JCI table of contents: March 23, 2009

... kallikrein proteins in anti-GBM antibodyinduced nephritis (a mouse model of Goodpasture syndrome) and spontaneous lupus nephritis in mice and humans. In the study, which was ... lupus erythematosus and spontaneous lupus nephritis were found to be associated with kallikrein ...

BioMarin and La Jolla Pharmaceutical Sign Worldwide (Excluding Asia Pacific) Development and Commercialization Agreement for Riquent

... reduces the frequency of renal flares in lupus nephritis patients. The ASPEN Phase 3 study is the largest clinical study ever conducted in lupus nephritis and there is increasing evidence that Riquent ... good strategic fit for BioMarin. Lupus nephritis is a serious and potentially fatal orphan disease ...

'Multi-target' immune therapy improves outcomes of severe lupus nephritis

... 40 patients with severe lupus nephritis. Lupus nephritis is inflammation of the kidneys occurring in ... of the kidneys. "This is a severe form of lupus nephritis that is traditionally treated with a single ... for patients with SLE. However, class V+IV lupus nephritis continues to be a major problemit has a poor ...

Researchers investigate ways to detect lupus-associated kidney disease

... Given that early intervention in lupus nephritis is associated with better treatment outcome, it ... itself. When the antibodies attack the kidneys, nephritis occurs, often shortening a patients life ... colleagues screened urine from mice with lupus nephritis for the presence of four compounds VCAM-1, ...

Lupus is a Significant Cost to Employers, According to Thomson Reuters Study

... for lupus patients, though absence costs were not. Lupus patients with nephritis had much higher medical expenses. The mean annual total medical ... were almost four times higher than those for lupus patients without nephritis and $46,862 higher than those of the control group. Using similar ...

What killed Naval hero John Paul Jones?

... failure as a result of viral or bacterial infection, which stimulated the development of a form of progressive glomerulonephritis. The interstitial nephritis was the end result of this progressive disease. He also had pneumonia, an incidental finding not likely related to his kidney disease." The ...

Ovarian function and fertility preserved in women with severe systemic lupus erythematosus

... by the difficult nature and impact of the disease itself." In this retrospective evaluation of 61 postmenopausal women with SLE treated for lupus nephritis (n=58), autoimmune hemolytic anemia (n=1) and central nervous system involvement (n=2), 39 patients received prolonged treatment with 1g/m2 ...

Lupus more severe in patients with Southern European ancestry

... mucocutaneous (skin) manifestations of SLE, whereas southern European ancestry contributes to more severe manifestations of the disorder such as nephritis (inflammation of the kidneys) and increased production of specific autoantibodies (antibodies that fail to recognise and therefore attack the body's ...

Black-white Life Expectancy Gap Reduces, Yet Remains Significant

... death, although demonstrating favorable trends, continue to keep the black-white gap unnecessarily large, and unfavorable mortality trends in nephritis [kidney disease] and septicemia [bloodstream infection] are currently contributing to widening the gap," the authors write. The authors ...

Nephritis in Medical Technology

Statement From the Lupus Foundation of America Regarding the Release of Top-Line Results From a Study of Rituxan for the Treatment of Lupus

... remember that there are a variety of promising therapies in the near-term pipeline - including an ongoing study of Rituxan for the treatment of lupus nephritis (kidney disease). That study assesses Rituxan's potential in a focused subset of lupus patients with a highly objective outcome. Thus, we remain ...

Aspreva and Roche Announce Preliminary Results for Phase III Study Evaluating CellCept in Lupus Nephritis

... study are consistent with those observed in lupus nephritis patients receiving immunosuppressive therapy. ... discuss these preliminary results. About Lupus nephritis Systemic lupus erythematosus (SLE), commonly ... new approved treatment options for SLE or lupus nephritis in the United States in over forty years. Current ...

Lupus Foundation of America Statement on Results for Clinical Study of CellCept Released by Aspreva Pharmaceutical Company

... IVC has been referred to as the "standard of care" for treatment of lupus nephritis it has never been approved by the FDA as a treatment for lupus. In ... available might be an important overall improvement in care for lupus nephritis patients. In line with this, the LFA is eager to see some subset analysis, ...

Nephritis in Medical Definition

Pathology

... ) Diseases of the glomerulus Lupus nephritis | Post-infectious glomerulonephritis | ... of the kidney Drug-induced interstitial nephritis | Obstructive nephropathy | Radiation nephritis | Reflux nephropathy | Sarcoidosis ...

Nephritis in Medical Dictionary

Hepatorenal syndrome

... proliferative glomerulonephritis Interstitial nephritis Lupus nephritis Malignant hypertension (arteriolar nephro ... hemorrhagic telangiectasia hereditary nephritis ... ...

Inflammation

... ... Inflammation of the kidney s, known as nephritis , is a potentially dangerous condition that ... is called glomerulonephritis , or simply nephritis . Many disease s can cause this inflammation , ... system. Inflammation of the kidney s, or nephritis , is the primary characteristic of acquired ...

Interstitial nephritis

... Interstitial nephritis The acute form of interstitial nephritis is common and may account for approximately 15% ... may be toxic to the kidney s. Interstitial nephritis is one of the lesion s associated with ...

Lupus nephritis

... Lupus nephritis is an inflammation of the kidney caused by ... skin , joints , kidney s, and brain. Lupus nephritis Definition: Lupus nephritis is a kidney disorder that is a complication of ...

Nephritis

... nephritis Related Category: Pathology (nfr´ts), inflammation of the kidney . nephritis , interstitial: nephritis due to disorders of the connective tissue ...

Nephropathy

... Tolerance (Pre- Diabetes ) ... Interstitial nephritis is one of the lesion s associated with ... to a drug ( acute interstitial allergic nephritis ) or as a side effect of medications. Related ... 2 diabetes . Alternative Names: Hereditary nephritis ; Hematuria - nephropathy - deafness ; ...

Nonsteroidal anti-inflammatory drugs

... anti-inflammatory drugs ) can cause interstitial nephritis . However, interstitial nephritis has other causes. See interstitial nephritis , also see analgesic nephropathy . Pictures ...

Alport syndrome

... of the eye . Alport syndrome is very similar to hereditary nephritis . There may be nerve deafness and congenital eye abnormalities ... a mutation in a gene for collagen . Alport syndrome , a form of nephritis , a kidney disease Canavan disease of the brain Congenital ...

Analgesic nephropathy

... of prolonged or chronic ingestion of analgesics, ... Interstitial nephritis is one of the lesion s associated with analgesic nephropathy , and can ... occur with allergic reaction to a drug ( acute interstitial allergic nephritis ) or as a side effect of medications. ...

Cockayne Syndrome

... Hunter syndrome Taybi oto-palato- digit al syndrome Hereditary nephritis Mohr syndrome Hurler syndrome Waardenburg syndrome Kartagener ... Hunter syndrome Taybi oto-palato- digit al syndrome Hereditary nephritis Mohr syndrome Hurler syndrome Waardenburg syndrome Kartagener ...

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Nephritis in Biological Technology

ZymoGenetics and Merck Serono Receive FDA Special Protocol Assessment for Atacicept Pivotal Study in Lupus Nephritis

... Approximately 200 patients with active lupus nephritis will be enrolled in this trial, aimed at ... ZymoGenetics will operationally conduct the lupus nephritis study. The companies plan to conduct a second ... the SPA review process is ongoing. About Lupus nephritis ...

Nephritis in Biological Definition

Gregor Mendel

... three times over the next thirty-five years. Mendel died on January 6 , 1884 in Brno , Austria-Hungary (now Czech Republic ), from chronic nephritis . Rediscovery of Mendel's work It was not until the early 20th century that the importance of his ideas was realized. In 1900 , his work ...

Kidney

... tumors Wilms tumor Renal cell carcinoma Renal failure (acute and chronic) Glomerulonephritis Diabetic nephropathy Lupus nephritis Dialysis and kidney transplants Generally, one can live fine with just one kidney. If both kidneys do not function properly, dialysis is ...

Nephritis in Biological Dictionary

Glomerulus

... used alone to designate one of the glomeruli of the kidney. ... glomerulus ... glomeruli . cyclooxygenase-2 (COX-2) glomerular. glomeruli . nephritis ... glomerulus synonyms. glomerulus usage examples and glomerulus quotes. ... glomeruli -·li′ (-lī′) any cluster or structure of blood ...