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Neurofibromatosis in Medical News

Researchers identify mechanism, possible drug treatment for tumors in neurofibromatosis

... Researchers studying neurofibromatosis type 1 a rare disease in which tumors grow ... cancer curbs tumor growth in a mouse model of neurofibromatosis type 1. A clinical trial of the drug is underway ... NIH's National Cancer Institute (NCI), and the neurofibromatosis Research Program of the U.S. Army Medical ...

Research to lead to brain tumor therapies

... The condition of multiple tumours is known as neurofibromatosis type two (NF2) and affects one in every 2,500 ... successful outcomes. Maria Toman, chair, the neurofibromatosis Association, commented: The neurofibromatosis Association ( www.nfauk.org ), as the only ...

Model found to determine cause, possible treatment of nerve tumors

... limited options for treating the disease, called neurofibromatosis type 1. We have developed a mouse model that ... mechanisms underlying the tumor formation in neurofibromatosis and to have a platform for therapeutic testing. ... report that because nerves from patients with neurofibromatosis type 1 have not been analyzed, direct comparisons ...

Cancer gene drives pivotal decision in early brain development

... in October in Cell Stem Cell, reveals that the neurofibromatosis 1 (NF1) gene helps push stem cells down separate ... in the inherited medical condition known as neurofibromatosis type 1. The new results show that scientists ... and director of the Washington University neurofibromatosis Center. "Neuroscientists have identified a number ...

NexGenix Pharmaceuticals to Present at Acumen BioFin Rodman & Renshaw 9th Annual Healthcare Conference

... the orphan- designated tumor suppressor disorder neurofibromatosis and related sporadic tumors, today announced that ... company focused on drug development for neurofibromatosis Types 1 and 2 and related sporadic tumors. ... a proprietary screening platform for both neurofibromatosis Type 1 and 2. NexGenix will soon seek an IND for ...

Study suggests existing drugs may be useful in treating brain tumors

... Research, was conducted in a mouse model of neurofibromatosis type 1 (NF1), a genetic condition that leads to ... in NF1 research and directs the University's neurofibromatosis Center, where the research took place. The ... were associated with loss of function of the neurofibromatosis gene, which causes NF1. "My lab had previously ...

Drug Shows Promise in Nervous-System Tumor Treatment

... report the first successful drug treatment of tumors in patients with neurofibromatosis type 2 (NF2). In people with NF2, benign tumors develop throughout ... National Institute of Neurological Disorders and Stroke has more about neurofibromatosis . -- Robert Preidt ...

Anti-angiogenesis treatment improves hearing in some NF2 patients

... Treatment with the angiogenesis inhibitor bevacizumab improved hearing and alleviated other symptoms in patients with neurofibromatosis type 2 (NF2). In a paper to appear in the July 23 New England Journal of Medicine , which is receiving early online release, researchers from ...

Cancer requires support from immune system to develop, UT Southwestern researchers report

... and the child's treatment was tailored to reflect the findings from the animal study. A phase 2 clinical trial of this treatment in people with neurofibromatosis has been approved and is under way. Dr. Parada cautioned, however, that further research is needed. A single human case, while encouraging, is not ...

Chemo Alone Effective in Treating Kids' Brain Tumors

... younger than 5 on the VC regimen averaged 2.2 years before disease progression. The study also found that chemotherapy was most effective among neurofibromatosis patients with low-grade gliomas. "If we can delay radiation, then we allow more time for our youngest patients to develop physically, which could ...
Neurofibromatosis in Medical Technology

Aeolus Pharmaceuticals' AEOL 10150 Highlighted in Nature Genetics Publication

... sclerosis (ALS), and Alzheimer's disease are often associated with mitochondrial dysfunction and the overproduction of reactive oxygen species. neurofibromatosis is a common neurogenetic disorder that afflicts 1 in 3,000 people worldwide. Humans that harbor mutant neurofibromatous-1 genes are at increased risk ...
Neurofibromatosis in Medical Dictionary

Neurofibromatosis

... neurofibromatosis (NF) consists of two very different disorders: neurofibromatosis type 1 (NF1) and neurofibromatosis type 2 (NF2). Search All of MedicineNet For: ...

Von Hippel-lindau Disease

... neurofibromatosis Von Hippel-Lindau disease multi ple ... s associated with pheochromocytoma include neurofibromatosis , von Hippel-Lindau disease , cerebellar ... (MEN2B), von Hippel-Lindau disease (VHL) and neurofibromatosis type 1 (NF1). ...

Sturge-Weber syndrome

... usually mean that Sturge-Weber syndrome is present. Next section ... neurofibromatosis Von Hippel-Lindau disease multi ple endocrine neoplasia (MEN) ... - telangiectasia ... Examples of overgrowth syndrome s include neurofibromatosis , Sotos syndrome , Beckwith -Wiedemann syndrome , Simpson-Golabi-Behmel ...

Tendinitis

... ( Tendinitis ) Biduoterian Fever ( Malaria ) Bi lateral Acoustic neurofibromatosis (BAN) ( neurofibromatosis 2) Bi lateral Hydronephrosis Bile Calculus ( Choledocholithiasis ) ...

Von Hippel-Lindau

... , brain, spinal cord, adrenal glands , or other parts of the body. neurofibromatosis Von Hippel-Lindau disease multi ple endocrine neoplasia (MEN) ... Neoplasia, type 2B (MEN2B), von Hippel-Lindau disease (VHL) and neurofibromatosis type 1 (NF1). ...

Acoustic

... develop gradually and are easy to miss or misinterpret. The earliest and most common symptoms of an acoustic neuroma are: ... acoustic neurofibromatosis A genetic condition in which tumor s form on the nerve s of the inner ear and cause loss of hearing and balance. Acoustic neuroma A ...

Birthmark

... tan "coffee colored" birthmark that may be normal. The presence of several of these spots, larger that 1", may be seen in the genetic disorder neurofibromatosis . Clothing and valuables are identified and recorded. The location and description of identifying marks, such as scars, tattoos, birthmark s , ...

Contracture

... ischemic contracture Volvulus - childhood Vomiting - persi stent - in pregnancy Von Gierke disease Von Recklinghausen neurofibromatosis Von Willebrand disease VSD Vulvitis Vulvovaginitis ... ...

Fragile X syndrome

... . (FMRP is an acronym composed of the first letters of Familial Mental Retardation Protein ). Examples of overgrowth syndrome s include neurofibromatosis , Sotos syndrome , Beckwith -Wiedemann syndrome , Simpson-Golabi-Behmel syndrome , Weaver syndrome , Proteus syndrome , Sturge-Weber syndrome ...

Hearing

... chronic glomerular disease , although it may also involve hearing or vision impairment . Having to do with sound or hearing . acoustic neurofibromatosis A genetic condition in which tumor s form on the nerve s of the inner ear and cause loss of hearing and balance. Your child may also tug at ...

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Neurofibromatosis in Biological News

Gene's newly explained effect on height may change tumor disorder treatment

... into an old mystery, revealing why patients with neurofibromatosis type 1 are frequently shorter than their peers. ... focused on to understand cancers in patients with neurofibromatosis type 1," says Washington University neurologist ... neurologist who treats individuals with neurofibromatosis at St. Louis Children's Hospital. "Given that ...

Chromosomal problems affect nearly all human embryos

... an X-linked disorder or the microdeletions (loss of a tiny piece of a chromosome) that can cause such disorders as the cancer predisposition syndrome neurofibromatosis type 1. The embryos are screened to avoid the implantation of one carrying that abnormality. Such embryos are the most representative of normal human ...

In just 5 years, gene discovery to clinical trial of potential treatment

... year phase 2 clinical trial, which began in 2007, is evaluating the FTI drug lonafarnib. In clinical studies in people with myeloid leukemia, neurofibromatosis and other conditions, FTIs' side effects were minimal. The 2003 discovery of the HGPS gene, named lamin A (LMNA), laid the groundwork for the ...

Anti-cancer drug prevents, reverses cardiovascular damage in mouse model of premature aging disorder

... Tipifarnib belongs to a class of drugs known as farnesyltransferase inhibitors (FTIs), which are being tested in people with myeloid leukemia, neurofibromatosis and other conditions. The team had previously found that FTI drugs could reverse structural abnormalities in skin cells taken from progeria patients ...

Statin does not appear helpful for children with learning disabilities caused by genetic disorder

... Use of simvastatin by children with neurofibromatosis type 1 (NF1), a genetic disorder that can cause learning disabilities, did not result in improved cognitive function, according to a study in the ...

UAB wins $5.7M neurofibromatosis grant

... point for the government funds. Bruce Korf, M.D., Ph.D., chair of the UAB Department of Genetics and an internationally recognized expert in neurofibromatosis type 1, said the goal of the consortium is to streamline and improve the way clinical trials are performed for this disease, and to break down past ...

Potential treatments for neurofibromatosis

... neurofibromatosis can leave its patients miserable and debilitated ... and allergic reactions. Mast cells play a role in neurofibromatosis because they also are involved in blood vessel ... in tumor formation in these malignancies." neurofibromatosis results from mutations in a gene called NF 1. In ...

Mouse brain tumors mimic those in human genetic disorder

... developed mouse model of brain tumors common in the genetic disorder neurofibromatosis 1 (NF1) successfully mimics the human condition and provides unique ... ML, Garbow JR, Perry A, Hernandez MR, Gutmann DH. Natural history of neurofibromatosis 1-associated optic nerve glioma formation in mice. Annals of Neurology, ...

Genetic fingerprints identify brain tumors' origins

... death in children, and the most common childhood brain tumor is the pilocytic astrocytoma (PA). Approximately 15 percent of all PAs are linked to neurofibromatosis 1 (NF1), a genetic condition that causes childhood brain tumors and is a primary focus of Gutmann's research. However, the genetic basis for the ...

Recreating 'Flowers for Algernon' with a happy ending

... of learning disabilities. The Nov. 8 issue of Current Biology reports the findings, which were studied in mice bred to develop the disease, called neurofibromatosis 1 (NF1). The results proved so hopeful, that the Food and Drug Administration approved the use of the drugs in three clinical trials currently ...

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Neurofibromatosis in Biological Technology

PTC Therapeutics Initiates Phase 2 Clinical Trial of PTC299 in Patients with Neurofibromatosis Type 2

... 2 clinical trial of PTC299 in adult patients with neurofibromatosis type 2 (NF2), a rare genetic disorder that causes ... Scott R. Plotkin, M.D., Ph.D., director of the neurofibromatosis Clinic at the Pappas Center for Neuro-Oncology in ... by a grant from the U.S. Department of Defense neurofibromatosis Research Program. About PTC299 PTC ...

NexGenix Pharmaceuticals Enters into Exclusive World-wide License to Develop Novel Hsp90 Inhibitors

... Company to develop for treatment of neurofibromatosis and cancer NEW YORK, Sept. 26 /PRNewswire/ -- ... on developing drugs to treat the genetic disorder neurofibromatosis and related sporadic tumors, today announced that ... company focused on drug development for neurofibromatosis Types 1 and 2 and related sporadic tumors. ...

PTC Therapeutics Receives $2.6 Million in Government Grants

... development programs in rare disorders. The U.S. Department of Defense neurofibromatosis Research Program has awarded an $822,345 grant to support a new open-label Phase 2 clinical trial of PTC's product candidate PTC299 in neurofibromatosis type 2 (NF2), a rare genetic tumor. Separately, the Food and Drug ...

Large-scale genetic study sheds new light on lung cancer

... Among the genes newly implicated in lung adenocarcinoma are: neurofibromatosis 1 (NF1). Mutations in this gene have previously been shown to cause neurofibromatosis 1, a rare inherited disorder characterized by unchecked growth of tissue ...

Unraveling the genetic picture of lung cancer

... from the same person. This approach enabled the BCM researchers to identify mutations with unprecedented sensitivity. As a result, genes such as neurofibromatosis 1 and retinoblastoma 1, and several more that had been previously associated with other cancers, were discovered to be involved in this type of lung ...
Neurofibromatosis in Biological Dictionary

Gene insertion

... are essentially defective retroviruses that retain a functional rt gene . ... However, an Alu insertion in the NF-1 gene is responsible for neurofibromatosis ... Researchers Identify Gene Involved in Dog Size: ... Gene Insertion Underlies Origin of Dogs With Short Legs. New Insights Into Novel ...
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(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
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