Enhanced skin cancer risk linked to defects in cellular aging controls
Researchers from Spain investigated the molecular mechanisms underlying skin cell telomere dysfunction using a mouse model of Xeroderma pigmentosum
(XP), a disease in which patients have increased sensitivity to ultraviolet (UV) radiation. Their studies revealed that these mice have impaired skin ...
Skin Cancer Risk Increases With Ultraviolet-B Radiation Exposure
... the commonest cause of skin cancer and is responsible for breaking DNA strands in exposed skin cells. Patients who have a condition called xeroderma pigmentosum
are unable to repair these broken strands and hence are at increased risk of developing skin cancer. Li-E Wang, M.D., and Qingyi Wei, M.D., Ph.D., of ...
pigmentosum in Medical Technology
pigmentosum in Medical Dictionary
... Xeroderma pigmentosum
: A genetic disease characterized by such ... skin cancer at a very early age. xeroderma pigmentosum
A genetic condition characterized by a ... skin sensitive to the sun, such as xeroderma pigmentosum
, albinism , and basal cell nevus syndrome ...
... at birth , a condition that can occur in all races. albino ... Disease s that make the skin sensitive to the sun, such as xeroderma pigmentosum
, albinism , and basal cell nevus syndrome Radiation therapy Medical conditions or drugs that suppress the immune system Personal ...
... patients. An ELISA test for HIV works by attaching HIV antigen s to a plastic well or beads. Enzyme lotion used in treating xeroderma pigmentosum
. T900607 A substance that is being studied as a treatment for cancer . It belongs to the family of drugs called tubulin-binding agents. ...
... . Proposed indication: topical agent for the prevention of cutaneous neoplasm s and other skin abnormalities in patients with xeroderma pigmentosum
(XP); product received orphan drug designation for this indication in 1989. Antineoplastic: Acting to prevent, inhibit or halt the development ...
... to medications ... Chronic skin inflammation or skin ulcers Disease s that make the skin sensitive to the sun, such as xeroderma pigmentosum
, albinism , and basal cell nevus syndrome Radiation therapy Medical conditions or drugs that suppress the immune system ... Two ...
pigmentosum in Biological News
Discovering the first steps in transcription-coupled repair
... from patients with Cockayne Syndrome (CS) versus those with xeroderma pigmentosum
(XP), two different hereditary diseases with a common feature: both entail ... because XPB and XPD, the other two proteins associated with xeroderma pigmentosum
that can cause Cockayne Syndrome when defective (in addition to XPG), are ...
Enzyme crystal structure reveals 'unexpected' genome repair functions
... excision repair (NER), as well as other cell processes.
"XPB was initially identified as the gene responsible for NER defects in xeroderma pigmentosum
patients, who are hypersensitive to light and have a dramatically increased risk of skin cancer," says John A. Tainer, a professor at Scripps ...
pigmentosum in Biological Technology
pigmentosum in Biological Dictionary
... to multiple basaliomas ... Xeroderma pigmentosum
is a rare ... Xeroderma pigmentosum
(XP) was first described in 1874 by ... A xeroderma pigmentosum
variant has also been described. ... ...