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Nucleotide in Medical News

Pharmasset Initiates Phase 1b Multiple Ascending Dose Clinical Trial of PSI-7851 in Chronic Hepatitis C Patients

... a multiple ascending dose trial with PSI-7851, a nucleotide analog polymerase inhibitor for the treatment of ... About PSI-7851 PSI-7851 is a uridine nucleotide analog currently in development for the treatment ... PSI-7851, an unpartnered, next generation HCV nucleotide analog, which recently began Phase 1 clinical ...

Pharmasset Nominates PSI-938 as a New Nucleotide Analog Inhibitor of Hepatitis C for Preclinical Development

... of chronic hepatitis C virus (HCV) infection. PSI-938 is a proprietary nucleotide analog polymerase inhibitor of HCV that is being advanced into studies ... stage candidates are PSI-7851, an unpartnered, next generation HCV nucleotide analog which recently began Phase 1 clinical studies and Racivir, for the ...

Ovarian Cancer Breakthrough Heralds New Era of Treatment

... cell tumors. The culprit is a single mutation out of 3 billion nucleotide pairs that make up the genetic code of the tumor. The mutation is present ... range of genetic abnormalities, researchers found a mutation in a single nucleotide in the FOXL2 gene in every sample. The research team further validated ...

Mayo Clinic-led researchers confirm gene variants associated with the most common adult leukemia

... chromosomes. The first analysis of this data focused on the seven single nucleotide polymorphisms (SNPs) that European researchers had found. An SNP is a variation that occurs within a single nucleotide - the structural units of DNA - within a gene, and in most studies like ...

UNC study supports role of circadian clock in response to chemotherapy

... the prevention of new cancers. The enzyme system implicated called nucleotide excision repair repairs many types of DNA damage that come not just from ... or UV radiation. This damage is usually repaired by a process called nucleotide excision repair, which cuts out and replaces sections of damaged DNA. ...

DNA editing tool flips its target

... cells, methylation usually appears on double stranded DNA where the nucleotide Cytosine (C) is followed by Guanine (G). The complementary sequence on the ... recognizes the hemi-methylated DNA, Cheng says. It flips the methylated nucleotide out of the DNA helix, which only had been seen previously in enzymes that ...

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Nucleotide in Medical Technology

Pharmasset Reports Positive Preliminary Antiviral Data With PSI-7851 for the Treatment of Hepatitis C

... C (HCV). PSI-7851 is a second generation nucleotide polymerase inhibitor of HCV. PSI-7851 ... safety data with PSI-7851, our second generation nucleotide analog," said Michelle Berrey, MD, MPH, ... that we have achieved our goal of identifying a nucleotide analog with good efficacy that can be ...

Idenix Pharmaceuticals Advances HCV Discovery Program to Clinic

... application. IDX184 is a once-daily, oral nucleotide prodrug polymerase inhibitor for the treatment of ... for the treatment of hepatitis C." IDX184 nucleotide Prodrug Polymerase Inhibitor IDX184 is a once-daily, oral nucleotide prodrug candidate based on Idenix's proprietary ...

Pharmasset Initiates First Time in Human Study of PSI-7851 for the Treatment of Hepatitis C (HCV)

... dose (SAD) study in healthy volunteers with PSI-7851, a second generation nucleotide analog polymerase inhibitor of hepatitis C virus (HCV). Pharmasset filed ... milestone for Pharmasset. PSI-7851 is a wholly owned, second generation nucleotide analog that was discovered by Pharmasset scientists" stated Dr. Michelle ...

Idenix Pharmaceuticals Initiates Proof-of-Concept Study of IDX184 for the Treatment of Hepatitis C Virus (HCV)

... that it has initiated a proof-of-concept study of IDX184, a liver-targeted nucleotide prodrug candidate for the treatment of HCV under an Investigational New ... and two to placebo. About IDX184 IDX184 is a once-daily, oral nucleotide prodrug candidate based on Idenix's proprietary liver-targeting ....

Isis Highlights Robust Drug Portfolio for Diabetes and Obesity at ADA Conference

... drug for a kidney target, ISIS 388626 is also unique due to its 12 nucleotide length rather than the more typical 18 - 21 nucleotide sequences that comprise Isis' other drugs. This attribute simplifies ...

Idenix Pharmaceuticals Reports First Quarter 2008 Financial Results

... programs, having presented data from preclinical studies of its lead nucleotide prodrug candidate, IDX184, and potential clinical candidates from its ... the EASL presentations.) -- The lead clinical candidate from the nucleotide prodrug program, IDX184, is on track for an investigational new ...

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Nucleotide in Medical Products

DyNA Quant™ 200 Fluorometer

Description:... of double-stranded DNA using the standard Hoechst 33258 dye binding assay, which minimizes interference from the presence of protein, RNA, and nucleotide ....
Company:GE Healthcare

Dynal RELI™ SSO

Description:... wash conditions, the probes remain bound only to their complementary sequence in the amplified DNA. The sensitivity of the system enables single nucleotide differences to be distinguished. The presence of the amplicon/probe complex is detected using a simple colorimetric reaction and appears as a blue ...
Company:Dynal Biotech, LLC

NanoChip Molecular Biology Workstation

Description:... Biology Workstation is an automated multi-purpose instrument that facilitates detection of known sequences, such as in the analysis of Single nucleotide Polymorphisms (SNPs) and Short Tandem Repeats (STRs) using the NanoChip Electronic Microarray. The unique, open-architecture design permits ...
Company:Nanogen, Inc.

ABI PRISM 7900HT Sequence Detection System

Description:... the high-throughput requirements of todays drug discovery process. Key applications include gene expression quantitation and the detection of single nucleotide polymorphisms (SNPs) using the fluorogenic 5 nuclease assay. Real-Time Throughput: Over 5,000 sample wells per day with 384-well block ...
Company:Applied Biosystems

CEQ 8800 Genetic Analysis System

Features:... fingerprinting techniques. Quantitative analysis is possible by using an option to export the peak heights. Allow simultaneous analysis of single nucleotide polymorphisms at multiple sites of a template (or different templates). Delivers precise DNA sizing, accurate allele assignment and automated data ...
Company:Beckman Coulter, Inc.

CEQ™ 8800 Genetic Analysis System

Features:... fingerprinting techniques. Quantitative analysis is possible by using an option to export the peak heights. Allow simultaneous analysis of single nucleotide polymorphisms at multiple sites of a template (or different templates). Delivers precise DNA sizing, accurate allele assignment and automated data ...
Company:Beckman Coulter, Inc.
Nucleotide in Medical Definition

Neuropsychiatry

... Kennedy, J.L., Sadovnick, A.D., Remick, R.A. & Keck, P.E, McElroy, S L, Alexander, L., Shaw, S.H., & Kelsoe, J. (2003) Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder. Molecular Psychiatry, 8, 546−557. ...
Nucleotide in Medical Dictionary

Simian crease

... finger a wide space between the big and the second toes ... Simian crease Simian virus 40 Single base change Single gene disease Single nucleotide polymorphism Single palmar flexion crease Single palmar flexion line Single transverse palmar crease Single transverse palmar line Single upper palm ...

Stress test

... stress test (NST) is currently considered to represent a thorough assessment of the fetus to rule out utero- placenta l ... The stress test , nucleotide stress test and echo cardiography are the most common. These procedures are often used to gauge both the effectiveness of medications at relieving ...
Nucleotide in Biological News

New nucleotide could revolutionize epigenetics

... to cytosine, creating a different but stable nucleotide called 5-methylcytosine. This modification in the ... in development. The discovery of a new nucleotide may make biologists rethink their approaches to ... result: x was 5-hydroxymethylcytosine, a stable nucleotide previously observed only in the simplest of life ...

Covering the bases: Quantum effect may hold promise for low-cost DNA sequencing, sensor applications

... been used to determine the identities of the four nucleotide basesadenine, thymine, cytosine and guaninewhich ... the hydrogen bonds work to join up appropriate nucleotide pairs like jigsaw piecesadenine with thymine and ... sample. When this tip is fitted with a particular nucleotide and brought in contact with its complementary ...

Case Western Reserve finds mechanism underlying alt. splicing of premessenger RNA into messenger RNA

... instance, sometimes the resulting mRNA includes nucleotide sequences that should have been deleted. ... the weak upstream site was present, changes in nucleotide type and order near the downstream splicing site ... unexpected. That means that small changes in a nucleotide sequence near a splice point can lead to large ...

Researchers discover the structural alphabet of RNA

... combine all the possible interactions between a nucleotide and its neighbors. The researchers ... introduced a new first-order object to represent nucleotide relationships, the nucleotide cyclic motif (NCM). We reasoned that using NCMs ...

New tool isolates RNA within specific cells

... built its tool with the enzyme uracil phosphoribosyltransferase (UPRT), a nucleotide salvage enzyme that prepares nucleotides for incorporation into newly synthesized RNA. By altering the nucleotide analog 4-thiouracil, the UPRT enzyme caused RNA to become tagged with ...

New therapeutic strategy could target toxic protein in most patients with Huntington's disease

... to me that you could," he recalled. The key was something called a single nucleotide polymorphism or SNP. A SNP is any place on the genetic code that varies ... as well. To prevent this error, Zamore and his colleagues changed one more nucleotide base on the siRNA. Now, the silencing RNA was different from the healthy ...

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Nucleotide in Biological Technology

Idenix Pharmaceuticals Reports Data From Three Hepatitis C Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver

... include data on IDX184, a once-daily, oral nucleotide polymerase inhibitor prodrug currently being ... an optimal combination therapy." IDX184 nucleotide Prodrug Polymerase Inhibitor IDX184 is a liver-targeted, oral nucleotide prodrug designed to enhance the formation of its ...

Pharmasset Reports Fiscal First Quarter 2009 Financial Results

... 30, 2009, Pharmasset filed an IND for PSI-7851, a nucleotide inhibitor of HCV, with the FDA and expects to ... filing an IND for PSI-7851, our second generation nucleotide for HCV and, strengthening our balance sheet by ... phase 1 studies with its second generation nucleotide inhibitor for HCV, PSI-7851 in the first quarter ...

Transgenomic Introduces SURVEYOR(R) Endonuclease Adaptor-Ligated Libraries (SEAL) for Determining Whole Genome Sequence Variation

... not limited to assessment of known common single nucleotide polymorphisms (SNPs). It thus bridges the current ... recognition of both the sequence of the variant nucleotide and the sequence context of the mutation. The ... of mismatches arising from the presence of single nucleotide polymorphisms (SNPs) or from small insertions or ...

Pharmasset Reports Fiscal Second Quarter 2009 Financial Results

... healthy volunteer in the phase 1 trial with PSI-7851, a second generation nucleotide inhibitor of HCV. "Our HCV pipeline continues to make ... collaboration with Roche; PSI-7851, an unpartnered, next generation HCV nucleotide analog, which recently began Phase 1 clinical studies and Racivir, for the ...

SeqWright to Invest in LaserGen's Novel Lightning Terminators(TM)

... while lowering cost. These benefits are achieved through LaserGen's nucleotide chemistry by attaching a special terminating group directly to the base, ... cleavage, however, Lightning Terminators(TM) restore the incorporated nucleotide back to its natural state. This distinguishes the LaserGen chemistry from ...

Idenix Announces Data Presentations from Three HCV Discovery and Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver (EASL)

... as follows: ANTIVIRAL ACTIVITY OF THE LIVER-TARGETED nucleotide HCV POLYMERASE INHIBITOR IDX184 CORRELATES WITH TROUGH SERUM LEVELS OF THE ... 16:00 - 18:00 IDX184, A LIVER-TARGETED nucleotide HCV POLYMERASE INHIBITOR: RESULTS OF A FIRST-IN-MAN SAFETY AND ...

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Nucleotide in Biological Products

CpG WIZ® DAP-KINASE AMPLIFICATION KIT from CHEMICON

Description:... region is defined as the sequence between the 3' nucleotide of the sense primer and the complement of the 3' nucleotide of the anti-sense primer for each gene promoter. The nucleotide numbering systems are those used in the GenBank ...
Company:CHEMICON

DNA OligoMix from LC Sciences

Description:... space. Customizable Based on conventional DMT nucleotide chemistry, our synthesis technology is very flexible and you may incorporate nucleotide modifications to suit your specific needs. Incorporation of nucleotide modifications substantially increases the number ...
Company:LC Sciences

Chicken Anti-DCTD (dCMP deaminase) Polyclonal Antibody, Unconjugated from GenWay Biotech, Inc.

Description:... Number: NP_001912.1 MW: 20016 Description: FUNCTION: Supplies the nucleotide substrate for thymidylate synthetase. CATALYTIC ACTIVITY: dCMP + H 2 O = ... One-Carbon Group Transferases; Dna Polymerase; Purine Metabolism; nucleotide Sugars Metabolism; Esterases; Glycosyltransferases; Cell Division; ...
Company:GenWay Biotech, Inc.

Nick Translation System from Invitrogen

Description:... labeling of DNA. The Nick Translation System: Provides five pre-mixed nucleotide solutions for flexibility in labeled nucleotide incorporation Yields >10 8 cpm/g control DNA using [-32P]-dCTP Includes ...
Company:Invitrogen

3-O-Methylguanosine 5-Triphosphate, Sodium from GE Healthcare, formerly Amersham Biosciences

Description:... 3'-O-Methylguanosine 5'-Triphosphate, Sodium, 1 umol. Category: Nucleotides & Enzymes & Biochemicals, Nucleotides, Additional nucleotide ....
Company:GE Healthcare, formerly Amersham Biosciences

GFX PCR DNA,Gel Band Purif,100 from GE Healthcare, formerly Amersham Biosciences

Description:... GFX PCR DNA,Gel Band Purif,100, 1 EA. Category: nucleotide Sample ....
Company:GE Healthcare, formerly Amersham Biosciences

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Nucleotide in Biological Definition

BLAST

... extremely fast alternative to BLAST that compares nucleotide sequences to the genome is BLAT ( B last L ike ... six-frame conceptual translation products of a nucleotide query sequence (both strands) against a protein ... family. It translates both query and target nucleotide sequences in all six possible frames and compares ...

Genetic code

... , each coding for a single amino acid. Each nucleotide sub-unit consists of a phosphate , deoxyribose sugar and one of the 4 nitrogenous nucleotide bases grouped into 2 categories, purine and ... amino acids long. ( DNA is also a sequence of nucleotide bases, but there thymine takes the place of ...

DNA

... Because DNA strands are composed of these nucleotide subunits, they are polymers . The diversity ... a nonliving system. Because pairing causes the nucleotide bases to face the helical axis, the sugar and ... the phosphates and the sugars that link one nucleotide to the next in the DNA strand. The role of ...

Genetic code

... , each coding for a single amino acid. Each nucleotide sub-unit consists of a phosphate , deoxyribose sugar and one of the 4 nitrogenous nucleotide bases grouped into 2 categories, purine and ... amino acids long. ( DNA is also a sequence of nucleotide bases, but there thymine takes the place of ...

Neutral theory of molecular evolution

... of existing species, the vast majority of single- nucleotide differences are selectively "neutral." That is, ... through the spontaneous mutation of a single nucleotide within the sequence of a gene. In single-celled ... reproducing , multicellular organisms, the nucleotide substitution must arise within one of the many ...

Nucleotide

... nucleotide codes Code Equivalence Complement ... V X or N A or C or G or T X A nucleotide is a monomer or the structural unit of nucleotide chains forming nucleic acids as RNA and DNA ...

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Nucleotide in Biological Dictionary

Tandem repeat sequence

... VNTR) is a location in a genome where a short nucleotide sequence is organized as a tandem repeat . ... sequences . Definition(s) The length of a nucleotide sequence that is repeated in a tandem ... Wednesday, August 12, 2009 ... genetics > nucleotide sequences > repetitive sequences > ...

Tandem repeat sequences

... repeat . variable number tandem repeat . nucleotide sequences . Microsatellite. Minisatellite ... ... Wednesday, August 5, 2009 ... genetics > nucleotide sequences > repetitive sequences > ... sequences . Definition(s) The length of a nucleotide sequence that is repeated in a tandem ...

Sequence Polymorphism

... other DNA sequence , allowing its ... single nucleotide polymorphism ( ¦siŋgəl ¦nüklēə′tīd ′pälē′mörfizəm ) ... nucleotide polymorphism in this gene that may affect ... in the other, this can prevent ... A Single nucleotide Polymorphism , or SNP (pronounced "snip"), is a ...

Ribonucleic acid

... of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, ... acid or RNA is a polymer or chain of nucleotide units, each ... Encyclopedia article about ...

Polymorphisms

... Polymorphisms and ... Single nucleotide Polymorphisms . What is SNPs? Single nucleotide Polymorphisms (SNPs) represent a natural ... Genome Project, enzymes ... Single nucleotide polymorphisms are minor alterations in the ...

Point Mutation

... that causes the replacement of a single base nucleotide with another nucleotide of the genetic material, DNA or RNA. Often the ... In biology, mutations are changes to the nucleotide sequence of the genetic material of an ...

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