Navigation Links
Nucleoside in Medical News

Pharmasset Initiates Phase 1b Multiple Ascending Dose Clinical Trial of PSI-7851 in Chronic Hepatitis C Patients

... more potent than Pharmasset's first generation nucleoside polymerase inhibitor, R7128. In vitro studies ... toxicities that may be associated with some nucleoside analogs. The half-life of the triphosphate in ... three clinical-stage product candidates: R7128, a nucleoside analog for chronic HCV infections, has initiated ...

HIV Drugs Linked to Increased Risk of Heart Attack

... drugs, which include a protease inhibitor and a nucleoside reverse transcriptase inhibitor such as abacavir ... heart attack. For commonly used drugs called nucleoside reverse transcriptase inhibitors such as ... increased risk for heart attack. However, the nucleoside reverse transcriptase inhibitors abacavir and ...

Access Pharmaceuticals Closes Acquisition of MacroChem Corp.

... oncology products, 4-thio Ara-C (Thiarabine), which is a next generation nucleoside analogue licensed from Southern Research Institute and sodium ... About Thiarabine : Thiarabine, or 4-thio Ara-C, is a next generation nucleoside analogue licensed from Southern Research Institute. The compound has been ...

Pharmasset to Webcast an Investor Event from the AASLD Meeting

... on the AASLD website (AASLD.org). R7128 "Antiviral Activity Of The HCV nucleoside Polymerase Inhibitor R7128 In HCV Genotype 2 And 3 Prior Non-Responders: ... M. M. Berrey. Abstract: LB10 "Potent Antiviral Response To The HCV nucleoside Polymerase Inhibitor R7128 For 28 Days With Peg-Ifn And Ribavirin: ...

Ninety-one Percent of BARACLUDE(R) (entecavir) Treated Patients in a Four-Year Cohort Demonstrated Virologic Suppression to Undetectable Levels

... for the Study of Liver Diseases (AASLD). Patients in this cohort were nucleoside naive e-antigen (HBeAg)-positive patients with chronic hepatitis B ... (entecavir) Discovered at Bristol-Myers Squibb, BARACLUDE is a nucleoside analogue indicated for the treatment of chronic hepatitis B virus ...

Pharmasset Presents R7128 14-Day Monotherapy Study Results for the Treatment of Chronic Hepatitis C

... R7128 is an orally administered prodrug of PSI-6130, a cytidine nucleoside analogue polymerase inhibitor of hepatitis C virus (HCV) that is being ... of chronic HCV infection. R7128 is a prodrug of PSI-6130, a pyrimidine nucleoside analog inhibitor of HCV RNA polymerase. A prodrug is a chemically modified ...

More>>

Nucleoside in Medical Technology

Pharmasset Reports Positive Preliminary Antiviral Data With PSI-7851 for the Treatment of Hepatitis C

... more potent than Pharmasset's first generation nucleoside polymerase inhibitor, RG7128 (formerly known as ... toxicities that may be associated with some nucleoside analogs. Like RG7128, PSI-7851 has demonstrated ... clinical-stage product candidates. RG7128, a nucleoside analog for chronic HCV infections, is in a Phase ...

Ground-Breaking Combination of All-Oral Agents Demonstrates Potential as Hepatitis C Treatment Regimen

... of R7227, protease inhibitor, and R7128, nucleoside polymerase inhibitor, shows significant potency ... of an oral protease inhibitor and an oral nucleoside polymerase inhibitor resulted in significant HCV ... protease inhibitor, with InterMune, and R7128, a nucleoside polymerase inhibitor, with Pharmasset. ...

Roche and Pharmasset Initiate Phase IIb Clinical Trial of R7128, Most Advanced Nucleoside Polymerase Inhibitor in Development for Chronic Hepatitis C

... has been dosed in a Phase IIb study of R7128, the nucleoside polymerase inhibitor most advanced in development ... support the efficacy and safety of R7128, and nucleoside polymerase inhibitors as a class," said Michelle ... Pharmasset's Chief Medical Officer. "We believe nucleoside inhibitors have a number of advantages over other ...

Pharmasset Initiates First Time in Human Study of PSI-7851 for the Treatment of Hepatitis C (HCV)

... About PSI-7851 PSI-7851 is a uridine nucleoside analog currently in developed for the treatment ... metabolite of Pharmasset's first generation nucleoside polymerase inhibitor, R7128. In vitro studies ... toxicities that may be associated with some nucleoside analogs. The half-life of the triphosphate in ...

Pharmasset Receives Notice of Allowance

... No. 10/828,753 titled, "Modified Fluorinated nucleoside Analogues," covering the composition of matter of ... property rights in our growing pipeline of HCV nucleoside polymerase inhibitors," stated Schaefer Price, ... is a prodrug of PSI-6130, a cytidine nucleoside analog inhibitor of HCV RNA polymerase. A prodrug ...

Idenix Pharmaceuticals Presents Positive Preclinical Data on HCV Programs at The Annual Meeting of The European Association for the Study of the Liver (EASL)

... this week in Milan, Italy. Second-Generation nucleoside Polymerase Inhibitor Program IDX184 is a ... potency than the first-generation HCV nucleoside clinical drug candidates currently in ... "The preclinical profiles emerging in our HCV nucleoside and protease inhibitor programs are very ...

More>>

Nucleoside in Medical Dictionary

Acidosis

... of lactic acid in the blood , which is potentially fatal. Symptoms include nausea , vomiting , fatigue , and shortness of breath. The use of nucleoside analogs can contribute to lactic acidosis . Metabolic acidosis (for example, caused by uncontrolled diabetes ) or alkalosis (for ...

Cytomegalovirus

... been infected. CMV-IGIV ( cytomegalovirus immune globulin, intravenous ) See CytoGam Coactinon (emivirine; formerly identified as MKC-442) A nucleoside analogue that functions as a non-nucleoside reverse transcriptase inhibitor in the treatment of HIV infection and ... CMV ( Cytomegalovirus ) ...

Fatigue

... the mitochondria, often characterized by muscular weakness and fatigue . It can lead to life-threatening conditions, such as lactic acidosis . nucleoside analogs may cause mitochondrial toxic ity. Deficient activity of the pituitary gland causing slowed growth in children, fatigue and decreased ...

Hiv infection

... lymph node s. Viral load in HIV infection Credits Related Drugs for Viral load in HIV infection : Protease inhibitors (PIs) for HIV , nucleoside reverse transcriptase inhibitors (NRTIs) for HIV , Nonnucleoside reverse transcriptase inhibitors (NNRTIs) for HIV , ... HIV Infection and ...

Lactic acidosis

... of lactic acid in the blood , which is potentially fatal. Symptoms include nausea , vomiting , fatigue , and shortness of breath. The use of nucleoside analogs can contribute to lactic acidosis . Lactic acidosis can be caused by taking large doses of acetaminophen and alcohol and by ...

Lactic acid

... of lactic acid in the blood , which is potentially fatal. Symptoms include nausea , vomiting , fatigue , and shortness of breath. The use of nucleoside analogs can contribute to lactic acid osis . lactic acid dehydrogenase One of a group of enzyme s found in the blood and other body tissue ...

More>>

Nucleoside in Biological News

American Chemical Society's Weekly PressPac -- Sept. 3, 2008

... strategies to date involves the use of so-called nucleoside analogues, artificial pieces of DNA that inhibit ... by substituting for natural segments. Most nucleoside analogues directly target the active site of the ... preliminary lab studies, could lead to improved nucleoside analogues with fewer side effects, he says. ...

Nobel Laureate finds 'elegant' explanation for DNA transcribing enzyme's high fidelity

... of the process. The researchers found that a portion of the enzyme known as the trigger loop acts like a “trap door,?swinging beneath a matching nucleoside triphosphate (NTP) building block, to close off the active center and form an extensive network of interactions with the NTP and other parts of the ...

Major WHO study concludes calcium supplements can reduce complications during pregnancy

... term, highly active antiretroviral therapy, or HAART therapy. Current HAART regimens generally include three antiretroviral drugs, usually two nucleoside analogs and either a protease inhibitor or a non-nucleoside reverse-transcriptase inhibitor. This drug regimen has, in some cases, been effective in ...

Computer simulation hints at new HIV drug target

... term, highly active antiretroviral therapy, or HAART therapy. Current HAART regimens generally include three antiretroviral drugs, usually two nucleoside analogs and either a protease inhibitor or a non-nucleoside reverse-transcriptase inhibitor. This drug regimen has, in some cases, been effective in ...

Viral 'fitness' explains different resistance patterns to aids drugs

... either one NNRTI or protease inhibitor (non-boosted or boosted with a small amount of another potent PI) and two different antiretrovirals from the nucleoside reverse transcriptase inhibitor class. ...

Hepatitis C responds best to combo of ribavirin and interferon, study concludes

... virus cells and inhibiting the ability of viruses to make new copies of themselves and proliferate. Ribavirin belongs to a class of drugs called nucleoside analogues, which includes some anti-HIV drugs such as AZT (zidovudine). Ribavirin used alone does not have any effect on HCV but in combination with ...

More>>

Nucleoside in Biological Technology

Idenix Pharmaceuticals Reports Data From Three Hepatitis C Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver

... systemic exposure to IDX184 and the resulting nucleoside metabolite (NM). IDX184 is fully active against ... (PK/PD) relationship between nucleoside metabolite concentrations in serum and viral load reductions in this study. Trough serum nucleoside metabolite levels were low, ranging from 2-8 ...

Pharmasset and Roche Obtain FDA Consent to Start a Phase 2b Study With R7128 in Treatment Naive HCV Patients

... final design for a phase 2b trial with R7128, a nucleoside inhibitor of hepatitis C (HCV), slated to ... Medical Officer. "R7128 is the most advanced nucleoside polymerase inhibitor in development and we ... R7128 is a prodrug of PSI-6130, a cytidine nucleoside analog inhibitor of HCV RNA polymerase. A prodrug ...

BioCryst to Present Three Posters During the 50th American Society of Hematology Annual Meeting and Exposition

... HCl and BCX-4208 are clinical-stage purine nucleoside phosphorylase (PNP) inhibitors. The ... follows: BCX-4208 (RO5092888), a Purine nucleoside Phosphorylase ( PNP ) Inhibitor is a Novel, ... Hall A A Phase II Study of the Purine nucleoside Phosphorylase (PNP) Inhibitor RO5092888 ...

Pharmasset Reports Preliminary Results of a 4-week Proof-of-Concept Combination Study of R7128 for the Treatment of Chronic Hepatitis C in Genotype 2 or 3 Non-Responders

... SOC therapy. R7128, a prodrug of PSI-6130, is a nucleoside analogue polymerase inhibitor of HCV that is ... prior interferon-based therapy. R7128, an HCV nucleoside polymerase inhibitor, may provide better ... is a prodrug of PSI-6130, a cytidine nucleoside analog inhibitor of HCV RNA polymerase. A prodrug ...

Pharmasset and Roche to Present R7128 Data at the 14th International Symposium on Hepatitis C Virus and Related Viruses

... Safety, and Tolerability of R7128, a Novel nucleoside Polymerase Inhibitor for HCV Following Single, ... Furman PA (Pharmasset). -- Abstract P-265: The nucleoside Inhibitors R1479, PSI-6130, and NM107 have a ... in preclinical studies. PSI-6130 is a pyrimidine nucleoside analog inhibitor of HCV RNA polymerase, an enzyme ...

Anadys Pharmaceuticals Receives FDA Clearance of Phase II Protocol to Study ANA598 in Combination With Interferon-Alpha and Ribavirin in HCV Patients

... in vitro against mutations conferring resistance to protease inhibitors, nucleoside polymerase inhibitors and non-nucleoside polymerase inhibitors that act at binding sites distinct from that of ANA598, and protease and nucleoside polymerase inhibitors retain full activity against mutations conferring ...
Nucleoside in Biological Products

Phosphate Colorimetric Assay Kit, PiBlue™ from BioAssay Systems

Description:... assays for phosphatase, lipase, nucleoside triphosphatases (ATPase, GTPase etc). HTS and follow up studies for phosphatase inhibitors. Quantitation of phosphate content in protein, lipids, and ...
Company:BioAssay Systems

Phosphate Colorimetric Assay Kit from BioAssay Systems

Description:... assays for phosphatase, lipase, nucleoside triphosphatases (ATPase, GTPase etc). HTS and follow up studies for phosphatase inhibitors. Quantitation of phosphate content in protein, lipids, and ...
Company:BioAssay Systems

Tunicamycin, Streptomyces lysosuperficus from Calbiochem

Description:... White to off-white solid. A nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against ...
Company:Calbiochem

T4 Polynucleotide Kinase from EPICENTRE Biotechnologies

Description:... T4 Polynucleotide Kinase (PNK) catalyzes the transfer of the gamma-phosphate from ATP to the 5'-hydroxyl of single- and double-stranded DNA, RNA, and nucleoside 3'-monophosphates. The enzyme also removes the 3'-phosphate from 3'-phosphoryl polynucleotides, deoxyribonucleoside 3'-monophosphates, and ...
Company:EPICENTRE Biotechnologies

Pyrophosphate Fluorometric (Blue) Assay Kit, EnzChek® from Molecular Probes (Invitrogen)

Description:... the presence of inorganic phosphate (Pi ), the substrate 2-amino-6-mercapto-7-methylpurine ribonucleoside (MESG) is converted enzymatically by purine nucleoside phosphorylase (PNP) to ribose 1-phosphate and 2-amino-6-mercapto-7-methylpurine (Figure 1). Enzymatic conversion of MESG results in a shift in ...
Company:Molecular Probes (Invitrogen)

Phosphate Colorimetric Assay Kit, 'EnzoLyte from AnaSpec

Description:... 96- and 384-well plates for high-throughput screening of enzyme inhibitors. The kit has been used for assaying phosphatase, phospholipase or lipase, nucleoside triphosphatase (ATPase, GTPase etc) and phytase. The kit has the following components: Highly purified Malachite Green reagent Assay buffer A mix ...
Company:AnaSpec

More>>

Nucleoside in Biological Definition

Adenosine triphosphate

... Other triphosphates Living cells also have other "high-energy" nucleoside triphosphates, such as guanosine triphosphate . Between them and ATP, energy can be easily transferred with reactions such as those catalyzed by nucleoside diphosphokinase : Energy is released when hydrolysis of the ...

Nucleoside

... can be phosphorylated by specific kinases in the cell, producing nucleotides , which are the molecular building blocks of DNA and RNA . nucleoside triphosphates are the energy rich end products of the majority of biochemical energy releasing pathways. See also Nucleobase ...

Nucleotide

... ribose in RNA, and the phosphate chain can be a monophosphate, diphosphate, or triphosphate. A nucleotide that lacks the phosphate group is called nucleoside . Contents showTocToggle("show","hide") 1 Nomenclature 2 Chemical structures 2.1 Nucleotides 2.2 Deoxynucleotides ...
Nucleoside in Biological Dictionary

Nucleoside

... from "http://en.wikipedia.org /wiki/ nucleoside " ... nucleobase, nucleoside , nucleotide and nucleic acid metabolic process. • DNA modification ... Purine nucleoside phosphorylase deficiency. ... Definition of ...

Transcriptase

... retroviruses need to reproduce. Information about transcriptase in the free online ... non-nucleoside reverse transcriptase inhibitor. NRTI. nucleoside analogue ... Shop for Transcriptase French Edition - Books at Shop.com. Magazines Transcriptase French Edition Books Psychology research, ...

Pyrimidine

... as ... Information on EC 2.4.2.2 - pyrimidine -nucleoside phosphorylase ... Use of 4-thiouridine and 4-thiothymidine in studies on pyrimidine nucleoside phosphorylases ... Definition and other additional information on Pyrimidine from Biology-Online.org dictionary. ... It is the parent compound ...

Purine

... a free ... purine derivatives, ... Link To purine . Best - Gout Treatments. Latest Gout Treatment News. What ... Purine -specific nucleoside N-ribohydrolase from Trypanosoma brucei brucei. ... EGO entry for GO code 0008477: purine nucleosidase ... Purine . You don't need to be ...

Oligonucleotide

... HISTOCHEMISTRY. Terminal ... For a 48 base oligonucleotide , 0.1µM is ... oligonucleotide at 1.5µM final ... Specialty oligonucleotide and nucleoside synthesis service. Oglionucletide Theraputic Society, Inc., is. ... and development of oligonucleotide therapeutics (RNAi, CpG, ... © ...

Nucleotide

...... Nucleic acids are polymeric macromolecules made from nucleotide monomers. ... nucleotide n. Any of various compounds consisting of a nucleoside combined with a phosphate group and forming the basic constituent of DNA and RNA nucleotide a phosphoric ester of a nucleoside; the basic ...

More>>

Other Contents
(Date:5/4/2015)... (PRWEB) May 04, 2015 For partners ... brand new lubricant -- Astroglide TTC™ (Trying to ... motility and alter pH levels, Astroglide TTC™ is specially ... , According to the Centers for Disease Control, an ... trouble getting pregnant or sustaining a pregnancy, and over ...
(Date:5/4/2015)... Peacock Alley knows we all feel ... mother was the most beautiful woman I ever saw.” ... feminine prints and textures to remind her just how ... Eloise Robe to get you there. The beautiful Monet-inspired print ... tapered waist. It is available in small/medium or large/extra large. ...
(Date:5/3/2015)... Barbara Crone has joined Women’s Excellence in ... of the men, women and families who seek her care, initially ... for families in the home. , “When the ... if I could complete their care with the delivery of their ... mentor Nurse Midwife, I knew it was time for me to ...
(Date:5/3/2015)... (PRWEB) May 03, 2015 Indiana Fiber ... Provider announces Bank Computer Services, Inc (BCS) has selected ... BCS’ President states, “The technology, service, and working relationship ... like is the local feel you get with IFN. ... managed company; IFN makes local decisions and operates as ...
(Date:5/3/2015)... (PRWEB) May 03, 2015 It is not too ... Brain Aneurysm Walk in Memory of Lissa Anne Been in ... organized this great family-friendly event to honor her loving memory. It ... inception. , Just having turned 37, Lissa suffered a ... away on August 24, 2012. This event is designed to serve ...
Breaking Medicine News(10 mins):Health News:Astroglide Announces the Birth of Its New Baby: Astroglide TTC 2Health News:Astroglide Announces the Birth of Its New Baby: Astroglide TTC 3Health News:Feminine Classics for Mother's Day Gifts from Peacock Alley 2Health News:Women's Excellence In Midwifery Welcomes Barbara Crone 2Health News:Bank Computer Services, Inc Selects Indiana Fiber Network, LLC as Fiber Transport Provider 2Health News:Bank Computer Services, Inc Selects Indiana Fiber Network, LLC as Fiber Transport Provider 3Health News:Renowned Brain Aneurysm Foundation to Benefit from Arnold, Missouri’s 3rd Annual Brain Aneurysm Walk in Memory of Lissa Anne Been 2
(Date:4/27/2015)... 27, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces that ... customers the first week of May, 2015 and will ... May. Gino Pereira , Chief ... the company as Wocket® enters the consumer market. We ...
(Date:4/21/2015)... Canada , April 21, 2015 ... and evolving government policies are boosting access control systems ... According to a recently published report by ... Opportunities, 2020 ", the access control systems market in ... nearly USD1.2 billion by 2020.The access control systems market ...
(Date:4/20/2015)... The announcement comes as demand ... Management (GRM), Ireland,s foremost records management ... built up an impressive track record of clients within the ... the records management sector in Dubai . ... staffbase and employ a further eight staff members at its ...
Breaking Biology News(10 mins):Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3
Other TagsOther Tags