Attacks of King George III's madness linked to key metabolism molecule
...C-1 mediates effects of nutrition on blood disease porphyria Dana-Farber Cancer Institute researchers say they...26 issue of Cell that the nutritional component of porphyria involves a key master metabolic molecule, PGC-1 alpha, in cells of the liver. The gene that makes PG......ty changes or mental disorders. "Also, people with porphyria can suffer sudden, acute attacks if they take certain tranquilizers and other drugs that interfere with this system," Schuetz said. "So our work contributes to the overall picture of how disruption of the biochemical pathway of heme production can ca...Arsenic May Have Been Responsible For The Madness Of King George III Of England
...at exposure to arsenic would exacerbate attacks of porphyria in a genetically predisposed individual. King George III was diagnosed to have suffered from Porphyria- a genetic defect leading to the faulty synthesis of a protein. However during his regime he suffered from five major episodes of prolonged and pr...Study Unveils New Insight To The Madness Of King George III
...the journal Cell that the nutritional component of porphyria involves a key master metabolic molecule, PGC-1 al...ge III’s hair contained arsenic, which can provoke porphyria attacks. PGC-1 alpha is a “transcriptional co activator” that acts as an on-off switch for a numbe...Colour Of Urine Can Reveal The Health Status Of The Patients
...ent Greeks first diagnosed the rare blood disorder porphyria by observing colourful urine and even named the illness after the Greek word for purple. Then in the Middle Ages, when urine analysis enjoyed its heyday, specimens were routinely examined in a matula, or urine glass, held up to the light. But uri......ty changes or mental disorders. 'Also, people with porphyria can suffer sudden, acute attacks if they take certain tranquilizers and other drugs that interfere with this system,' Schuetz said. 'So our work contributes to the overall picture of how disruption of the biochemical pathway of heme production can ca...