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Oligonucleotide in Medical News

Kinovate Life Sciences, Inc. and Nitto Denko Corporation Announce Successful Development of NittoPhase™ HL High Loading Solid Support for Oligonucleotide Synthesis

... Inc, the market leader in solid support for oligonucleotide synthesis, will be announcing the successful ... solid support product NittoPhase™HL for oligonucleotide synthesis at the TIDES meeting commencing in Las ... and economic outcomes for all segments of the oligonucleotide industry. Solid support is the base structure ...

Industry Experts and Global Regulators to Discuss Oligonucleotide-Based Therapeutics Issues

... Association (DIA), in collaboration with the FDA, oligonucleotide Therapeutics Society, Health Canada, and the ... (DIA)]], in collaboration with the FDA, oligonucleotide Therapeutics Society, Health Canada, and the ... Dependent Oligonucleotides Antisense oligonucleotide Discovery and Development ...

Quark Pharmaceuticals to Participate in IBC's Oligonucleotide Therapeutics: From Concept to Implementation Conference

... Pharmaceutical Development, will participate in multiple roles at IBC's oligonucleotide Therapeutics: from Concept to Implementation Conference. The conference ... the pioneer in systemic siRNA administration. We are at the forefront in oligonucleotide therapeutic development and look forward to discussing practical ...

Orochem Technologies Acquires Oligonet, a Custom Oligo Synthesis Business

... markets today announced the acquisition of Oligonet, Inc. a Custom oligonucleotide Synthesis Business located in Gaithersburg, MD. With this acquisition, ... player in the custom oligo synthesis market having already been supporting oligonucleotide synthesis establishment with several products that range from synthesis ...

TriLink BioTechnologies, Inc. Announces Sales and License Agreement With Glen Research Corporation for CleanAmp(TM) Amidites

... Amidites available through Glen Research allows institutions with oligonucleotide synthesis capabilities to manufacture CleanAmp(TM) Primers in-house. Learn ... Research is dedicated to bringing the very best research products to the oligonucleotide synthesis market. So we are delighted to be able to offer CleanAmp(TM) ...

MWG and Operon Are Joining Forces

... in order to create a new worldwide leader in the competitive custom oligonucleotide market. With about $US 50M in revenue and state of the art high-throughput ... years overcapacity in the market has put a lot of pressure on all custom oligonucleotide synthesis service suppliers. Prices have decreased to a level where very ...
Oligonucleotide in Medical Technology

Another LNA-based RNA Inhibitor Enters Clinical Trials

... LNA-based PIK3CA antagonist" "EZN-3042, a novel locked nucleic acid oligonucleotide against survivin, inhibits survivin expression and confers taxol sensitivity" "EZN-3920, an LNA antisense oligonucleotide RNA antagonist, down modulates HER3 expression and PI3K/Akt signaling ...

University of Michigan Study Shows SEQUENOM's MassARRAY Technology Identifies HPV Infections Missed by Standard Hybridization Test

... gene expression analysis, quantitative methylation marker analysis, comparative sequence analysis of haploid organisms, SNP discovery, and oligonucleotide quality control. About SEQUENOM SEQUENOM is a life sciences company committed to providing the best genetic analysis products that ...

Quark Pharmaceuticals Presents at Asia TIDES Conference

... Ph.D., Vice President, Pharmaceutical Development presented an overview of Quark's novel pipeline of synthetic siRNA compounds at the Asia TIDES oligonucleotide and Peptide(R) Technology and Product Development Conference, held February 24th, 2009 in Tokyo, Japan. Dr. Thompson's presentation, entitled ...

ATL/TV1102 Trial Results Presented at World Congress on Treatment and Research in Multiple Sclerosis

... provide login details on its website http://www.antisense.com.au once these are confirmed. Conference abstract follows: VLA-4 Antisense - An oligonucleotide targeting VLA-4 mRNA (ATL1102) significantly reduces new active lesions in patients with RR-MS Volker Limmroth(1), Frederik Barkhof(2), Nuket ...

Genta Clinical Programs Featured at American Society of Hematology Meeting

... featured press briefing sponsored by ASH on Sunday December 9 at 9:30 am. -- Oblimersen (Genasense(R)), a phosphorothioate Bcl-2 antisense oligonucleotide (ASO), can be safely administered by bolus subcutaneous (SC) injection and brief IV Infusion. Publication. -- Phase 1 assessment of G4544, an ...

Genta Initiates First Clinical Trial with New Oral Drug (G4544) to Treat Bone Disease

... (RNA- and DNA- based medicines) and small molecules. Genasense(R) (oblimersen sodium) Injection is the Company's lead compound from its oligonucleotide program. The leading drug in Genta's small molecule program is Ganite(R) (gallium nitrate injection), which the Company is exclusively marketing in ...

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Oligonucleotide in Medical Products

Dynal RELI™ SSO

Description:... that flank the specific target region of an HLA locus. This is followed by hybridisation of the resulting amplicon to an array of Sequence Specific oligonucleotide probes immobilised on a nylon membrane. The immobilisation of these probes is referred to as a Reverse Line blot and thus gives rise to the acronym ...
Company:Dynal Biotech, LLC
Oligonucleotide in Medical Dictionary

Carrier

... membrane carrier systems) A drug delivery technology/system which employs a lipid envelope to encapsulate intravenous chemo therapeutic and oligonucleotide drugs, ... electromotive; electromotive force; electromotor; electro-muscular; electromuscular sensibility; electromyogram; electromyograph; ...

Membrane

... membrane carrier systems) A drug delivery technology/system which employs a lipid envelope to encapsulate intravenous chemo therapeutic and oligonucleotide drugs, ... sore nasal membrane s a tear or other damage to the membrane that separates the left and right nostrils nosebleeds ...
Oligonucleotide in Biological News

A new gene silencing platform -- silence is golden

... polyA tail addition in a gene specific manner. Further, the domains of the oligonucleotide are independent so transcript binding and U1 snRNP binding can be ... used 5'-end-mutated U1 snRNA," Gunderson explained. "The U1 Adaptor is an oligonucleotide version of this older method and instead targets the 3' end processing ...

Leroy Hood to receive 2008 Pittcon Heritage Award

... genomics: the DNA and protein sequencers and synthesizers and the ink-jet oligonucleotide synthesizer. The DNA sequencer in particular has revolutionized genomics ... at the University of Washington, where he developed the ink-jet oligonucleotide synthesizer, which synthesizes DNA chips, and initiated systems studies on ...

ISU researchers find possible treatment for spinal muscular atrophy

... because of the presence of a specific intronic sequence in the gene or DNA. To make SMN2 behave as SMN1, Singh has introduced a small antisense oligonucleotide that blocks this specific intronic sequence. When the intronic sequence is blocked, SMN2 produces normal proteins and acts, in effect, like SMN1. ...

Strong immune response to new siRNA drugs in development may cause toxic side effects

... Inc. (www.liebertpub.com) The article is available free online at www.liebertpub.com/oli siRNAs are duplex structures comprised of short oligonucleotide sequences. The discovery that naturally occurring and synthetic siRNAs can effectively prevent expression of a disease gene sparked intense interest ...

Researchers take first look at the genetic dynamics of inbreeding depression

... researchers also crossed the three highest inbred lines to one another, creating outbred lines that could be compared with the inbred ones. Using oligonucleotide microarrays, which can measure the activity of all of an organism's genes at once, the researchers were able to see which genes were more or less ...

Less can be more, for plant breeders too

... crops and it may provide an important new avenue to enhance agronomic performance and nutritional value. Computer software to design the required oligonucleotide sequences and detailed protocols to produce amiRNAs are provided free of charge on the authors web site, at http://wmd2.weigelworld.org. Similarly, ...

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Oligonucleotide in Biological Technology

Ambry Genetics Announces the Addition of Array CGH Services Through Partnership With Baylor College of Medicine

... of Comparative Genomic Hybridization (CGH) using oligonucleotide arrays through a partnership with Baylor College ... ) Ambry's CSO, Anja Kammesheidt states, "The oligonucleotide array was developed at Baylor College of ... congenital anomalies. Each array contains 105K oligonucleotide probes, spaced at 30K through the genome with ...

Quark Pharmaceuticals to Present at American Society for Pharmacology and Experimental Therapeutics Annual Meeting

... of a session titled "Discovery and Development of oligonucleotide Therapeutics," which is sponsored by ASPET's ... talk will be on the past, present, and future of oligonucleotide therapeutics. Other leaders in RNAi will also ... at AVI BioPharma (topic: Pharmacokinetics of oligonucleotide therapeutics). Daniel Zurr, Ph.D., President ...

Aegera Therapeutics' phase 1/2 clinical trial results selected for oral presentation at 2008 ASH Annual Meeting

... entitled "Phase I/II Trial of the XIAP Antisense oligonucleotide (AEG35156) in Combination with Idarubicin and ... Study of Phase 1/2 Trial of the XIAP Antisense oligonucleotide (AEG35156) in Combination with Chemotherapy in ... Title: Phase I/II Trial of the XIAP Antisense oligonucleotide (AEG35156) in Combination with Idarubicin and ...

A New Era in the Application of Lab-on-a-Chip to Rapid Point-of-Care Diagnosis

... highly advanced nucleic acid sequence-based amplification - enzyme-linked oligonucleotide capture (NASBA-EOC). The VDS technology has an advantage of not requiring ... with a choice of technology platforms, either NASBA-EOC (enzyme-linked oligonucleotide capture) or a recently developed, patented and validated NASBA-POC ...

Isis Awarded $1.5 Million NIH Grant to Improve Chemical Properties of RNAi-Based Therapeutics

... the National Institutes of Health (NIH) for up to $1.5 million to design oligonucleotide drugs that can exploit the RNA interference (RNAi) antisense mechanism for ... support from the NIH in our ongoing efforts to apply our RNA technologies, oligonucleotide chemistries and expertise to exploit antisense mechanisms, such as RNAi, ...

SEQUENOM Announces Launch of MassARRAY Compact 96 System

... gene expression analysis, quantitative methylation marker analysis, comparative sequence analysis of haploid organisms, SNP discovery, and oligonucleotide quality control. About SEQUENOM SEQUENOM is a life sciences company committed to providing the best genetic analysis products that ...

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Oligonucleotide in Biological Products

HEEBO Human Genome Set 200 pmol from Invitrogen

Description:... Genome Set and MEEBO (Mouse Exonic Evidence Based oligonucleotide ) Genome Set contain a collection of open source ... Genome Set contains 48,958 70mer 5 amino modified oligonucleotide probes in 128 384-well plates. The set includes ... MEEBO set contains 38,467 70mer 5 amino modified oligonucleotide probes in 101 384-well plates. The set includes ...
Company:Invitrogen

Custom 60-mer Oligonucleotide Microarrays from Agilent Technologies

Description:... slide) or 22,575 features per array (1 array/slide). Features 60-mer oligonucleotide probe length - This extended length delivers higher sensitivity compared ... 1 microarray/slide Probes arrayed on 1" x 3" glass slides - oligonucleotide probes are arrayed on glass slides designed for optimal results in the ...
Company:Agilent Technologies

Oligo Synthesis from Biosearch Technologies

Description:... Since the early 80s Biosearch Technologies has been at the forefront providing advanced oligonucleotide tools to accelerate the discovery and application of genomic information. Whether you need dual-labeled FRET probes and primers or 100 or 100,000 ...
Company:Biosearch Technologies

XpressPack™ Luminescent Amplification Detection System, required for luminescent XpressPack™ from CHEMICON

Description:... under alkali conditions to separate the two DNA strands. The single-stranded amplicon is captured to the plate via hybridization with a specific oligonucleotide probe immobilized to the reaction well (target specific probe-coated plate included in the XpressPack gene-specific kit). The hybrid complex is then ...
Company:CHEMICON

XpressPack™ Colorimetric Amplification Detection System, required for colorimetric XpressPack™ from CHEMICON

Description:... under alkali conditions separating the two DNA strands. The single-stranded amplicon is captured to the plate via hybridization with a specific oligonucleotide probe immobilized to the reaction well (target specific probe-coated plate included in the XpressPack™ gene-specific kit). The hybrid complex ...
Company:CHEMICON

Amplifluor UniPrimer II Fluorescein from CHEMICON

Description:... is a hairpin primer labeled with a fluorescent energy transfer pair (fluorescein and non-fluorescent quencher) and a 3 single-stranded oligonucleotide tail. The UniPrimer is identical to the UniPrimer provided in the Amplifluor Universal Detection System (S7901) and is provided at a concentration ...
Company:CHEMICON

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Oligonucleotide in Biological Dictionary

Oligonucleotide

... An oligonucleotide is a short nucleic acid polymer, typically ... precursors. Automated ... oligonucleotide synthesis is the chemical synthesis of ... in current laboratory practice because ... oligonucleotide n. A short polymer of two to twenty nucleotides. ...

Allele-specific PCR

... An Allele Specific oligonucleotide (or ASO) is a short piece of synthetic DNA ... target DNA sequence, ... Allele specific oligonucleotide An Allele Specific oligonucleotide (or ASO ) is a short piece of ... to detect ...

Primer extension

... assay design, bio-rad bioplex Primer Extension . • Allele Specific oligonucleotide Ligation. • Sequencing ... One can label the primer and apply the ... DNA sequence is ... 2.4 Primer extension . 2.5 5'- nuclease. 2.6 oligonucleotide ligase assay ... Because, primer extension is based on the highly ...

CDNA array

... ... be transitioning from the nylon membrane cDNA arrays to oligonucleotide arrays ... Each spot on these arrays contains 10 nanograms of PCR ... bound with cDNA produced by reverse ... Software and methods for oligonucleotide and cDNA array data analysis ... The cDNA array experiment ...

Oligodeoxyribonucleotide

... online resource for all laboratory protocols ... Versatile synthesis of oligodeoxyribonucleotide –oligo spermine conjugates ... An antisense oligonucleotide phosphorothioate, previously shown to inhibit HIV-1 viral expression in chronically infected H9 cells, was fluorescently labeled to ... ... ...

Melting temperature

... STRUCTURE & MELTING TEMPERATURE . REPEATS, SECONDARY STRUCTURE ... Knowing the melting temperature of a fragment of DNA or of an oligonucleotide is ... Freezing and Melting | World of Earth Science. Freezing and Melting summary with 4 pages of encyclopedia ... a solid to a liquid as ...

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