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Neutropenia in Medical News

Centocor Ortho Biotech Statement on the FDA ODAC Opinion Regarding DOXIL(R) for Treatment of Advanced Breast Cancer

... absolute neutrophil count, hemoglobin level, or neutropenia with fever) may require dose reduction, delay in ... or hemorrhage Sepsis occurring during neutropenia has resulted in discontinuation of treatment and ... 5 percent (DOXIL vs topotecan, respectively) were neutropenia (12 percent vs 76 percent) and anemia (6 percent ...

Amgen Highlights Data to Be Presented at ASCO

... Neulasta (R) (pegfilgrastim) neutropenia is a common and potentially dangerous side effect ... mortality in cancer patients experiencing febrile neutropenia (neutropenia with fever) based on clinical ... in patients with cancer experiencing febrile neutropenia Lead Author: Barron R Abstract ...

European Commission and United States Food and Drug Administration (FDA) Both Approve New Options for Patients With Certain Primary Brain Tumors

... and adverse events were combined, Grade 3 or 4 neutropenia occurred in 8% and Grade 3 or 4 platelet ... 9.5% of patients over age 70 experienced Grade 4 neutropenia or thrombocytopenia in the first cycle, ... equal to age 70, 7% and 5.5% experienced Grade 4 neutropenia or thrombocytopenia in the first cycle, ...

Prescription Copay Assistance for Patients taking Gleevec or Tasigna for Philadelphia chromosome-positive Chronic Myelogenous Leukemia (Ph+ CML)

... adverse reactions were thrombocytopenia (28%), neutropenia (28%), elevated lipase (15%), and hyperglycemia ... adverse reactions were thrombocytopenia (37%), neutropenia (37%), anemia (23%), and elevated lipase (17%). ... (NCI Grades 3/4) lab abnormalities - including neutropenia (3.6%-48%), anemia (1%-42%), thrombocytopenia ...

Scientists identify new congenital neutropenia syndrome and causative gene mutation

... a new syndrome associated with severe congenital neutropenia (SCN), a rare disorder in which children lack ... in this newly defined group of severe congenital neutropenia patients," said Christoph Klein, M.D., Ph.D., ... lead author of the study. Severe congenital neutropenia (SCN) is a rare disorder, with an incidence of ...

Novel treatments show improvements in survival and response rates for leukemia and lymphoma

... favorable. There were four cases of febrile neutropenia with eight patients requiring a dose-modification ... mucositis (14 percent), anemia (12 percent), and neutropenia (11 percent). Immunochemotherapy With ... in the FC arm. While FCR was found to cause more neutropenia (33.6 percent versus 20.9 percent) and leukopenia ...

Novel Treatments Demonstrate Improvements in Overall Survival and Response Rates in Difficult-To-Treat Forms of Leukemia and Lymphoma

... quite favorable. There were four cases of febrile neutropenia with eight patients requiring a dose-modification ... mucositis (14 percent), anemia (12 percent), and neutropenia (11 percent). Immunochemotherapy ... in the FC arm. While FCR was found to cause more neutropenia (33.6 percent versus 20.9 percent) and leukopenia ...

Study Showed ALIMTA(R) (pemetrexed for injection) Improved Survival in Certain Types of Non-Small Cell Lung Cancer

... NSCLC were anemia (8 vs 7); leukopenia (5 vs 28); neutropenia (5 vs 40); thrombocytopenia (2 vs 1); ALT elevation (3 vs 1); febrile neutropenia (2 vs 13); infection without neutropenia (6 vs 4); infection/febrile neutropenia - other ...

ASCO Study Confirms Importance of Histology in Treatment of Non-Small Cell Lung Cancer With ALIMTA (pemetrexed for injection)

... NSCLC were anemia (8 vs 7); leukopenia (5 vs 28); neutropenia (5 vs 40); thrombocytopenia (2 vs 1); ALT elevation (3 vs 1); febrile neutropenia (2 vs 13); infection without neutropenia (6 vs 4); infection/febrile neutropenia -- other ...

New IDSA Clinical Practice Guidelines Recommend NOXAFIL(R) (Posaconazole) for Antifungal Prophylaxis in Certain High-Risk Patients

... with hematologic malignancies with prolonged neutropenia from chemotherapy. In October 2006, the FDA ... for AML or MDS expected to result in prolonged neutropenia and HSCT recipients who are undergoing high-dose ... refractory OPC patients included fever (13%) and neutropenia (10%). Coadministration with the CYP3A4 ...

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Neutropenia in Medical Technology

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

... (NCI Grades 3/4) lab abnormalities-including neutropenia (3.6%-48%), anemia (1%-42%), thrombocytopenia ... included anemia (17%), thrombocytopenia (17%), neutropenia (8%), and increased creatinine (8%). In ... abnormalities (400 mg/day; 600 mg/day)--including neutropenia (10%; 11%), anemia (3%; 9%), thrombocytopenia ...

Study Finds DOXIL(R) Combination Therapy Delays Disease Progression for Patients With Metastatic Breast Cancer

... toxicities and infections, including: - neutropenia - 66% (Grade 3/4 57%) versus 65% (Grade 3/4 59%), with febrile neutropenia reported in 7% versus 6% of patients - ... neutrophil count, hemoglobin level, or neutropenia with fever) may require dose reduction, delay in ...

Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma

... (each 20%), rash (18%), arthralgia (17%), neutropenia and dizziness (excluding vertigo) (each 17%), ... toxicity, most commonly thrombocytopenia (5%) and neutropenia (3%). A total of 50% of patients experienced ... respectively, were thrombocytopenia (52% vs 47%), neutropenia (49% vs 46%), nausea (48% vs 28%), peripheral ...

Video: Tasigna(R) Demonstrates Rapid Response as Initial Therapy in Life-Threatening Form of Leukemia

... adverse reactions were thrombocytopenia (28%), neutropenia (28%), elevated lipase (15%), and hyperglycemia ... adverse reactions were thrombocytopenia (37%), neutropenia (37%), anemia (23%), and elevated lipase (17%). ... (NCI Grades 3/4) lab abnormalities -- including neutropenia (3.6%-48%), anemia (1%-42%), thrombocytopenia ( ...

Prolonged Progression-Free Survival Demonstrated by VELCADE(R) (Bortezomib) for Injection Based Induction Regimens in Transplant-Eligible Previously Untreated Multiple Myeloma Patients

... (each 20%), rash (18%), arthralgia (17%), neutropenia and dizziness (excluding vertigo) (each 17%), ... most commonly thrombocytopenia (5%) and neutropenia (3%). A total of 50% of patients experienced ... were thrombocytopenia (52% vs 47%), neutropenia (49% vs 46%), nausea (48% vs 28%), peripheral ...

CHMP Recommends Approval in the European Union (EU) for New Options for Patients With Certain Primary Brain Tumors

... and adverse events were combined, Grade 3 or 4 neutropenia occurred in 8% and Grade 3 or 4 platelet ... 9.5% of patients over age 70 experienced Grade 4 neutropenia or thrombocytopenia in the first cycle, ... equal to age 70, 7% and 5.5% experienced Grade 4 neutropenia or thrombocytopenia in the first cycle, ...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

... (NCI Grades 3/4) lab abnormalities -- including neutropenia (3.6%-48%), anemia (1%-42%), thrombocytopenia ... adverse reactions were thrombocytopenia (28%), neutropenia (28%), elevated lipase (15%) and hyperglycemia ... adverse reactions were thrombocytopenia (37%), neutropenia (37%), anemia (23%) and elevated lipase (17%). ...

Zevalin(R) Following Short-Course Chemotherapy with CHOP + Rituximab (CHOP-R) Doubles Complete Remission Rate in First-Line Treatment of Follicular Non- Hodgkin's Lymphoma

... CHOP-R related toxicities included grade 3 to 4 neutropenia occurred in 23 (39%) patients and grade 3 to 4 ... with Zevalin was myelosuppression. Grade 3 to 4 neutropenia occurred in 28 (51%) of patients with one incidence of febrile neutropenia requiring hospitalization. Grade 3 to 4 ...

Early Data Show Potential for Imatinib Mesylate Tablets to Treat Life-Threatening Form of Pulmonary Artery Disease

... (NCI Grades 3/4) lab abnormalities--including neutropenia (3.6%-48%), anemia (1%-42%), thrombocytopenia ... included anemia (17%), thrombocytopenia (17%), neutropenia (8%) and increased creatinine (8%). In GIST, ... abnormalities (400 mg/day; 600 mg/day)--including neutropenia (10%; 11%), anemia (3%; 9%), thrombocytopenia ...

Early Data Presented at ASCO Show Potential of RAD001 to Enhance Efficacy of, and Overcome Resistance to, Breast Cancer Treatments

... The most commonly reported adverse events were neutropenia and mouth sores. "These preliminary results are ... Grade 2 and 3 mouth sores and grade 3 and 4 neutropenia were seen. Among 11 patients evaluated ... arm, grade 2 and 3 mouth sores and grade 3 and 4 neutropenia were seen. About breast cancer Breast cancer ...

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Neutropenia in Medical Definition

Hematopathology

... ) Myeloid : Myeloid leukemia ( AML , CML ) • MPD Ph- ( Essential thrombocytosis , Polycythemia vera , Myelofibrosis ) • MDS • neutropenia Red blood cells / anemia / hemoglobinopathy Nutritional anemia: ( Iron deficiency anemia , Plummer-Vinson syndrome , Pernicious anemia ...

Pathology

... ) Myeloid : Myeloid leukemia ( AML , CML ) • MPD Ph- ( Essential thrombocytosis , Polycythemia vera , Myelofibrosis ) • MDS • neutropenia Red blood cells / anemia / hemoglobinopathy Nutritional anemia: ( Iron deficiency anemia , Plummer-Vinson syndrome , Pernicious anemia ...
Neutropenia in Medical Dictionary

Neutropenia

... neutropenia Definition neutropenia is an abnormally low level of neutrophil s in ... in the bone marrow that ingest bacteria . neutropenia is a severe drop in white blood cells. ...

Chemotherapy

... reduces the numbers of neutrophil s significantly, a condition called neutropenia develops. Patients with neutropenia are at increased risk of infection , according to National Cancer ...

Febrile

... to decrease the incidence of infection , as manifested by febrile neutropenia , ... Petit mal seizure (brief "loss of contact" type seizures ) ... brain damage. Serious toxic ity (≥grade 3), especially febrile neutropenia , was more frequent among CMF-treated patients. ...

Leukopenia

... Format ... " Hematology and Oncology : Leukopenia ; neutropenia ." In The Merck Manual of Diagnosis and Therapy. 16th ed. Ed. Robert ... Research Labor atories, 1992. A low number of white blood cells ( neutropenia , leukopenia ) is a rare side effect. The white blood cell count ...

Agranulocytosis

... Thromboplastin Time) Auto immune Thrombocytopenia ( Idiopathic Thrombocytopenic Purpura ) Bleeding Disorders Blood Transfusion ... neutropenia is sometimes called agranulocytosis or granulocytopenia because neutrophil s make up about 60% of WBCs and have granules inside their cell ...

Alport syndrome

... mutation in a gene for collagen . Alport syndrome , a form of nephritis , a kidney disease Canavan disease of the brain Congenital neutropenia , a blood condition Ehlers-Danlos syndrome , a connective tissue disease Ellis -van Creveld syndrome , a birth defect ... Alport ...

Bleeding in the stomach

... s. Increased bruising . Stomach irritation. Allergic reaction. Low platelet count ( thrombocytopenia ), low white blood cell count ( neutropenia ), and low red cell count ( anemia ). However, sometimes massive or very rapid bleeding in the stomach causes b right red stools . ...

Canavan disease

... excretion of a substance (its substrate) called N-acetyl aspartic acid (NAA) in the urine . Canavan disease of the brain Congenital neutropenia , a blood condition Ehlers-Danlos syndrome , a connective tissue disease Ellis -van Creveld syndrome , a birth defect Familial ...

Canavan

... excretion of a substance (its substrate) called N-acetyl aspartic acid (NAA) in the urine . Canavan disease of the brain Congenital neutropenia , a blood condition Ehlers-Danlos syndrome , a connective tissue disease Ellis -van Creveld syndrome , a birth defect Familial ...

Congenital

... hypogonadism ( congenital or acquired)—testicular failure due to cryptorchidism , bi lateral torsion, orchitis , ... Congenital neutropenia , a blood condition Ehlers-Danlos syndrome , a connective tissue disease Ellis -van Creveld syndrome , a birth defect Familial ...

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Neutropenia in Biological News

New potential therapeutic target discovered for genetic disorder -- Barth syndrome

... which help fight infections. The various symptoms of BTHS, in addition to cardiolipin deficiency, include cardiomyopathy (weakness in heart muscle), neutropenia (a reduction in neutrophils or white blood cells that fight bacterial infections), muscle weakness & fatigue (caused by cellular deficiency), growth ...

Eribulin mesylate demonstrated anti-tumor activity in patients with advanced breast cancer

... neuropathy were included in the study. The most frequently reported Grade 3 (severe) or Grade 4 (disabling or life- threatening) adverse events were neutropenia (a decrease in the number of granular white blood cells, 54%); febrile neutropenia, 5.5%, leukopenia (low white blood cell count, 14%), and ...

UNC study questions FDA genetic-screening guidelines for cancer drug

... analyzed data from nine previous studies of irinotecan. They found that patients who received a medium or high dose of the drug had greater risk of neutropenia if they had two copies of a variation of the gene UGT1A1, known as UGT1A1*28. At lower doses, however, the risk was the same regardless of what ...

Eisai announces Phase II data on E7389, a potential new therapy for the treatment of breast cancer

... response rate (15%) appears promising. Based on the preliminary results of this study, the predominant serious side effect related to E7389 was neutropenia (low white blood cell counts). Other side effects were considered mild to moderate and included nausea, fatigue, dehydration, arthralgias, dyspnea ...
Neutropenia in Biological Technology

Centocor Ortho Biotech Data to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting

... absolute neutrophil count, hemoglobin level, or neutropenia with fever) may require dose reduction, delay in ... hemorrhage Sepsis occurring during neutropenia has resulted in discontinuation of treatment and ... in >5% (DOXIL vs topotecan, respectively) were neutropenia (12% vs 76%) and anemia (6% vs 29%) ...

Gleevec Receives FDA Priority Review as First Therapy to Reduce Recurrence of Gastrointestinal Stromal Tumors After Surgery

... (NCI Grades 3/4) lab abnormalities -- including neutropenia (3.6%-48%), anemia (1%-42%), ... included anemia (17%), thrombocytopenia (17%), neutropenia (8%) and increased creatinine (8%). In GIST, ... (400 mg/day; 600 mg/day) -- including neutropenia (10%; 11%), anemia (3%; 9%), thrombocytopenia ...

FDA Approves IXEMPRA(TM) (ixabepilone), a Semi-Synthetic Analog of Epothilone B, for the Treatment of Advanced Breast Cancer

... events (greater than or equal to 20%) included: neutropenia (Grade 3/4: 54%) and leukopenia (Grade 3/4: 49%). ... in combination with capecitabine included: neutropenia (Grade 3/4: 68%) and leukopenia (Grade 3/4: 57%). ... treated with capecitabine alone included: neutropenia 11% and leukopenia 6%. IMPORTANT SAFETY ...

Pixantrone Significantly Increases Complete Remissions, Overall Response Rates, Frequency of Durable Remissions and Progression Free Survival in Patients with Relapsed and Refractory Aggressive Non-Hodgkin's Lymphoma

... most common grade 3, 4 adverse event observed on the pixantrone arm was neutropenia in 41.2% of patients versus 19.4% on the comparator arm. However, the incidence of grade 3, 4 febrile neutropenia was only 7.4% versus 3.0% in the comparator arm. Grade 3, 4 infections had ...

Sunesis Pharmaceuticals Provides Year-End Clinical Update on Voreloxin

... generally well-tolerated at 48 and 60 mg/m2, with an incidence of febrile neutropenia of below 10%. An increase in febrile neutropenia is observed at 75 mg/m2, although the incidence remains below 20%. ...

First Taxane-Based Non-Anthracycline Containing Chemotherapy in Combination With Herceptin (TCH) for HER2 Positive Early Breast Cancer Patients Obtains Approval From the FDA

... AC-TH). Tolerance The most common adverse event was grade 3-4 febrile neutropenia (AC-T: 9.1%, AC-TH: 11.0%, TCH: 9.8%). Other common grade 3-4 adverse ... arm, 5.1% in the AC-TH arm, and 4.9% in the TCH arm) and infection without neutropenia (7.0% in the AC-T arm, 5.5% in the AC-TH arm, and 3.6% in the TCH arm). ...

Taxotere(R)-Based Chemotherapy Significantly Improved Overall Survival Compared With Standard Anthracycline-Based Chemotherapy in Early Stage Breast Cancer

... of TC irrespective of age, hormonal status or Her2 status. Grade 3-4 neutropenia occurred in 60% of younger (<65 years) and 52% of older (greater than or ... the AC group. Among younger patients, the frequencies of Grade 3-4 febrile neutropenia were 4.4% with TC and 2.3% with AC, while in older patients the ...

Entry of Biogenerics and Decreasing Use of Amgen's Epogen and Johnson & Johnson's Procrit Will Cause a $2.8 Billion Decline in the Drug Market for Chemotherapy-Induced Anemia by 2016

... $1.7 billion in 2016. The report also finds that the chemotherapy-induced neutropenia market will decrease $1 billion by 2016 because of the entry of biogeneric ... to the report, the market is dominated by therapies that manage anemia and neutropenia effectively for most patients, but considerable opportunity remains for ...

Low Occurrence of Severe Cardiac Side Effects Despite Extensive Prior Doxorubicin Treatment Reported in Pixantrone Pivotal Trial

... with no patients in the standard chemotherapy arm achieving a confirmed complete remission. Pixantrone recipients had a low incidence of severe neutropenia complicated by either fever or documented infections, or severe vomiting or diarrhea. Pixantrone patients also experienced a low incidence of hair ...

Vanda Pharmaceuticals to Present Data on Fanapt(TM) and Tasimelteon at the 162nd American Psychiatric Association Annual Meeting

... malignant syndrome; tardive dyskinesia; hyperglycemia and diabetes mellitus; weight gain; seizures; orthostatic hypotension and syncope; leukopenia, neutropenia and agranulocytosis; hyperprolactinemia; body temperature regulation; dysphagia; suicide; priapism; potential for cognitive and motor impairment. ...
Neutropenia in Biological Definition

Colchicine

... treatment of gout and also for familial Mediterranean fever , amyloidosis , and scleroderma . Side-effects include gastro-intestinal upset and neutropenia . Starting the drug early during an attack of gout can exacerbate the symptoms. High doses can also damage bone marrow and lead to anemia . It's ...
Neutropenia in Biological Dictionary

Neutrophils

... at the sites of infection and ... Read about neutropenia, a condition of an abnormally low number of neutrophils (white blood cells). Causes of neutropenia include infections, medications, vitamin ... Lifestyle, fitness & health information about Neutrophils . ... extreme -- just a little ...

Granulocyte

... mean? ... granulocyte /gran·u·lo·cyte/ (gran'u-lo-sīt ... Granulocyte ... Granulocyte autoantibodies are the main cause of autoimmune neutropenia (AIN).1 ... Serum granulocyte colony-stimulating factor levels are not increased in patients ... Eosinophil Granulocyte . Extraglomerular ...
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