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Polymorphic in Medical News

LOH analysis on 4q in sporadic colorectal carcinoma

... Thirteen fluorescent labeled polymorphic microsatellite markers were analyzed in 83 cases of colorectal carcinoma and matched normal tissue DNA by polymerase chain reaction (PCR). PCR ...

The American College of Cardiology, American Heart Association and the Heart Rhythm Society Release Updated Cardiac Device-Based Therapy Guidelines

... heart failure, congenital heart disease and sudden cardiac arrest. Guidelines also address treatment for genetic disorders such as catecholaminergic polymorphic VT, Brugada syndrome, arrhythmogenic right ventricular cardiomyopathy and short QT syndrome. Revised ICD indications reflect the new developments ...

American Chemical Society's Weekly PressPac -- Feb. 13, 2008

... formation, thereby preventing fat bloom. MTS ARTICLE #1 FOR IMMEDIATE RELEASE Effect of Antibloom Fat Migration from a Nut Oil Filling on the polymorphic Transformation of Cocoa Butter DOWNLOAD FULL TEXT ARTICLE http://dx.doi.org/10.1021/jf072151s CONTACT: Kevin W. Smith, Ph.D. Unilever R&D ...

Childhood Abuse Increases the Risk of Alcoholism

... M.D., a visiting fellow in NIAAAs Laboratory of Neurogenetics in Bethesda, Maryland. DNA variations occur within a regulatory area the MAOA-linked polymorphic region (MAOA-LPR) -- of the MAOA gene. Two such MAOA-LPR variants occur most frequently and result in high or low MAOA enzyme activity. In a ...

Young People Who Died Suddenly, Inexplicably Had Genetic Heart Defects

... spelling errors in the genetic code. The defects produced one of two abnormal heart rhythm conditions: Long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT). Both syndromes can declare their presence silently and catastrophically with a sudden death episode as the first ...

Alcohol Dehydrogenase Gene may Protect from Developing Alcoholism

... Alcohol dehydrogenase (ADH) is one of the major enzymes involved in alcohol metabolism. The genes for ADH are polymorphic at two loci, ADH1B and ADH1C.// The three alleles at the ADH1B locus have previously been linked with protection from alcohol dependence, a new ...

Does Aspirin Crystallize?

... one polymorph or the other. Aspirin is the first case in which two different “polymorphic” structures exist in one single crystal. So is aspirin polymorphic or not? Should the definition of polymorphism be updated? Such questions are not just philosophical in nature, but could have tangible implications ...

Allergies can prevent brain cancer

... multiforme (GBM) might be prevented by the same genetic factors that cause allergies. Researchers had found that the different kinds of polymorphic forms of two genes are responsible for people being susceptible to allergic conditions and having a minor risk of GBM. The current study ...

Risk for Diabetes type II may be in the genes

... Texas and 858 Caucasians living in Dallas, Texas. While 25% of the people in Chennai belonging to the non-diabetic group were carrying the gene polymorphic ENPP1 121Q allele, 34% of the diabetics in Chennai had the same gene. For the subjects in Dallas, the prevalence of the gene in the non-diabetic ...

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Polymorphic in Medical Technology

Optimer Pharmaceuticals Receives Production Patent for Lead Product Candidate Fidaxomicin

... of our lead product candidate, fidaxomicin," said Michael N. Chang, Ph.D., President and CEO of Optimer. "We believe this patent and the issued polymorphic Form A patent, along with additional pending patent applications, will enhance our intellectual property protection for fidaxomicin." ...

Synvista Therapeutics Presents New Preclinical Data Demonstrating the Value of Haptoglobin Genotype Testing In Diabetes at ACC Scientific Sessions

... prevented the impairment of reverse cholesterol transport in diabetic mice with the Hp2-2 genotype. About Haptoglobin 2-2 The Hp protein is polymorphic in humans, occurring with two alleles, 1 and 2, existing at the Hp genetic locus. Three phenotypes linked to the three genotypes, Hp 1-1, Hp 1-2 and ...

Pharmasset Announces Clevudine and R7128 Presentations at HEP-DART

... were analyzed for the presence of the S282T substitution. S282T results in a small loss in the antiviral activity of PSI-6130 and is not highly polymorphic in the wild-type HCV population. These in vitro data indicate that there is a high genetic barrier to resistance to PSI-6130. Since PSI-6130 is ...

The Past, Present and Future of HLA Typing

... The Human Leukocyte Antigen (HLA) region, located on the short arm of chromosome 6 (6p21.3), is a highly polymorphic region containing about 200 genes. The HLA region is the human equivalent of the Major Histocompatibility Complex (MHC), and as such contains a set ...
Polymorphic in Medical Dictionary

Chromosome

... who "determines" the genetic sex of the child. A cluster of genes on chromosome 6 in humans, encoding cell surface molecules that are polymorphic and that code for antigen s which lead to rapid graft rejection between members of a single species which differ at these loci. AneuVysion ...

Graft

... heals, the metatarsal and toe are the correct size. A cluster of genes on chromosome 6 in humans, encoding cell surface molecules that are polymorphic and that code for antigen s which lead to rapid graft rejection between members of a single species which differ at these loci. Surgery may ...

Lead

... separated. Swimming head-down may indicate stress . A cluster of genes on chromosome 6 in humans, encoding cell surface molecules that are polymorphic and that code for antigen s which lead to rapid graft rejection between members of a single species which differ at these loci. NCSBN's ...
Polymorphic in Biological News

New research reveals why chili peppers are hot

... were able to arrive at these conclusions because at least three of the approximately 15 species of chilies that grow in the Bolivian wild are polymorphic for pungency, which means that some individuals of those species produce pungent fruit and others produce non-pungent fruit. This provided the ...

Tomato stands firm in face of fungus

... evolutionary change in plant diseases is to make use of the innate immune system of plants. Growers can cross into targeted plant varieties certain polymorphic resistance genes that occur in related plants, thereby naturally boosting the plants immune system. In this study, Dr. Martijn Rep and his team ...

Researchers link two more genes to sudden infant death syndrome

... CAV3 as a novel LQTS-causing gene. RyR2 was targeted because of its involvement in a distinct genetic heart rhythm disease known as catecholaminergic polymorphic ventricular tachycardia (CPVT). "For a parent whose infant died suddenly and mysteriously even five years ago, we were essentially unable to ...

Swiss researchers develop all-in-one remote control gene expression tool

... can now be turned off when the desired effect is achieved, thus preventing unharnessed growth ?otherwise known as cancer. "It's an extremely polymorphic tool, useful in testing therapies and in preclinical studies," says Trono. "Using it we can control the gene expression in vivo in an extraordinary ...
Polymorphic in Biological Technology

BioNanomatrix Awarded New NIH Grant for Development of Nanoscale Platform for Single-Molecule DNA Mapping and Haplotype Applications

... designed to accommodate massively parallel analyses of individual DNA molecules to permit standardized, high-throughput mapping of sequence motifs or polymorphic sites along the DNA. Such capabilities could transform biological analyses, permitting highly sensitive detection of genetic information for ...

ARCA biopharma Appoints James Carr as Vice President of Marketing

... at Buffalo School of Pharmacy. He earned a Doctor of Pharmacy degree from the University of Minnesota and conducted post-graduate work in the area of polymorphic drug metabolism of beta-blockers, also at the University of Minnesota. About ARCA biopharma ARCA biopharma, Inc. is a privately held company ...

Synvista Therapeutics Increases Commercial Focus by Appointing David C. Tantillo Senior Director of Marketing and Sales

... MPH and MBA degrees from Illinois Benedictine College, and a BS in Mechanical Engineering from Iowa State University. About Haptoglobin The polymorphic haptoglobin (Hp) protein is derived from two alleles, 1 and 2, existing at the Hp genetic locus. Three phenotypes linked to the three genotypes, Hp ...

Synvista Therapeutics Highlights Newly Published Data Demonstrating the Value of Haptoglobin Genotype Testing In People with Diabetes

... cardiovascular events in patients with Hp 2-2 taking Vitamin E, as the primary endpoints had been met. About Haptoglobin 2-2 The Hp protein is polymorphic in humans, occurring with two alleles, 1 and 2, existing at the Hp genetic locus. Three phenotypes linked to the three genotypes, Hp 1-1, Hp 1-2 and ...

Interleukin Genetics Enters into New Clinical Research Collaboration with Alticor

... Genetics will be conducting various clinical studies, which shall be fully funded by Alticor. Studies will look to correlate single nucleotide polymorphic (SNPs) gene variations to the risk of osteoporosis or cardiovascular disease in Asian populations. Other studies will seek to identify genetic ...

Amplified Fragment Length Polymorphism (AFLP) Analysis on Applied Biosystems Capillary Electrophoresis Systems

... can rapidly and accurately identify common and polymorphic peaks among large numbers of samples. Genotyping ... in GeneMapper software for easy identification of polymorphic peaks (red arrow) and common peaks (black arrow). For example, in the data shown in Figure 4, a polymorphic peak can be easily identified in the P1 sample ...

Using the DCode System to Identify DNA Sequence Variation for Studies of Population Structure in Marine Organisms

... larger ones. This two-pronged approach may be used in developing polymorphic markers when available universal primers are inadequate. Using ... genetics surveys and genetic mapping require numerous polymorphic DNA markers. Denaturing gel electrophoresis, in its various ...

Detection of Mutations in the Fas Antigen of Lymphoma Tumors by RT-PCR and Denaturing Gradient Gel Electrophoresis

... ethidium bromide staining, we were able to easily identify 5% polymorphic RNA, and even as little as 1% was detectable. ... FasIII cDNAs with DraI results in an 368 bp fragment when the polymorphic codon is expressed, while this enzyme does not cut the wild ...

Glossary for The BioPharm Guide to Fermentation and Cell Culture

... teristics of life. DNA fingerprinting Sequences of nucleic acids in specific areas (loci) on a DNA molecule are polymorphic , meaning that the genes in those locations may differ from person to person. DNA fragments can be cut from those sequences using ...

Endotoxins and their Relevance in R&D ApplicationsLPS Detection & Removal Methods

... shock. LPS causes a very strong stimulation of different cells of the immune system, such as monocytes, macrophages, B cells, polymorphic nuclear- and endothelial vascular cells. LPS is biologically effective even in lowest concentrations (lower pg/ml ...

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Polymorphic in Biological Products

SNP Scoring Service from Polymorphic DNA Technologies, Inc.

Description:... Accurate To score SNPs, polymorphic uses proven, validated Sanger dideoxy DNA ... capillary sequencing instrumentation. The polymorphic locus can be confirmed by sequencing in both ... further confirming the location of the polymorphic site. Rapid turnaround Assay development is ...
Company:Polymorphic DNA Technologies, Inc.

General DNA Sequencing Services from Polymorphic DNA Technologies, Inc.

Description:... polymorphic DNA Technologies also offers a DNA sequencing service. We can sequence a ... optimized for automated reaction setup and dye terminator removal. polymorphic DNA Technologies employs automated high throughput capillary ...
Company:Polymorphic DNA Technologies, Inc.

SNP Discovery Service from Polymorphic DNA Technologies, Inc.

Description:... Complete Solution polymorphic DNA Technologies offers a comprehensive SNP discovery service. We provide ... DNA sequencing and data analysis. Accurate For SNP discovery, polymorphic uses the gold standard in DNA analysis, Sanger dideoxy DNA sequencing. We ...
Company:Polymorphic DNA Technologies, Inc.
Polymorphic in Biological Definition

Gene pool

... cause reduced fitness and an increased chance of extinction . When many alleles exist for a given gene or locus , a population is said to be polymorphic with respect to that gene or locus. When no variation exists, it is labelled monomorphic . See also genetic drift small population ...

Major histocompatibility complex

... polypeptide chain (the α-chain) and a β 2 microglobulin (which is encoded elsewhere, not in the MHC). The α chain has two polymorphic domains, α 1 , α 2 , which present peptides derived from cytosolic proteins to the immune system. The peptides are short, consisting ...

Microsatellite

... locus, one would expect to see a sequence of ... The number of repeats at a particular locus is hypervariable (highly polymorphic ) between individuals of the same species. It is for this reason that microsatellite sequences can be used for genetic fingerprinting and ...
Polymorphic in Biological Dictionary

RAPD

... RAPD stands for Random Amplification of polymorphic DNA. It is a type of PCR reaction, but the ... change your subscription ... Random amplified polymorphic DNA ( RAPD ) variation in Fagopyrum tataricum ... using ... The RAPD (random amplified polymorphic DNA) technique (10, 12) has been widely ... RAPD ...

Polymorphic loci

... Comparison of agarose type (non- polymorphic loci ) ... These primers amplify polymorphic loci , and alleles of different sizes can be observed. ... Many polymorphic loci have been identified, and scientists have ...

Simple Sequence Repeat

... ... Microsatellites, or Simple Sequence Repeats (SSRs), are polymorphic loci present ... ISSR (for inter- simple sequence repeat ) is ... 1991) ... Microsatellites, or Simple Sequence Repeats (SSRs), are polymorphic loci present ... ISSR (for inter- simple sequence repeat ) is a ...

Single locus probe

... ... ... Restriction Fragment From Human Genome for Developing Single Locus Probe ... For developing a single locus probe , a highly polymorphic human Bkm positive ... ... reflected in the shift from Multi Locus Probe . systems (MLP) to Single Locus Probe (SLP) approaches. ... ...

Sequence Polymorphism

... Instruction. Sequence analyses ... DnaSP: estimates several measures of DNA sequence ... 1 Types of polymorphism . 2 Assembling polymorphic genomes. 2.1 Getting started ... If sequence is present in one allele but missing in the other, this can prevent ... A Single Nucleotide ...

Heterozygosity

... or ... In this book a panel of expert international mycologists critically review the ... The heterozygosity far exceeds that found in other polymorphic genomes such as ... Free radical articles relating to ' heterozygosity ' ... Association of presenile cataracts with heterozygosity for ...

Genomic clone

... The Spot e-News. Points to Consider. Presentations ... Diagnostic Services > SignatureChip® Clone List. Clone List ... ... of an EST(s) or polymorphic marker(s) within a genomic clone , PCR primers, ... To map the genomic clone to chromosomal location, unfertilized eggs were used to ... ...

Agarose gels

... through hydrogen bonding and ... Agarose gels can be run at various voltages, depending on the separation desired ... Agarose gels and polymorphic loci. As depicted also in Fig. 7, agarose ... Agarose gels separate DNA fragments differing by a hundred or more base pairs, ... dishes, ...

AFLP

... fingerprinting and ... (See AFLP Procedure Diagram) It is based ... back to AFLP Analysis. back home ... tion Fragment Length polymorphic ( AFLP ) DNA ... example, in a comparative study of AFLP , RFLP, and ... (1996) reported that AFLP gave a number of discrimi ... posted to ...

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