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Myosin in Medical News

St. Jude Scientists Discover a New Mechanism Controlling Neuronal Migration

... produced evidence that a molecular motor called myosin II might power the migration. Myosins are ... microscopic time-lapse imaging to establish that myosin II and actin made up the machinery of neuronal ... the investigators used fluorescent dyes to label myosin II and actin proteins, as well as key cell ...

From mother to daughters: A central mystery in cell division solved

... As happens during muscle contraction, the myosin filaments move along the actin filaments and ... actin filaments, which serve as tracks on which myosin filaments move along to drive constriction," said ... preventing them from being efficient tracks for myosin filament movement." "This discovery will ...

Molecular motor works by detecting minute changes in force

... in nearly all cells. In two specific cases, myosin I puts tension on the specialized spring-like ... piconewton and nanometer level) to discover that myosin I motors are regulated by force. The motors pull ... ATP to generate force and motion. Humans have 40 myosin genes that sort into ...

The structural basis of familial hypertrophic cardiomyopathy is revealed

... FHC is thought to be caused by a mutation in the myosin heavy chain, one of the components of muscle ... level caused by the R403Q point mutation in myosin is linked to the characteristic misalignment of ... Hanein (Burnham Institute), used smooth muscle myosin to investigate the structural effects of the ...

Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29

... its option to the worldwide rights (excluding Japan) of Cytokinetics' cardiac contractility program, which includes CK-1827452, a novel cardiac myosin activator being developed for the treatment of heart failure. Emerging Pipeline: The Company provided an update on several of its clinical ...

Results from 8 late-breaking clinical trials presented at Heart Failure 2009

... in stable heart failure patients and was well tolerated in a proof of concept study. CK-1827452 is a new drug in a class known as Selective Cardiac myosin Activators. Bigger trials are now needed to assess safety and effect on clinically meaningful endpoints. Pre-RELAX-AHF is another proof of ...

Heart regenerates after infarction -- first trials with mice

... exist. So far, these cells had not been characterized clearly. They could demonstrate that two markers for heart cells the structural protein alpha myosin heavy chain and the transcriptionfactor Tbx5 - are also expressed on heart precursor cells. "The evidence of cells with these markers in the adult ...

Researchers gain new insight on wonder of cell division

... a cell divides into two identical daughter cells. The researchers have opened a new window on the assembly and activity of a ring of actin and myosin filaments that contract to pinch a cell at just the right time. They focused on key proteins whose roles drive signaling mechanisms that promote the ...

MYH9 gene variations help explain high rate of kidney disease in African-Americans

... Institutes of Health (NIH) in Bethesda, MD, and Johns Hopkins University published independent studies showing that variations of the "non-muscle myosin heavy chain 9" gene (MYH9) are linked to certain types of kidney disease that are more common in African Americans, including focal segmental ...

Researchers find new way to block destructive rush of immune cells

... control whether or not the tail end of the T cell can let go (de- adhesion). Data revealed for the first time that a protein called non-muscle myosin heavy chain-IIA (MyH9) is recruited to LFA-1 at the trailing end of migrating T lymphocytes. Experiments that interfered with the association between ...
Myosin in Medical Technology

Cytokinetics Announces Non-clinical Data to be Presented at the 2007 AACR Annual Meeting

... Cytokinetics' lead compound, CK-1827452, a novel small molecule cardiac myosin activator, is anticipated to enter Phase II clinical trials for the ... and Amgen will conduct research with activators of cardiac myosin in order to identify potential treatments for patients with heart failure. ...

Cytokinetics Reports Additional Clinical Trials Data for Ispinesib

... from this program, CK-1827452, a novel small molecule cardiac myosin activator, recently entered Phase II clinical trials for the treatment of ... and Amgen Inc. plan to conduct research with activators of cardiac myosin in order to identify potential treatments for patients with heart ...

Research Documents Scalable Production, Survival Following Engraftment and Positive Impact on Cardiac Function in Infarcted Rats for Geron's Human Embryonic Stem Cell-Based Therapeutic for Heart Failure

... zone of rats, the GRNCM1 cells survived for at least four weeks and formed grafts expressing key markers of human cardiomyocytes, including Beta myosin heavy chain. Echocardiographic and magnetic resonance imaging analysis showed that the animals transplanted with GRNCM1 cells had improved (smaller) ...
Myosin in Medical Definition

Proteopathy

... Lactoferrin Pulmonary alveolar proteinosis Surfactant protein C (SP-C) Critical illness myopathy (CIM) Hyperproteolytic state of myosin ubiquitination References ^ Walker LC and LeVine H (2000). "The cerebral proteopathies". Neurobiol Aging 21 : 559-561. ...
Myosin in Medical Dictionary

Smooth muscle

... Both inv(16)(p13q22) and t(16;16)(p13;q22) result in the fusion of the core binding factor-β (CBFβ) gene at 16q22 to the smooth muscle myosin heavy chain (MYH11) gene at 16p13, thereby forming the fusion gene CBFβ/MYH11. Damage to nerve s, arteries, smooth muscle s, and fibrous ...
Myosin in Biological News

Study offers clues to beating hearing loss

... The Leeds team has discovered that the myosin 7 motor protein - found in the tiny hairs of the ... deaf-blindness." There are around 40 myosin motor proteins in the human body, the most familiar of which is the type of myosin found in skeletal and heart muscle. But all ...

Ancient protein offers clues to killer condition

... researchers have found that a motor protein, myosin 2, remains structurally identical in both ... Sciences: This is an astonishing discovery. myosin 2s function is to make the smooth muscle in ... completely different regulatory mechanisms: the myosin in a turkeys gizzards allows it to chew food in ...

Media highlights in the Dec. 15 issue of Biophysical Journal

... cardiac contraction; interfilament spacing; myosin cross-bridges; x-ray diffraction The ... sensing the spacing between the filaments of myosin and actin as the heart fills with blood. The ... complex nature involving binding of both Ca2+ and myosin (a linear force-generating motor) to actin ...

Dense tissue promotes aggressive cancers

... mechanotransduction. Proteins that generate contractile forces, such as myosin "motors," are important players in mechanotransduction. Weaver and colleagues confirmed that myosin motors are involved in sparking more degradation by invadopodia in ...

Policing cells demand ID to tell friend from foe, say University of Pennsylvania cell engineers

... to coexist and move on. The team found that both actin and non-muscle myosin were involved in the attack of foreign sheep cells due to recognition of ... CD47 affects its receptor, SIRP-alpha, which in turn inactivates the myosin by preventing the addition of a phosphate group to the brawny molecule. By ...

How molecular muscles help cells divide

... been known that the contractile ring is made up of muscle-like actin and myosin contractile proteins that are involved a process in some ways similar to ... grow in random directions until they encounter another node, where myosin motors in the contacted node pull on the actin filament, bringing the two ...

Muscle atrophy through thick but not thin

... in a specific order. The researchers hypothesize that removal of certain thick filament components first permits subsequent MuRF1 access to the myosin heavy chain. However, MuRF1 doesn't exert the same power over the thin filament, which began to come apart even when MuRF1 was absent. "Up to now, ...

Why 'lazy Susan' has a weak heart

... flow. Dr. Benjamin Meder and Christina Laufer from Dr. Wolfgang Rottbauer's research group (Department of Cardiology) examined its muscle protein myosin light chain-1, which is involved in contraction of the heart muscle. They discovered the crucial change in the amino acid Serine 195, which was lost ...

Rong Li Lab offers insight into adaptive ability of cells

... treatment. The work was published in the November 26 issue of Cell . Working with yeast cells, the team disabled a motor protein, type II myosin which normally powers cell division and observed the cellular response. As predicted, blocking division initially resulted in severe growth and ...

UIC researchers make promising finding in severe lung disease

... to death in 30 percent to 40 percent of cases. There is no effective treatment. It has previously been shown that the enzyme, called nonmuscle myosin light-chain kinase, or MYLK, plays a pivotal role in the disruption of the endothelial barrier -- a single thin layer of cells that line blood ...

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Myosin in Biological Technology

Amgen Exercises Option for Exclusive License to Cytokinetics' Cardiac Contractility Program That Includes CK-1827452

... The license includes CK-1827452, a novel cardiac myosin activator being developed for the treatment of ... of CK-1827452 CK-1827452, a novel cardiac myosin activator, has been the subject of a clinical ... reported previously. Background on Cardiac myosin Activators and Cardiac Contractility ...

Laser Capture Microdissection of muscle fiber populations and expression analysis by RT-PCR

... staining with a mouse-monoclonal slow myosin heavy chain (MyHC) antibody (NOQ7-5-4D) 6 . SIFs ... Cat. # KIT0201) ◊ Slow myosin MyHC Antibody NOQ7-5-4D ◊ PCR ... 3. Rubinstein NA, Hoh JF. The distribution of myosin heavy chain isoforms among rat extraocular muscle ...

Easily Amplify Genomic DNA with Long-Distance PCR

... from ear clips is suitable for amplifying large DNA fragments with TaqPlus Long DNA polymerase, we genotyped the smooth muscle myosin heavy chain (SMHC) gene ( Figure 1 ). Two microliters of DNA were added to 16 l of PCR mixture [2 l of 10X TaqPlus Long low-salt PCR ...
Myosin in Biological Products

Rabbit Anti-Nonmuscle Myosin II Heavy Chain B (MHC-B) Polyclonal Antibody, Unconjugated from Covance Research Products, Inc

Description:... Polyclonal Antibody against Nonmuscle myosin II Heavy Chain Isoform B Affinity Purified Antibody (Stored in TBS + 0.03% ... the peptide SDVNETQPPQSE corresponding to the C-terminus of nonmuscle myosin heavy chain isoform B (MHC-B) This antibody is effective in immunoblotting ...
Company:Covance Research Products, Inc

Mouse Anti-Myosin, heavy chain I, smooth muscle Monoclonal Antibody, Unconjugated, Clone 3F8 from Abcam

Description:... Mouse monoclonal [3F8 ] to smooth muscle myosin heavy chain I ( Abpromise for all tested applications). entrezGeneID: 4629 SwissProtID: ...
Company:Abcam

Rabbit Anti-Myosin VIIa Polyclonal Antibody, Unconjugated from Abcam

Description:... Rabbit polyclonal to myosin VIIa (rating: *****) ( Abpromise for all tested applications). entrezGeneID: 4647 SwissProtID: ...
Company:Abcam

Mouse Anti-Myosin, light chain 1, cardiac Monoclonal Antibody, Unconjugated, Clone MLM544 from Abcam

Description:... Mouse monoclonal [MLM544] to cardiac myosin light chain 1 ( Abpromise for all tested applications). entrezGeneID: 4634 SwissProtID: ...
Company:Abcam
Myosin in Biological Definition

Actin

... cells they play an essential role, along with myosin , in muscle contraction . In the cytosol , ... article: Muscle contraction Together with myosin filaments actin it forms Actomyosin , which ... energy. The ATP allows, through hydrolysis , the myosin head to extend up and bind with the actin ...

Actin

... cells they play an essential role, along with myosin , in muscle contraction . In the cytosol , ... article: Muscle contraction Together with myosin filaments actin it forms Actomyosin , which ... energy. The ATP allows, through hydrolysis , the myosin head to extend up and bind with the actin ...

Myosin

... myosin is a motor protein filament found in muscle tissue . Together with actin filaments, myosin provides the mechanism for muscle contraction , ... the thick filament system consisting of myosin as well as the elastic filament system ...

Phylogenetic tree

... Fig. 2: Unrooted tree for myosin gene A phylogenetic tree is a tree ... depicts an unrooted phylogenetic tree¹ for myosin , a superfamily of proteins . Links to other ... Footnote T. Hodge, M.J.T.V. Cope (2000) A myosin Family Tree . Journal of Cell Science 113, ...

Muscle

... ; myofibrils contain sarcomeres , which are composed of actin and myosin . Individual muscle cells are lined with endomysium . Muscle cells are ... have significant differences, but all use the movement of actin against myosin to produce contraction and relaxation. In skeletal muscle, contraction is ...

Protein

... skin, hair, and cartilage . Another class are the motor proteins such as myosin , kinesin, and dynein. Muscles are composed largely of the proteins myosin and actin . Working with proteins Proteins can be picky about the ...

Biomechanics

... , and cell biology have much to offer in the way of explaining the active and passive properties of living tissues. For example, the binding of myosin to actin is based on the biochemical reaction, where C a 2 + and ATP move the troponin and tropomyosin to allow for the crossbridges ...

Cytoskeleton

... in some cell-to-cell or cell-to-matrix junctions and the transduction of signals. They are also important for cytokinesis and, along with myosin , muscular contraction . Intermediate Filaments Main article: intermediate filaments These 8 to 11 nanometers in diameter filaments are ...

List of gene families

... immune system proteins Major histocompatibility complex (MHC) Related protein families Motor proteins myosin Kinesin Dynein Signal transducing proteins Receptor tyrosine kinases G-proteins Transporters ABC ...

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Myosin in Biological Dictionary

Myosin

... Part of the myosin II structure. ... Thus, although myosin was originally thought to be restricted to muscle cells ... eukaryotic cells contain myosin isoforms. ... ...

Muscle contraction

... Muscle fiber generates tension through the action of actin and myosin cross-bridge cycling. While under tension, the muscle may lengthen, shorten or remain the same. Though the term ' contraction ' implies ...

Multi-gene family

... - gene sets ( IGF family ' and IGF signaling ... Pfam is a large collection of protein families, represented by multiple ... isoforms of myosin heavy chains, coded for by a multi - gene family PUBMED:2806546. ... ... is accelerated by all six members of the antiapoptotic BCL family ...

Microfilament

... micro-fleece lining; soft microfilament polyester sleeve lining; roomy fit ... Other microfilament proteins such as talin, gelsolin, myosin II and profilin ... All of the microfilament -related proteins determined to be most enriched by MS ... When compared to the microfilament ...

Elongation factor

... EEF1A2 - eukaryotic translation elongation factor 1 alpha 2 - Bioportfolio ... Translation elongation factor eEF1A binds to a novel myosin binding protein ... TCEA1 (transcription elongation factor A (SII), 1), Authors: Dessen P, Le Minor S. Published in: Atlas Genet Cytogenet ...

Dynein

... activated Trks to promote survival of target-dependent neurons. ... stalk coiled coil of dynein couples ATPase and microtubule binding. ... myosin and kinesin, in dynein the microtubule-binding domain ... dynein motor unit is constructed around a series of AAA ... for intra- dynein ...

Drosophila

... receptor-linked, DPTP99A ... Molecular requirements for actin-based lamella formation in Drosophila S2 cells ... jaguar - Drosophila myosin VI, a pointed end directed molecular motor ... Drosophila melanogaster is an extraordinarily attractive model organism owing to ... We ask that ...

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