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Phospholipid in Medical News

FDA Clears Cellectar's IND Application for Lead Drug Candidate

... About (131)I-CLR1404 Cellectar's (131)I-CLR1404 is a small-molecule, phospholipid ether analog that combines lipid-like properties with a cancer therapeutic ... Cellectar's novel product candidates combine lipid-like molecules, phospholipid ethers (PLEs) analogs, with radioisotopes that can either image or destroy ...

Peregrine Pharmaceuticals Awarded Broad New U.S. Patent for Vascular Imaging Applications of Its PS-Targeting Platform

... the first broad coverage of imaging claims under Peregrine's PS-targeting platform, which includes Peregrine's lead antibody bavituximab. PS is a phospholipid that becomes exposed on the surface of tumor blood vessel cells. Since PS is typically not exposed on the surface of normal tissues, it represents a ...

Interleukin Genetics to Present Research Linking Perilipin Genes to Diet Response at the ADA Annual Meeting

... resistance to body weight and fat loss in overweight study subjects who were provided a calorie restricted diet. "Perilipin is a protein in the phospholipid outer layer of fat cells that plays an important role in both the storage and metabolism of triglycerides. This study confirms the results of other ...

Amira Pharmaceuticals, Inc. Expands its Scientific Advisory Board and Appoints Dr. Paul Anderson, Professor Jerold Chun and Professor Andrew Tager

... is a small molecule pharmaceutical company focused on the discovery and early development of compounds to treat inflammatory disease linked to the phospholipid pathways. Amira has a strategic partnership with GlaxoSmithKline for the development of FLAP (5-lipoxygenase activating protein) inhibitors in ...

Amira Announces the Successful Completion of GLP Toxicity Studies for a Novel DP2 Antagonist.

... is a small molecule pharmaceutical company focused on the discovery and early development of compounds to treat inflammatory disease linked to the phospholipid pathways. Amira has a strategic partnership with GlaxoSmithKline for the development of FLAP (5-lipoxygenase activating protein) inhibitors in ...

Nutrition 21 Launches Iceland Health(R) Advanced Memory Formula via Direct Response Channel

... healthy blood sugar, which is important because glucose helps fuel the brain. -- Phosphatidylserine (PS) is a naturally occurring phospholipid nutrient essential to the functioning of all cells of the body, but is most concentrated in the brain. PS supports communication between ...

Solution to Bacterial Mystery Promises New Drugs

... Therefore, the way gram-positive bacteria make phospholipid building blocks remained a mystery for over more ... two enzymes, called PlsX and PlsY, to kick off phospholipid synthesis. “In fact, the biochemical ... fatty acid to G3P. These steps initiate membrane phospholipid formation required for cell growth. “Our ...

Lecithin lowers cholesterol absorption in body

... and his associates found that a particular egg phospholipid interferes with the absorption of egg cholesterol ... lowers its uptake by the intestine. When the phospholipid is saturated, its inhibitory effect is further ... conditions to specifically look at egg phospholipid and its effect on cholesterol absorption.Even ...

The Link Between Oxidized Phospholipids And Coronary Artery Disease

... Tsimikas (University of California, San Diego) examined whether oxidized phospholipid levels were related to CAD in 504 patients undergoing angiography. The oxidized phospholipid content per particle of apo B-100 - otherwise known as the oxidized ...
Phospholipid in Medical Technology

Results From Trials of DHA in Alzheimer's Disease and Age-Related Cognitive Decline

... taking DHA supplements made significantly fewer errors on the PAL compared to when they started the study (-1.63 + or - 0.76, p<0.03). Plasma phospholipid DHA levels doubled over the course of the study in those people taking the supplements, and correlated with the PAL response (p<0.04). ...

Moffitt Cancer Center Signs Licensing Agreement with Frantz BioMarkers, LLC

... cancer diagnosis TAMPA, Fla., May 14 /PRNewswire/ -- Moffitt Cancer Center and Frantz BioMarkers, LLC have signed a license agreement on phospholipid biomarkers of ovarian cancer. Frantz BioMarkers, which has been granted exclusive worldwide rights to Moffitt's interests in the biomarkers, will ...

Athera Biotechnologies and Dyax Announce a Collaboration to Discover and Develop Antibodies for Cardiovascular Inflammation

... treatment of CVD. The company was founded in 2002 to exploit findings made by Professors Johan Frostegard and Ulf de Faire on the critical role of phospholipid antibodies (aPL) in the inflammatory process of cardiovascular disease. Athera is based in Karolinska Institutet Science Park in Stockholm and main ...

Omega 3 Fatty Acids Bound to Phospholipids has Potential Benefit for Attention-Deficit Hyperactivity Disorder (ADHD)

... that are utilized to process all other fish oils. This patented process provides an excellent advantage for the consumer, as the finished phospholipid complex is in tablet form, requiring only one tablet per day, with no regurgitation or fishy after-taste. "Omega 3 oils containing EPA/DHA have ...

New Clinical Data Further Supports Chromium Picolinate's Role in Enhancing Brain Activity in Older Adults

... mineral that promotes healthy blood sugar levels, which is important because glucose helps fuel the brain. -- PS is a naturally occurring phospholipid nutrient essential to the functioning of all cells of the body, but is most concentrated in the brain. PS supports communication between ...

Cellectar Expands Clinical Management Team

... about Cellectar, visit the company website at http://www.cellectar.com . About CLR1404 Cellectar's lead product candidate, CLR1404, is a phospholipid ether (PLE) combined with the radiolabel 131Iodine. Preclinical studies have shown that this compound is selectively retained in malignant cells. ...

Data Presented at AACR Meeting Shows Peregrine's Immunocytokine Fusion Proteins Reduce Growth of B-Cell Lymphoma Tumors by 85% in Preclinical Studies

... Vascular Targeting Agent platform for cancer therapy," said Steven W. King, president and CEO of Peregrine. "We have long thought that our anti- phospholipid antibodies would be ideal for the delivery of cytokines for cancer therapy based on their inherent immunostimulatory effects combined with the ...
Phospholipid in Medical Products

Bausch & Lomb Concentrated Cleaner

Description:... is a sterile, concentrated homogeneous surfactant solution containing alkyl ether sulfate, ethoxylated alkyl phenol, tri-quaternary cocoa-based phospholipid and silica gel as cleaning ....
Company:Bausch & Lomb, Inc.

Hexagonal Phospholipid Neutralization

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' ...
Company:ARUP Laboratories
Phospholipid in Biological News

Dominant cholesterol-metabolism ideas challenged by new research

... enzyme plays a major role in the transfer of a phospholipid called phosphatidylserine (PS) from the inside ... membrane of normal cells showed that the rate of phospholipid transport into the cell is not affected by the ... ABC1 in apoptosis. Did ABCA1 cause or activate phospholipid transport across the cell membrane only during ...

Too hot to handle! Scientists identify heat sensing regulator

... that Pirt interacts with yet another molecule in the cell, a so-called acidic phospholipid, allowing access to TRPV1. According to Dong, through this phospholipid Pirt somehow changes the TRP channel, perhaps by opening it wider, or maybe by causing it to stay open longer. And the result is elevated pain ...

Biophysical Society announces winners of 2008 Student Travel Awards

... of Colorado, Boulder, Stepping of Individual RecBCD Molecules. Thomas Chadwick, North Carolina State University, Molecular Mechanism of phospholipid Transfer by Lipid Transporter Protein Sec14p. Hao Chen, Purdue University, Predicting the Error of Template-Based Protein Structure Modeling ...

New clinical data shows chromium picolinate improves cognitive function

... an essential trace mineral that promotes healthy blood sugar, which is important because glucose helps fuel the brain. PS is a naturally occurring phospholipid nutrient essential to the functioning of all cells of the body, but is most concentrated in the brain. PS supports communication between brain cells ...

Solution to bacterial mystery promises new drugs

... Therefore, the way gram-positive bacteria make phospholipid building blocks remained a mystery for over more ... two enzymes, called PlsX and PlsY, to kick off phospholipid synthesis. "In fact, the biochemical pathway ... fatty acid to G3P. These steps initiate membrane phospholipid formation required for cell growth. "Our ...

Liposome finding implies electrical effect on cell development

... liposomes ?cell-like "water balloons" composed of artificially created phospholipid bilayers similar to natural cell membranes ?have revealed unexpected ... microtubules were observed to immediately form and extend from the phospholipid balloon, like a seed putting forth a stalk or root. Hayes believes that ...

Bugs expose underground carbon traffic system 10 times more important than fossil fuel burning

... transporting carbon from plants to soil. As a final check the researchers examined both the cores with and without Collembola for a particular phospholipid fatty acid (PLFA) that is characteristic for AM mycelia. They found that this particular PLFA contained significant amounts of 13C in cores not ...

Beyond genes: Lipid helps cell wall protein fold into proper shape

... looked at how a protein called GabP, which transports an amino acid across the membrane of the bacterium E. coli, is affected by the presence of a phospholipid named phosphatidylethanolamine, or PE for short. Phospholipids, unlike their fatty acid and cholesterol cousins, include a phosphate group that ...

Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin

... Discher in the mid-1990s, function much like the bilayered membranes of living cells. Whereas cell membranes are created from a double layer of fatty phospholipid chains, a polymersome is comprised of two layers of synthetic co-polymers. Like a living cell, the polymersome membrane has a hydrophobic core. The ...

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Phospholipid in Biological Technology

Neptune Krill Oil, NKO(R), enters WALGREENS, the largest U.S. retail pharmacy chain, under the brand name Schiff(R) MegaRed(TM)

... unique composition of proprietary bioactive ingredients of functionalized phospholipid omega-3 fatty acids and powerful anti-oxidants enables the positioning of ... capacity," added Mr. Thierry Houillon. NKO(R) is a proprietary phospholipid omega-3 composition extracted from Antarctic Krill and patented for its ...

Cellectar, Inc. Begins GMP Production

... of additional molecules." Cellectar's lead drug candidate, CLR1404, is a phospholipid ether (PLE) analog radiolabeled with iodine-131, a radioactive isotope ... Cellectar's novel product candidates combine lipid-like molecules, phospholipid ethers (PLEs) analogs, with radioisotopes that can either image or destroy ...

BRAHMS, Cezanne and Lumiphore Announce Partnership for Diagnostic Tests

... ) for the drug discovery research market; Echelon Biosciences Inc. ( www.echelon-inc.com ) for novel cancer assays involving phospholipid signaling; and Biophor Diagnostics Inc. for diagnostic tests for drugs of abuse. About BRAHMS Aktiengesellschaft The BRAHMS AG conducts ...

Neptune Products to be commercialized by BAYER HealthCare

... Inc. Neptune is an industry-recognized leader in the innovation, production and formulation of science-based and clinically-proven novel phospholipid products for the nutraceutical and pharmaceutical markets. The Company focuses on growing consumer health markets including cardiovascular, ...

SemBioSys' plant-derived Apo AI(Milano) demonstrates encouraging biologic activity in seven preclinical models

... "good cholesterol", which naturally removes plaque from arteries. Published studies have shown that Apo AI(Milano), which is a variant of Apo AI in a phospholipid formulation, could reduce plaque volume at a level and speed unattainable with any current drug therapy. If successfully commercialized, predicted ...

Neptune Technologies Reports Fiscal 2009 Results - Record revenue and profitability growth in nutraceutical business

... Inc. Neptune is an industry-recognized leader in the innovation, production and formulation of science-based and clinically-proven novel phospholipid products for the nutraceutical and pharmaceutical markets. The Company focuses on growing consumer health markets including cardiovascular, ...

Amira Initiates Phase I Clinical Trial of Novel DP2 Antagonist

... is a small molecule pharmaceutical company focused on the discovery and early development of compounds to treat inflammatory disease linked to the phospholipid pathways. Amira has a partnership with GlaxoSmithKline for the development of FLAP (5-lipoxygenase activating protein) inhibitors in respiratory and ...

Neptune Technologies to expect Record Revenues; Fiscal 2009 Third Quarter and Year-End Results

... NKO(R) achieved a significantly higher bioavailability compared to successfully marketed nutraceutical and pharmaceutical omega-3 and NKO(R) like phospholipid formulations supporting the claim of the superiority of Neptune's omega-3 phospholipids. Completion of $2.75 million private placement with 10% ...

HybridSPE(TM)-Precipitation Technology Wins SelectScience.net 2009 Scientists' Choice Award for Best New Separations Product in 2008

... (HybridSPE-PPT) technology is a simple and generic sample preparation platform designed for the gross level removal of endogenous protein and phospholipid interferences from biological plasma and serum prior to LC-MS or LC-MS/MS analysis. In pharmaceutical bioanalysis, researchers develop and run ...

Lumiphore Partners with Biophor Diagnostics, Inc. to Develop Tests for Drugs of Abuse; Appoints Ibis Biosciences Founder David J. Ecker to Board

... ) for the drug discovery research market and Echelon Biosciences Inc. ( http://www.echelon-inc.com ) for novel cancer assays involving phospholipid signaling and lipid-protein interactions. The company today also announced the appointment of Dr. David J. Ecker to its board of directors. Dr. ...
Phospholipid in Biological Products

Apoptotic Cell Isolation Kit from MBL International

Description:... using annexin V magnetic beads (MagBeads). Annexin V is a Ca2+-dependent phospholipid binding protein with high affinity for phosphatidylseri The Apoptotic ... using annexin V/magnetic beads (MagBeads). Annexin V is a Ca2+-dependent phospholipid binding protein with high affinity for phosphatidylserine (PS), which is ...
Company:MBL International
Phospholipid in Biological Definition

Phospholipid

... as phosphoglycerides. There is only one type of phospholipid with a sphingosine backbone; sphingomyelin . ... Due to its polar nature, the head of a phospholipid is attracted to water (it is hydrophilic ). ... fluid properties, in which embedded proteins and phospholipid molecules are constantly moving laterally across ...

Cell membrane

... plasma membrane or plasmalemma ) is a thin and structured bilayer of phospholipid and protein molecules that envelopes the cell . It separates a ... organelles and other subcellular compartments. The foundation is a phospholipid bilayer , and the membrane as a whole is often described as a 'fluid ...

Hormone

... Sterol hormones such as calcitriol are a homologous system. Lipid and phospholipid hormones are derived from lipids such as linoleic acid and ... Vitamin D derivatives calcitriol Lipid and phospholipid hormones ( eicosanoids ): prostaglandins leukotrienes ...

Mitochondrion

... mitochondrial membranes The outer and inner membranes are composed of phospholipid bilayers studded with proteins , much like a typical cell membrane . ... more than 100 different polypeptides , and has a very high protein to phospholipid ratio (more than 3:1 by weight, which is about 1 protein for 15 ...

Mitochondrion

... mitochondrial membranes The outer and inner membranes are composed of phospholipid bilayers studded with proteins , much like a typical cell membrane . ... more than 100 different polypeptides , and has a very high protein to phospholipid ratio (more than 3:1 by weight, which is about 1 protein for 15 ...

Cell membrane

... plasma membrane or plasmalemma ) is a thin and structured bilayer of phospholipid and protein molecules that envelopes the cell . It separates a ... organelles and other subcellular compartments. The foundation is a phospholipid bilayer , and the membrane as a whole is often described as a 'fluid ...

Apoptosis

... Biochemical signals for safe disposal The dying cells that have just been described display "eat me" signals, like phosphatidylserine (PS, a phospholipid from the inner cell-membrane). Phagocytic scavengers, such as macrophages, have specialized receptors that recognize PS and carry out their disposal ...

Chloroplast membrane

... , vital for their function. Like mitochondria , chlorplasts have a double-membrane envelope, called the chloroplast envelope . Each membrane is a phospholipid bilayer , between 6 and 8 nm thick, and the two are separated by a gap of 10-20nm, called the intermembrane space. The outer membrane is permiable ...

Glycolipid

... in the cell surface membrane . The carbohydrates are found on the outer surface of all eukaryotic cell membranes. They extend from the phospholipid bilayer into the aqueous environment outside the cell where it acts as a recognition site for specific chemicals as well as helping to maintain the ...

Lipid

... Figure 1: Structure of a Lipid. Many lipids consists of a polar head group ( P ) and a nonpolar tail ( U for unpolar). The lipid shown is a phospholipid (two tails). The image on the left is a zoomed version of the more schematic image on the right, which will be used from now on to represent lipids ...

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Phospholipid in Biological Dictionary

Plasma membrane

... of nerve cells. ... Plasma membrane phospholipid bilayer. The plasma membrane consists of a ... membranes have nearly one cholesterol per phospholipid molecule. ... Content : - Plasma membrane ... plasma membrane is composed of a bilayer of phospholipid molecules, plus ... A cell membrane (also ...

Phospholipid bilayer

... phospholipids to play an important role in the phospholipid bilayer . ... Lipid bilayer - ... - Sphingolipids - Sterols. v • d • e ... the phospholipid bilayer can be achieved by the use of either. a cushioning polymer film ... within the phospholipid bilayer remain fully mobile and active. 432 ......

Phospholipid

... The 'head' of a phospholipid is hydrophilic (attracted to water) whereas the ... Some types of phospholipid can be split to produce products that function as ... (Redirected from phospholipid bilayer) Jump to: navigation, search ... The ...

Myelin

... current ... In neuroscience, myelin is an electrically insulating phospholipid layer that ... The Myelin Project. Athabasca University Biological ... research ... Search " Myelin " ... Myelin is an electrically-insulating phospholipid layer that ... When the myelin is destroyed, nerve messages are sent ...

Myelin sheath

... Store for Myelin Sheath Support, 90 tabs. Great prices and next day shipping! In neuroscience, myelin is an electrically insulating phospholipid layer that ... The main consequence of a myelin layer (or sheath ) is an increase in the speed ... Shop for vitamins, supplements & ...

Liposomes

... the potential for many beneficial ... liposome n. An artificial microscopic vesicle consisting of an aqueous core enclosed in one or more phospholipid layers, used to convey vaccines, Phospholipids are the basic building block of every cell membrane in the human body. ... Liposomes are ...

Fluid mosaic model

... ... The fluid mosaic model of the structure of cell membranes" ... The fluid mosaic model of a biological membrane defines a phospholipid bilayer ... Fig. Fluid mosaic membrane model of the outer and inner membranes of a bacterial ... mosaic properties of cell membranes. ...

Chemiosmosis

... the way in which ... chemiosmosis ... Chemiosmosis . ATP is produced in the chloroplast by Chemiosmosis . Chemiosmosis requires a phospholipid bilayer, a proton pump, protons and ATPase. ... Cristae (singular crista) are the internal compartments formed by the inner ... As a result, ...

Cell membrane

... basics of biology and life science to everyone! ... The cell membrane is not one solid piece. ... The cell membrane is composed of a phospholipid bilayer studded with proteins. ... "Cartoon of a typical cell membrane . Proteins are embedded in a matrix of ... The structure of a cell ...

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