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Neuroblastoma in Medical News

PET can help guide treatment decisions for a common pediatric cancer

... is an important tool for depicting the extent of neuroblastoma in some patients, particularly for those in the early stages of the disease. neuroblastoma accounts for six to ten percent of all childhood ... disease. Fluorodeoxyglucose (FDG) PET imaging of neuroblastoma is increasing, but questions remain regarding ...

Long-term health and social outcomes for neuroblastoma survivors

... Survivors of the childhood cancer neuroblastoma are eight times more likely to have chronic ... information exists on the long-term outcomes for neuroblastoma survivors. Caroline Laverdiere, M.D., of the ... and colleagues looked at data for 954 5-year neuroblastoma survivors who were diagnosed from 1970-1986 and ...

After Neuroblastoma, Chronic Problems Often Await

... News) -- Adult survivors of the childhood cancer neuroblastoma face long-term health and social problems, ... data on 954 people who had been diagnosed with neuroblastoma -- a cancer that forms in the nerve tissues -- ... risk factors for long-term complications of neuroblastoma treatment and second malignant neoplasms." The ...

Gene findings revealing reasons for neuroblastoma risk

... Originating in the peripheral nervous system, neuroblastoma is the most common solid cancer of early ... "Now we have unlocked a lot of the mystery of why neuroblastoma arises in some children and not in others." ... particular gene is made within normal nerve and neuroblastoma cells. This study, Maris added, opens up a new ...

Genes May Raise Risk of Neuroblastoma in Kids

... in Philadelphia. Although not well known, neuroblastoma is the second most common form of cancer in ... develop it each year in the United States. neuroblastoma strikes young children and infants, and is fatal ... The American Cancer Society has more on neuroblastoma . SOURCES: John Maris, ...

New therapy enlists immune system to boost cure rate in a childhood cancer

... appears as a solid tumor in the chest or abdomen. neuroblastoma accounts for 7 percent of all childhood cancers, ... childhood cancer deaths. Yu will present the neuroblastoma study results on June 2 at the annual meeting of ... first substantial increase in cure rate for neuroblastoma for more than a decade," said Maris. The ...

Immunotherapy effective against neuroblastoma in children

... and the Moores UCSD Cancer Center. "High-risk neuroblastoma has always been a frustrating cancer to treat ... sugar chain found on the surface of cells) on neuroblastoma cells called GD2, which inhibit the immune system ... types of immune cells to attack the cancer. neuroblastoma in which the cancer cells arise from nerve cells ...

Immune Therapy May Aid Kids With Neuroblastoma

... we treat it with aggressive therapy, high-risk neuroblastoma often returns, and most patients do not survive," ... -- targets a key sugar-and-fat molecule lying on neuroblastoma cells called GD2. Left alone, the molecule ... The University of Chicago has more on neuroblastoma in children . -- E.J. ...

JCI online early table of contents: May 1, 2009

... outcome For a number of cancers, including neuroblastoma (the second most common tumor in children), tumor ... V-alpha-24-invariant NKT cells indirectly affect neuroblastoma growth by killing tumor-associated cells that promote the growth of neuroblastoma cells. In the study, human tumor-associated ...

JNCI April 28 tip sheet

... as a Tumor Suppressor Gene in Mouse Models of neuroblastoma Reduced expression of clusterin in a mouse model of neuroblastoma led to an increased number of tumors compared ... assessed the impact of these changes in neuroblastoma cell lines and in animal models of neuroblastoma. ...

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Neuroblastoma in Medical Technology

Gene Findings Unlocking Reasons for Neuroblastoma Risk

... Originating in the peripheral nervous system, neuroblastoma is the most common solid cancer of early ... "Now we have unlocked a lot of the mystery of why neuroblastoma arises in some children and not in others." ... particular gene is made within normal nerve and neuroblastoma cells. This study, Maris added, opens up a ...

New Therapy Enlists Immune System to Boost Cure Rate in a Childhood Cancer

... appears as a solid tumor in the chest or abdomen. neuroblastoma accounts for 7 percent of all childhood cancers, ... childhood cancer deaths. Yu will present the neuroblastoma study results on June 2 at the annual meeting of ... the first substantial increase in cure rate for neuroblastoma for more than a decade," said Maris. The ...

Gene That Causes Childhood Cancer Neuroblastoma Is Found

... those drugs in children with neuroblastoma." neuroblastoma is the most common solid cancer of early ... Because only about 600 new cases of all forms of neuroblastoma occur annually in the U.S., familial (inherited) neuroblastoma is a very rare subset of a relatively uncommon ...

Keryx Biopharmaceuticals, Inc. Commences Phase 1 Study of KRX-0401 (Perifosine) in Recurrent Pediatric Solid Tumors at Memorial Sloan-Kettering Cancer Center

... single agent perifosine not only induced tumor regression and delayed tumor growth, but that perifosine also improved the survival of mice bearing neuroblastoma tumors. Moreover, in a Phase 2 study conducted at Memorial Sloan-Kettering Cancer Center, perifosine induced responses and delayed disease ...

Bayer Announces Leukine(R) Data Presentations at 45th American Society of Clinical Oncology (ASCO) Annual Meeting

... PA Abstract 2, Plenary Presentation, Sunday, May 31, 1:00 PM to 4:00 PM, Level 2, West Hall D2 neuroblastoma A phase III randomized trial of the chimeric anti-GD2 antibody ch14.18 with GM-CSF and IL2 as immunotherapy following dose ...

Researchers Use Poliovirus to Destroy Neuroblastoma Tumors in Mice

... form of poliovirus is effective in obliterating neuroblastoma tumors in mice, even when the mice had been ... attenuated strain of poliovirus directly into neuroblastoma tumors transplanted into 12 mice engineered ... is known to reoccur following chemotherapy. neuroblastoma is the most common form of solid tumor ...

Neuroblastoma Expert Reviews Progress and Challenges in Fighting Difficult Pediatric Cancer

... are fortunately rare, but among them, neuroblastoma is a special case, accounting for 7 percent of ... of the body's sympathetic nervous system. neuroblastoma is what physicians call a heterogeneous ... of Philadelphia, describes the current status of neuroblastoma treatment and trends for the near future, in the ...

In Vitro and In Vivo Data Show Alfacell's Onocanse is Active Against Naive and Chemoresistant Neuroblastoma Cells

... is active against naive and chemoresistant neuroblastoma cells. The pre-clinical in vitro and in vivo ... studies presented indicate that ONCONASE inhibits neuroblastoma cell growth and induces caspase-independent cell death in neuroblastoma cells independently of P-gp expression or p53 ...

Kosan Presents Preclinical Antitumor and Safety Data On Next-Generation Epothilone KOS-1803 at AACR

... xenograft models, KOS-1803 has demonstrated antitumor activity in breast, lung, prostate and colorectal cancers, as well as in ovarian cancer and neuroblastoma where the extent and duration of tumor regression was curative. Kosan is currently advancing KOS-1803 through later-stage preclinical studies with ...

MGI Pharma, Inc. Summarizes Data Presented at the 2007 American Society of Clinical Oncology (ASCO) Annual Meeting

... with myeloid metaplasia" Abstract # 9565 "Decitabine (DAC) in combination with doxorubicin (DOX) and cyclophosphamide (CTX) in relapsed neuroblastoma (NBL): A Children's Oncology Group Study" Abstract # 2036 "Phase II trial of Gliadel plus O6-benzylguanine (O6-BG) for patients with recurrent ...

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Neuroblastoma in Medical Dictionary

Neuroblastoma

... neuroblastoma : A leading childhood form of cancer that ... system that is related to the ad renal gland . neuroblastoma is the most common solid tumor outside the brain in infants and children. neuroblastoma is a disease in which malignant ( cancer ) ...

Adrenal glands

... also use drugs called, anti - androgen s or peripheral blockers. neuroblastoma - A malignant neoplasm that consists of immature nerve cells. neuroblastoma s occur frequently in infants and children in the mediastinal and ...

Catecholamines

... measured in the urine . Elevations may be seen in pheochromocytoma or neuroblastoma . Catecholamines Family of neurotransmitters containing dopamine, ... s, ... In Japan a program was initiated to screen infants for neuroblastoma by testing for substances called catecholamines (made by the tumor ) ...

Chill

... FDA approved. Bur chill SA, Lewis IJ, Abrams KR, et al.: Circulating neuroblastoma cells detected by reverse transcriptase polymerase chain reaction for ... hydroxylase mRNA are an independent poor prognostic indicator in stage 4 neuroblastoma in children over ... chill s fever hives chest pain After ...

Colon Cancer

... cancer , colon cancer , prostate cancer , sarcoma , bladder cancer , neuroblastoma , and Wilm's tumor . However, almost any cancer has the capacity to ... metastasize to the liver include colon cancer , breast cancer , neuroblastoma , lung cancer , and Hodgkin's disease . blood loss, which can occur ...

Neoplasm

... Benign bone tumors are not cancer ous or often life-threatening. neuroblastoma - A malignant neoplasm that consists of immature nerve cells. neuroblastoma s occur frequently in infants and children in the mediastinal and ...

Norepinephrine

... amount of the hormone s dopamine and norepinephrine may be a sign of neuroblastoma . Family of neurotransmitters containing dopamine, norepinephrine and ... measured in the urine . Elevations may be seen in pheochromocytoma or neuroblastoma . A pheochromocytoma is an ad renal gland tumor that secretes ...

Olfactory

... are mixed with new stimulation to our olfactory sense. Esthesio neuroblastoma ( olfactory neuroblastoma ) is a very rare, small round- cell tumor arising from the nasal neuro ...

Smell

... believed that teething caused no other health problems. Esthesio neuroblastoma ( olfactory neuroblastoma ) is a very rare, small tumor that begins in the olfactory bulb (the ...

Behavior

... to do with the way the brain affects emotion, behavior , and learning. Some cancer s or their treatment may cause neurobehavioral problems. neuroblastoma Cancer that arises in immature nerve cells and affects mostly infants and children. Use of personal protective equipment and operating room ...

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Neuroblastoma in Biological News

Genetic finding could lead to targeted therapy for neuroblastoma

... makes our study so important is that although neuroblastoma accounts for 7 percent of childhood cancers, it ... (tumor formation) of neuroblastoma." neuroblastoma forms in developing nerve cells, with tumors most ... were derived from the Children's Oncology Group neuroblastoma Tumor Bank, and 803 healthy patients in a control ...

Researchers identify promising gene target for neuroblastoma therapy

... a small "targeted" molecule inhibitor caused neuroblastoma cell lines carrying two of the mutations to die ... parents of a young Dana-Farber patient to support neuroblastoma research. The study appears in the Oct. 16 ... mutations in ALK in 8 percent of the neuroblastoma tumor samples studied. The mutations were all in ...

Biomarkers allow doctors to match therapy to patient

... ODC1 is associated with poor outcome in childhood neuroblastoma and represents an important therapeutic target: ... delayed or prevented the development of neuroblastoma in a clinically relevant animal model, suggesting ... We could actually delay, and in some cases block, neuroblastoma formation in our transgenic MYCN mouse model by ...

Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors

... of two particularly stubborn solid tumor cancers neuroblastoma and peripheral nerve sheath tumors without ... human cancer cells and mice designed to develop neuroblastoma or peripheral nerve sheath tumors, rQT3 reduced ... growth that can feed tumors, Dr. Cripe said. neuroblastoma is a solid tumor cancer that begins in the ...

Protein that promotes cancer cell growth identified

... and director of the Cancer Center at Burnham, showed that Caspase-8 caused neuroblastoma cancer cells to proliferate and migrate. For the first time, Caspase-8 was ... regulator protein, MAPK. This same signaling pathway stimulates neuroblastoma cells to migrate and invade neighboring tissues--a critical process in ...

Texas Medical Center researchers win collaborative grants

... their knowledge of nanotechnology and the physiology of extracranial neuroblastoma tumors in children to come up with a delivery system for peptide-based ... that peptides small strings of amino acids are unable to penetrate neuroblastoma cells. But when shaped into fullerenes, they can pass through the cell's ...

A double-barreled immune cell approach for neuroblastoma

... for a protein called diasialoganglioside GD2, which is found in human neuroblastoma cells. "We took the T-lymphocytes' with specificity for Epstein-Barr ... lasted as long as 18 months and at higher levels than the other cells. neuroblastoma is a tumor of primitive cells that go on to form the sympathetic nervous ...

JCI table of contents: Aug. 16, 2007

... as MYCN, which has been associated with many different types of cancer, by neuroblastoma cells decreases their secretion of a soluble factor (CCL2) that attracts ... MYCN regulates localization of NKT cells to the site of disease in neuroblastoma AUTHOR CONTACT: Leonid S. Metelitsa Childrens Hospital Los Angeles, Los ...

Children's National researchers develop novel anti-tumor vaccine

... WASHINGTON, DCA novel anti-tumor vaccine for neuroblastoma and melanoma developed by scientists and clinicians at Children's National Medical Center in collaboration with investigators from the University ...

Customized gene chip provides rapid detection of genetic changes in children's cancer

... The most common cancer found in infants, neuroblastoma strikes the peripheral nervous system, often ... in a child's chest or abdomen. Some types of neuroblastoma are low risk, resolving after surgeons remove the ... in a region of chromosome 11 allows aggressive neuroblastoma to take hold. The new microarray can detect such ...

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Neuroblastoma in Biological Technology

Ascenta Therapeutics Announces Results of Preclinical Evaluation of AT-406 in Multiple Cancer Models

... data on chemotherapy resistance patterns in neuroblastoma cell lines, highlighting AT-101's inhibition of ... in the development of chemotherapy resistance in neuroblastoma (Abstract # 3269). Using human-derived neuroblastoma cell lines, these investigators demonstrated ...

Keryx Biopharmaceuticals Presents Encouraging Preclinical Data at Annual Meeting of the American Association of Cancer Research

... 3205: Perifosine, as a single agent, inhibits neuroblastoma tumor cell growth in in vitro and in vivo ... # 13 Abstract Summary: In vitro studies in neuroblastoma cell lines indicate that perifosine treatment ... treatment led to significant increases in neuroblastoma tumor bearing mouse survival. In summary, ...

Exosome Diagnostics Announces Additions to Management Team

... as a diagnostic tool for cancers and metabolic diseases. Exosome Diagnostics' lead program is a blood-based diagnostic test for the management of neuroblastoma patients. For more information, visit http://www.exosomedx.com . Media Contacts: Robert Flamm, Ph.D., or David Schull Russo Partners ...

Lixte Biotechnology Holdings, Inc. Announces the Initial Trading of Its Common Stock Under the Symbol: LIXT

... in late 2008 or early 2009. Lixte will also evaluate the anti-cancer activity of its new compounds against two life- threatening cancers of children, neuroblastoma and medulloblastoma, and against several common cancers of adults in addition to GBM. About the National Institute of Neurological Disorders and ...

The Bio-Rad Silver Stain, Rev E

... partially reversible for 3 H with a photochemical stain, Anal. Biochem 116, 248255 (1981) 82. Van Zoelen EJ et al., neuroblastoma cells express c-sis and produce a transforming growth factor antigenically related to the platelet-derived growth factor, Mol ...

Streamline Your siRNA Transfections

... cell lines, including MCF-7 (breast adenocarcinoma cells), SKOV3 (ovarian cancer cells), A549 (lung carcinoma cells), SKNAS (bone marrow neuroblastoma cells), and BJ cells (primary foreskin fibroblast cells) (data not shown). Figure 2. Efficient ...
Neuroblastoma in Biological Definition

Cancer

... incidence of cancer in children occurs during the first year of life. neuroblastoma is the most common infant malignancy, followed by the leukemias and the ... Childhood cancers include, from most frequently occurring to least: neuroblastoma , leukemia , central nervous system, retinoblastoma , Wilms' tumor , ...
Neuroblastoma in Biological Dictionary

Schwann cells

... or more ... Original Article from The New England Journal of Medicine -- Role of Ploidy, Chromosome 1p, and Schwann Cells in the Maturation of neuroblastoma In this study, we have utilized subarachnoid route to transplant Schwann cells and ... In tracing group, Schwann cells (labeled with ...
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