TGen and USC researchers find genetic markers to help fight diabetes
TZDs are a class of insulin-sensitizing drugs used to treat type 2 diabetes mellitus (T2DM). TZDs are agonists for the nuclear receptor peroxisome
proliferator-activated receptor-g (PPARG). Although the exact mechanism by which TZDs act is not yet known, data indicate that TZDs improve insulin ...
Roche to Commence Phase III Trials with Innovative Treatment Designed to Lower Cardiovascular Risk in Diabetes Patients with Recent Heart Attack
... available at www.RocheExchange.com .
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(1) Henry R et al. The dual peroxisome
proliferator-activated receptor alpha/gamma: results from SYNCHRONY, a phase II, randomized, dose-ranging study in patients with type 2 diabetes. ...
EXT Life Sciences Announces New Biotech Treatment that Tackles Root Cause of Graying Hair
... the cosmeceutical and medical fields," said Dr. Terlecky.
EXT's targeted catalase technology, called CatSKL(TM), reintroduces catalase into the peroxisome
(a compartment) of aged cells to reestablish the balance of pro- and anti-oxidants and has already earned patent protection in several countries. Dr. ...
Is telmisartan effective in treating non-alcoholic steatohepatitis?
... endpoint was to prove certain superiority of telmisartan vs valsartan probably linked to its specific insulin sensitizing action releated to the peroxisome
proliferator activated receptor (PPAR) gamma - modulatory effects. This is one of the first human blinded trials evaluating the effects of ...
Willa A. Hsueh, M.D., Joins Bionovo's Scientific Advisory Board
... for women."
Dr. Hsueh and her team were the first to identify a potentially protective
role for the activation of nuclear receptors of the peroxisome
activated receptor family (PPAR) in vascular injury. Dr. Hsueh was one of the
earliest investigators to suggest that diabetes is a major ...
Mini heart attacks lessen damage from major ones
... treatment effect. Past studies found that LNO2 inhibits Nfkappa B, a protein known to switch on genes that drive inflammation. LNO2 also activates peroxisome
proliferator activated receptor gamma and heme oxygenase 1, both of which block inflammation.
The major finding of the study is that LNO2 is ...
Genetic disease treatments and pharmacogenetics: From scientific discovery to medical delivery
... of protein aggregates a key pathological feature of most neurodegenerative disorders.
Specifically, the current results indicate that PPARd (a peroxisome
proliferator-activated receptor that is positively modulated by PGC1-a) interacts with the huntingtin protein, and altered function of PPARd ...
Study in Circulation Research details how diabetes drives atherosclerosis
... endothelial nitric oxide synthase (eNOS) to produce more nitric oxide and dilate blood vessels. It also activates Kruppel-like factor 2 (KLF2) and peroxisome
proliferator-activated receptor-g (PPARg), both of which block the ability of pro-inflammatory immune cells to home in on and adhere to diseased ...
Diabetes Drug Avandia Could Weaken Bones
... the point of view of both heart failure and bone degradation could be substantial, experts say.
Avandia affects a key cellular protein called the peroxisome
proliferator-activated receptor (PPAR-gamma). In their study, the California team discovered that, in mice, activating this receptor also stimulates ...
InteKrin Therapeutics, Inc. Appoints Former Amgen Clinical Development Executive Chief Medical Officer
... leaders who
brought earlier PPAR agonists to market. InteKrin's lead therapeutic candidate, INT131, is a potent non-TZD
SPPARM (Selective peroxisome
Proliferator-Activated Receptor Modulator)
that was specifically engineered to have equal or better efficacy to the
currently marketed TZDs without ...
Peroxisome in Medical Technology
Peroxisome in Biological News
Pulmonary hypertension in children may result from reduced activity of gene regulator
In a surgically created animal model of a congenital heart defect that causes too much pulmonary blood flow, they have already shown PPARs peroxisome
proliferator-activated receptors are down regulated. In these lambs, whose four-chambered hearts are essentially identical to humans, agonists to ...
Resveratrol prevents fat accumulation in livers of 'alcoholic' mice
... found that the increased expression of SIRT1 and AMPK led to:
Reduction of sterol regulatory element binding protein (SREBP-1)
Activation of peroxisome
proliferator-activated receptor gamma co-activator alpha (PGC-1α)
Elevation of circulating adiponectin, a hormone produced by fat cells, which ...
Biologists at UC San Diego identify key protein in cell's 'self-eating' function
... understand how and why they are selected by the lysosome for degradation.
What the biologists found, he said, is that this new protein can mediate peroxisome
selection during pexophagy that is, it is necessary for pexophagy, but not for other autophagy-related processes.
Suresh Subramani, a professor ...
Hormone helps mice 'hibernate,' survive starvation
... at play during starvation and fasting.
They focused on a nuclear receptor – a protein that turns genes on and off in the body – called peroxisome
proliferator-activated receptor alpha, or PPAR-alpha, which is known to control the use of fat as energy. Starving mice without PPAR-alpha become ...
Fat screen delivers plant-derived chemical with antidiabetic effects
... or TZDs, work through a counterintuitive mechanism: they restore insulin sensitivity by activating a central promoter of fat tissue production called peroxisome
proliferator-activated receptor ã (PPARã).
"The current explanation for this paradoxical mode of action is the idea that the body needs a place ...
Gut research yields new anti-cancer approach
... a new way to fight colorectal cancer, and potentially cancers of the esophagus, liver and skin. Early work shows that a group of compounds called peroxisome
proliferator-activated receptor-gamma (PPARgamma) inhibitors may have an unexpected cancer-fighting effect, according to research published today in ...
New understanding of parasite cell structures may provide treatments for serious tropical diseases
The new research will open areas for further investigation.
"Before this work in trypanosomes, there was no evidence that we could 'catch' peroxisome
proteins moving to the ER" said Mensa-Wilmot. "With better understanding of the process we could begin looking for compounds that may act as drugs by ...
Opposing fat metabolism pathways triggered by a single gene
... expression of another gene fat-7, which, by reducing acs-2, increases fat content. In its function, nhr-49 resembles a mammalian NHR, called peroxisome
proliferator-activated receptors (PPARs). Further investigation of this link may lead to better understanding of the functions of PPARs and provide ...
Peroxisome in Biological Technology
Peroxisome in Biological Products
Peroxisome in Biological Definition
... as D-amino acid oxidase and urease oxidase .
contains the enzyme catalase which converts H 2 ... to accumulate. All of the enzymes found in a peroxisome
are imported from the cytosol . Each enzyme transferred to a peroxisome
has a special sequence at one end of the protein, ...
... organelles include:
Other related structures:
Peroxisome in Biological Dictionary
... Contribution of the endoplasmic reticulum to peroxisome
formation" ... origin of peroxisomes: an ER- peroxisome
connection" ... PeroxisomeDB: peroxisome
-Database ... ...