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Osteosarcoma in Medical News

FDA Approves Expanded Use of Lilly's FORTEO(R) [teriparatide (rDNA origin) injection] to Treat Glucocorticoid-Induced Osteoporosis

... section of the label regarding the risk of osteosarcoma to reinforce that FORTEO should not be used in ... further evaluate the long-term safety of FORTEO. osteosarcoma is a serious but rare cancer which occurs at a ... of about four cases per million people, per year. osteosarcoma has been reported rarely in people who took ...

Takeda to Acquire IDM Pharma, Adding MEPACT(R) (Mifamurtide), the First Treatment Approved for Osteosarcoma in More Than 20 Years, to Its Oncology Franchise

... indicated for the treatment of non-metastatic osteosarcoma (malignant bone cancer) following surgical ... in children, adolescents and young adults. osteosarcoma is a rare and often fatal disease, with ... was integral to providing access to the first new osteosarcoma treatment in more than 20 years," added Timothy ....

Immune-based drug approved in Europe for pediatric cancer patients

... 20 years to improve the long-term survival of osteosarcoma patients. Eugenie Kleinerman, M.D., head of ... proposed the use of this immune therapy for osteosarcoma after Isaiah J. Fidler, D.V.M., Ph.D., professor ... stimulated human immune cells to react against osteosarcoma cells." MEPACT works by stimulating certain ...

IDM Pharma's MEPACT(R) (Mifamurtide, L-MTP-PE) Receives Approval in Europe for Treatment of Patients with Non-Metastatic, Resectable Osteosarcoma

... First New Agent Approved to Treat osteosarcoma in More Than 20 Years IRVINE, Calif., March ... in Europe, giving them access to the first new osteosarcoma treatment option in 20 years," said Timothy P. ... and dedication to children and young adults with osteosarcoma and brings real hope for a patient population in ...

Researchers identify potential therapeutic target in osteosarcoma

... alpha (IL-11Ra) - is highly expressed in primary osteosarcoma and in lung metastases from these tumors. Their ... of delivering therapeutic agents directly to osteosarcoma cells by targeting the receptor with circulating ... of the natural ligand that binds IL-11Ra. osteosarcoma is the most common primary malignant tumor of ...

IDM Pharma Joins NORD to Raise Awareness of Rare Diseases

... attention to the impact rare diseases -- like osteosarcoma -- have on the lives of young patients and their ... after treatment with mifamurtide. About osteosarcoma Between two and three percent of all childhood cancers are osteosarcoma. Because osteosarcoma usually develops from osteoblasts, it most ...

Research increases possibilities of personalizing treatment of infant osteosarcoma

... Doctor Marta Zalacain, who suffered an osteosarcoma when she was 11 years old, and for which she was ... in all of Spain, 45 child patients suffering from osteosarcoma are detected on average each year there. Thus, ... The survival prognosis of infant patients with osteosarcoma at the University Hospital of Navarra, including ...

Novel model of osteosarcoma

... present a new mouse model of osteosarcoma. osteosarcoma is the most common type of malignant bone cancer, ... statistic drops steeply once the cancer spreads. osteosarcoma results from the dysregulated growth of ... rapid growth. While the precise causes of osteosarcoma are unknown, it is evident that two tumor ...

IDM Pharma Announces Data Supporting Improved Overall Survival Advantage in Newly Diagnosed Patients with Metastatic Osteosarcoma Treated with Mifamurtide (L-MTP-PE)

... all childhood cancers are osteosarcoma. Because osteosarcoma usually develops from osteoblasts, it most ... movement can occur as the tumor grows. osteosarcoma is an orphan disease with fewer than 1,000 new ... Oncology Group, the survival of children with osteosarcoma has remained at 60-65 percent since the ....

FDA Approves the Opening of a Phase II Registration Protocol Using REXIN-G(R) for Osteosarcoma in California U.S.A.

... Phase II Registration Protocol using Rexin-G for osteosarcoma in the United States. Following the accelerated ... intravenous Rexin-G for recurrent or metastatic osteosarcoma that is refractory to known therapies. The study ... process that is unique to the manner in which osteosarcoma responds favorably to therapy, i.e., with ...
Osteosarcoma in Medical Technology

Another Study Links Fluoride to Bone Cancer

... levels were significantly higher in patients with osteosarcoma than in control groups, according to research ... found to be significantly higher in patients with osteosarcoma as compared to the other two groups," writes ... showing a link between water fluoridation and osteosarcoma in young boys.(2) A 1992 New Jersey ...

IDM Pharma Provides Update on Mifamurtide (L-MTP-PE) Regulatory Status Following September Meeting of European Committee for Medicinal Products for Human Use (CHMP)

... a significant overall survival benefit for osteosarcoma patients and meets an important unmet treatment ... all childhood cancers are osteosarcoma. Because osteosarcoma usually develops from osteoblasts, it most ... movement can occur as the tumor grows. osteosarcoma is an orphan disease with fewer than 1,000 new ...

IDM Pharma Provides Update on Mifamurtide (L-MTP-PE) Regulatory Status Following June Meeting of European Committee for Medicinal Products for Human Use (CHMP)

... all childhood cancers are osteosarcoma. Because osteosarcoma usually develops from osteoblasts, it most ... movement can occur as the tumor grows. osteosarcoma is an orphan disease with fewer than 1,000 new ... Oncology Group, the survival of children with osteosarcoma has remained at 60-65 percent since the ....

IDM Pharma Announces Updated Data From Mifamurtide (L-MTP-PE) Compassionate Access Program

... 3 clinical trial in patients with non-metastatic osteosarcoma are being supported in patients with lung ... Study design and findings Twenty-nine high-risk osteosarcoma patients (ages 10 - 21) were enrolled and 27 have ... program had documented diagnosis of high grade osteosarcoma with relapsed or recurrent disease (locally or ...

IDM Pharma Announces Availability of Mifamurtide (L-MTP-PE) Through Compassionate Access Study

... mifamurtide (L-MTP-PE) to eligible, high-risk osteosarcoma patients through a compassionate access study. ... by providing L-MTP-PE access to high-risk osteosarcoma patients for whom current therapy is not ... will have a confirmed diagnosis of high grade osteosarcoma with relapsed or recurrent disease, locally or ...

IDM Pharma Announces Phase 3 Mifamurtide (L-MTP-PE) Study Demonstrating Improved Survival Published in the Journal of Clinical Oncology

... Chemotherapy Reduced the Risk of Death by 30% in osteosarcoma Patients IRVINE, Calif., Feb. 4 ... 662 patients with newly diagnosed non-metastatic osteosarcoma treated in the Phase 3 trial and demonstrated ... in patients with newly diagnosed resectable osteosarcoma without metastatic disease. Patients received ...

IDM Pharma Announces Non-Binding Opinion of the European Committee for Medicinal Products for Human Use (CHMP) that Mifamurtide (L-MTP-PE) Provides a Possible Clinical Benefit in Survival

... limited movement can occur as the tumor grows. osteosarcoma is an orphan disease with fewer than 1,000 new ... Oncology Group, the survival of children with osteosarcoma has remained at 60-65 percent since the mid-1980s. The standard treatment for osteosarcoma is tumor resection with combination chemotherapy ...

IDM Pharma Announces Updated Phase 3 Mifamurtide (L-MTP-PE) Data Confirms Statistically Superior Overall Survival in Osteosarcoma Patients

... the critically ill children and young adults with osteosarcoma who need an innovative treatment option for this ... to chemotherapy in patients with resectable osteosarcoma without metastatic disease. There were 672 with newly diagnosed, non-metastatic, resectable osteosarcoma included in the COG analyses. In the analyses by ...

FORTEO(R) Increased Spine Bone Mineral Density in Patients with Glucocorticoid-Induced Osteoporosis

... teriparatide caused some rats to develop osteosarcoma, a bone cancer. osteosarcoma in humans is a serious but very rare cancer. Osteosarcoma occurs in about ... product. FORTEO also has a "boxed warning" in its package insert about the osteosarcoma findings in rats during preclinical testing. For full prescribing ...

ASEAN News: Epeius Biotechnologies Gains Commercial Approval for Rexin-G(R), a Tumor-Targeted Gene-Based Medicine for Metastatic Cancer

... sarcoma. Based again on unprecedented single-agent efficacy and over-all safety, the US FDA recently approved a Phase II Registration Protocol for osteosarcoma which includes participation of children and adolescents. For additional information about ongoing clinical trials in the United States, contact our ...
Osteosarcoma in Medical Definition

Pathology

... - Lipoma / liposarcoma - Leiomyoma / leiomyosarcoma - Rhabdomyoma / rhabdomyosarcoma - Mesothelioma - Angioma / angiosarcoma - Osteoma / osteosarcoma - Chondroma / chondrosarcoma - Glioma - Lymphoma / leukemia Treatment Surgery - Chemotherapy - Radiation therapy - ...

Ocular oncology

... - Lipoma / liposarcoma - Leiomyoma / leiomyosarcoma - Rhabdomyoma / rhabdomyosarcoma - Mesothelioma - Angioma / angiosarcoma - Osteoma / osteosarcoma - Chondroma / chondrosarcoma - Glioma - Lymphoma / leukemia Treatment Surgery - Chemotherapy - Radiation therapy - ...
Osteosarcoma in Medical Dictionary

Amputation

... standard means of treating distal femoral osteosarcoma s. Amputation Amputee Coalition of ... ; eccentric; eccentric amputation ; ... osteosarcoma is treated by surgical removal of the cancer ... , and dislocation s. Between 70% and 90% of osteosarcoma s in the limbs can be treated with limb -sparing ...

Osteosarcoma

... What is osteosarcoma ? osteosarcoma is a disease in which cancer (malignant) ... It is the most common type of bone cancer . osteosarcoma most often occurs in adolescents and young ...

Osteomyelitis

... of bone and marrow ), osteopetrosis (stonelike bone), osteoporosis , osteosarcoma , etc. A biologies license application (BLA) has been submitted ... ). periosteal implantation; periosteal layer of dura mater; periosteal osteosarcoma ; periosteal reaction; periosteal reaction patterns; periosteal reflex; ...

Adrenocortical carcinoma

... ... The spectrum of cancer s in LFS has been shown to include breast cancer , soft tissue sarcoma s, brain tumors , a bone tumor called osteosarcoma , leukemia , and a tumor of the ad renal gland ( adrenocortical carcinoma ): an incredible range of malignancies. ...

Bladder Cancer

... bladder cancer , colon cancer , or melanoma ) that has only spread a limited amount to the lung can ... The most common secondary cancer is osteosarcoma ( cancer of the bone). However, retinoblastoma has been linked to ovarian, breast , lung, prostate , and bladder cancer s much later in life. ...

Bone cancer

... ous or often life-threatening. Ewing's sarcoma is another kind of bone cancer , but the cancer cells look different under a microscope than osteosarcoma cancer cells. (Refer to the PDQ summary on Ewing's Family of Tumor s Treatment for more information.) ... The purpose of the ...

Breast Cancer

... as avoidance of sun, cigarette smoking , balanced diet s, ... Alterations in the RB1 gene have also been found in other tumor s, including osteosarcoma and breast cancer . Most children with inherited retinoblastoma generally have tumor s involving both eyes . For example, breast cancer ...

Osteomalacia

... For: search help Printer-Friendly Format ... Osteochondrosis ( Osgood-Schlatter Disease ) Osteogenesis Imperfecta Osteogenic Sarcoma ( osteosarcoma ) Osteomalacia Osteomalacia in Children ( Rickets ) ... High ALP levels can be caused by bone diseases , such as Paget's disease , ...

Osteopathy

... their allied health professionals, such as physical therapists, psychologists, and registered nurses. periosteal layer of dura mater; periosteal osteosarcoma ; periosteal reaction; periosteal reaction patterns; periosteal reflex; periosteal sarcoma ; periosteitis; periosteo-; peri osteoma ; ...

Radiation therapy

... radiation therapy and surgery has boosted the five-year survival rate to 80 percent. The most common forms of bone cancer in children are osteosarcoma and Ewing's sarcoma . For most people, the cancer can be cured or controlled by surgery and, in some cases, by combinations of radiation ...

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Osteosarcoma in Biological News

A longer lasting tumor blocker

... structural support they need to grow. Meanwhile, the scaffold of mice treated with anti-VEGF remained intact. M-CSF levels soar in patients with osteosarcoma (a malignant bone cancer), breast cancer and prostate cancer, making these cancers potentially the most responsive to M-CSF-blocking drugs Whether or ...
Osteosarcoma in Biological Technology

IDM Pharma Receives Not Approvable Letter for Mifamurtide (L-MTP-PE) for the Treatment of Osteosarcoma

... profile of L-MTP-PE for the treatment of osteosarcoma and are committed to obtaining regulatory ... with chemotherapy and after tumor resection to osteosarcoma patients in the Phase 3 trial, L-MTP-PE provided ... of patients with non-metastatic, resectable osteosarcoma receiving combination chemotherapy. IDM Pharma ...

IDM Pharma Reports 2008 Financial Results

... acquisition transaction. "2008 was a significant year for the Company with December's recommendation for approval of MEPACT for the treatment of osteosarcoma in Europe and the formal approval of the centralized marketing authorization following in early March of 2009," said Timothy P. Walbert, president ...

Oncolytics Biotech Inc.'s REOLYSIN(R) Exceeds Primary Statistical Endpoint in U.S. Phase 2 Sarcoma Study

... Ewing's sarcoma 9* SD ------------------------------------------------------------------------- osteosarcoma 9* SD (tumour resection after cycle 4) ...

Rexin-G Returns to The Big Apple: Clinical Trials for Pancreatic Cancer and Breast Cancer Open in Manhattan

... these clinical trials to the East Coast. Rexin-G has gained orphan drug status from the U.S. FDA for three clinical indications: pancreatic cancer, osteosarcoma and soft tissue sarcoma. The New York clinical trials will be conducted at the Bruckner Oncology Center in Manhattan, New York with Howard W. ...

Epeius Biotechnologies' Tumor-Targeted Rexin-G Receives FDA Orphan Drug Designation for the Treatment of Osteosarcoma

... to function within the context of the human circulatory system, the demonstration of single agent-efficacy by Rexin-G in Stage IV or metastatic osteosarcoma (ASCO, 2008) is an indication of the remarkable clinical potential of the precision targeting technologies embodied in its design. The Orphan Drug ...

Epeius Biotechnologies Awarded U.S. Patent for Targeted Injectable Gene Delivery In Vivo

... breast or pancreas and for bone and soft tissue sarcoma respectively. Additionally, a Phase II Registration Protocol is underway for chemo-resistant osteosarcoma in Los Angeles, California. About Epeius Biotechnologies Epeius Biotechnologies Corporation is a privately held biopharmaceutical company ...

IDM Pharma Names Dr. Jeffrey W. Sherman Chief Medical Officer and Senior Vice President of Research and Development

... Company's Phase 3 trial do not provide substantial evidence of effectiveness of L-MTP-PE in the treatment of patients with non-metastatic, resectable osteosarcoma receiving combination chemotherapy would have upon the determination by the FDA whether to approve the marketing application for L- MTP-PE, which ...
Osteosarcoma in Biological Definition

Cancer

... , mesothelioma - in the pleura or pericardium , oral cancer , osteosarcoma - in bones , ovarian cancer , pancreatic cancer , prostate cancer , ... (MEN types 1, 2a, 2b) Li-Fraumeni syndrome (various tumors such as osteosarcoma , breast cancer, soft-tissue sarcoma , brain tumors ) due to mutations of ...

Tumor

... of mesenchymal origin: connective tissue: fibroma , fibrosarcoma myxoma , myxosarcoma chondroma , chondrosarcoma osteoma , osteosarcoma (osteogenic sarcoma) lipoma , liposarcoma muscle: leiomyoma , leiomyosarcoma rhabdomyoma , rhabdomyosarcoma ...
Osteosarcoma in Biological Dictionary

Viral oncogene

... 176 cDNA libraries. ... Homo sapiens FBJ murine osteosarcoma viral oncogene -like B variant 8 (FOSB) mRNA, ... (avian) - Bioportfolio FOS - v-fos FBJ murine osteosarcoma viral oncogene homolog - Bioportfolio ... v-fos FBJ murine osteosarcoma viral oncogene homolog. c-Fos interacts with ....
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