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Promoter in Medical News

Promising biomarker and candidate tumor suppressor gene identified for colorectal cancer

... and biomarker. The researchers analyzed NDRG4 promoter methylation and expression in human colorectal ... chain reaction was used to examine NDRG4 promoter methylation as a biomarker in fecal DNA from 75 ... subjects. The researchers found that NDRG4 promoter methylation was more prevalent in colorectal ...

A breakthrough in gastric carcinogenesis

... (CHFR) is a mitotic stress checkpoint gene whose promoter is frequently methylated in various kinds of cancer. In gastric cancer, CHFR promoter hypermethylation has been reported to lead to ... University examined the methylation status of the promoter region of CHFR and microsatellite instability ...

Synthetic gene circuit allows precise dosing of gene expression

... yeast's DNA. The gene circuit starts with a promoter that launches the tetracycline repressor gene, which then blocks yEGFP via a promoter for that gene, shutting down its expression. ... and an amplifier The team then made the promoter for the repressor identical to that used for ...

Mouth may tell the tale of lung damage caused by smoking

... 39 individuals (95 percent) with p16 and/or FHIT promoter methylation in the oral samples had promoter methylation in at least one matched bronchial ... 59 of the 86 (69 percent) individuals without the promoter methylation in the oral samples. Similar ...

Farnesoid X receptor regulates cystathionase

... In the present study the analysis of the human Cystathionase gene promoter demonstrates the presence of an inverted repeat sequence. Administration ... four copies of this putative IR1 resulted in transactivation of the CSE promoter in presence of an FXR ligand, while the mutation of the IR1 binding site ...

Scientists identify gene in breast cancer pathway

... that ZBP1 silencing occurs when a methyl group (CH3) attaches to ZBP1's promoter region (the segment of a gene where gene expression is initiated). The attachment of CH3 prevents the promoter from binding to a protein called beta-catenin. And without beta-catenin, ...

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Promoter in Medical Technology

Video: The Journal, Human Genetics, Publishes Results Supporting Interleukin Genetics' Heart Health Test

... the results of clinical studies that support the company's Heart Health Genetic Test to assess cardiovascular risk. The article, titled, "IL1B Gene promoter Haplotype Pairs Predict Clinical Levels of Interleukin-1beta and C-reactive Protein," was published in the journal Human Genetics (123:387-398; May ...

Celldex Therapeutics Receives Fast-Track Designation for CDX-110, a Novel EGFRvIII Vaccine for Glioblastoma

... of primary brain cancer and carries a very poor prognosis with current therapy. CDX-110 is an immunotherapy that targets the tumor-specific growth promoter EGFRvIII that can be expressed by GBM. In the ACTIVATE Phase 2a study, GBM patients treated with CDX-110 showed a median survival time of 30 ...

Celldex Therapeutics Announces Orphan Drug Designation for CDX-110, a Novel EGFRvIII Vaccine for Glioblastoma Multiforme

... Multiforme (GBM). GBM is the most common and aggressive form of brain cancer. CDX-110 is an immunotherapy that targets the tumor-specific growth promoter EGFRvIII. Celldex Therapeutics announced a definitive merger agreement with AVANT Immunotherapeutics, Inc. (Nasdaq: AVAN ) in October 2007. In the ...

Lpath Demonstrates Preclinical Efficacy of Lpathomab(TM) and Initiates Humanization Process

... England, to humanize Lpathomab to create a lead antibody for pre- clinical development. LPA is a bioactive lipid long recognized as a significant promoter of cancer-cell growth and metastasis in a broad range of tumor types, as well as a significant contributor to neuropathic pain. "Humanizing our ...

Gene Therapy Eradicates Pancreatic Cancer in Preclinical Trial Targeting System's Success in Mouse Model Reported in Cancer Cell

... mutant gene delivered via a less-targeted viral promoter driven expression system ... C-VISA-BikDD. They used a gene-based targeting promoter called CCKAR known to be active in pancreatic ... after delivery. A system using a viral promoter such as CMV has the opposite problem: strong ...

Merck at ASCO 2007: Encouraging Results in Progression-Free Survival in Patients With Aggressive Brain Tumors (glioblastoma) Using Cilengitide in Phase I/IIa Study

... of 8.1 months. In a defined patient subgroup with the methylated MGMT gene promoter in the tumor tissue, 91% of patients had six months PFS and the median has ... 54% 6 months PFS, median PFS of 6.9 months;(1) methylated MGMT gene promoter subgroup: 69% PFS and 10.3 months median PFS].(2) Lead investigator ...

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Promoter in Medical Definition

Neuropsychiatry

... Remick, R.A. & Keck, P.E, McElroy, S L, Alexander, L., Shaw, S.H., & Kelsoe, J. (2003) Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder. Molecular Psychiatry, 8, 546−557. Baughman, F.A., & Hovey, J. ...
Promoter in Medical Dictionary

Cardiac

... are as follows: ... Control of cardiac -specific troponin T gene expression- We have defined cis-regulatory elements of cardiac troponin T promoter and continued to clone transactivating factors that are required for cardiac -specific expression of troponin T gene . iv. In complex cases, ...
Promoter in Biological News

UT Southwestern researchers identify new targets for RNAs that regulate genes

... interact with a non-gene region of DNA called a promoter region, a sequence of DNA occurring spatially in front of an actual gene. This promoter must be activated before a gene can be turned on. ... This type of RNA is found in association with the promoter regions that occur in front of the ....

Researchers uncover mechanism of action of antibiotic able to reduce neuronal cell death in brain

... colleagues were interested in identifying how the promoter region of the EAAT2 gene controlled the ... examined all the regions and sequences in the promoter region and systematically eliminated them to then ... they identified critical regions in the EAAT2 promoter that might regulate activity, they found that ...

Regulation of TATA-less promoters

... machinery recognizes and binds to specific core promoter sequences in the gene. While some genes contain a TATA box core promoter element that is recognized by TBP (the TATA-box ... TRFs) have been identified, but their core promoter recognition functions have not yet been ...

NIA uses Genomatix in stem cell research, suggests novel transcription factors for stemness

... transcripts by SAGE and qRT-PCR methods. Then they employed extensive DNA promoter analysis based on the integrated Genomatix system in order to identify conserved cis-elements and putative trans-regulators. Framework analysis for promoter organization, as introduced by Genomatix, increased likeliness for ...

Media highlights in the January issues of Biophysical Journal

... variations in DNA accessibility between a non-promoter and two promoter nucleosomes were noted in the H2A-H2B depleted complexes. The ability of ... for differential recognition of specific nucleosomes, such as those on key promoter elements. Significant sequence-dependence nucleosome stability is not ...

Weizmann Institute scientists discover: A 'risk distribution law' for evolution

... They found that a genetic 'phrase' that regularly shows up in the promoter region of genes (the bit of genetic code responsible for activating the ... The expression of a gene that contains the sequence TATA in its promoter is more likely to have evolved than that of a gene that does not have TATA ...

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Promoter in Biological Technology

New Collaboration Aims To Expand Seed-Based Technologies, Benefit Farmers

... computational approaches, to identify promoter candidates. Once specific promoter sequences are identified, the information can be further used to design ... Padgette, vice president of biotechnology for Monsanto. "A robust promoter toolbox can further leverage Monsanto's extensive gene library and lead to ...

Updated Online Tutorials for DBTSS, Pfam and PDB

... Protein Databank (PDB). DBTSS is a public resource for the analysis of promoter regions. Pfam is a comprehensive database of protein families ... These tutorials will teach users: DBTSS to examine human promoter regions, and those in selected other species as well to locate ...

Debiopharm Group and Moffitt Cancer Center Sign Development and Commercialisation Agreement for Small Molecule Debio 0928 in Early Preclinical Development for Treatment of Solid Tumours

... many types of cancer, could open the door to more effective oncology treatments in the future." "The disruption of the binding of the tumour promoter Raf-1 to the tumour suppressor Rb with Debio 0928 is a novel, first-in-class therapeutic strategy that has the potential for targeting a wide ...

BASF Sues DuPont for Patent Infringement

... patented technology that confers tolerance to a key class of herbicides. Specifically, DuPont's Optimum GAT corn product incorporates BASF's patented promoter which is an important genetic component that enables successful tolerance toward an herbicide class known as AHAS or ALS inhibitors. BASF Plant ...

Tigris Pharmaceuticals Presents Results of Breast Cancer Research at AACR Annual Meeting

... of CYP1A1) from the cytoplasm to the nucleus, and its subsequent interaction with the xenobiotic-response element (XRE) sequence on the CYP1A1 promoter region, causing induction of CYP1A1 transcription. This enzyme expression converts AF to metabolites that are covalently bound to DNA. This results ...

DNA2.0 Introduces Freedom of Expression With a New Family of Bacterial Expression Vect:ors

... ensure optimal repression prior to induction. These vectors are available with either the T7 or T5 promoter. DNA2.0's research has shown that the T5 promoter routinely expresses proteins at higher levels comparable to T7 pET vectors and works in any E. coli host. Cloning into the pJexpress series is free ...

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Promoter in Biological Products

pAcAB4 Baculovirus Transfer Vector from BD Biosciences Pharmingen

Description:... that contains two copies of the AcNPV polyhedrin promoter and two AcNPV p10 promoters. Downstream of the ... Upstream of this, an inverted polyhedrin promoter has been inserted containing Xba I and Stu I as ... Additionally, there is another polyhedrin promoter and BamH I cloning site downstream of the first ...
Company:BD Biosciences Pharmingen

FRT flanked, Pro and Euk. Neomycin Selection Cassette plus loxP site(FRT-PGK-gb2-neo-FRT-loxP) from Gene Bridges GmbH

Description:... cells, respectively. It combines a prokaryotic promoter (gb2) for expression of kanamycin resistance in E.coli with a eukaryotic promoter (PGK) for expression of neomycin resistance in mammalian cells. The prokaryotic promoter gb2 is a slightly modified version of the Em7 ...
Company:Gene Bridges GmbH

loxP flanked, Pro and Euk. Neomycin Selection Cassette (loxP-PGK-gb2-neo-loxP) from Gene Bridges GmbH

Description:... resistance gene which combines a prokaryotic promoter (gb2) for expression of kanamycin resistance in E.coli with a eukaryotic promoter (PGK) for expression of neomycin resistance in mammalian cells. The prokaryotic promoter gb2 is a slightly modified version of the Em7 ...
Company:Gene Bridges GmbH

FRT flanked, Pro and Euk. Neomycin Selection Cassette (FRT-PGK-gb2-neo-FRT) from Gene Bridges GmbH

Description:... resistance gene which combines a prokaryotic promoter (gb2) for expression of kanamycin resistance in E.coli with a eukaryotic promoter (PGK) for expression of neomycin resistance in mammalian cells. The prokaryotic promoter gb2 is a slightly modified version of the Em7 ...
Company:Gene Bridges GmbH

* Quick & Easy Conditional Knock Out Kit - FRT from Gene Bridges GmbH

Description:... selection in prokaryotic and eukaryotic cells. It combines a prokaryotic promoter (gb2) for expression of kanamycin resistance in E.coli with a eukaryotic promoter (PGK) for expression of neomycin resistance in mammalian cells. The ...
Company:Gene Bridges GmbH

* Quick & Easy Conditional Knock Out Kit - loxP from Gene Bridges GmbH

Description:... selection in prokaryotic and eukaryotic cells. It combines a prokaryotic promoter (gb2) for expression of kanamycin resistance in E.coli with a eukaryotic promoter (PGK) for expression of neomycin resistance in mammalian cells. The ...
Company:Gene Bridges GmbH

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Promoter in Biological Definition

Promoter

... for disambiguation of the term promoter, see the promoter Wiktionary article In genetics , a promoter is a DNA sequence that enables a gene to be transcribed . The promoter is recognized by RNA polymerase , which then ...

Operon

... An operon is a group of genes including an operator , a common promoter , and one or more structural genes that are controlled as a unit to ... and two associated segments of DNA : an operator (the switch) a promoter (a binding site for the transcription enzyme ). The switch of an ...

Bioinformatics

... to that expression data to determine which genes are co-expressed. Further analysis could take a variety of directions: one 2004 study analyzed the promoter sequences of co-expressed (clustered together) genes to find common regulatory elements and used machine learning techniques to predict the ...

Bioinformatics

... to that expression data to determine which genes are co-expressed. Further analysis could take a variety of directions: one 2004 study analyzed the promoter sequences of co-expressed (clustered together) genes to find common regulatory elements and used machine learning techniques to predict the ...

Enhancer

... article in Science , where researchers Wedel, et. al., made two linked circles of DNA, one circle with the enhancer sequence and the other with its promoter . An abstract can be found here .) An enhancer does not need to bind close to the transcription initiation site to affect its transcription, as ...

Gene

... DNA strand is expressed into a trait only if it is transcribed to RNA . Because the transcription starts from a specific base-pair sequence (a promoter ) and stops at another (a terminator ), our DNA strand needs to be correctly placed between the two. If not, it is considered as junk DNA , and is ...

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Promoter in Biological Dictionary

Transversion

... event in rat neuroblastomas. ... The promoter sequence having this transversion has a higher promoter activity ... Nuclear dbpA expression and the T-to-G transversion in the promoter region of dbpA ... it is a beautiful clutch ...

Response element

... element is a short sequence of DNA within the promoter of a gene that is able to bind a specific ... ... The response element is part of the promoter of a gene. ... the zinc-finger domain needed ... hormones , a short sequence of DNA within the promoter of a gene CREB 'CREB' redirects here. For ...

Promoter site

... In genetics, a promoter is a region of DNA that facilitates the ... SEOs Transcription start site . The basal promoter . An Analogy ... Link to a discussion of how the DNA sequence of promoter sites can be determined. ... ... ...

Promoter

... In genetics, a promoter is a region of DNA that facilitates the ... strand and upstream . An entertainment promoter is a person or company in the business of ... or other live events. Find out what being a promoter involves and decide if this job is right for ... ...

Pribnow box

... six nucleotides that is an essential part of a promoter site on DNA for transcription to occur in ... sequences > regulatory sequences > promoter regions > Pribnow box ... Resources in ... (TATAAT) located 10 bases pairs upstream ... promoter ( Pribnow box , TATA box ) - Operon (gal ...

Mutagenesis

... us to ... mutagenesis , construction of promoter libraries, phenotypic ... Saturation ... is a simple method that can be used to scan a promoter ... Map of the bop gene cluster, the minimal bop promoter and ...

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Other Contents
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Breaking Medicine News(10 mins):Health News:MetroMD Offers Revolutionary Anti-aging Hormone Therapy in Hollywood Area 2Health News:National Association of Hispanic Nurses (NAHN) Receives Five-Year Federal Grant from the National Institutes of Health (NIH) 2Health News:National Association of Hispanic Nurses (NAHN) Receives Five-Year Federal Grant from the National Institutes of Health (NIH) 3Health News:Seedstock Sustainable Agriculture Conference’s Urban Farm Field Trip to Offer First Look at Los Angeles’ Premier Food Business Incubator 2Health News:Seedstock Sustainable Agriculture Conference’s Urban Farm Field Trip to Offer First Look at Los Angeles’ Premier Food Business Incubator 3Health News:For the 8th Time, Verndale Has Been Honored on the Inc. 5000 List 2
(Date:8/19/2014)... From this week,s Eos: Long-Term Ecological Research and Network-Level ... track how a wide range of ecosystems was responding ... would be particularly powerful if it coupled multiple decades ... large-scale, long-term experiments and models from dozens of different ... It is the Long-Term Ecological Research (LTER) Network, which ...
(Date:8/19/2014)... the world, leprosy and tuberculosis live side-by-side. Worldwide ... per year, with nearly all of them occurring ... vaccine Bacille Calmette-Guerin, or BCG, provides only partial ... more potent vaccine is needed to combat both ... weapon against both diseases., In a study published ...
(Date:8/19/2014)... CAMBRIDGE, MA -- MIT chemical engineers have devised a ... that are released slowly over a few weeks. When ... induces the body to rapidly form new bone that ... This type of coated scaffold could offer a dramatic ... which involves transplanting bone from another part of the ...
Breaking Biology News(10 mins):This week from AGU: Long-term ecological research, predicting cholera outbreaks 2New vaccine shows promise as stronger weapon against both tuberculosis and leprosy 2Engineering new bone growth 2Engineering new bone growth 3
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