathy as ...

Lilly Files for European Approval of ALIMTA(R) (pemetrexed for injection) for First-Line Treatment of Non-Small Cell Lung Cancer

... 20% of patients and is rarely dose-limiting. Common: Diarrhoea, oral toxicity (mainly soreness and erythema), and constipation. Renal: Very common: proteinuria and haematuria, rarely clinically significant. Rare: Haemolytic uraemic syndrome and renal failure of unknown aetiology. GEMZAR should be withdrawn ...

New Data Presented on Micardis (Telmisartan) Tablets in Hypertensive Patients With Type 2 Diabetes

... with losartan (p= 0.0284).(1) At baseline proteinuria was similar for both groups. The change from ... vs. losartan 0.80 (95% CI; 0.74, 0.87)].(1) proteinuria (high levels of protein in the urine) is a ... trials have shown that reductions in proteinuria of >30% at six months are strongly linked to ...

New Study Shows That telmisartan has Greater Renoprotective Potential Thanlosartan in Hypertensive Patients With Type 2 Diabetes

... Milan. The results from this study show that telmisartan reduces proteinuria to a significantly greater extent than losartan.(1) Commenting ... of adverse events was observed between the two treatments groups(1). proteinuria (high levels of protein in the urine) is a very important signal for ...
Proteinuria in Medical Products

Lyphochek Quantitative Urine Control

Description:... biogenic amines and hormones. It also contains hCG (for qualitative pregnancy tests) and microalbumin at levels suitable for monitoring early proteinuria and associated ....
Company:Bio-Rad Laboratories
Proteinuria in Medical Dictionary

Proteinuria

... proteinuria describes a condition in which urine contains ... Names : Albumin - Urine , Albumin uria, proteinuria , Urine Albumin , Urine Protein Definition ... measures the amount of protein in urine . proteinuria : Excessive protein in the urine . PROTOCOL: ...

Hematuria

... Hematuria The presence of blood in the urine . Patella The kneecap. proteinuria Excess protein in the urine . Alternative Names: Hematuria ; Blood ... following an upper respiratory infection Protein in the urine ( proteinuria ) Swelling ( edema ) in the hands and feet High blood pressure ...

Nephrotic syndrome

... is a condition marked by very high levels of protein in the urine ( proteinuria ); low levels of protein in the blood ; swelling , especially around ... syndrome with excessive filtration of protein into the urine ( proteinuria ), high blood pressure ( hypertension ), and progressively impaired ...

Edema

... parts of the body One or more of these symptoms can be the first sign of kidney disease . But how would you know, for example, whether you have proteinuria ? Before seeing a doctor, you may not. EDEMA (Dropsy) SYMPTOMS" Swelling of the hands, ankles, feet, face, abdomen , or other areas of the ...

High Cholesterol

... atherosclerosis . Membranous nephropathy , also called membranous glomerulopathy, is the second most common cause of the nephrotic syndrome ( proteinuria , edema , high cholesterol ) in U.S. adults after diabetic nephropathy . Everyone should limit their saturated fat intake to less than 10 ...

Hypertension

... by pheochromocytoma may be sustained or paroxysm al and is often severe with occasional malignant features of encephalopathy, retinopathy , and proteinuria . Ocular Hypertension - A condition in which the intra ocular pressure is elevated above normal and which may lead to glaucoma . Ocular ...

Inflammation

... Inflammation in the glomeruli is called glomerulonephritis , or simply nephritis . Many disease s can cause this inflammation , which leads to proteinuria . Inflammation of the bile ducts ( cholangitis ) produces similar symptoms (plus jaundice ) to inflammation of the gallbladder , but the ...

Kidney transplant

... suffer from renal failure need to have the blood cleaned artificially with a dialysis machine, or require a kidney transplant . urine ( proteinuria ), high blood pressure ( hypertension ), and progressively impaired kidney function. When it is severe, diabetic nephropathy leads to kidney ...

Retinopathy

... by pheochromocytoma may be sustained or paroxysm al and is often severe with occasional malignant features of encephalopathy, retinopathy , and proteinuria . Retinopathy and associated visual loss or blindness Broncho pulmonary dysplasia (BPD) Heart disease Severe intestinal inflammation ...

Sore Throat

... sore throat , and enlarged lymph node s. The most common complaint is a sore throat . For example, PSGN can cause severe symptoms ( hematuria , proteinuria , edema ) within 2 to 3 weeks after a sore throat or skin infection develops. The patient may temporarily require dialysis to replace renal ...

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Proteinuria in Biological News

Simple screening questionnaire for kidney disease outperforms current clinical practice guidelines

... and a simple scoring system based on seven risk factors for CKD -- age, sex, hypertension, diabetes, cardiovascular disease (CVD), anemia and proteinuria (the presence of excessive protein in the urine). All risk factors for CKD are supported by scientific theory and have been validated by national ...
Proteinuria in Biological Technology

Exelixis Announces Third Quarter 2007 Financial Results and Business Update

... phase 2 trial of XL784 did not meet its primary endpoint of reducing proteinuria compared with placebo in patients with proteinuria associated with diabetic nephropathy. Various subgroup analyses suggest ...

PTC Therapeutics Initiates Phase 2 Clinical Trial of PTC299 in Patients with Neurofibromatosis Type 2

... in severity, did not require intervention, and were not clearly related to PTC299. In addition, adverse events such as bleeding, hypertension and proteinuria were not observed. The Phase 2 clinical trial of PTC299 is supported by a grant from the U.S. Department of Defense Neurofibromatosis Research ...

BioMarin Announces Fourth Quarter and Full Year 2008 Financial Results

... C study -- 1Q09: Results from Phase 2 PAH trial -- 1Q09/2Q09: Initiation of Phase 1 trial for GALNS for MPS IVA -- 2Q09: Results from proteinuria in chronic kidney disease trial -- 2Q09: Results from PEG-PAL Phase 1 trial -- 2Q09: Initiation of PEG-PAL Phase 2 trial Upcoming ...

BioMarin Announces Third Quarter 2008 Financial Results

... -- 1Q09: Results from Phase 2 PAD trial -- 1Q09: Results from BH4+Vitamin C study -- 1Q09: Results from Phase 2 PAH trial -- 1Q09: Results from proteinuria in chronic kidney disease trial -- 1Q09: Initiation of Phase 1 trial for GALNS for MPS IVA -- 1Q09/2Q09: Results from PEG-PAL Phase 1 trial -- ...

JCI table of contents: April 22, 2008

... . View the PDF of this article at: https://www.the-jci.org/article.php?id=32691 ACCOMPANYING COMMENTARY TITLE: Linking adiponectin to proteinuria AUTHOR CONTACT: Rexford S. Ahima University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. Phone: (215) 573-1872; Fax: ...
Proteinuria in Biological Definition

Ebola

... to vomiting , diarrhea , oropharyngeal lesions , conjunctivitis , organ damage (notably the kidney and liver ) by co-localized necrosis , proteinuria (the presence of proteins in urine), and bleeding both internal and external, commonly through the gastrointestinal tract . Death or recovery to ...
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