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Nuclease in Medical News

Protein's essential role in repairing damaged cells revealed

... entire MRN complex. Taking out the amino acid in Mre11 responsible for nuclease activity caused the mice to develop growth defects, chromosomal ... the kinase, but it also acts in the repair of double-strand breaks via the nuclease functions. Therefore, it prevents the two individual steps that lead to ...

Sangamo BioSciences Reports First Quarter 2009 Financial Results

... by HIV. Brief exposure of cells to Sangamo's ZFNs results in the permanent disruption of the CCR5 gene. This trial is the first zinc finger nuclease therapeutic study in humans. Individuals interested in participating in this trial should visit http://www.clinicaltrials.gov/ Sangamo ...
Nuclease in Medical Technology

Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

... Open Monoclonal Technology, Inc. (OMT) and INSERM today announced the creation of the first genetically modified mammals developed using zinc finger nuclease (ZFN) technology. (Photo: http://www.newscom.com/cgi-bin/prnh/20090723/CG50357 ) In a paper published in the July 24, 2009 issue ...

Sangamo BioSciences Announces Achievement of Key Milestone in Cell Engineering Agreement With Genentech

... of cell lines with novel characteristics for pharmaceutical protein production purposes using Sangamo's proprietary zinc finger DNA-binding protein nuclease (ZFN) technology. Genentech scientists demonstrated the successful knockout of two preselected genes in a Chinese hamster ovary (CHO) cell line. The ...

Sangamo BioSciences Provides Update on Company's 2008 Progress and 2009 Objectives

... to be nothing short of revolutionary for research applications," commented Dr. Smoller. "Marketed under the trademark CompoZr, the zinc finger nuclease (ZFN) technology makes available, for the first time, simple, efficient genomic editing. CompoZr(TM) ZFN reagents can be used to efficiently create ...

Silence Therapeutics to Receive $1.9m Milestone Payment as Pfizer and Quark Commence Phase II Trial

... RNA ('siRNA') molecules, AtuRNAi, which provide a number of advantages over conventional siRNA molecules, including increased stability against nuclease degradation. In addition, the Company has developed a proprietary systemic delivery system, AtuPLEX. This system enables the functional delivery of ...

Silence Therapeutics Announces Board Changes

... RNA ('siRNA') molecules, AtuRNAi, which provide a number of advantages over conventional siRNA molecules, including increased stability against nuclease degradation. In addition, the Company has developed a proprietary systemic delivery system, AtuPLEX. This system enables the functional delivery of ...

Sangamo BioSciences Announces Presentation of Data on ZFP Therapeutic for Glioblastoma at American Association for Cancer Research (AACR) Meeting

... and should therefore be available to destroy tumor cells. The aim of the collaboration is to use Sangamo's zinc finger DNA-binding protein nuclease (ZFN) gene modification technology to delete the GR in T-cells engineered to express the zetakine. The specific deletion of GR in the ...

Arrowhead Subsidiary, Calando Pharmaceuticals Publishes Study on Targeted, Systemic Delivery of siRNA

... formulation self assembles into nanoparticles that protect the siRNA from nuclease degradation in serum. One important result of the study was the lack of a ... approximately 50-80 nm diameter that fully protect the siRNA from nuclease degradation in serum. The siRNA delivery system has been designed to allow ...

Calando Pharmaceuticals Publishes the First Non-Human Primate Study on Targeted, Systemic Delivery of siRNA in National Academy of Sciences Journal

... "backbone" of the siRNA. The polymer and siRNA self-assemble into nanoparticles of approximately 50-80 nm diameter that fully protect the siRNA from nuclease degradation in serum. The siRNA delivery system has been designed to allow for intravenous injection. Upon delivery to the target cell, the targeting ...

Calando Pharmaceuticals Publishes Study Showing Anti-Cancer Effect with Lead RNAi Candidate

... "backbone" of the siRNA. The polymer and siRNA self-assemble into nanoparticles of approximately 50-80 nm diameter that fully protect the siRNA from nuclease degradation in serum. The siRNA delivery system has been designed to allow for intravenous injection. Upon delivery to the target cell, the targeting ...

Arrowhead Subsidiary Calando Pharmaceuticals Publishes Study Showing Anti-Cancer Effect with Lead RNAi Candidate

... of the siRNA. The polymer and siRNA self-assemble into nanoparticles of approximately 50-80 nm in diameter that fully protect the siRNA from nuclease degradation in serum. The siRNA delivery system has been designed to allow for intravenous injection. Upon delivery to the target cell, the targeting ...

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Nuclease in Medical Products

ABI PRISM 7900HT Sequence Detection System

Description:... process. Key applications include gene expression quantitation and the detection of single nucleotide polymorphisms (SNPs) using the fluorogenic 5 nuclease assay. Real-Time Throughput: Over 5,000 sample wells per day with 384-well block configuration and standard thermal cycling protocol (requires ...
Company:Applied Biosystems
Nuclease in Biological News

The structure of the Mre11 protein bound to DNA

... ends. Another part of each subunit, called the nuclease domain, accesses individual nucleotides, ... known as a "resection," which also depends on nuclease activity. The branching complex handles the ... fork in a different way. Where capping and nuclease domains meet, the twin Mre11s clamp onto the ...

Harnessing microbes, one by one, to build a better nanoworld

... instrument, software, and chemistries to deliver unambiguous gene results that are highly sensitive and reproducible. The PCR process and the 5' nuclease detection process are covered by patents owned by Roche Molecular System, Inc. and F. Hoffmann-La Roche Ltd ("Roche"). Performing services using ...

Applied Biosystems Introduces Advanced Gene Expression Service Provider Program

... instrument, software, and chemistries to deliver unambiguous gene results that are highly sensitive and reproducible. The PCR process and the 5' nuclease detection process are covered by patents owned by Roche Molecular System, Inc. and F. Hoffmann-La Roche Ltd ("Roche"). Performing services using ...
Nuclease in Biological Technology

Transgenomic Completes Licensing Option With Dana-Farber Cancer Institute on Cold-PCR for Enrichment of DNA Mutations

... of Transgenomic's WAVE DHPLC and Surveyor nuclease products for mutation detection in cancer and ... that coupling Cold-PCR with DHPLC and Surveyor nuclease promises a significant solution to high ... an alternative offering, Transgenomic's SURVEYOR nuclease cleaves such heteroduplexes with high specificity ...

Polycystic Kidney Disease Assay at Cornell University Uses Transgenomic's Surveyor Nuclease & WAVE Technology

... key advantages of using Transgenomic's Surveyor nuclease technology for mutation scanning of PKD1 and ... of scanning technology based upon Surveyor nuclease and the WAVE System." said Dr. Eric Kaldjian, CSO ... by DNA sequencing were shown by Surveyor nuclease to be heterozygous." ADPKD occurs at a rate ...

Sigma-Aldrich Launches Breakthrough Genome-Editing Tools

... CompoZr(TM) Zinc Finger nuclease Platform enables Precise, Permanent, and ... launched its CompoZr(TM) platform of zinc finger nuclease (ZFN) reagents. The CompoZr ZFN platform of ... including rats and rabbits. "Zinc Finger nuclease technology has held significant promise for ...

Frost & Sullivan Awards Precision Biosciences for Technology Innovation and Molecular Design Process in the Genomics Market

... for Technology Innovation of the Year. The company's radical Directed nuclease Editor(TM) (DNE) technology allows it to target and modify regions of a ... the field of genomic molecular biology. Precision's proprietary Directed nuclease Editor(TM) (DNE) technology enables the production of custom genome ...

Sangamo BioSciences Reports Fourth Quarter and Full Year 2008 Financial Results

... subjects. Based on Sangamo's zinc finger DNA-binding protein (ZFP) nuclease (ZFN(TM)) technology, SB-728-T has been shown to lead to an increase in ... Roche with non-exclusive, worldwide rights for the use of Sangamo's ZFP nuclease (ZFN(TM)) technology to develop cell-lines and transgenic animals with ...

Sangamo BioSciences Reports Third Quarter 2008 Financial Results

... Official launch of Sigma-Aldrich CompoZr(TM) platform of zinc finger nuclease (ZFN) reagents for gene-editing. In September, Sangamo's partner, ... pathways. For more information on Sigma-Aldrich's CompoZr zinc finger nuclease technology platform, visit http://www.compozrzfn.com or contact a ...

Silence Therapeutics Receives Allowance from United States Patent and Trademark Office for its Core RNAi Patent

... over conventional siRNA molecules, including increased stability against nuclease degradation and an increased serum half-life, while retaining therapeutic ... over conventional siRNA molecules, including increased stability against nuclease degradation. In addition, the Company has developed a proprietary systemic ...

Sangamo BioSciences and Sigma-Aldrich Announce Research and License Agreement With Roche for the Use of ZFN Technology for Generation of Transgenic Animals

... non-exclusive, worldwide rights for the use of its proprietary zinc finger nuclease (ZFN) technology to develop cell-lines and transgenic animals that have ... genes of interest. ZFNs are engineered forms of ZFPs that also contain a nuclease component which can facilitate modification of a target gene of interest. ...

Sangamo BioSciences Reports Second Quarter 2009 Financial Results

... successful knockout of two pre-selected genes in a Chinese hamster ovary (CHO) cell line using Sangamo's proprietary zinc finger DNA-binding protein nuclease (ZFN) technology. Genentech is using ZFN technology to generate cell lines with novel characteristics for pharmaceutical protein production purposes. ...

OMT announces a breakthrough in the development of a novel human antibody platform

... is essential for human antibody expression in genetically engineered animals. To solve this problem, we explored a new application for Zinc Finger nuclease (ZFN) technology, which enabled a technique that could revolutionize the genetic engineering of animals." In the study, OMT scientists and its ...

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Nuclease in Biological Products

Mung Bean Nuclease from Promega

Description:... Mung Bean nuclease catalyzes the degradation of single-stranded DNA ... yield 5-phosphoryl terminated products. While the nuclease prefers ssDNA over dsDNA by 30,000-fold, at very ... DNA from both ends (1,2). Mung Bean nuclease has been used for transcript mapping studies ...
Company:Promega

Antisense oligonucleotides from Thermo Scientific

Description:... a sulphur atom. This modification stabilises the oligonucleotide against nuclease degradation. PTOs are available as Full-PTOs All internucleotide ... methyl residue at the 2-OH of the ribose stabilises the oligo against nuclease ....
Company:Thermo Scientific

TRIMMER-Direct cDNA Normalization Kit from Evrogen JSC

Description:... cDNA samples in which individual cDNA sizes range from 0.5 to 4.5 kb. The normalization is based on unique properties of novel Duplex Specific nuclease (Zhulidov et al., Nucl. Acids. Res. 2004, 32: e37). It is performed prior to cDNA cloning, and does not include physical separation steps. ...
Company:Evrogen JSC

Rabbit Reticulocyte Lysate, Untreated from Promega

Description:... Lysate is prepared from New Zealand white rabbits in the same manner as treated lysates with the exception that it is not treated with micrococcal nuclease ....
Company:Promega

MEGAscript RNAi Kit from Ambion

Description:... systems. The MEGAscript RNAi Kit is based on Ambions patented high-yield transcription technol-ogy and includes reagents for transcription, nuclease digestion and clean ....
Company:Ambion

Polymer-Aide PCR Enhancer from Sigma-Aldrich

Description:... effective PCR enhancer for GC-rich templates. Polymer-Aide is designed for molecular biology applications and has been tested for the presence of nuclease activity (RNase, DNase, and ....
Company:Sigma-Aldrich

S1 Nuclease from Promega

Description:... S1 nuclease degrades single-stranded DNA and RNA endonucleolytically to yield 5-phosphoryl-terminated products. Double-stranded nucleic acids (DNA:DNA, DNA:RNA ...
Company:Promega

MultiScribe Reverse Transcriptase from Applied Biosystems

Description:... that uses single-stranded RNA as a template in the presence of a primer to synthesize a complementary DNA (cDNA) strand. The PCR process and 5' nuclease process are covered by patents owned by Roche Molecular Systems, Inc. and F. Hoffmann-La Roche, ....
Company:Applied Biosystems

Benzonase Nuclease HC, Purity > 90% from Novagen

Description:... Benzonase nuclease is a genetically engineered endonuclease. This unique enzyme degrades all forms of DNA and RNA while having no proteolytic activity. It is effective ...
Company:Novagen

S1 Nuclease from Invitrogen

Description: Request ...
Company:Invitrogen

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Nuclease in Biological Dictionary

S1 nuclease

... S1 nuclease is an endonuclease that is active against ... breaks in ... A nuclease is an enzyme capable of cleaving the ... "nucleodepolymerase". What is S1 nuclease ? Meaning of S1 ...

Nuclease

... A nuclease is an enzyme capable of cleaving the ... or "nucleodepolymerase". nuclease n. Any of several enzymes, such as endonucleases and exonucleases, that hydrolize nucleic ... A nuclease is an enzyme capable of cleaving the ... ...

RNase

... Ribonuclease (commonly abbreviated RNase ) is a type of nuclease that catalyzes ... RNase P is one of two known multiple turnover ribozymes in nature (the other ... Ribonuclease P ( RNase P) is a type of ...

Ribonuclease

... Ribonuclease is a type of nuclease that catalyzes the degradation of RNA into smaller components. Ribonucleases can be divided into endoribonucleases and exoribonucleases, and ...

PolyA tail

... A tail ? Meaning of Poly A tail medical term. What does Poly A tail mean? ... The poly(A ) tail protects the mRNA from digestion with nuclease and greatly ... Molecular dissection of mRNA poly(A ) tail length control in yeast. ... Poly(A ) Tail -dependent Exonuclease AtRrp41p from ...

Northern blot

... the northern blot technique. Includes information on the history and ... The standard northern blot method is relatively less sensitive than nuclease ... Northern blotting is in principle the same as Southern blotting except that RNA ... Throughout the Northern blot experiment, be ...

Northern blotting

... information on the history and development of northern blotting . ... The standard northern blot method is relatively less sensitive than nuclease ... Northern blot analysis allows the detection and quantification of specific RNA species from a ... The blot is probed in Northern ...

Exonuclease

... VII catalyses exonucleolytic cleavage in either ... Information about exonuclease in the free online English ... exonuclease - a nuclease that releases one nucleotide at a time (serially) ... The Exonuclease III, E.coli (ExoIII) exhibits four catalytic activities (1) ... Rogers, ...

Endonuclease

... ... Information about endonuclease in the free online English ... restriction endonuclease , restriction enzyme, restriction nuclease - any of the ... The European Bioinformatics Institute ... The active site of Serratia endonuclease contains a conserved magnesium-water ...

Deoxyribonuclease

... A wide variety of deoxyribonucleases are known, ... Deoxyribonuclease I, is an enzyme coded by the human gene DNASE1. DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate terminated ...

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