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Oncogene in Medical News

Cancer-Causing Gene Discovery Suggests New Therapies

... paper with Barna. "The ability of the Myc oncogene to directly alter this process may well explain ... in DNA activity in the cell nucleus. But how the oncogene affected the subsequent production of proteins, a ... that was cancer-prone and overexpressed the Myc oncogene and one that was newly engineered to lower ...

Cancer drug works by overactivating cancer gene

... melanoma tumor cells because it causes the c-MYC oncogene to overproduce a cell-death promoter called NOXA. ... treatment could be to actually exacerbate oncogene function, to promote such a dysregulation of cell ... cell death, surprisingly turned out to be the oncogene c-MYC. The discovery of the oncogenes role in ...

Gene Connections Key to Brain Tumor Growth

... genes. The hub gene is the EGFR (epidermal growth factor receptor) oncogene on chromosome 7, according to the study. It is amplified in about 45 ... researchers reported. A decrease in the function of ANXA7 shoots the EGFR oncogene into overdrive, contributing to the development and progression of ...

Study pinpoints novel cancer gene and biomarker

... as this finding was, it was hardly enough to prove that GOLPH3 is an oncogene -- a contributor to cancer when overexpressed within a cell. Demonstrating ... Medical School. In addition to identifying GOLPH3 as a bona fide oncogene and an indicator of whether rapamycin is likely to be effective against ...

NYU Langone Medical Center's tip sheet to the 45th Annual Meeting of ASCO

... # 11034, Sunday, May 31, 2009, 2 p.m. to 6 p.m. Overexpression of an oncogene linked to worse melanoma prognosis Iman Osman, M.D., associate ... Institute present preliminary evidence that overabundant expression of an oncogene called Skp2 was associated with a worse melanoma prognosis. The activity ...

Blocking Oncogene Can Stop Spread of Ovarian Cancer

... MONDAY, Dec. 15 (HealthDay News) -- Blocking proteins produced by the oncogene MYC can stop the spread of ovarian cancer, researchers say. An oncogene is a gene that has the potential to help cause cancer. In up to 60 ...

Cellular senescence a double-edged sword

... For example, normal cells that acquired a highly active version of the RAS oncogene became senescent and secreted higher levels of SASP components. This very ... or cancer cells that have lost the p53 tumor suppressor gene, or gained an oncogene such as RAS, promote cancer so efficiently," Campisi said. These ...

Colon Cancer Oncogene Discovered

... important work," Brooks said. "They have identified what apparently is an oncogene associated with some colorectal cancers." Dr. William Hahn, of the ... beginning of that pathway," Brooks added. "All they have shown is this oncogene seems to be associated with a significant number of cancer ... ...

Research Uncovers Clues to Lymphoma

... the B-cell receptor on the surface of B-cells can cooperate with the MYC oncogene to accelerate the development of lymphomas. They also found that ... are genes thought to encourage cancer. It was already known that the oncogene MYC played an important role in the development of lymphomas. It wasn't ...

Crucial factors in lymphoma development and survival discovered

... The B-cell receptor on the surface of B cells can cooperate with the MYC oncogene to accelerate the development of lymphomas. The research team, led by ... , and about 19,000 people die of it. It has long been known that the oncogene MYC plays a crucial role in the development of lymphomas. One unanswered ...

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Oncogene in Medical Technology

Cequent to Present First Proof of Activity of an Oral RNAi Drug in Non-Human Primates at February Keystone Conference

... CEQ501, an orally administered tk RNAi therapeutic targeting the primary oncogene (beta-catenin, CTNNB1) in FAP (familial adenomatous polyposis). FAP is an ... that our tk RNAi technology effectively suppresses beta-catenin, a key oncogene in FAP. These new results are very encouraging, and represent another ...

Nektar Announces Expanded Phase 2 Clinical Development Plan For NKTR-102 (PEG-irinotecan)

... Phase 2 Study for NKTR-102 Will Target Newly-Identified K-Ras Mutated oncogene Population in Patients with Advanced Colorectal Cancer New Phase 2 ... Meeting shows colorectal cancer (CRC) patients with tumors that have K-Ras oncogene mutations (K-Ras mutant types) do not respond to EGFR-inhibitors, such as ...

ARUP Laboratories Applauds FDA's Decision on the Value of KRAS-Mutation Testing in Colorectal Cancer

... therapeutic strategy should be used by oncologists. Most colorectal cancer is caused by somatic mutations and is not hereditary. Mutations in the oncogene KRAS are seen in over 40 percent of sporadic colorectal cancers. While several laboratories in the United States offer this test, ARUP ...

Boehringer Ingelheim to Present New Phase II Clinical Data on Two Lead Oncology Compounds at ASCO 2009

... References Li D et al. "BIBW2992, an irreversible EGFR/HER2 inhibitor highlyeffective in preclinical lung cancer models." oncogene 2008;27:4702-4711 Shih J-Y et al. "A Phase II study of BIBW 2992, a novel irreversible dual EGFR and HER2 tyrosine kinase inhibitor (TKI), ...

Cequent tkRNAi Technology to be Presented at the Centennial Meeting of the American Association for Cancer Research

... of Cequent's lead drug candidate Poster CEQ508, an orally administered tkRNAi therapeutic Presentation targeting the primary oncogene (beta-catenin, CTNNB1) in FAP (familial adenomatous polyposis). FAP is an inherited gastrointestinal ...

Ipsogen Launches a New Test to Determine Tumor HER2 Status and Guide Herceptin(R) Prescription in Breast Cancer

... HER2 Clinical Rationale The amplification of the HER2-region of chromosome 17 results in the constitutive overexpression of the HER2 oncogene protein and fuels uncontroled tumor growth in approximately 15 to 30% of breast tumors. HER2 is considered today as a predictive marker for clinical ...

Micromet Presents Data at the 23rd Annual Meeting of the International Society for Biological Therapy of Cancer on the Activity of Human Antibody Adecatumumab against KRAS-mutated Colon Cancer Cells

... for patients with KRAS wild-type tumors, however, show limited or no efficacy in the treatment of colon cancer patients with a mutated KRAS oncogene in their cancer cells. These findings recently led to the approval of cetuximab for first-line therapy in patients with KRAS wild-type tumors. As a ...

Use of Sequenom's MassARRAY System Leads to Significant Scientific Advances in Understanding Cancer, Diabetes and Drug-Resistant Malaria

... recognized peer-reviewed journals as follows: -- In "High-Throughput oncogene Mutation Profiling in Human Cancer," published in the February issue of ... and scalability, utilized MassARRAY technology to assay 238 known oncogene mutations across 1,000 human tumor samples. The results enable researchers ...

News from the Battlefield of Metastatic Cancer: Epeius Biotechnologies Draws the Sword of Targeted Gene Delivery (Rexin-G) from the Stone of Chemistry and Physics

... of genetic medicine with the development and commercialization of its proprietary targeted delivery systems. Credited with innovations ranging from oncogene discovery, to designer therapeutic genes, to pathotropic (disease-seeking) targeting, to high-performance vector engineering, to advanced ...
Oncogene in Medical Dictionary

Pol

... Pol M, et al.: Identification of the critical region of 12p over-representation in testicular germ cell tumor s of adolescents and adults. oncogene 16 (20): 2617-27, 1998. [PUBMED Abstract] ... [The influence of vitamin A on production of oxygen free radicals and activity of granulocyte ...

Reservoir

... REZ-er-vwahr) A device surgically placed under the scalp and used to de liver anti cancer drugs to the fluid surrounding the brain and spinal cord. oncogene ... Ommaya reservoir : Children and some adult patients receive intra thecal chemotherapy through a special catheter called an Ommaya ...
Oncogene in Biological News

Cancer-causing gene discovery suggests new therapies

... on the paper with Barna. "The ability of the Myc oncogene to directly alter this process may well explain ... in DNA activity in the cell nucleus. But how the oncogene affected the subsequent production of proteins, a ... that was cancer-prone and overexpressed the Myc oncogene and one that was newly engineered to lower ...

CSHL team develops mouse models of leukemia that predict response to chemotherapy

... identified by Lowe's team in AML patients have been well studied. The oncogene AML1/ETO previously has been associated with a favorable therapeutic ... correct. Just as in humans, leukemias in mice that received the AML1/ETO oncogene were also sensitive to chemotherapy and soon regressed, whereas ...

Tracking the molecular pathway to mixed-lineage leukemia

... When the MLL gene is fused to the AF4 gene, a potent cancer-causing oncogene is created. Although researchers have known that the MLL-AF4 protein ... causes leukemia, they had not been able to determine precisely how this oncogene disrupted cells' normal protein production. To pinpoint the ...

Biomarkers allow doctors to match therapy to patient

... production of ornithine decarboxylase (ODC1), a gene driven by the MYCN oncogene that is a powerful predictor of death from this disease. Researchers ... with chemotherapeutic drugs alone, suggesting that targeting this oncogene for suppression is a potentially valuable therapeutic approach. We ...

Epigenetic regulation by the MMB/dREAM complex

... University) and colleagues demonstrate that proteins encoded by the Myb oncogene and the RB tumor suppressor gene function together in the Drosophila ... progression. Drosophila MMB/dREAM includes proteins encoded by the Myb oncogene and the RB and Mip130/Lin-9 tumor suppressor genes, as well as the E2F2 ...

Protein identified as critical to insulating the body's wiring could also become treatment target

... and Charcot-Marie-Tooth neuropathy, a genetic, progressive disease that weakens muscles. Cancer is an issue because the ErbB2 receptor also is an oncogene highly expressed in tumors. ErbB2 helps cancer cells grow and spread so finding its role in the receptor's stability and function provides a ...

Skin cancer study uncovers new tumor suppressor gene

... to slow -- and in some cases even sped up -- tumor growth. Now, it turns out that one of the most often mutated MMP genes in melanoma is not an oncogene at all. In its study, the team led by researchers from the National Human Genome Research Institute (NHGRI) found that MMP-8 actually serves as a ...

Small molecules block cancer gene

... HOUSTON (March 10, 2009) Finding molecules that block the activity of the oncogene Stat 3 (signal transducer and activator of transcription) required screening literally millions of compounds, using computers that compared the ...

NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis

... a miRNA is over-expressed in metastatic melanoma cell lines and tissues. The lab found that the elevated expression of miRNA 182 turns it into an oncogene (a gene involved in cancer tumor initiation or progression), by increasing the invasive capacity of melanoma cells in vitro and stimulating the ...

Festschrift Issue honoring Judah Folkman, M.D. in Lymphatic Research and Biology

... Lymphangiogenesis?," Yihai Cao explains the processes behind increased lymphatic supply to cancerous lesions. Dean Felsher explores the phenomena of oncogene addiction, cellular senescence, and the angiogenic switch in a report entitled, "Reversing Cancer From Inside and Out." In a forward-looking review, ...

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Oncogene in Biological Technology

EpiCept to Present Pre-clinical Advances of Myc Oncogene Directed Drug Discovery at Assays and Cellular Targets Conference

... into pre-clinical testing of drug discovery efforts targeting the Myc oncogene pathway utilizing EpiCept's Anti-cancer Screening Apoptosis Platform ... and optimization of lead product candidates related to the Myc oncogene pathway which utilized the cell- and caspase-based apoptosis induction ...

Cequent Names F. Stephen Laroux, Ph.D., Director, Immunology and Inflammatory Diseases

... IBD program. "While we are furthest along with our drug candidate CEQ508, an orally administered tk RNAi therapeutic targeting the primary oncogene (beta-catenin, CTNNB1) in FAP (familial adenomatous polyposis) -- our IBD program is actually the company's largest, and Stephen has been critical to ...

NFGC Conducts Multi-Institutional Research Project in Ovarian Cancer

... in ovarian cancer. For the first phase of the project, the group will use a biologically-driven approach to characterize gene expression and oncogene activation of copy number and point mutations in preclinical models by profiling ovarian cancer cells and ovarian cancer stem cells. The consortium ...

Festschrift Issue Honoring Judah Folkman, M.D. in Lymphatic Research and Biology

... Yihai Cao explains the processes behind increased lymphatic supply to cancerous lesions. Dean Felsher explores the phenomena of oncogene addiction, cellular senescence, and the angiogenic switch in a report entitled, "Reversing Cancer From Inside and Out." In a forward-looking review, ...

Oncomine(TM) Again Key to Prostate Cancer Discovery

... in his continued role as a research investigator at the University of Michigan, led the Oncomine analysis that identified SPINK1 as a candidate oncogene in prostate cancer. Further experimental work by many of the same scientists that previously identified ETS-family gene fusions in prostate cancer ...

Ortho Biotech Oncology Research & Development Unites Johnson & Johnson Biopharmaceutical Oncology R&D Assets

... ORD has the potential to generate new opportunities to improve cancer care." About Our Compound Targets Human Double Minute 2 (Hdm2) The Hdm2 oncogene is activated in cancers through various mechanisms, including gene amplification and deletion of upstream tumor suppressors. Hdm2 over-expression ...

Micromet is Presenting Four Posters on BiTE(R) Antibodies at the International AACR-NCI-EORTC Conference

... proto- oncogenes (abstract C175). This establishes EpCAM as a signal transducer of cancer cells and explains how EpCAM induces cell proliferation and oncogene expression. EpCAM is found widely expressed on human cancers and is also found on so called 'cancer stem cells' from colon, pancreas, prostate and ...

Micromet Data Presented at the International AACR-NCI-EORTC Conference Support the Development of Adecatumumab (MT201) in Earlier Stage Cancer Disease Settings

... C175). These data not only establish EpCAM as a signal transducer of cancer cells, but could explain how the protein induces cell proliferation and oncogene expression, and support a critical role of EpCAM in cancer stem cell regulation. "All of these new findings correlate well together and highlight ...

Cancer-Related miRNAs Uncovered by the mirVana miRNA Microarray Platform

... miRNAs as Regulators of oncogene Expression To address ... miRNAs and Their Putative oncogene Targets. Measuring the Effect of miRNAs on oncogene Expression Confirming ...

Functional Cloning Using ViraPort Retroviral cDNA Expression Libraries

... Screening for Oncogenes The ability of oncogene expression to confer deregulated growth on ... 2.3 vav-1 oncogene Onco-1 ... 2.0 raf-1 oncogene Onco-3 ...

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Oncogene in Biological Products

Rabbit Anti-Human RAB32 Polyclonal Antibody, Unconjugated from Proteintech Group, Inc.

Description:... RAB32, member RAS oncogene family, mRNA (cDNA clone MGC:13500 IMAGE:4280407), complete ...
Company:Proteintech Group, Inc.
Oncogene in Biological Definition

Oncogene

... An oncogene is a gene that can cause a cell to develop ... 1 Protooncogene 1.1 Activation 2 oncogene 2.1 Growth factors 2.2 Protein kinases ... articles Protooncogene A proto oncogene is a gene that is involved in signal ...

Cancer

... in both types of genes are necessary, as a mutation limited to an oncogene would be suppressed by normal mitosis control. Mutations can have ... retroviruses , herpesviruses and papillomaviruses , usually carry some oncogene or tumor suppressor inactivating gene in their genome . It is ...
Oncogene in Biological Dictionary

Viral oncogene

... If the viral LTRs are close enough to that oncogene , they will upregulate ... called viral - oncogene (v-onc), and the infected cell is transformed ... as ... v-rel reticuloendotheliosis viral oncogene homolog (avian), also known as REL, is a human ...

Proto-oncogene

... An oncogene is a gene that, when mutated or expressed at ... cell into a cancer cell. The RET proto - oncogene encodes a receptor tyrosine kinase for ... ... ... of this gene is "ret proto - oncogene ." RET is the gene's official symbol. ... ret ...

Oncogene

... An oncogene is a gene that, when mutated or expressed at ... that carries the ability to induce cancer. An oncogene is a sequence of deoxyribonucleic acid (DNA) ... or mutated from its original form, the proto- oncogene . Operating as a positive growth regulator, the ...

G2 phase

... chromatids), the cell moves onto the G2 phase . G2 Phase ... oncogene is one of the world's leading cancer journals. ... Once induced in G2 ... D1 expression became Ras independent through the next G1 phase . ... oncogene is one of the world's leading cancer journals. ... UV radiation causes ...

Transversion

... Discuss topics of TransVersion ) - this ... ... efficiently extended implicating O2-Et-dT in transversion mutagenesis in vivo. ... of the oncogene neu by an A.T----T.A transversion event in rat neuroblastomas. ... The promoter sequence having this transversion has a higher promoter ...

Trans-splicing

... specialized trans - splicing reactions are very efficient. In mammals, however, trans - splicing of conventional pre-mRNAs appears to be ... oncogene is one of the world's leading cancer journals. ... In mammals, trans - splicing can be used to reprogram or interfere with specific ... Trans ...

MicroRNA

... and cancer. Human gene count drops again ... MicroRNA . Diophantine equations. Cytokine storms ... Pair Of MicroRNA Molecules Controls Major oncogene In Most Common Leukemia (12 ... Labels: cancer, let-7, microRNA , Myc, news dump, stem cells ... He also presents recent discoveries in the ...

AP-1

... Press ( AP ), and the Bowl Championship Series (BCS) ... AP Top 25. Rankings Not Available. USA Today Poll. 1 . Florida (53) 0-0 1 ,466 ... oncogene is one of the world's leading cancer journals. ... Upon induction, TAM-67 was expressed and AP - 1 activity was inhibited in these cells. ... ...

Amino Terminus

... the acetylationof of lysines in preparation for mass ... After acetylation the amino terminus of the protein should be modified giving ... oncogene is one of the world's leading cancer journals. ... The cytoplasmic amino - terminus provides the structural information whereby ... The ...

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Other Contents
(Date:7/9/2014)... sudden, acute episodes of low back pain are not ... pressure, wind direction and precipitation. Findings published in ... American College of Rheumatology (ACR), indicate that the risk ... speed or wind gusts, but was not clinically significant. ... nearly everyone experiences low back pain at some point ...
(Date:7/9/2014)... in almost all types of cancer sends the protein ... fuel a tumour,s uncontrolled growth, new research suggests. , ... a molecular trigger responsible for ratcheting up activity of ... makes the building blocks cancer cells need to keep ... called SREBP, controls the flow of messages to the ...
(Date:7/9/2014)... have found that fecal transplantation is effective and safe ... This is the result of a study led by ... Women,s Gastrointestinal Medicine at The Women,s Medicine Collaborative. The ... advance of print in the American Journal of ... C. diff , has increased to epidemic proportions over ...
(Date:7/9/2014)... has been a sharp increase in the number of ... the online, interactive service that allows patients to view ... schedule appointments, and renew prescriptions. , Over a six-year ... each year increased five-fold, while the number of ... to a study by Dr. David Gerber , ...
(Date:7/9/2014)... National Institute of Allergy and Infectious Diseases (NIAID), ... launched an early-stage clinical trial of CRS3123, an ... difficile ( C. difficile ) infection. CRS3123 ... that inhibits C. difficile growth while sparing normal ... enroll up to 30 healthy men and women ...
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(Date:7/9/2014)... from the oils produced by algae may offer a ... goal, optimization of cost effective strategies for large-scale algae ... Sapphire Energy has developed an innovative solution to the ... described in Industrial Biotechnology , a peer-reviewed journal ... available on the Industrial Biotechnology website ...
(Date:7/9/2014)... URBANA, Ill. With over 100 diseases that can ... the top of the most wanted list? University of ... reason that more research is needed on the fungus ... associated with cool, damp growing conditions but Macrophomina ... hot and dry drought conditions. , "As the climate ...
(Date:7/9/2014)... from China challenges the commonly held belief that birds ... to fly. The birdlike fossil is actually not a ... of a tiny tree-climbing animal that could glide, say ... Blanding, Utah, and Alan Feduccia of the University of ... of Ornithology . , The fossil of the ...
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