JCI table of contents: Sept. 4, 2007
... the muscle Skeletal and heart (cardiac) muscles are composed of muscle fibers that contain many myofibrils, the contractile unit of muscles. myofibrils are, in turn, built of many repeating units known as sarcomeres. As the proteins of the sarcomere are therefore crucial for muscle contraction, their ...FAU Receives Patent for Invention Which Induces and Restores Cardiac Muscle Function
... axolotls (salamanders), these researchers identified a major protein that was deficient in these axolotl hearts which prevented the organization of myofibrils (contractile machinery) and the ability to beat. Using these findings, Lemanski, Zhang and their colleagues were able to show that this mutant defect ...Media highlights in the Dec. 15 issue of Biophysical Journal
... RNA Sciences, NIST, and the National Science Foundation. Non-Linear Force-Length Relationship in the ADP-Induced Contraction of Skeletal myofibrils Yuta Shimamoto, Waseda University Fumiaki Kono, Waseda University Madoka Suzuki, Consolidated Research Institute for Advanced Science and ...First direct mechanical communication of mitochondria, cardiomyocyte nucleus shown
... that "the existence of such mechanical signaling between mitochondria and myofibrils opens a new possibility to search for drugs capable of increasing cardiac ... myocyte, that "mitochondria could push and compress nearby structures like myofibrils and modulate their functional properties." This additional evidence of ...