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Placebo in Medical News

Surgery, 'Sham' Equal in Treating Compression Fracture Pain

... Injecting cement into spine no better than placebo procedure, study finds WEDNESDAY, ... a "sham" surgery without cement. Those in the placebo arm went through the motions of surgery, ... of the cement," Kallmes said. It could be the placebo effect or something as simple as the effect of ...

Boehringer Ingelheim to Commence Phase III Study Investigating the Role of BIBW 2992 as First-Line Treatment for Non-Small Cell Lung Cancer (NSCLC) Patients with EGFR Mutations

... 2008;27:4702-4711. (2) BIBW 2992 and BSC Versus placebo and BSC in Non-Small Cell Lung Cancer Patients ... 1: BIBF 1120 Plus Docetaxel as Compared to placebo Plus Docetaxel in 2nd Line NSCLC. Available at: ... Lung 2: BIBF 1120 Plus Pemetrexed Compared to placebo Plus Pemetrexed in 2nd Line Nonsquamous NSCLC. ...

Advanced targeted therapies effective as first-line treatment for lung cancer

... progression-free survival (PFS) over those on placebo a 29 to 31 percent reduction in risk of ... them with either 150mg/day of erlotinib or placebo after four cycles of platinum-based doublet ... 3. EFFICIENCY OF MAINTENANCE ERLOTINIB VERSUS placebo IN PATIENTS WITH UNRESECTABLE STAGE III NON-SMALL ...

FDA Approves INVEGA(R) SUSTENNA(TM) for the Acute and Maintenance Treatment of Schizophrenia

... to placebo. INVEGA SUSTENNA was superior to placebo in improving positive and negative syndrome scale ... and significantly delayed time to relapse vs. placebo in the longer-term maintenance study. The ... (10% [n=15/156]) compared with those in the placebo group (34% [n=53/156]). Because ...

FDA Approves TYVASO (Treprostinil) Inhalation Solution for the Treatment of Pulmonary Arterial Hypertension

... in six-minute walk distance over those taking placebo (p<0.0005). The safety and effectiveness in ... side effects (>= 10%) seen with TYVASO in the placebo controlled clinical study were cough, headache, ... side effects (>= 10%) seen with TYVASO in the placebo controlled clinical study were cough, headache, ...

NHLBI stops study of pulmonary hypertension treatment in sickle cell patients

... found that, compared to participants on placebo (dummy pill), participants taking sildenafil ... were randomly assigned to receive sildenafil or placebo for 16 weeks. Participants could also receive ... -- compared to 8 percent of participants in the placebo group. "Although these preliminary results ...

Quigley Corporation Announces Final Results of Quigley Pharma's Phase IIb Study

... no statistical differences, between active and placebo groups for the primary and secondary endpoints ... was a double-blind, randomized, parallel-group, placebo controlled study conducted at 22 sites with 1 to ... to the feet three times daily (tid) with placebo or QR-333 for 12 weeks. Number of ...

Nexavar in Combination with Chemotherapy Shown to Extend Progression-Free Survival in Patients with Advanced Breast Cancer

... to receive 400 mg of oral Nexavar or matching placebo twice daily, in addition to 1000 mg/m(2) of ... of causality was 15% for Nexavar vs. 8% for placebo and the incidence of treatment-emergent cardiac ... respectively, were 45% for Nexavar vs. 32% for placebo and 38% for Nexavar and 28% for placebo. Women of ...

96-Week Safety and Efficacy Findings Presented for INTELENCE(TM) (etravirine) As Part of HIV Combination Therapy

... plus background regimen (BR) compared with placebo plus BR. These findings were presented today at ... compared to 36 percent of patients in the placebo arm (p<0.0001). "These data are ... INTELENCE 200 mg twice daily (599 patients) or placebo (604 patients), each given in addition to a BR. ...

-Contrave(R) Obesity Research Phase 3 Program Meets Co-Primary and Key Secondary Endpoints; Exceeds FDA Efficacy Benchmark for Obesity Treatments-

... after 56 weeks, approximately three times the placebo categorical response rates of 16.4% and 17.1%, ... weeks, more than double the 18.9% of patients on placebo (p<0.001). Contrave patients also showed a ... Patients were randomized to receive either placebo or Contrave, BID, with a four week titration ...

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Placebo in Medical Technology

Labopharm files New Drug Submission with Health Canada for novel antidepressant

... positive results from a North American Phase III placebo controlled clinical trial (study 04ACL3-001), ... of the study in the trazodone group versus the placebo group. Statistical significance was achieved for ... demonstrated significant improvements versus placebo in all three quality of sleep end points, with an ...

Video: FDA Approves INVEGA(R) SUSTENNA(TM) for the Acute and Maintenance Treatment of Schizophrenia

... placebo. INVEGA(R) SUSTENNA(TM) was superior to placebo in improving positive and negative syndrome scale ... and significantly delayed time to relapse vs. placebo in the longer-term maintenance study. The ... (10% [n=15/156]) compared with those in the placebo group (34% [n=53/156]). Because ...

Wyeth Reports Publication of Phase 3 Data for Bazedoxifene/Conjugated Estrogens, an Investigational Compound Being Studied for the Treatment of Menopausal Symptoms

... bleeding was not statistically different from placebo and the rate of endometrial hyperplasia in doses ... significantly different from those reported with placebo over two years of study. 2. ... with BZA/CE was not statistically different from placebo over two years of therapy. 3. Evaluation ...

Unlikely Treatment Identified by BrainCells Neurogenesis Platform Improved Clinical Outcomes in Patients Suffering From Depression

... three arms, BCI-952 (n=67), buspirone (n=34) or placebo (n=33). Co-primary endpoints were the Clinical ... at week six demonstrated improvement relative to placebo using the MITT LOCF, MITT MMRM. The mean CGI-I scores were statistically significant relative to placebo using the MITT MMRM (p=0.046).The responders ...

R788 in TASKi3 Clinical Trial Does Not Meet Efficacy Endpoints in RA Patients Who Had Previously Failed Biologic Therapies - Results Incongruent

... ACR 50, ACR 70 and DAS28 response rates than the placebo group at three months, and therefore, the trial ... range in this patient population, the reported placebo response rates were considerably higher than seen ... the reported response rates between R788 and placebo were significantly different) and month 3 (when ...

Human Genome Sciences and GlaxoSmithKline Announce Positive Phase 3 Study Results for BENLYSTA(TM) in Systemic Lupus Erythematosus

... event rates comparable between belimumab and placebo treatment groups. (Logo: ... of care was superior in this study to that of placebo plus standard of care, while the safety profile ... significantly reduced SLE disease activity versus placebo based on a number of other measures, including ...

Rigel's R788 Significantly Improves Rheumatoid Arthritis in Phase 2b Clinical Trial

... ACR 50, ACR 70 and DAS28 response rates than the placebo group. The efficacy results for the two dosing ... ACR 20 ACR 50 ACR 70 DAS28<2.6 placebo 153 53 (35%) 29 (19%) 16 (10%) 9 ... these were generally evenly distributed among the placebo and active dose groups. The mean increase in ...

AcelRx Announces Positive Phase 2 Results from a Study of ARX-01 Sufentanil NanoTabs in Treating Post-Operative Pain

... either 10 mcg or 15 mcg doses of ARX-01, or placebo for post-operative pain. Study drug was ... endpoint, was also significantly different from placebo (p<0.001) for both treatment groups. ARX-01 ... of ARX-01 which was indistinguishable from placebo in both studies." About Acute ...

Data Suggest Sodium Oxybate Significantly Improves Pain and the Core Symptoms of Fibromyalgia

... VAS score, compared with 35.2% of patients taking placebo using Last Observation Carried Forward analysis. ... as early as Week 1 after dosing compared with placebo as measured by the Fatigue VAS (p<0.001). ... improvement in sleep patterns compared to placebo as measured by the Jenkins Sleep Scale ...

New Analysis Shows Efficacy of SIMPONI(TM) (golimumab) in Anti-TNF Experienced Rheumatoid Arthritis Patients

... compared with 18 percent of patients receiving placebo ( p <0.001). Thirty-four percent of patients ... compared with 20 percent of patients receiving placebo ( p =0.027). "Golimumab has shown promise ... responders at week 14 in the combined SIMPONI vs. placebo groups. A subset of patients receiving a single ...

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Placebo in Medical Dictionary

Clinical Trials

... infections . As with many clinical trials , placebo ('dummy') drugs were used as a way of ensuring ... that Chinese herbs are more effective than a placebo . However, more trials are needed, particularly ... pain and redness at the injection site. placebo An inert substance often used in clinical ...

Placebo

... placebo -controlled: A term used to describe a method of research in which an inactive substance (a placebo ) is given to one group of participants, while ... ) being tested is given to another group. placebo : A " sugar pill" or any dummy medication or ...

Rheumatism

... , 43(9): 1905-1915. Pincus T, et al. (2004). Patient preference for placebo , acetaminophen (paracetamol) or celecoxib efficacy studies (PACES): Two randomised, double blind, placebo controlled, ... Felson DT, Zhang Y. An update on the epidemiology of ...

Adenoma

... polyp carries a very high risk of cancer . APC study Multi center trial to evaluate the efficacy and safety of celecoxib (Celebrex) versus placebo in preventing or decreasing the occurrence of adenoma tous polyp s, a possible precursor to colorectal cancer . Two infertile women (one with ...

Bovine

... clinical trials for its effectiveness in reducing the frequency and severity of relapse s. Preliminary data indicate no difference between it and placebo . Alternative treatment ... Most insulin being used today is 'human insulin ', although some people still use the older bovine and porcine ...

Burns

... Extreme sensitivity to the sun, leaving the patient prone to sunburn s. This can be a side effect of some cancer drugs and radiation. placebo An inert substance often used in clinical trials for comparison. There are also many health benefits for you because breastfeeding does the ...

Camphor

... labor atory. It has a very unique smell and taste and is used in commercial products (for example, mothballs). A randomized, double blind, placebo controlled trial of a topical cream containing glucosamine sulfate, chondroitin sulfate, and camphor for osteoarthritis of the knee . J ...

Delayed ejaculation

... Delayed Gastric Emptying ( Gastroparesis ) Delirium Delirium Tremens Delta Agent ( Hepatitis D) ... In a recent double-blind placebo -controlled trial of men with lifelong rapid ejaculation , paroxetine delayed ejaculation the most, and fluvoxamine delayed ejaculation the ...

Diabetic neuropathy

... such as diabetic neuropathy ... Max MB, Kishore-Kumar R, Schafer SC, et al.: Efficacy of desipramine in painful diabetic neuropathy : a placebo -controlled trial. Pain 45 (1): 3-9; discussion 1-2, 1991. [PUBMED Abstract] ... ...

EEG

... By monitoring their brain activity during sleep using electroencephalograms ( EEG s), the researchers found that, compared to those taking a placebo drink before bed, the women with alcohol in their system experienced reduced REM sleep, or dreaming. All of the information, based on the im ...

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Placebo in Biological News

Your brain on -- and off -- caffeine

... which involved the administration of caffeine and placebo capsules. Each participant's response to the caffeine or placebo was measured using three different measures ... of chronic caffeine maintenance with chronic placebo maintenance, which provides unique information ...

Lancet study supports new, highly effective treatment for blood disorder

... control group received the standard of care and a placebo pill. By the end of the 43-day testing ... compared with 16 percent of subjects in the placebo group. A safe-level platelet count is between ... likely to reach the target platelet counts as the placebo group. Currently, patients are treated with ...

Genes determine whether sugar pills work

... have now found gene variants that can impact the placebo effect and a mechanism in the brain that ... under one fourth of the subjects were given a placebo instead of a drug. This was a double-blind ... was decoded, it turned out that 40 percent of the placebo group had received the same degree of anxiety ...

Vitamin K does not stem BMD decline in postmenopausal women with osteopenia

... to receive either 5 mg of vitamin K1 or a placebo daily for two years. Two hundred and sixty one of ... by similar amounts in both the vitamin K and the placebo groups. Over the four-year period, fewer women ... K group had fractures (9 versus 20 women in the placebo group) and fewer women had cancer (3 versus 12). ...

Scientists suspect omega-3 fatty acids could slow acute wound healing

... of IL-1b in their blister wounds than did the placebo group 24 hours after the wounds were created. The ... in their blisters over time than did the placebo group, but those differences in levels were not ... group and an average of 9.8 days in the placebo group, but the difference was not significant. ...

Wellmune WGP supplementation alleviates

... daily with either 250mg of Wellmune WGP or a placebo for 90 days. Wellmune WGP is a natural ... wellness and vitality. In contrast with the placebo group, study participants who received Wellmune ... with 1.38 days of work/school missed for the placebo group). In addition, although there were no ...

Effective ADHD treatment found for children with fragile X syndrome

... months, which involved 500 milligrams of LAC or a placebo given twice daily. Patients were evaluated by an ... months and 12 months. The effects of the drug and placebo were evaluated using a set of neuropsychological ... to stimulants. The patients treated with the placebo also showed reduced hyperactive behavior, ...

New clinical data shows chromium picolinate improves cognitive function

... enhanced motor speed relative to those receiving placebo (p = 0.16). Another component of the study ... from the chromium picolinate group and from the placebo group showed that the subjects receiving the ... with working memory. The subjects receiving placebo showed no such change. At the completion of ...

HGS announces positive Phase 2 LymphoStat-B at ACR meeting

... laboratory abnormalities remaining comparable to placebo or decreasing through 2.5 years of treatment ... reductions in SLE disease activity versus placebo as measured by the SELENA SLEDAI and BILAG ... over time in patients crossing over from placebo to LymphoStat-B after 52 weeks. If the Phase 2 ...

New Actemra data shows significant benefit for patients suffering from rheumatoid arthritis

... (8mg/kg) every four weeks plus DMARDs weekly or placebo infusions plus DMARDs weekly. The multicentre ... versus 25%, 9% and 3%, respectively, in the placebo plus DMARDs arm. Disease remission was ... every four weeks plus methotrexate weekly or placebo infusions plus methotrexate weekly. The study ...

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Placebo in Biological Technology

Neurocrine Biosciences Reports Second Quarter 2009 Results

... and placebo. After the initial three months, the placebo arm was re-randomized into one of the two ... study is designed as a randomized, double-blind, placebo and active controlled trial with four treatment ... We expect top-line data (first three months of placebo and active controlled treatment) to be available ...

Anesiva Receives NASDAQ Delisting Staff Determination Letter

... endpoint of reduced post-surgical pain versus placebo (p=0.03) following total knee arthroplasty (TKA) ... in opioid medication consumption compared to placebo (p=0.005). The Phase 3 TKA trial, known ... and wound sensory function were similar to placebo over the study duration. ...

Study Published in Child and Adolescent Psychiatry and Mental Health Demonstrated Once-Daily Vyvanse(R) (lisdexamfetamine dimesylate) CII Provided Significant Improvement of ADHD Symptoms for Children at 13 Hours After Administration

... their optimal dose of Vyvanse the first week and placebo the second week. The second group received placebo the first week and their optimal dose of Vyvanse ... and time of onset of Vyvanse compared with placebo as measured by SKAMP Attention (SKAMP-A), and ...

REMERON(R) Now Approved in Japan for the Treatment of Depression in Adult Patients

... Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) ... of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and ...

Study Showed VYVANSE(R) (lisdexamfetamine dimesylate) CII Provided Significant Efficacy at 14 Hours After Administration in Adults with ADHD in an Adult Simulated Workplace Environment

... of VYVANSE, 30 mg, 50 mg, and 70 mg, compared to placebo in 142 adults with ADHD using the adult simulated ... the duration of efficacy of VYVANSE compared to placebo using PERMP; the PERMP total score is the sum of ... for the VYVANSE group compared to 289.5 for the placebo group; P <.0001. Also, at each postdose ...

Repligen Reports Fourth Quarter and Fiscal Year 2009 Financial Results

... depression will receive either RG2417 or a placebo twice a day for eight weeks. The study is ... in which 83 patients received either RG2417 or a placebo twice a day for six weeks. Over the six-week ... in the patients receiving RG2417 when compared to placebo on the MADRS (p=0.01) and the CGI-BP-C (p=0.04). ...

Human Genome Sciences Reports Positive Long-Term Data for BENLYSTA(TM) (Formerly LymphoStat-B(R)) in Patients With Active Systemic Lupus Erythematosus

... serious infections were similar for belimumab and placebo during the 52-week double-blind period, and ... infections, were similar for belimumab and placebo during the 52-week double-blind period, and ... (BENLYSTA) plus standard of care, versus placebo plus standard of care. A total of 449 patients ...

AEterna Zentaris Discloses Preliminary Phase 2 Trial Results for Perifosine in Combination with Radiotherapy for Non-Small Cell Lung Cancer

... rate, one year after end of therapy in the placebo group. It was hypothesized that the addition of ... perifosine and 12 of 82 patients (14.6%) in the placebo control group. No difference between treatment ... towards longer survival than patients of the placebo control group despite the short duration of ...

Orexigen(R) Therapeutics Presents Additional NB-302 Contrave(R) Data at American Diabetes Association (ADA) 69th Scientific Sessions

... by patients treated with Contrave versus placebo (p< 0.01), as well as previously reported ... in the Contrave group, compared to 20.2% in the placebo group. Furthermore, 29.1% of patients lost ... in the Contrave group; compared to 10.9% in the placebo group. All of these findings were highly ...

FDA Approves Labeling Change for VYVANSE(R) (lisdexamfetamine dimesylate) CII to Include Supplementary Clinical Data Supporting Efficacy at 13 Hours Postdose in Children Aged 6 to 12 with ADHD

... VYVANSE Demonstrated Significant Efficacy Versus placebo at 13 Hours Postdose The study that led to ... their optimal dose of VYVANSE the first week and placebo the second week. The second group received placebo the first week and their optimal dose of VYVANSE ...
Placebo in Biological Definition

Drug

... (user or patient) the user's expectations or beliefs about the drug ( placebo effect ) Distribution Two patterns of distribution, licensed and ... drug trade Route of administration 1971 Misuse of Drugs Act placebo effect Prohibition (drugs) Recreational drug use Responsible ...

Cancer

... whether men taking daily selenium or vitamin E or both experience a reduced incidence of prostate cancer in comparison to men taking placebo pills. Daily use of tamoxifen , a selective estrogen receptor modulator, for up to 5 years, has been demonstrated to reduce the risk of ...
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(Date:7/23/2014)... (PRWEB) July 23, 2014 According to ... Market by Form Factor (Integrated Circuit IP, SOC IP), ... DSP), Application, Geography and Verification IP - Forecast & ... market is expected to grow at a CAGR of ... in 2020. , Browse more than 76 market data ...
(Date:7/23/2014)... The Centers for Disease Control and Prevention ... from 2010 to 2012. Formerly known as “the nation’s ... access to some of the strongest opiates, such as Oxycontin, ... enforcement launched an initiative to crack down on these rampant ... 65 that existed in the state just a few years ...
(Date:7/23/2014)... Asian women has identified three genetic changes linked to ... by Vanderbilt University investigators, was published online July 20 ... is one of the most common malignancies among women ... the disease have focused on women of European ancestry. ... exposures between East Asian women and those of European ...
(Date:7/23/2014)... 2014 The Circuelle Foundation compiled ... institutions uncovering the importance of breast self-exams (BSE). ... for breast self-exams is contradictory and can be ... for keeping this healthy ritual. , “Women are ... significance of breast self-exams and becoming breast aware,” ...
(Date:7/23/2014)... 23, 2014 Five years ago, when the ... were few options for babies diagnosed with a medical condition ... across the country for innovative fetal therapies. Since then, nearly ... to care for their babies in the womb, and the ... , “A number of the babies we see are ...
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(Date:7/23/2014)... the principal bacteria that cause dental caries, has ... time, possibly coinciding with dietary change linked to ... in a study by researchers from the Universitat ... de Genmica para la Biodiversidad (National Laboratory of ... first time, have sequenced genetic material from this ...
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