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Phenotypic in Medical News

January American Naturalist highlights

... selection on morphological traits and drive phenotypic divergence. "Genetic constraints and ... the form that matches the season. This is called phenotypic plasticity, and in this species it has evolved as ... evolution of lifespan is closely associated with phenotypic plasticity. Is it a general mechanism" We think ...

AdvanDx Receives FDA 510(k) Clearance for GBS PNA FISH(R) for Rapid Detection of Group B Strep from Lim Broths

... taken for further culture workup and identification using conventional, phenotypic methods. This process can take anywhere from 3 to 4 days, and while Lim ... sensitive and selective for Group B Strep, the subsequent workup and phenotypic identification can be time consuming and may miss some true positive ...

Coalition for Pulmonary Fibrosis and American Thoracic Society Announce Recipients of 2009-10 Research Awards

... the extent of EMT in bleomycin induced pulmonary fibrosis and identify the phenotypic differences between EMT derived and non-EMT derived fibroblasts, and ... Acquiring knowledge regarding the origins of lung fibroblasts and specific phenotypic characteristics of subtypes of this cell population will improve ...

Sex Hormone Protein May Predict Type 2 Diabetes

... the researchers found. "To our knowledge, there are few biomarkers for type 2 diabetes prediction that have presented both genetic and plasma phenotypic evidence like ours," Liu said. The report was published in the Aug. 5 online edition of the New England Journal of Medicine . For the study, ...

GeneGo Awarded NIH Grant to Develop Pharmacogenomics Software Suite

... an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. ...

New HIV Study Shows That Large Numbers of Women and People of Color Can Be Successfully Enrolled In U.S. HIV Clinical Studies

... following points should be considered when initiating therapy with PREZISTA/rtv: Treatment history and, when available, genotypic or phenotypic testing should guide the use of PREZISTA/rtv. The use of other active agents with PREZISTA/rtv is associated with a greater likelihood of ...

Eli Lilly and Company Announces New Drug Discovery Initiative

... and Company will be engaging researchers from around the world in a new and unique drug discovery initiative. The initiative, called the Lilly phenotypic Drug Discovery Initiative, or PD2 (pronounced PD-squared)*, uses Lilly-developed disease-state assays and a secure web portal to evaluate the ...

GeneGo and OmicSoft Announce Integration

... integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. ...

Advanced Analytical Reveals New Platform for Rapid Genotypic Identification of Microorganisms at ASM 2009

... Clinic, added; "We evaluated the differentiation of various microorganisms on a prototype instrument and compared it with other genotypic and phenotypic methods. The instrument is capable of identifying organisms quickly and easily. The implementation of such technology in the clinical laboratory ...

iZumi Bio and Kyoto University Form Collaboration to Advance Induced Pluripotent Stem Cell Technology

... aortic valve disease." iZumi and CiRA respectively offer the capability to take skin cells from a diseased patient with known genotypic and phenotypic information and reprogram the cells to behave similarly to human embryonic stem cells. These iPS cells can then be changed into various cell types in ...

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Phenotypic in Medical Technology

Cognition Therapeutics Closes Series A Financing to Advance Drug Candidates for Alzheimer's Disease

... disease and other neurodegenerative diseases. These assays emphasize phenotypic or functional responses of mature primary neurons to the toxic proteins. ... platforms harken back to the origins of the pharmaceutical industry, when phenotypic responses were the sole screening method and natural product derivatives ...

The Pittsburgh Life Sciences Greenhouse Relocates Therapeutics Company to Pittsburgh

... Alzheimer's disease. PLSG's investment will support the deployment of the phenotypic assay technology platform. "Our approach is to target the toxic proteins ... loss," said Dr. Susan Catalano, Chief Science Officer and inventor of the phenotypic assay platform technology. "We are thrilled to welcome Cognition to ...

Long-Term Study Evaluates Boosted PREZISTA(R) Vs. Lopinavir/Ritonavir as Part of HIV Combination Therapy in Treatment-Naive Adults

... patients, the following points should be considered when initiating therapy with PREZISTA/r: treatment history and, when available, genotypic or phenotypic testing, should guide the use of PREZISTA/r. The use of other active agents with PREZISTA/r is associated with a greater likelihood of treatment ...

Journal of Clinical Oncology Publishes Leukine(R) Study Demonstrating Positive Survival Outcomes in Patients with High-Risk Melanoma

... and safe medicines." About The Study In addition to clinical outcomes, patients underwent phenotype analysis of dendritic cells. Dendritic cell phenotypic analysis was performed at baseline and again at two, four, eight and 12 weeks. Control values for this analysis were established prior to the trial ...

IDX899 Demonstrates Rapid and Profound Inhibition of HIV Replication in a Phase I/II Clinical Trial in Treatment-Naive HIV-Infected Patients

... In a preclinical resistance study, IDX899 and other marketed and investigational NNRTIs were compared to evaluate in-vitro genotypic resistance and phenotypic cross-resistance profiles. IDX899 demonstrated potent antiviral activity against established NNRTI-resistant clinical isolates. Compared to efavirenz ...

DHHS Guidelines Support Use of Trofile(TM) Assay Prior to CCR5 Inhibitor Use

... whether or not the patient's HIV experienced a shift in viral tropism while on the therapy. The DHHS guidelines recommend only high- throughput phenotypic assays be used for co-receptor testing for CCR5 therapeutics at this time and acknowledge that genotypic assays, while under investigation, are ...

Supplemental New Drug Application for PREZISTA(TM) Submitted to U.S. Food and Drug Administration

... The following points should be considered when initiating therapy with PREZISTA/r: -- Treatment history and, when available, genotypic or phenotypic testing should guide the use of PREZISTA/r. -- The use of other active agents with PREZISTA/r is associated with a greater likelihood of ...

Aptivus(R) (tipranavir) Capsules Granted Full Approval by the U.S. FDA

... recommended. -- The use of other active agents with APTIVUS/r is associated with a greater likelihood of treatment response. -- Genotypic or phenotypic testing and/or treatment history should guide the use of APTIVUS/r. The number of baseline primary protease inhibitor mutations affects the ...

Monogram Provides Update on Trofile(TM) Co-Receptor Tropism Assay

... alone, and -- that patients receiving Selzentry experienced similar adverse events to those receiving an optimized regimen alone. Monogram's phenotypic resistance tests were used to optimize background therapy in Selzentry's clinical trials. Selzentry is designed to work differently from other ...

New Phase 3 Study in Treatment-Naive Adults with HIV Evaluates Efficacy and Safety of Once-Daily PREZISTA(TM)/ritonavir vs. KALETRA(R) as Part of HIV Combination Therapy

... The following points should be considered when initiating therapy with PREZISTA/r: -- Treatment history and, when available, genotypic or phenotypic testing should guide the use of PREZISTA/r. -- The use of other active agents with PREZISTA/r is associated with a greater likelihood of ...
Phenotypic in Medical Dictionary

Drug Resistance

... marked by a constant struggle between evolving drug -resistant parasites and the search for new drug formulations. PhenoSense HIV A rapid phenotypic drug resistance assay that directly measures the sensitivity or resistance of a patient's HIV to currently available antiretro viral drugs; ...

Mutation

... Any change in the hereditary material of genes . Purkinje's cellsLarge branching cells of the nervous system. RecessiveProducing little or no phenotypic effect when occurring in heterozygous condition with a contrasting allele. somatic mutation An alteration in DNA that occurs after conception . ...

Resistance

... Some have argued that the biology of RAEB-t is distinct from AML and should be retained as a diagnostic category of MDS. PhenoSense HIV A rapid phenotypic drug resistance assay that directly measures the sensitivity or resistance of a patient's HIV to currently available antiretro viral drugs; ...
Phenotypic in Biological News

7th annual [BC]2 Basel Computational Biology Conference 'Molecular Evolution' June 18-19, 2009

... process. Richard E. Lenski, who will be speaking about the "Dynamics of phenotypic and Genomic Evolution During a 40,000-Generation Experiment with E. coli", ... findings in this project providing new insights on the dynamic coupling of phenotypic and genomic evolution and the role of complex mutations in the origin of ...

Researchers document rapid, dramatic 'reverse evolution' in the threespine stickleback fish

... a widely held theory behind rapid evolutionary change, the idea of phenotypic plasticity when an organism can take on different characteristics ... diet growing up, Peichel said. Our findings challenge the primary role of phenotypic plasticity in rapid evolutionary change. The gene that controls for ...

Tiny genetic differences have huge consequences: McGill researchers

... protein coding sequences could be responsible for the enormous variety of phenotypic differences between individuals. It had previously been shown that ... distinguish you and me, and yet it would be very hard to explain all the phenotypic differences in the way we look, grow, and behave just by the handful of ...

Measuring intellectual disability

... suggest that "[this] method should prove to be a powerful tool for further investigation of the relationships between FMRP and the diverse clinical phenotypic domains [of fragile X syndrome]." "Such domains include not only autism and autism spectrum disorders, but also developmental delay, behavioral ...

Did the North Atlantic fisheries collapse due to fisheries-induced evolution?

... has, on average, decreased nearly one centimeter per year. The changes observed very likely are evolutionary genetic changes and not simply plastic phenotypic responses to the environment. They are comparable to changes that preceded the collapse of northern cod at Newfoundland. This finding further ...

The neurobiology of musicality related to the intrinsic attachment behavior?

... music together may add group cohesion. Thus, it is justified to hypothesize that music perception and creativity in music are linked to the same phenotypic spectrum of human cognitive social skills, like human bonding and altruism both associated with AVPR1A. We have shown for the first time in the ...

A genome may reduce your carbon footprint

... sequence assembly nor gene annotation is required to apply these techniques. In a species such as switchgrass there exists a great deal of phenotypic variation derived from latitudinal adaptation across its natural range and local adaptation to soil, temperature, and moisture conditions. It is ...

Color test enhances tomato analyzer software

... to analyze the morphology of tomato fruit. The researchers in this study developed a module for color measurement "to expand the array of objective phenotypic analyses implemented". TACT was applied to fruits and vegetables of various color and color uniformity. "TACT was designed to be user-friendly ...

Identifying mega-targets for high-yield plant breeding

... programs. Results from this research are published in the January 2009 issue of the journal Crop Science . The researchers found that all phenotypic traits had significant genetic diversity, but only seven of the 20 traits evaluated showed differences in the amount of diversity among the breeding ...

BioScience tip sheet, February 2009

... research articles: Biological Resource Centers and Systems Biology. Yufeng Wang and Timothy G. Lilburn. The authors propose leveraging phenotypic data from the few bacteria in resource collections that are well characterized with the larger numbers of bacteria for which there exist genetic ...

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Phenotypic in Biological Technology

Sensitivity Enhancements to Monogram's Trofile(TM) Assay Demonstrate Improved Power to Select Patients for CCR5 Antagonist Therapy

... Additional work described at the meeting focused on the use of Monogram's phenotypic and genotypic technology to identify specific markers of HIV resistance to ... HIV infection. Determining a patient's HIV profile at the molecular and phenotypic level, and the effect of therapy on that profile, is not only an ...

GeneGo Donates Proprietary Cytokine Pathway Maps to ISICR

... an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. ...

New Test from Quest Diagnostics Helps Physicians Choose HIV Antiretroviral Therapy in Patients with History of Drug Resistance

... found that the Quest Diagnostics HIV-1 Coreceptor Tropism laboratory developed test demonstrated 74 percent agreement with Trofile(TM), the leading phenotypic tropism test available from Monogram Biosciences, and 74 percent agreement with SensiTrop(TM) II, a genotypic tropism test previously available from ...

Prometheus Research Signs 3-Year Contract With Simons Foundation to Expand HTSQL Informatics System for Autism Research

... The SFARI database, known as SFARI Base, is a new resource for autism research that provides the scientific community access to genetic and phenotypic information on 2000 families. "Researchers need flexible, adaptive, and secure informatics systems that empower them to uncover critical data ...

Amnis Launches New ImageStreamX Imaging Flow Cytometer

... Officer. "No other cell analysis platform gives you as much information in a single experiment or allows you to combine detailed functional and phenotypic studies," added Ortyn. "The modularity of the new ImageStreamX allows it to fit into a much wider range of budgets, while its performance ...

Sigma-Aldrich Introduces MISSION(R) esiRNA for Low Cost, High Specificity Pooled RNAi Screening

... School , which has invested in a human genome-wide esiRNA library, is using esiRNA to help identify the human genes that enable HIV propagation. "The phenotypic results from the initial tests of MISSION esiRNA using our assay for finding HIV dependency factors demonstrated very effective knockdown over a wide ...

Cardiff University Becomes a GeneGo Center of Excellence

... integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. ...

Children's Memorial Research Center, Chicago Becomes a Member of GeneGo's MetaMiner Stem Cell Partnership Program

... integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. ...

VisualSonics to Sell Mauna Kea Technologies' Cellvizio(R) LAB on a Worldwide Basis to Animal Imaging Market

... to conduct research in cardiovascular, cancer, and developmental biology areas. The technology supports applications that include genetic research, phenotypic studies and drug development. VisualSonics platforms combine high-resolution, real time in vivo imaging at reasonable cost with ease-of-use and ...

Van Andel Institute Joins the MetaMiner Oncology Partnership Program

... integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. ...

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Phenotypic in Biological Products

Guava EasyCyte from Guava Technologies

Description:... is equipped with a blue laser (488 nm), three fluorescence detectors, forward scatter (FSC) and sides scatter (SSC) to identify cells with specific phenotypic markers or specific properties. The unique capability, not provided with other assay systems, of direct, absolute cell counts, is displayed as ...
Company:Guava Technologies

Alkaline Phosphatase Detection Kit from CHEMICON

Description:... CHEMICONs Alkaline Phosphatase Detection Kit (Catalog number SCR004) is a specific and sensitive tool for the phenotypic assessment of ES cell differentiation by the determination of AP activity. Available separately from CHEMICON are the monoclonal antibodies TRA-2-49 ...
Company:CHEMICON

ES Cell Characterization Kit from CHEMICON

Description:... TRA-1-81 [Andrews and Banting, 1984]. • CHEMICONs ES Cell Characterization Kit (Catalog number SCR001) is a specific and sensitive tool for the phenotypic assessment of the differentiation status of ES cells by measuring their AP activity, cell-surface stage-specific antigens (SSEA-1, SSEA-4) as well as ...
Company:CHEMICON
Phenotypic in Biological Definition

Experimental evolution

... journals . Further reading W. H. Dallinger (1887). The president's address. J. Roy. Microscop. Soc. , 185-199. R. E. Lenski (2004). phenotypic and genomic evolution during a 20,000-generation experiment with the bacterium Escherichia coli . Plant Breeding Reviews 24 , 225-265. S. F. ...

Homeobox

... very early and that the basic mechanisms of morphogenesis are the same for many organisms. Mutations to homeobox genes can produce easily visible phenotypic changes. Two examples of homeobox mutations in the above-mentioned fruit fly are legs where the antennae should be, and a second pair of wings. ...

Phenotype

... physiological and behavioral) determined by an interaction between its genotype and environment (see genotype-phenotype distinction and phenotypic plasticity for a further elaboration of this distinction). The idea of the phenotype has been generalized by Richard Dawkins to include effects ...
Phenotypic in Biological Dictionary

Quantitative trait

... inheritance refers to the inheritance of a phenotypic characteristic that varies in degree and can be ... genes results in a continuous distribution of phenotypic values. ... Is A Quantitative Trait Locus? ... quantitative trait is one that has measurable phenotypic variation owing to ... Our study of ...

Phenotypic variance

... phenotypic variation (due to underlying heritable genetic variation) is a ... Without phenotypic variation, there would be no evolution by ... In genetics, Heritability is the proportion of phenotypic variation in a population that is attributable ...

Genetic assimilation

... assimilation is a mechanism facilitating phenotypic evolution that was proposed by ... Murren & ... absence of selection for the ... Nanjundiah, V. phenotypic plasticity and evolution by genetic ... assimilation to be a ubiquitous feature of phenotypic evolution: ... Genetic assimilation is a ...

Polygenic inheritance

... traits or polygenic inheritance refers to the inheritance of a phenotypic characteristic that varies in degree and can be attributed to the ... Inheritance of quantitative traits refers to the inheritance of a phenotypic ... The paradigm of polygenic inheritance as being used to define ...

Pleiotrophy

... Pleiotropy occurs when a single gene influences multiple phenotypic traits. Consequently, a new mutation in the gene may have an effect on ... Pleiotropy , a situation in which a single gene influences multiple phenotypic traits, can ... complex eukaryotes, pleiotropy may lead to major ...

Genetic interactions

... the use of genetic interactions . Genetic interactions describe the phenotypic consequences of combinations of ... The Phenotypes and Genetic ... the use of genetic interactions . Genetic interactions describe the phenotypic consequences of combinations of ... These two modes can illustrate the ...

Gene interaction

... Gene–environment interaction is the phenotypic effect of interactions between genes and the environment. Gene ... interaction (or genotype–environment interaction or GxE ) is the phenotypic effect of interactions The heritability of human traits is often ...

Euploidy

... eupraxia. Eurasier. Eurax ... Aneuploidy. Development of Aneuploids. phenotypic Effects of Aneuploidy. Genetics of Aneuploidy ... Euploidy . Euploidy ... ... Euploidy in plants ... Aneuploidy. Development of Aneuploids. phenotypic Effects of Aneuploidy. Genetics of Aneuploidy ... Euploidy and Plant ...

Transcapsidation

... of transcapsidation is the encasing of genetic material ... ... ELISA to investigate heterologous encapsidation ( transcapsidation and phenotypic ... that among BYDV isolates transcapsidation is more common between distantly ... Transcapsidation , however, is not needed for umbravirus ...

Trait

... class, a template class in the C++ programming language. Trait (abstract type), a model for ... A trait is a distinct variant of a phenotypic character of an organism that may be inherited, environmentally determined or somewhere in between. For example, eye color is a character or ...

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(Date:4/24/2014)... and stressful outcomes for parents who have a child ... says a recent study led by a researcher at ... numerous and life-changing and stress levels high, the vast ... reported positive outcomes as well, a phenomenon known as ... issue of the American Journal of Orthopsychiatry . ...
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