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Proliferation in Medical News

New Insight Into Primate Eye Evolution

... only a minor difference in the timing of cell proliferation can explain the multiple anatomical differences ... cellular and genetic pathways that coordinate proliferation during development have been fine-tuned since the ... by studying how changes in the regulation of proliferation during development can lead to dramatic changes ...

Process controlling T cell growth and production identified

... on how ELF4 affected the process of inhibiting proliferation of CD8 T cells. Using mice generated to lack ... the absence of ELF4 eliminated control over the proliferation of CD8 T cells. "If we can control ELF4 ... understanding the process that controls T cell proliferation will help in future research. ...

Progen Technology Switches on Cancer Fighting Genes and Inhibits Tumor Growth

... Progen also presented an update on its cell proliferation technology at the AACR Conference. Progen's lead cell proliferation product, PG11047, targets hyper-proliferating ... latest findings in Progen's epigenetics and cell proliferation technologies represented another important ...

Also in the April 7 JNCI

... TGF- is a cytokine that promotes cell proliferation in a variety of tissues and its expression has ... gastric cancer cell lines. They then investigated proliferation of these cells in culture and tumor growth and ... receptor did not increase cancer cell proliferation in vitro but increased tumor growth when the ...

JCI online early table of contents: Nov. 6, 2008

... into the signaling molecules that control the proliferation of HCC cells, and suggest that targeting one of ... into mice. Mechanistically, decreased proliferation and tumor development were associated with ... human HCC cells transplanted into mice. TITLE: proliferation of human HCC cells and chemically induced mouse ...

Protein 'switch' suppresses skin cancer development

... a sentry, monitoring and, when necessary, halting proliferation of these important cells. In the first mouse ... functions as a sentry that monitors keratinocyte proliferation and then induces terminal differentiation. In one ... factors previously found to regulate keratinocyte proliferation and differentiation. Another experiment ...

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Proliferation in Medical Technology

Mutant Genes in High-Risk Childhood Leukemias Identified

... in the on position, triggering the uncontrolled proliferation of white blood cells that is seen in leukemia." ... of many kinases known to be components of the proliferation machinery of white blood cells. The team analyzed ... could switch them on to drive the blood cell proliferation that is characteristic of ALL," said Stephen ...

XTL Biopharmaceuticals Announces the Acquisition of the Use Patent on Recombinant Erythropoietin (rHuEPO) for the Treatment of Multiple Myeloma

... malignancy characterized by the accumulation and proliferation of clonal plasma cells in the marrow, leading to ... of erythroid progenitor cells, promoting their proliferation and differentiation and maintaining their ... malignancy characterized by the accumulation and proliferation of clonal plasma cells in the marrow, leading to ...

Cylene Pharmaceuticals Initiates Phase I Trial With CX-4945 -Breakthrough First-in Class Inhibitor of CK2

... a wide range of cancers. CK2 drives the excessive proliferation phenotype of cancer cells through its ... drives key cell survival pathways and proliferation of cancer cells, but it has been notoriously ... is of central importance in driving cancer cell proliferation as well as in angiogenesis. As such, CX-4945 is ...

Semafore Broadens Pipeline With Multi-Targeted Kinase Inhibitors

... and PI3K. SF2523 demonstrated potent anticancer proliferation activity across a broad range of 18 cancer ... and multiple myeloma). Notably, SF2523 inhibited proliferation in multiple cell lines with KRAS mutations, ... of new blood vessels for cancer growth), proliferation and metastasis. Semafore's innovative PI3K ...

Injection Reverses Heart-Attack Damage

... production of a cellular receptor for NRG1, known as ErbB4, cardiomyocyte proliferation was further enhanced, demonstrating that NRG1 works by stimulating this ... placed over the site of cardiac injury in rats, it induced cardiomyocyte proliferation and improved heart function ( Nature Medicine 2007; 13:962-9). Similar ...

Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, Is Well Tolerated and Demonstrates Activity in Phase I Solid Tumor Patients

... ATM and PIM-1. SF1126 is designed to inhibit both angiogenesis and cell proliferation by targeting and binding to integrins that are expressed on the surface of ... are important in controlling cell growth/angiogenesis, differentiation, proliferation and survival/apoptosis. Dysregulation of the PI3 kinase signaling ...

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Proliferation in Medical Products

Eftiar Octane

Description:... the vitreoretinal surgeon a temporary tamponade for efficient re-attachment of the retina, release of subretinal fluid, dissection of fibro-vascular proliferation and controlling retinal bleeding. Eftiar Octane and Eftiar Decalin liquid is indicated for use as an aid in temporary flattening of the retina. ...
Company:Dutch Ophthalmic, USA

Eftiar®-Decalin

Description:... the vitreoretinal surgeon a temporary tamponade for efficient re-attachment of the retina, release of subretinal fluid, dissection of fibro-vascular proliferation and controlling retinal bleeding. (Sterile, 5 ml. ...
Company:Dutch Ophthalmic, USA

Eftiar®-Octane

Description:... the vitreoretinal surgeon a temporary tamponade for efficient re-attachment of the retina, release of subretinal fluid, dissection of fibro-vascular proliferation and controlling retinal bleeding. (Sterile, 5 ml. ...
Company:Dutch Ophthalmic, USA

SDS 200: 200 L Reservoir

Description:... directly by the Elix or RiOs system ASM Automatic Sanitization Module The optional ASM Automatic Sanitization Module prevents bacterial proliferation and the build-up of a bacterial biofilm on the inner surface of S.D.S. reservoirs. The ASM module contains a 254 nm UV lamp, selected for its ...
Company:Millipore

SDS 350: 350 L Reservoir

Description:... directly by the Elix or RiOs system ASM Automatic Sanitization Module The optional ASM Automatic Sanitization Module prevents bacterial proliferation and the build-up of a bacterial biofilm on the inner surface of S.D.S. reservoirs. The ASM module contains a 254 nm UV lamp, selected for its ...
Company:Millipore

200 L Storage & Distribution System without pump

Description:... directly by the Elix or RiOs system ASM Automatic Sanitization Module The optional ASM Automatic Sanitization Module prevents bacterial proliferation and the build-up of a bacterial biofilm on the inner surface of S.D.S. reservoirs. The ASM module contains a 254 nm UV lamp, selected for its ...
Company:Millipore

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Proliferation in Medical Definition

Hematopathology

... as chronic leukemia and acute leukemia . Chronic leukemia is the proliferation of too many mature blood cells , and is called that because it is a ... leukemia and chronic lymphocytic leukemia . Acute leukemia is the proliferation of too many immature blood cells, called myeloblasts , which have lost ...

Pathology

... through the formation of granulation tissue . Healing involves the proliferation of connective tissue cells and blood vessel -forming cells as a result ... function. [8] Neoplasia Neoplasia , or "new growth," is a proliferation of cells which is independent of any physiological process. The most ...

Biotextile

... and triclosan are at the present time the most used molecules. This original property allows to fight the development of bad smells, bacterial proliferation in the diabetic foot etc. New developments In the new paradigm of tissue engineering , professionals are trying to develop new ...

Canadian Health Libraries Association

... The formation of this Ad-hoc committee arose at this meeting (it was not specifically on the pre-circulated agenda), as it was clear that the proliferation of Canadian health library groups was not in the best interests of Canadian health sciences librarians. It was important then, as now, that Canadian ...

Nuclear medicine

... warfare • Nuclear arms race • Nuclear weapon design • Effects of nuclear explosions • Nuclear testing • Nuclear delivery • Nuclear proliferation • List of states with nuclear weapons • List of nuclear tests ...

Thymocyte

... , the cells are considered mature T cells, and not thymocytes. Cancer Thymocytes that gain oncogenic mutations allowing uncontrolled proliferation can become thymic lymphomas . Alternative lineages As well as classical T cells, a number of alternative cell lineages develop in the ...

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Proliferation in Medical Dictionary

Proliferation

... Cell proliferation is regulated by several control points, termed ... checkpoints may lead to cancer . cell proliferation An increase in the number of cells as a result ... . cell respiration ... T LYMPHOCYTE proliferation ASSAY: Measures the strength of response of T ...

Acute lymphocytic leukemia

... associated with a poor prognosis . The most common leukemia affecting children is acute lymphocytic leukemia (ALL), marked by abnormal proliferation of a type of white blood cell known as lymphocyte s. This form affects about 80 to 85 percent of children with the disease . Acute ...

Ambulatory

... Therapy Services, Pulmonary Physiology Labor atory and the Di vision of Pulmonary /Critical Care Medicine. Dr. information, the proliferation of affordable, relatively easy-to-use portable ultrasound machines, and the greater number of skilled clinicians have all contributed to the ...

Amniotic fluid

... A, Lehnert A, Schink M, et al.: Effect of Viscum album L. on rapidly proliferating amniotic fluid cells. Sister chromatid exchange frequency and proliferation index. Arzneimittelforschung 45 (1): 81-3, 1995. [PUBMED Abstract] ... Before birth , a kidney malformation in the fetus may cause an ...

Brain tumor

... and often require surgery . Brain tumor Primary brain tumor Definition: A brain tumor is any growth of abnormal cells or uncontrolled proliferation of cells in the brain. GLIOBL AST OMA MULTI FORME - May be subdivided into primary brain tumor s and the more common, secondary brain tumor ...

Craniopharyngioma

... , glioma, ependymoma, neuroglioma, oligodendroglioma, gliobla stoma multi forme, meningioma , medullobla stoma ) arise from the uncontrolled proliferation of cells within the brain. Malabsorption disorders such as Celiac disease Inflammatory bowel disease AIDS Achondroplasia Russell ...

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Proliferation in Biological News

UCSB scientists show how certain vegetables combat cancer

... substances in these vegetables inhibit cell proliferation was unknown until now. Scientists in the UC ... the surprising discovery that SFN inhibits the proliferation of human tumor cells by a mechanism similar to ... cancer preventive agent because it inhibits the proliferation and kills precancerous cells," said Wilson. It ...

New molecular insight into vertebrate brain development

... central nervous system, as well as the controlled proliferation and differentiation of neural progenitor cells ... signaling serves as a brake on cell growth and proliferation by preventing another protein, YAP, from entering ... by restricting instructing the survival, proliferation and differentiation of neural precursor cells. In ...

Green tea may delay onset of type 1 diabetes

... be rapidly reproducing in the control group. The proliferation was suppressed in the EGCG-fed group. "It's kind of counterintuitive why would there be proliferation of the glandular cells occurring when the present ... for his master's research project at MCG. The proliferation phenomenon also can be observed in psoriasis, an ...

CSHL scientists identify new drug target against virulent type of breast cancer

... proteins. Brk acts as an accelerator of proliferation Further experiments by Muthuswamy's team revealed that although Brk does not induce cancerous proliferation on its own, it enhances the proliferation of cells that also express ErbB2 by speeding up ...

Imiquimod, an immune response modifier, is dependent on the OGF-OGFr signaling pathway

... of apoptosis. The mechanism of imiquimod on cell proliferation is unclear. The research team, led by Dr. Ian ... inhibitory pathway is known to regulate cell proliferation by modulating cyclin dependent kinase inhibitors, ... chemistry - has been discovered to regulate cell proliferation by imidazoquinolines." Co-author, Moshe ...

A study reveals how cells communicate to activate the cell division machinery

... neighboring cells in order to activate the cell proliferation machinery that results in the organized growth of ... between the molecular elements that regulate proliferation for the correct development of the wing, explains ... could provide clues about how to repress the cell proliferation signals in cancer. The context is relevant ...

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Proliferation in Biological Technology

Data for Oncothyreon's PX-12 and PX-866 presented at AACR Annual Meeting

... of these cells with PX-866 blocked their proliferation and inhibited tumor growth, demonstrating not ... cancer cells have been linked to the aggressive proliferation of solid tumors, including colon, lung, and ... and cervical cancers, where it leads to increased proliferation and inhibition of apoptosis (programmed cell ...

Oncothyreon announces clinical data from three product candidates presented at American Society of Clinical Oncology (ASCO) Annual Meeting

... glioma, colon, ovarian, prostate and melanoma, where it leads to increased proliferation and inhibition of apoptosis (programmed cell death). PX-866 has been shown ... provides control over a number of transcription factors affecting cell proliferation and death through the mechanism of redox regulation. An initial Phase 1 ...

Preclinical Data From Amgen's Oncology Pipeline to be Presented at AACR

... AMG 479, a novel IGF-1R antibody, inhibits endometrial cancer cell proliferation through disruption of the P13K/Akt and MAPK pathways Overview: ... the effect of a novel antibody to the IGF-1R (AMG 479) on cell proliferation and expression of key targets involved in IGF-1R signaling in ...

Spectrum Pharmaceuticals and Cell Therapeutics to Jointly Market ZEVALIN, a Proprietary, Marketed Oncology Drug

... NHL. Non-Hodgkin's lymphoma (NHL) is caused by the abnormal proliferation of white blood cells and normally spreads through the lymphatic system, a ... Lymphoma Non-Hodgkin's lymphoma (NHL) is caused by the abnormal proliferation of white blood cells and normally spreads through the lymphatic system, a ...

Ipsogen Launches MapQuant Dx(TM) Genomic Grade Test to Identify Breast Cancer Patients who Benefit From Chemotherapy

... of breast tumor sections under a microscope, could not describe the proliferation ability of 30 to 60 % of tumors. By contrast, the Genomic Grade index could capture proliferation in most tumors and showed superior prognostic and classification value ...

Exelixis Submits XL139 Diligence Report to Bristol-Myers Squibb

... pathway. Hedgehog plays a critical role in regulating cell growth, proliferation and differentiation in normal development. The pathway is deregulated in ... that hedgehog signaling may play a key role in cancer stem cell (CSC) proliferation and the resistance of CSCs to chemotherapeutics and radiotherapy. "One ...

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Proliferation in Biological Products

ES Cell Characterization Kit from CHEMICON

Description:... because they raise several fundamental issues concerning the regulation of proliferation and differentiation. Embryonic stem (ES) cells are derived from totipotent ... the early mammalian embryo and are capable of unlimited, undifferentiated proliferation in vitro [Evans and Kaufman, 1981; Martin, 1981; Morrison, 1997]. ...
Company:CHEMICON

Mouse Anti-Human gp340 Monoclonal Antibody, Unconjugated, Clone HYB213-01 from MBL International

Description:... Anti-gp340 Monoclonal Antibody Description: 100 g Research Focus: cancer & cell proliferation Storage: -20C Shipping Temperature: ...
Company:MBL International

Rabbit Anti-Ki67 Polyclonal Antibody, Unconjugated from GeneTex

Description:... Rabbit polyclonal to Ki67 - proliferation Marker, prediluted Ki67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active ...
Company:GeneTex

Cell Proliferation Kit from GE Healthcare, formerly Amersham Biosciences

Description:... Cell proliferation Kit, For 100 slides. Immunocytochemistry.Sample types: suitable for in vivo and in vitro tissue labeling.Recommended cell number: 10 6-107 ...
Company:GE Healthcare, formerly Amersham Biosciences

Mouse Anti-CDX-2 Monoclonal Antibody, Unconjugated, Clone CDX2-88 from BioGenex

Description:... CDX2, a member of the caudal-related homeobox family, is an intestine-specific transcription factor that regulates both proliferation and differentiation in intestinal epithelial cells. It plays an important role in triggering cells towards the phenotype of differentiated villus ...
Company:BioGenex

Mouse Anti-DNA Polymerase a Monoclonal Antibody, Unconjugated, Clone CL22-2-42B from MBL International

Description:... Anti-DNA Polymerase a, Human Description: 50 l Research Focus: cancer & cell proliferation Storage: 4C Shipping Temperature: ...
Company:MBL International

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Proliferation in Biological Definition

Apoptosis

... renewed by their respective progenitor cells; but proliferation has to be compensated by cell death. This ... human adult. In a year, this amounts to the proliferation and subsequent destruction of a mass of cells ... in order to maintain an equilibrium between cell proliferation and death in a particular tissue (see ...

Cancer

... regulation of cells. Cell multiplication ( proliferation ) is a normal physiologic process that occurs in ... digestive tract ). Normally the balance between proliferation and cell death is tightly regulated to ensure the ... processes. The uncontrolled and often rapid proliferation of cells can lead to either a benign tumor or ...

Oncogene

... secreted by a few special cells to induce cell proliferation in other cells. If a cell that usually does not ... it will thereby induce its own uncontrolled proliferation ( autocrine loop ), as well as the proliferation of neighboring cells. Protein kinases and ...

Cartilage

... The cartilage covering bones in joints (articular cartilage) is degraded, resulting in limitation of movement and pain. Achondroplasia : Reduced proliferation of chondrocytes in the epiphyseal plate of long bones results in a form of dwarfism . Costochondritis : Inflammation of cartilage in the ribs ...

Immune system

... (T H cells) activate infected macrophages (cells that ingest dangerous material), and also produce cytokines ( interleukins ) that induce the proliferation of B and T cells. In addition, there are Regulatory T cells (T reg cells) which are important in regulating cell-mediated immunity. ...

Signal transduction

... is used in a multitude of processes, among them muscle contraction, release of neurotransmitter from nerve endings, vision in retina cells, proliferation , secretion , cytoskeleton management, cell motion , gene expression and metabolism . The three main pathways that lead to Ca 2+ activation ...

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Proliferation in Biological Dictionary

Transferrin receptor

... expressed on a cell is ... TFRC ( transferrin receptor (p90, CD71)), Authors: M Tevfik Dorak. Published in: Atlas ... related to cell proliferation is the receptor for transferrin . ... ...

Sex cells

... Germ cells are progenitors of the gametes. These singled-out cells move through the gut to the developing gonads and undergo mitotic proliferation followed by meiosis and differentiation into either eggs or sperm . Plants do not have a germ line set aside in ... sex cell n. A ...

Oncogene

... form, the proto- oncogene . Operating as a positive growth regulator, the proto- oncogene is involved in promoting the differentiation and proliferation of normal cells. A variety ... No single oncogene can, by itself, cause cancer. ... It is estimated that fully 1% of the 25,000 or so genes ...

Multi-gene family

... gene family of vertebrates. ... ... Stephen Proulx studies gene families to explore how ... One path to diversity in a genome involves the proliferation of genes into multi - gene families. ... ... multi - gene subsets were chosen, one upstream of the IGF receptor ( IGF family ' ... ...

Lymphocytes

... IN BAL ... Lymphocytes present in the mucociliary epithelium of the trachea and bronchi are ... Lymphoid tissues represent the sites of proliferation and differentiation of lymphocytes . ... Identify lymphocytes and thymic corpuscles. ... The two major classes of lymphocytes are: B cells, ...

Intron

... Depot 2 - Books at Shop.com. Intron Depot 2 Fiction|Diamond Comic Distributors|Books|Paperback |Masamune Shirow Intron Depot 2 Books Intron proliferation and Maintenance. Discussion. References ... Such intron -debilitating mutations will result in either the expansion or ... We divided 147,796 ...

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