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Organelle in Medical News

Researchers decipher blood stem cell attachment, communication

... laboratory of Jennifer Lippincott-Schwartz, Chief of the NICHD Section on organelle Biology. The study's first author was Jennifer Gillette, also of the Section on organelle Biology. Other authors were Andre Larochelle and Cynthia E. Dunbar of the ...

'Artificial Golgi' may provide new insight into key cell structure

... note. Their study is scheduled for the Aug. 12 issue of the Journal of the American Chemical Society , a weekly publication. The Golgi organelle is named for Camillo Golgi, the Italian scientist and Nobel Prize winner who discovered the structure in 1898. It is composed of a network of sacs, ...

Experimental Biology 2009 meets April 18-22

... chromatin regulation; protein synthesis and turnover; protein folding, aggregation and chaperones; enzymology; membrane proteins, dynamics and organelle biogenesis; drug discovery and design; metabolism and disease mechanisms; receptor signaling, lipid signaling and metabolism. Three Nobel Laureates ...

Researchers identify toehold for HIV's assault on brain

... to protect themselves from changes in levels of calcium. The scientists discovered another effect of Tat as well. Tat has a dramatic effect on an organelle known as the endoplasmic reticulum, where proteins are actually assembled and folded. Gelbard's team discovered that it's Tat's effects on the ...

Sullivan wins NSF Career Award for research on therapeutic drug carriers

... the rough-and-tumble journey from a blood vessel, through the connective tissue, through the cell membrane, and finally into the nucleus or other organelle within a target cell where the package will open up to deliver its contents. "It's a challenge to achieve because in protecting the DNA or drug, ...

UC Davis researchers find evidence of mature heart cell potential in embryonic stem cells

... to those signals. This link, called the excitation-contraction coupling, is dependent on the cells ability to move calcium ions across an internal organelle known as sarcoplasmic reticulum, or the so-called calcium store. The ability to handle calcium is disrupted in the cells of patients who experience ...

Customized virus kills brain tumor stem cells that drive lethal cancer

... devour themselves until they die. This self-cannibalization, called autophagy, occurs when a cell forms a membrane around part of its cytoplasm or an organelle and then digests the contents, leaving a cavity. A cell that dies from autophagy is riddled with cavities. Cells normally employ autophagy ...

Unfolded Proteins May Protect Cells from Dying

... autosomal dominant retinitis pigmentosa (ADRP), which causes blindness. Unfolded proteins linked to ADRP accumulate in the endoplasmic reticulum, an organelle where proteins are manufactured and packaged for transport to the cell surface, unlike some other forms of the unfolded protein response that occur ...

Montreal Researchers And US Develop Model Of Key Immune-System Component

... time, using a systems biology approach, they have developed a model that facilitates the study of the function of the phagosome. The phagosome is the organelle responsible for the destruction of infectious pathogens that cause such diseases as tuberculosis and salmonellosis, as well as pathogens that could ...
Organelle in Medical Technology

Raven Announces Initiation of a RAV12 Phase 2 Clinical Trial in Metastatic Pancreatic Cancer

... directly cytotoxic to a human colon cancer cell line in vitro through induction of oncotic cell death, a form of cell death characterized by cell and organelle swelling and loss of membrane integrity; second, the antibody mediates antibody-dependent cellular cytotoxicity; third, the antibody mediates ...

Raven Announces Completion of Enrollment in the Phase 1/2a Clinical Trial of RAV12 Therapeutic Antibody for the Treatment of Adenocarcinomas

... directly cytotoxic to a human colon cancer cell line in vitro through induction of oncotic cell death, a form of cell death characterized by cell and organelle swelling and loss of membrane integrity; second, the antibody mediates antibody-dependent cellular cytotoxicity; third, the antibody mediates ...

Raven Announces Continued Enrollment of Phase 1/2a Clinical Trial of RAV12 Therapeutic Antibody for Treatment of Adenocarcinomas

... directly cytotoxic to a human colon cancer cell line in vitro through induction of oncotic cell death, a form of cell death characterized by cell and organelle swelling and loss of membrane integrity; second, the antibody mediates antibody-dependent cellular cytotoxicity; third, the antibody mediates ...

Raven Announces Phase 1 Clinical Trial Results of RAV12 Therapeutic Antibody for Treatment of Adenocarcinomas

... directly cytotoxic to a human colon cancer cell line in vitro through induction of oncotic cell death, a form of cell death characterized by cell and organelle swelling and loss of membrane integrity; second, the antibody mediates antibody-dependent cellular cytotoxicity; third, the antibody mediates ...

Protein Found to Shield Pancreatic Cancer Cells from Self-Destruction

... called vacuoles. When autophagy occurs, a double membrane forms around a cell organ, or organelle. This autophagosome then merges with a digestive organelle called a lysosome and everything inside is consumed, leaving the vacuole and a residue of digested material. If enough of this happens, the cell ....
Organelle in Biological News

Proteomics study yields clues as to how tuberculosis might be thwarting the immune system

... of proteins in the membrane of a phagosome, an organelle of macrophages (a type of white blood cell) that ... proteomic studies, which profiled the entire organelle and focused on abundant water-soluble protein ... light on the diverse functions and pathways an organelle may engage in." The LC3-II protein is a ...

Undergrad has sweet success with invention of artificial Golgi

... to solve it. Cells build sugars in a cellular organelle known as the Golgi Apparatus. Under a microscope, ... to a stack of pancakes. The strange-looking organelle finishes the process of protein synthesis by ... to the natural Golgi, but he gives the ancient organelle a very high-tech makeover. His chip looks similar ...

Features of replication suggest viruses have common themes, vulnerabilities

... his colleagues all had narrow necks that transcended the membrane of the organelle to the cytoplasm, the medium inside the cell and in which the organelle is suspended. The neck is a gateway that appears to permit substrates ...

Yale researchers uncover secrets of salmonella's stealth attack

... within a tiny bubble-like compartment called a vesicle. SopB's second trick helps prevent the vesicle from being sucked into the lyosome, the organelle within the cell that degrades proteins. In order to accomplish this, SopB must move from the plasma membrane of the cell to the membrane of the ...

A budding role for a cellular dynamo

... of filaments that give the cell structural plasticity while driving many essential functions, from cell motility and division, to vesicle and organelle transport within the cell. In a groundbreaking new study in the current issue of Developmental Cell , Brandeis researchers raise the curtain on how ...

How Toxoplasma gondii gets noticed

... They find that the parasite gets noticed by the immune system when the membrane of the bug-containing vesicle fuses to the endoplasmic reticuluman organelle normally involved in presenting pathogens to T cellsallowing a swap of parasitic peptides. ...

IRB Barcelona to coordinate two European projects on biomedicine

... alterations in a disease". The six groups that comprise the consortia seek to identify the processes that occur in mitochrondria an intracellular organelle that transforms molecules from the food we ingest into energy -, and that are responsible for insulin resistance. Insulin is a hormone generated by ...

Bacterial biofilms as fossil makers

... undergo "autolysis," or self-destruction, as digestive enzymes get free and wreak havoc. Without oxygen, autolytic enzymes remain stuck inside their organelle prisons. "The next step, we believe, is that bacteria able to survive in low-oxygen conditions must then infest the cells of the dying embryo," ...

Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer

... Biomdiques August Pi i Sunyer (IDIBAPS), is centred in the mitochondrion and its role in programmed cell death or apoptosis. The mitochondrion is the organelle in charge of the cell's respiration and of energy generation to satisfy important metabolic functions, which are altered in cancer. In an article ...

72 new members chosen by Academy

... Institute of Theoretical Physics, department of physics, Stanford University, Stanford, Calif. LIPPINCOTT-SCHWARTZ, JENNIFER; chief, section on organelle biology, cell biology and metabolism branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md. ...

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Organelle in Biological Technology

Researchers at the University of Georgia Discover Protein is Crucial to Reproduction of Parasites Involved in Disease

... functions, and it is these functions that the parasites require. Since humans do not have chloroplasts, the parasite's dependence on this organelle is viewed by reseachers as an Achilles heel. Scientists are interested in the group to which Toxoplasma belongs, the Apicomplexa, because it ...

Raven Announces RAV12 Phase 1/2a Study Results To Be Presented at ASCO

... directly cytotoxic to a human colon cancer cell line in vitro through induction of oncotic cell death, a form of cell death characterized by cell and organelle swelling and loss of membrane integrity; second, the antibody mediates antibody-dependent cellular cytotoxicity; third, the antibody mediates ...

Glossary for The BioPharm Guide to Fermentation and Cell Culture

... practices required by FDA regulations. Golgi body A cell organelle consisting of stacked membranes where post translational ... usually by removing the normal constraints on its growth. organelle A structurally discrete component that performs a certain func tion ...

A Robust LC/MS/MS Method for the Quantitation of Very Long Chain Fatty Acids for Research into the Characterization of Peroxisomal Disorders

... Purpose The peroxisome is a cellular organelle that plays an important role in a number of functions, including the beta-oxidation of very long chain fatty acids (VLCFA). Peroxisomal disorders are ...

Sub-Micron Gold Particles Are Superior to Larger Particles for Efficient Biolistic Transformation of Organelles and Some Cells

... mitochondria in the green alga Chlamydomonas, Meth. Enzymol., 264 , 279-296 (1996). 4. Butow, R. A. and Fox, T. D., organelle transformation: shoot first, ask questions later, Trends in Biochem., 15 , 465-468 (1990). 5. Butow, R. A., Belcher, S. M., ...

Separation and Comparison of Proteins From Virulent and Nonvirulent Strains of the Fish Pathogen Flavobacterium psychrophilum, Using a 2-D Electrophoretic Approach

... To identify hydrophilic (primarily cytoplasmic nonmembrane proteins) and hydrophobic proteins associated with cell or organelle membranes, a method for sequential extraction was developed using the ReadyPrepTM sequential extraction kit. Briefly, proteins ...

The Bio-Rad Silver Stain, Rev E

... Biochem 141, 311315 (1984) 65. Noll H et al., Characterization of toposomes from sea urchin blastula cells: a cell organelle mediating cell adhesion and expressing positional information, Proc Natl Acad Sci USA 82, 80628066 (1985) 66. Oesch B et al., A ...

Getting Started with MicroRNA Research

... studies require quantitative, phenotypic assays (e.g., protein level, activity, or modification; protein or organelle transport; cell morphology or number; cell cycle status; membrane potential; calcium content; etc.) that ...

New Mammalian Expression Vectors Employ Stable, High-Level Fluorescence Humanized Renilla GFP Reporter

... subcellularly localized proteins. In Figure 3, each fluorescent microscope photograph shows hrGFP expression localized to the organelle that corresponds to the appropriate fusion protein. These data confirm that the phrGFP-N1 and phrGFP-C protein fusion vectors provide ...

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Organelle in Biological Definition

Mitochondrion

... mitos thread + khondrion granule) is an organelle found in most eukaryotic cells , including ... can resemble the standard sausage-shaped organelle pictured to the right, ranging from 1 to 4 m in ... The membranes of the mitochondrion divide the organelle into two distinct compartments: one within the ...

Mitochondrion

... mitos thread + khondrion granule) is an organelle found in most eukaryotic cells , including ... can resemble the standard sausage-shaped organelle pictured to the right, ranging from 1 to 4 m in ... The membranes of the mitochondrion divide the organelle into two distinct compartments: one within the ...

Ribosome

... (7) Stalk. (8) Front. A ribosome is an organelle composed of rRNA (synthesized in the ... internal fluid of the cell) or bind to another organelle called the endoplasmic reticulum . Since ... proteins that are used in the cytosol or in the organelle they occur in. Membrane bound ribosomes ...

Cell nucleus

... , the nucleus (from Latin nucleus or nuculeus , kernel) is an organelle , found in the majority of eukaryotic cells , which contains most of ... needed for cellular division . The nucleus, being the largest organelle , varies in diameter from 10 to 20 micrometres . It is enclosed by a ...

Biological membrane

... attempting to cross it will determine whether they succeed to do so. Selective permeability is essential for effective separation of a cell or organelle from its surroundings. If a particle is too large or otherwise unable to cross the membrane by itself, but is still needed by a cell, it could ...

Cell biology

... Endoplasmic reticulum Flagella Glycolysis Golgi apparatus Lipid bilayer Membrane Mitochondrion Nucleus organelle Passive transport Ribosome Signal transduction Vesicle Important publications in cell biology External links The ...

Centriole

... A centriole in biology is a hollow cylindrical organelle found in most animal cells , and cells of fungi and algae though not frequently in plants . The walls of each centriole are composed of ...

Centrosome

... A centrosome , the connecting point of a centriole , an organelle , is the portion of a cell where microtubules are manufactured. Its structure, since it acts as a nexus for cell activity, facilitates cell ...

Endoplasmic reticulum

... The endoplasmic reticulum or ER (endoplasmic means "within the cytoplasm ", reticulum means "little net") is an organelle found in all eukaryotic cells . The ER modifies proteins , makes macromolecules , and transfers substances throughout the cell. Prokaryotic ...

Endomembrane system

... of the cell. The nuclear envelope is the membrane around the nucleus of the cell. The endoplasmic reticulum is a synthesis and transport organelle [the endoplasmic reticulum is an extension of the nuclear envelope]. The Golgi apparatus acts as the packaging and delivery system for ...

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Organelle in Biological Dictionary

Vacuole

... A vacuole is a membrane organelle which is present in all plant and fungal ... contractile vacuole n. A membrane-bound organelle found in certain protists that pumps fluid in a ... to maintain the ... A vacuole is a membrane organelle which is present in all plant and fungal ...

Ribosome

... as the site of assembly ribosome an organelle in the cytoplasm of a living cell; ribosomes ... (A) and large subunit (B) ... A ribosome is an organelle composed of rRNA (synthesized in the nucleolus) ... ... In cell biology, a ribosome is an organelle composed of RNA and ribosomal ... A triennial ...

Organelles

... rest of the cell by lipid bi-layers ... organelle ( ) n. A differentiated structure within a cell, ... n. , pl. -dria . A spherical or elongated organelle in the cytoplasm of nearly all eukaryotic ... of organelles as small organs. ... NCBI organelle Genome Resources is a collection of ...

Organelle

... In cell biology, an organelle gəˡnɛl/) is a specialized subunit within a cell ... own lipid membrane. In cell biology, an organelle is a specialized subunit within a cell that ... own lipid membrane. In cell biology, an organelle is one of several structures with specialized ......

Nucleus

... center", is a membrane-enclosed organelle found in eukaryotic cells. It contains most of ... ... The nucleus is a highly specialized organelle that serves as the information and ... 10 ... The nucleus is a highly specialized organelle that serves as the information and ...

Mitochondrion

... a mitochondrion is a membrane-enclosed organelle found in most eukaryotic cells. These ... as "cellular ... membrane-bound organelle found in the cytoplasm of almost all ...... In cell biology, a mitochondrion is an organelle found in the cells of most eukaryotes. ...

Mitochondria

... a mitochondrion is a membrane-enclosed organelle found in most eukaryotic cells. These ... n. , pl. -dria . A spherical or elongated organelle in the cytoplasm of nearly all eukaryotic ... from lung tissue. The mitochondria is an organelle found in eukaryotic cells that performs ... ...

Lysosome

...engulfed... lysosome ( ) n. A membrane-bound organelle in the cytoplasm of most cells containing ... that function in intracellular lysosome an organelle found in the cytoplasm of most cells ... is to digest things. ... Lysosome is an organelle of eukaryotic cells that contains hydrolytic ...

Golgi apparatus

... The Golgi apparatus is an organelle found in most eukaryotic cells. It was ... ) ( cell and molecular biology ) A cellular organelle that is part of the cytoplasmic membrane system; ... ... The Golgi Apparatus is an important organelle found in eukaryotic cells that helps with the ...

Endoplasmic reticulum

... The endoplasmic reticulum (ER) is a eukaryotic organelle that forms an interconnected network of tubules, ... Reticulum - Wrapping it Up. Another organelle in the cell is the ... The endoplasmic ... The endoplasmic reticulum , or ER, is an organelle found in all eukaryotic cells. ... Endoplasmic ...

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