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Phenylalanine in Medical News

Patents Issued Covering Stable Tablet Formulation and Once Daily Dosing Regimen for Kuvan

... indicated in the United States to reduce blood phenylalanine (Phe) levels in patients with ... enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. ... world, is caused by a deficiency of the enzyme phenylalanine hydroxylase. PAH is required for the metabolism ...

Results From Phase 1 Clinical Study of PEG-PAL in PKU and Update on Phase 2 Clinical Study

... clinical study of PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase) for the treatment of ... PEG-PAL PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase) is an investigational enzyme ... candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is in clinical development ...

BioMarin Receives 2009 Corporate Award for the Development of Kuvan

... for PKU. Kuvan is indicated to reduce blood phenylalanine (Phe) levels in patients with ... candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase I ... world, is caused by a deficiency of the enzyme phenylalanine hydroxylase. PAH is required for the metabolism ...

BioMarin Re-Acquires Rights to Kuvan in Canada From Merck Serono

... Tablets is indicated to reduce blood phenylalanine (Phe) levels in patients with ... cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. BioMarin and ... disease, and PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase) for the treatment of PKU. For ...

Drug therapy for PKU reverses heart damage

... (BH4). In PKU, this enzyme coworker helps break down the molecule phenylalanine whose buildup is toxic to the brain. In the heart, BH4 helps build the ... oxygen free radicals. Doctors have used BH4 and diets that exclude phenylalanine for almost a decade to treat PKU, a so-called inborn error of metabolism ...

Fairview Specialty Pharmacy Signs Contract With BioMarin for Distribution of Kuvan(TM)

... (sapropterin dihydrochloride) Tablets is indicated to reduce blood phenylalanine (Phe) levels in patients with hyperphenylalaninemia (HPA) due to ... a naturally occurring enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. BioMarin and Merck Serono estimate ...

BioMarin Announces Second Quarter 2009 Financial Results

... in partnership with Merck Serono, a division of Merck KGaA of Darmstadt, Germany. Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in development for the treatment of PKU and GALNS (N-acetylgalactosamine 6-sulfatase), which is currently in Phase ...

Patient Enrollment Complete for Phase I/II Clinical Trial for GALNS for Morquio A Syndrome

... in partnership with Merck Serono, a division of Merck KGaA of Darmstadt, Germany. Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase I clinical development for the treatment of PKU. For additional information, please visit www.BMRN.com. ...

Vegetable Amino Acid Lowers Blood Pressure

... Similar but lesser effects on lowering blood pressure have been found for other amino acids more common in vegetable protein, such as proline, phenylalanine and serine, Brown said. "The solution to improving blood pressure is not based around a single nutrient," he said. "We are looking at a whole ...

BioMarin to Host Second Quarter 2009 Financial Results Conference Call and Webcast on Thursday, July 30 at 5:00 p.m. ET (23:00 CET)

... in partnership with Merck Serono, a division of Merck KGaA of Darmstadt, Germany. Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is in clinical development for the treatment of PKU and GALNS (N-acetylgalactosamine 6-sulfatase), which is currently in Phase ...
Phenylalanine in Medical Technology

BioMarin Initiates Phase 1 Clinical Study of PEG-PAL in PKU

... clinical study of PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase) for the treatment ... About PEG-PAL PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase) is an investigational enzyme ... disease, and PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase 1 ...

BioMarin Announces FDA Approval for Kuvan

... disease." Kuvan is indicated to reduce blood phenylalanine (Phe) levels in patients with ... Tablets is indicated to reduce blood phenylalanine (Phe) levels in patients with ... cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. BioMarin and ...

Positive Kuvan(TM) Pivotal Phase 3 Trial Results Published in The Lancet

... compared with placebo for reduction of blood phenylalanine in patients with PKU. The secondary objective was ... patients in the placebo group had a blood phenylalanine concentration below the recommended 600 uM/L level (p=0.003). * Blood phenylalanine concentrations fell by about 200 uM/L after one ...

BioMarin Initiates Phase 1/2 Clinical Trial for GALNS for Morquio A Syndrome

... in partnership with Merck Serono, a division of Merck KGaA of Darmstadt, Germany. Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase 1 clinical development for the treatment of PKU. For additional information, please visit www.BMRN.com . ...

BioMarin Announces Positive Results From Phase 2A Clinical Study of 6R-BH4 in Sickle Cell Disease

... in Phase 2 clinical development for the treatment of peripheral arterial disease and sickle cell disease, and PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase 1 clinical development for the treatment of PKU. For additional information, please visit ...

Peptimmune Announces Grant of United States Patent for PI-2301 Peptide Copolymer for Multiple Sclerosis

... the brain and other parts of the body is disrupted. The '790 patent claims "A linear random copolymer YFAK comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K)," )." which was licensed from Harvard University. The copolymer technology was developed in conjunction with ...
Phenylalanine in Medical Dictionary

Metabolize

... the body cannot metabolize a protein c alled phenylalanine . It is estimated that one baby in 10,000 to ... disorder. Causes an inability to metabolize phenylalanine , an amino acid that's a common part of many ... foods that contain large amounts of phenylalanine , one of the ingredients in aspartame. People ...

Phenylalanine

... phenylalanine : An essential amino acid . (The human body cannot make it so it is essential to the diet .) phenylalanine that is ingested is largely transformed ... which is used in protein s ynthesis. phenylalanine ; ...

Phenylketonuria

... recessive manner, as are lesser degrees of phenylalanine hydroxylase deficiency . Phenylketonuria is ... the body cannot metabolize a protein c alled phenylalanine . It is estimated that one baby in 10,000 to ... disorder. Causes an inability to metabolize phenylalanine , an amino acid that's a common part of many ...

Pku

... caused by the absence of a specific enzyme ( phenylalanine hydroxylase). The absence of this enzyme , a ... trait, prevents the body from making use of phenylalanine ... PKU is a genetic disorder with a ... the body cannot metabolize a protein c alled phenylalanine . It is estimated that one baby in 10,000 to ...

Protein

... that relieves pain . Aspirin and acetaminophen are mild analgesics. phenylalanine is present in high protein foods . After the body has absorbed enough for its needs, an enzyme normally converts some phenylalanine to tyrosine, another essential amino acid ; in PKU , however, that ...

Acid

... dichloroacetic acid ) topically to treat plantar warts . After the body has absorbed enough for its needs, an enzyme normally converts some phenylalanine to tyrosine, another essential amino acid ; in PKU , however, that vital enzyme is absent or insufficient, so conversion to tyrosine does not ...

Aspartic acid

... alanine, arginine, asparagine, aspartic acid , cysteine, glutamic acid , glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine , proline, serine, threonine, tryptophan , tyrosine, and valine. ...

Autosomal recessive

... A mutation in a single gene causes PKU . This gene contains the instructions for making an enzyme needed to process the amino acid called phenylalanine . Amino acids are the building blocks for protein . Autosomal recessive inheritance Supportive treatment Normally the cerebellum (an area ...

Cavity

... result from the spinal cord damage. The cavity of the canal leading from the mouth and nasal passages to the larynx and the esophagus . phenylalanine ... Intra cavity radiation often is used for gynecologic cancer s. Under general or spinal anesthesia , hollow applicators are placed directly ...

Enzyme

... protective effect on the kidney in people with diabetes . After the body has absorbed enough for its needs, an enzyme normally converts some phenylalanine to tyrosine, another essential amino acid ; in PKU , however, that vital enzyme is absent or insufficient, so conversion to tyrosine does not ...

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Phenylalanine in Biological News

UW-Madison study reveals new options for people with PKU

... we eat in everyday foods. While small amounts of phenylalanine are essential for PKU patients, excess amounts ... most of his daily protein, but the amount of phenylalanine in his blood actually starting going down after ... among individual subjects, but the overall blood phenylalanine levels measured after meals were comparable in ...

Unique whey protein is promising supplement for strict PKU diet

... avoid protein because, while small amounts of phenylalanine are required for life, excess amounts stay in ... also looked at the brains of mice with PKU, where phenylalanine causes problems. Perhaps the most interesting ... is that they had a 20 percent decrease in phenylalanine in their brains (compared to those fed the ...

Researchers discover natural herbicide released by grass

... would normally provide negative feedback for phenylalanine biosynthesis" and, thereby, suppress plant ... to the toxin themselves. They found that when phenylalanine was added to plants dying from m-tyrosine ... that these fescue varieties may overproduce phenylalanine to save themselves from their own toxin. People ...

New drug holds out promise of normal diet for sufferers of devastating PKU genetic disease

... genetic disease that is characterized by a deficiency in an enzyme called phenylalanine hydroxylase (PAH). Without PAH, the body cannot metabolize the amino ... in humans," she said. "Certainly in the animal models we showed that the phenylalanine levels came down to normal. The treatment itself is enzyme therapy, so ...

Nationwide Children's Hospital involved in expanded access program for treatment of PKU

... Individuals with PKU are born with a deficient enzyme called phenylalanine hydroxylase (PAH). With little or no PAH activity, they are unable to metabolize an essential amino acid, called phenylalanine (Phe), which is found in most foods including meat, eggs, dairy, nuts, ...

UF researchers develop improved gene therapy agent

... To do that, the researchers replaced tyrosine with another amino acid, phenylalanine. The two amino acids are identical except for one thing phenylalanine lacks the part that attracts phosphate. We didnt change anything except the amino acid that does not allow phosphorylation to occur, he said. It ...

Gene's 'selective signature' aids detection of natural selection in microbial evolution

... bacterium that has adapted to life near sulfurous hydrothermal vents in the ocean floor, the genes involved in metabolizing sugar and the amino acid phenylalanine underwent significant changes (over hundreds of millions of years) that may help the bacterium obtain carbon from amino acids rather than from ...

Biophysical Society announces winners of 2008 Student Travel Awards

... Changes Associated with Antigen-Mediated IgE Receptor Signaling in Mast Cells. Isabelle C. Dragomir, Drexel University, Characterization of phenylalanine Based Short Peptides at Varying pHs, Temperatures, and Concentrations via Electronic Circular Dichroism and Absorption Spectroscopy. Kyle P. ...

Paradigm shift in Alzheimers's research: new treatments

... processing of APP, the precursor of A", and its proteases responsible for generating A". Ragged peptides with a major species beginning with phenylalanine at position 4 of Ab have been reported already in 1985 by Masters et al.1. In 1992, Mori et al. first described the presence of A"N3(pE) using ...
Phenylalanine in Biological Technology

Kuvan Receives Priority Review Status From Health Canada

... indicated in the United States to reduce blood phenylalanine (Phe) levels in patients with ... enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. Kuvan ... world, is caused by a deficiency of the enzyme phenylalanine hydroxylase. PAH is required for the metabolism ...

BioMarin Receives Notice of Allowance for Once Daily Dosing Patent for Kuvan

... indicated in the United States to reduce blood phenylalanine (Phe) levels in patients with ... enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. Kuvan ... world, is caused by a deficiency of the enzyme phenylalanine hydroxylase. PAH is required for the metabolism ...

Kuvan Receives Marketing Approval in the European Union

... indicated in the United States to reduce blood phenylalanine (Phe) levels in patients ... enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. ... cell disease, and PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase 1 ...

Data to Be Presented at 58th Annual Meeting of The American Society of Human Genetics

... Tablets is indicated to reduce blood phenylalanine (Phe) levels in patients with ... enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. BioMarin and ... disease, and PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase 1 ...

Kuvan Receives Positive Opinion From CHMP for European Approval

... Tablets is indicated to reduce blood phenylalanine (Phe) levels in patients with ... cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. BioMarin and ... disease, and PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase 1 ...

Biopten (Sapropterin Dihydrochloride) Approved by Japanese Ministry of Health for the Treatment of PKU

... Tablets is indicated to reduce blood phenylalanine (Phe) levels in patients with ... cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. BioMarin and ... cell disease, and PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase) which is currently in Phase ...

Kuvan, Naglazyme and Aldurazyme Data to Be Presented at the 57th Annual Meeting of the American Society of Human Genetics

... dihydrochloride (sapropterin) increases phenylalanine (Phe) tolerance in children with phenylketonuria ... in children with phenylketonuria (PKU) on a phenylalanine (Phe)-restricted diet (Grange) -- 2230 -- ... dihydrochloride (sapropterin) on blood phenylalanine (Phe) in patients with phenylketonuria (PKU) ...

BioMarin to Present at the Jefferies Healthcare Conference

... in partnership with Merck Serono, a division of Merck KGaA of Darmstadt, Germany. Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase I clinical development for the treatment of PKU and GALNS (N-acetylgalactosamine 6-sulfatase), which is ...

BioMarin to Present at the Goldman Sachs Healthcare Conference

... in partnership with Merck Serono, a division of Merck KGaA of Darmstadt, Germany. Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase I clinical development for the treatment of PKU and GALNS (N-acetylgalactosamine 6-sulfatase), which is ...

BioMarin to Present at the Deutsche Bank Health Care Conference

... in partnership with Merck Serono, a division of Merck KGaA of Darmstadt, Germany. Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase I clinical development for the treatment of PKU and GALNS (N-acetylgalactosamine 6-sulfatase), which is ...
Phenylalanine in Biological Products

Ribonucleic acid, transfer, phenylalanine specific from brewer's yeast from Sigma-Aldrich

Description:... Note: Prepared by method of Wimmer, E., et al., Biochemistry, 7, 2623 (1968). Quality Clarifier: Acceptor Activity: approx. 1000 picomoles phenylalanine per A 260 unit (not determined by ...
Company:Sigma-Aldrich
Phenylalanine in Biological Definition

Enzyme

... in humans is phenylketonuria (PKU). The enzyme phenylalanine hydroxylase , which usually converts the essential amino acid phenylalanine into tyrosine does not work, resulting in a buildup of phenylalanine that leads to mental retardation. Enzymes in the ...

Amino acid

... amino acids are lysine , leucine , isoleucine , methionine , phenylalanine , threonine , tryptophan , valine , and (in children) histidine and ... acidic 147.13 3.15 2.10 9.47 4.07 F Phe phenylalanine hydrophobic 165.19 5.49 2.20 9.31 G Gly ...

Genetic code

... 2nd base U C A G 1st base U UUU (Phe/F) phenylalanine UUC (Phe/F) phenylalanine UUA (Leu/L) Leucine UUG (Leu/L) Leucine , Start UCU ...

Genetic code

... 2nd base U C A G 1st base U UUU (Phe/F) phenylalanine UUC (Phe/F) phenylalanine UUA (Leu/L) Leucine UUG (Leu/L) Leucine , Start UCU ...

Neurotransmitter

... Derived from amino acids : aspartate glutamate GABA glycine Monoamines (in the order of their synthesis): from phenylalanine and tyrosine : dopamine ( da ) norepinephrine ( ne /noradrenaline) epinephrine ( epi /adrenaline) from tryptophan : ...

Protein

... in two forms: complete proteins contain all eight of the amino acids ( threonine , valine , tryptophan , isoleucine , leucine , lysine , phenylalanine , and methionine ) that humans cannot produce themselves, while incomplete proteins lack or contain only a very small proportion of one or more. ...
Phenylalanine in Biological Dictionary

Norepinephrine

... by the adrenal medulla and the nerve endings of the A compilation of neurotranmitter and amino acid information and how it affects you. ... phenylalanine and tyrosine are precursors to norepinephrine and epinephrine. ... Norepinephrine or noradrenaline is a hormone and a neurotransmitter; it ...

Anticodon

... the ... The codon (and, reciprocally, the anticodon ) codes for a specific amino acid. ... Anticodon : 3' CGA 5' Codon: 5' GCU 3' ... Example: phenylalanine tRNA with the anticodon 3' AAG 5' recognizes not only UUC ... Information about anticodon in the free online English dictionary and ... ...
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