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Platelet in Medical News

Centocor Ortho Biotech Statement on the FDA ODAC Opinion Regarding DOXIL(R) for Treatment of Advanced Breast Cancer

... monitor complete blood count (including platelet count), at least prior to each dose of DOXIL ... Kaposi's sarcoma, hematologic toxicity (based on platelet count or absolute neutrophil count) may require ... multiple myeloma, hematologic toxicity (based on platelet count, absolute neutrophil count, hemoglobin ...

Portola Pharmaceuticals Announces Several Scientific Presentations at International Society on Thrombosis and Haemostasis XII Congress

... A Functional Pool of P2Y12 Receptors Exposed Upon platelet Activation Persists in Mice Treated with High ... p.m. Location: Poster Area, platelet Biology New Directions in Antithrombotic ... Elinogrel (PRT060128) in Patients with High platelet Reactivity During Clopidogrel Therapy ...

Experts reach consensus on diagnosis and treatment of bleeding disorders in women

... factor (VWF), a protein necessary for normal platelet adhesion and protection of factor VIII (FVIII) ... A hematologic evaluation of the patient's platelet number and function and her coagulation factor ... such as VWD, rare bleeding disorders and platelet disorders, which remain underdiagnosed in women ...

3SBio Inc. Files for SFDA Approval for TPIAO Label Extension for the Treatment of ITP

... of chemotherapy induced thrombocytopenia, or platelet deficiency. The aim of this filing is to extend ... potentially resulting in dangerously low platelet counts. There are today approximately eighty ... increasing platelet production to outpace platelet destruction by the immune system. ...

Bioreactors might solve blood-platelet supply problems

... critical blood components. About 13 million platelet concentrates are collected annually in the United ... only five days. As a result, 20 to 40 percent of platelet concentrates are discarded. Red blood cells, by ... to the other arm. The method yields four to six platelet units per donor. For this study, Lasky and his ...

Ad de Waard Appointed Vice President of International Sales and Marketing at Accumetrics, Inc.

... products, including products in the area of platelet function analysis. Prior to Accumetrics, ... committed to advancing medical understanding of platelet function and enhancing quality of care for ... and widely accessible diagnostic tests for rapid platelet function assessment. Accumetrics' ...

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Platelet in Medical Technology

Schering-Plough's Investigational Oral Thrombin Receptor Antagonist Meets Primary Endpoint in a Newly Published Study

... and was Well Tolerated When Given With Standard platelet Therapy KENILWORTH, N.J., March 12 ... thrombin-receptor agonist peptide (TRAP)-induced platelet aggregation inhibition, a secondary endpoint. Thrombin is the most potent platelet activator, which leads ...

Nplate(R) Approved in the European Union for the Treatment of Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP)

... First and Only Approved platelet Producer in Europe Represents New Treatment ... Nplate, the first and only approved platelet producer in Europe, has been granted marketing ... 2008. Nplate works by raising and sustaining platelet counts, representing a novel approach for the ...

New Research Suggests Platelet 'Stickiness' May be the Single Most Important Risk Factor in Patients Treated with Coronary Stents - Findings May be Applicable to Anyone with Vascular Disease

... at Sinai Hospital of Baltimore, indicate that platelet aggregation or "stickiness" may be the single ... yet the pivotal event that kills the patient - platelet aggregation isn't being assessed in any way," ... never have a cardiac event because they had low platelet aggregation. Along with his team at Sinai, ...

Study Finds DOXIL(R) Combination Therapy Delays Disease Progression for Patients With Metastatic Breast Cancer

... monitor complete blood count (including platelet count), at least prior to each dose of DOXIL ... sarcoma, hematologic toxicity (based on platelet count or absolute neutrophil count) ... hematologic toxicity (based on platelet count, absolute neutrophil count, hemoglobin ...

Portola Pharmaceuticals Initiates Phase II Trial of Novel IV and Oral Anti-Platelet Drug in Non-Urgent Percutaneous Coronary Intervention

... agents through immediate, high-level platelet inhibition in the acute setting and a seamless transition to predictable platelet inhibition in the chronic setting. Additionally, ... and demonstrated predictable, dose-dependent platelet inhibition. INNOVATE-PCI is designed to ...

Long-term Follow Up Interim Data Show Nplate(TM) Increased and Sustained Platelet Counts in Adult Chronic ITP Patients

... "These data show Nplate increased platelet counts in most patients for most of the time, and ... are at risk of serious bleeding events if their platelet counts drop to less than 30,000 per ... 74 percent of patients (160/215) achieved a platelet response defined as ...

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Platelet in Medical Products

Model 700 Whole Blood/Optical Lumi-Aggregometer

Description:... configuration. This new Aggregometer measures platelet function on patient samples using electrical ... tool. Direct measurement of ATP secretion during platelet aggregation provides unequivocal evidence of ... provides a better insight into the mechanism of platelet ....
Company:Chrono-log Corporation

Plateletworks Combo-25 Kit

Description:... hematology profile, including a standard CBC with platelet count plus platelet aggregation. Aggregation testing is based on performing a platelet count before and after ...
Company:Helena Laboratories

Ichor Hematology Analyzer

Description:... a hematology profile of a standard CBC with platelet count plus platelet aggregation within five minutes. The test is ... on the Ichor hematology analyzer. CBC, including platelet count, is available within ....
Company:Helena Laboratories

VerifyNow IIb/IIIa Assay

Description:... whole- blood assay designed to assess platelet function based upon the ability of activated ... Within the well is an activator that induces the platelet to change the conformation of the GP IIb/IIIa ... occurs. If the GP IIb/IIIa receptors on the platelet are inhibited by abciximab or eptifibatide, there ...
Company:Accumetrics

VerifyNow Aspirin Assay

Description:... is a qualitative test to aid in the detection of platelet dysfunction due to aspirin (ASA) ingestion in ... based optical detection system which measures platelet induced aggregation as an increase in light ... preparation of human fibrinogen-coated beads, platelet agonist, preservative and buffer. The patient ...
Company:Accumetrics

VerifyNow System

Description:... for use on the system is to assess GP IIb/IIIa platelet inhibition in response to abciximab or ... use on the system is to aid in the detection of platelet dysfunction due to aspirin ingestion. The ... stroke, and other vascular events by causing platelet dysfunction, so that platelets will not ....
Company:Accumetrics

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Platelet in Medical Dictionary

Acquired platelet function defect

... Acquired platelet function defect s are non-hereditary disease s or associated conditions that cause the platelet s (the blood cells essential for coagulation) ... Images Blood Clot Formation ... Acquired platelet function defect Congenital ...

Aplastic

... including red and white blood cells as well as platelet s. Aplastic anemia frequently occurs without ... of blood cells: red cells, white cells, and platelet s. Aplastic anemia falls into three ... , AIDS , lupus , or Cushing's syndrome . platelet s Low ...

Aplastic anemia

... including red and white blood cells as well as platelet s. Aplastic anemia frequently occurs without a ... of blood cells: red cells, white cells, and platelet s. Aplastic anemia falls into three basic ... , AIDS , lupus , or Cushing's syndrome . platelet s Low ...

Bleeding time

... the lower back, into the spinal canal. Normal platelet count Prolonged bleeding time Reduced von Willebrand factor level Reduced platelet aggregation ( platelet aggregation test) Ristocetin co-factor is ...

Bone marrow

... in white blood cells, red blood cells, and platelet s. Bone marrow A spongy tissue located ... Marrow contains stem cells, the precursors to platelet s and red and white blood cells. Bone ... into red blood cells, white blood cells, and platelet s. Red blood cells carry oxygen throughout ...

CBC

... corpuscular hemoglobin concentration) The platelet count is also usually included in the CBC . ... of red blood cells, white blood cells, and platelet s. Blood tests - A complete blood count ( ... of red blood cells, white blood cells, and platelet s in a sample of blood . Also called complete ...

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Platelet in Biological News

Lancet study supports new, highly effective treatment for blood disorder

... pediatrician and director of the Program for platelet Disorders at NewYork-Presbyterian Hospital/Weill ... showed that eltrombopag was effective in raising platelet counts and lowering bleeding in adult subjects ... percent of subjects receiving Promacta achieved platelet counts at or over 50,000 per L of blood, compared ...

Researchers explore new driver of transplant rejection: Platelets

... Morrell and his team noted that increased platelet interactions led to increased and prolonged white ... in reaction to the transplanted tissue sparked platelet activation and white cell recruitment. Studies ... immune system. The newest kid on the block is the platelet and it represents an opportunity to target the ...

A novel target for therapeutics against Staph infection

... at a site that is also responsible for inducing platelet activation and thrombosis (clot inside a blood ... structural differences in how staphylococcal and platelet receptor proteins recognize fibrinogen. By ... not interfere with the interaction of Fg with the platelet integrin, therefore avoiding unwanted side ...

Johns Hopkins scientists discover what drives the development of a fatal form of malaria

... parasite and found that this did, indeed, induce platelet activation. The researchers then infected ... and two others treated with aspirin or Plavix, platelet inhibitors that prevent the release of PF4. ... When researchers started treating mice with platelet inhibitors one day after infecting them, those ...

Eltrombopag effective for hepatitis C patients with low blood-platelet counts

... For patients with hepatitis C, having a low blood platelet count is a frequent complication associated with ... treatment for the disease can further reduce platelet numbers to dangerously low levels, effectively ... drug, eltrombopag, appears to significantly boost platelet counts, opening the door to effective treatment. ...

How cancer spreads by aggregating platelets

... platelets that plays a key role in cancer-induced platelet aggregation. These results could help design new ... these chemicals, called podoplanin, binds to the platelet cells and stimulate their aggregation. Although ... has been known since 1990, how it induces platelet cell aggregation has been a mystery until now. ...

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Platelet in Biological Technology

Centocor Ortho Biotech Data to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting

... monitor complete blood count (including platelet count), at least prior to each dose of DOXIL ... Kaposi's sarcoma, hematologic toxicity (based on platelet count or absolute neutrophil count) may require ... multiple myeloma, hematologic toxicity (based on platelet count, absolute neutrophil count, hemoglobin ...

Accumetrics, Inc. Announces European Distribution Channels for France, Austria, Switzerland, Netherlands, Belgium and Luxembourg

... committed to advancing medical understanding of platelet function and enhancing quality of care for ... and widely accessible diagnostic tests for rapid platelet function assessment. Accumetrics' VerifyNow ... solutions serving customer needs in hemostasis, platelet function testing and cardiology. The company ...

deCODE genetics Announces First Quarter 2008 Financial Results

... DG041 has been shown to dramatically inhibit platelet aggregation as well as platelet activation mediated specifically through ... (VASP), a biomarker useful for measuring platelet activity. These effects have been shown to be ...

deCODE Genetics Announces Full-year 2007 Financial Results

... 2007, DG041 was shown to dramatically inhibit platelet aggregation as well as platelet activation mediated specifically through ... (VASP), a biomarker useful for measuring platelet activity. These effects were ...

JCI table of contents: Dec. 3, 2007

... An inflammatory mediator drives maturation of platelet precursor cells Infection and inflammation ... sometimes accompanied by an excess of circulating platelet cells, a condition called thrombocytosis. In a ... relationship between inflammatory disease and platelet formation in mice. Cellular differentiation is ...

deCODE genetics Announces Third Quarter 2007 Financial Results

... the end of 2007. With DG041, our Phase II anti- platelet compound, we have recently completed two ... manner DG041 dramatically inhibits platelet activation mediated through vasodilator- stimulated phosphoprotein (VASP) as well as platelet aggregation. Moreover, the desired effect on ...
Platelet in Biological Products

Prostaglandin E1-d4 from Cayman Chemical

Description:... animals. Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM. The vasorelaxant and anti-hypertensive effects of PGE1 are used to treat male erectile dysfunction and to provide emergency ...
Company:Cayman Chemical

8-iso Prostaglandin E2 from Cayman Chemical

Description:... from arachidonic acid during lipid peroxidation. It is a potent renal vasoconstrictor in the rat. 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 µM, respectively. When infused into the renal artery of the rat at a concentration of 4 mg/kg/min, ...
Company:Cayman Chemical

Human / Mouse / Rat Blood Vessels (CD31 / Von Willebrand Factor (vWF)) IHC staining Kit from CHEMICON

Description:... cells synthesize von Willebrand factor, therefore a small percentage of these vascular-rich tumors might not stain with this antibody. CD31 or platelet endothelial adhesion molecule (PECAM-1), is a type I integral membrane glycoprotein and a member of the immunoglobulin super family of cell surface ...
Company:CHEMICON
Platelet in Biological Definition

Full blood count

... about other cells that are not normally present in peripheral blood, but may be released in certain disease processes. Platelets platelet numbers are given, as well as information about their size and the range of sizes in the blood. ...
Platelet in Biological Dictionary

Platelets

... megakaryocytes.  The average lifespan of a platelet is between 8 and 12 ... A 250 ml bag of ... from donated whole blood is called a " platelet concentrate" ... Find out what you need ... of low blood platelets , how to get tested for platelet count, and the common causes of low platelets . ...

Ubiquitin

... protein gene shares several structural ... "Effect of ubiquitin on platelet functions: possible identity with platelet ... This classical function of ubiquitin is associated with ...

Blood count

... RBC or ERCS. 4.00 - 6.00. 1012 / Litre ... ... Low blood platelet count , Infection-prevention guidelines for ... LOW RED BLOOD CELL ... cell count measures your body's ability to fight infection. ... The platelet count looks at the cells that help your blood to clot. ... ...

Thrombocytes

... irregularly-shaped anuclear cells, 2-3 µm in diameter, which are derived from fragmentation of precursor megakaryocytes.  The average lifespan of a platelet is between 8 and 12 ... Indication for HLA-selected or HPA-selected thrombocytes . Method of administration ... Thrombocytes are essential ...

Sarcoplasmic reticulum

... large stores of calcium, ... sarcoplasmic reticulum and human blood platelets using a monoclonal antibody, FIIlb5. ... The 190 kDa platelet and sarcoplasmic reticulum proteins were ... The sarcoplasmic reticulum was first obtained as paniculate material from ... Since the ...

Quantitative trait loci

... and more. ... Quantitative Trait Loci Summary ... QTL resources - Quantitative trait loci maps, baseline white blood cell count, platelet count, mapping of PLTP, links to other publications. formed quantitative trait locus / loci (QTL) analyses ... 7. Chen J, Harrison DE ...

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(Date:10/14/2014)... tumors scavenge and hoard copper that is an essential ... a fatal weakness. , Researchers at Duke Medicine ... by delivering a trove of copper along with a ... the mineral, leaving non-cancer cells healthy. , The combination ... other uses, could soon be tested in clinical trials ...
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