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Myelin in Medical News

Gray matter under attack in multiple sclerosis

... nervous system. It has long been assumed that myelin is the most important target for the misdirected ... The protein Contactin-2 is produced both in the myelin sheathing and by neurons in the gray matter and ... "It could even be that proteins existing both in myelin and in the gray matter are in fact the critical ...

Tysabri May Treat Myelin Sheath Damage From MS

... to regenerate and stabilize damage done to the myelin sheath in people with multiple sclerosis (MS), a ... by MS patients are caused by damage to the myelin sheath that surrounds and protects nerve cells. ... repair and possibly restore some of the damaged myelin sheath that protects nerve fibers. Results from ...

Cat Food-Linked Illness Yields Clues to MS

... that the felines' nerve fibers had lost the fatty myelin insulation that helps signals pass along these ... though, the cats' bodies reestablished thinner myelin sheaths that allowed the cats to recover fully, ... with MS and similar nerve disorders in which myelin has degraded -- but the nerves are still ...

Study gives more proof that intelligence is largely inherited

... determining how well nerve axons are encased in myelin the fatty sheath of "insulation" that coats our ... were able to compare each group to show that myelin integrity was determined genetically in many ... identifying the genes that promote high-integrity myelin is critical to forestalling brain diseases like ...

Heavy marijuana use may damage developing brain in teens, young adults

... suggest damage or an arrest in development of the myelin sheath that surrounds brain cells," said Ashtari. myelin provides a coating around brain cells similar to insulation covering an electrical wire. If myelin does not function properly, signaling within the ...

Turning down gene expression promotes nerve cell maintenance

... transmission. Normal nerve cells have a myelin sheath, which, much like the insulation on a ... are studying the pathways that control myelin formation and maintenance. A new study by ... while lamin is necessary in the initial stages of myelin formation, too much lamin ...

New Pathways Studied to Repair Nerves

... about extrapolating from mice." The Genentech myelin approach is not new, Snider noted. "People have known in general that myelin down-regulates nerve cell growth capacity, ... that is true," he said. One belief is that the myelin mechanism is designed to prevent errors at times ...

Breakthroughs Offer Hope to MS Patients

... the fibers conduct electrical impulses. With MS, myelin is lost in multiple areas, leaving scar tissue ... Sometimes, the fiber itself is harmed. When myelin or the nerve fiber is destroyed or damaged, the ... has successfully used stem cells to help replace myelin in the brains of mice. "This discovery has shed ...

Brain Stem Cells Reverse Myelin Deficiency in Mice

... in the June issue of Cell Stem Cell . myelin is a structure, comprised of protein and fat, ... insulated to prevent signal loss over distance, myelin ensures that nerve impulses can traverse long ... the central nervous system without degrading. myelin is formed by neural support cells called ...

Human Stem Cell Transplant Helps Brain-Impaired Mice

... of electrical signals between nerve cells. When myelin is missing or damaged, electrical signals aren't ... cell transplantation for restoring absent or lost myelin to diseased nerve fibers. But, until now, no ... in a wide range of hereditary and ischemic myelin disorders in both children and adults." The ...

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Myelin in Medical Technology

Myelin Removal Beads: Premium Efficiency for Neural Cell Separations and Antibody Stainings

... the worldwide and exclusive release of myelin Removal Beads. Myelin is a specialized membrane ... During preparation of single-cell suspensions, myelin membrane fragments represent the major ... Research Products at Miltenyi Biotec. "Removal of myelin leads to higher purity and recovery of ...

Heavy Marijuana Use May Damage Developing Brain in Teens, Young Adults

... suggest damage or an arrest in development of the myelin sheath that surrounds brain cells," said Ashtari. myelin provides a coating around brain cells similar to insulation covering an electrical wire. If myelin does not function properly, signaling within the ...

Modigene Awarded Israeli Government Grant to Support Development of Its Longer-Acting Interferon Beta

... from MS, an autoimmune neurological disorder affecting the insulating myelin layers of the brain and spinal cord. If unchecked, over time the immune system attack on myelin leads to poor coordination, severe disabilities and premature death. ...

Dirucotide Does Not Meet Primary Endpoint in Phase III MAESTRO-01 Trial in Secondary Progressive Multiple Sclerosis

... whether as a result of new information, future events or otherwise. (i) Wucherpfennig KW, Weiner HL, Hafler DA. T-cell recognition of myelin basic protein. Immunology Today, 1991; 12: 277-282. (ii) Ransohoff, R.M. Natalizumab for Multiple Sclerosis. New England Journal of Medicine, 2007 ...

Shire Enhances its Orphan Drug Pipeline With the Acquisition of a New Clinical Candidate for Metachromatic Leukodystrophy

... Symptoms and Patient Outlook Sulfatide accumulation in the central and peripheral nervous system leads to destruction of the myelin sheath (demyelination). MLD has a spectrum of disease which can arise in infants and young children with a range of symptoms, though most are related ...

Opexa Presents Tovaxin Research at Federation of Clinical Immunology Societies Annual Meeting

... poster, entitled "Identifying New Immunodominant myelin Peptides in Relapsing Remitting Multiple ... to identify several myelin protein peptides from myelin basic protein (MBP), myelin proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) as being ...

Opexa Therapeutics Reports Positive Top-line Data in Phase I/II Extension Trial with Tovaxin for Multiple Sclerosis

... demonstrated that T-cell vaccination depletes myelin reactive T-cells in peripheral blood. In the extension study patient population, the myelin reactive T-cell frequencies were reduced by 84% ... 12 months on study, respectively. Reductions in myelin reactive T-cell frequencies in the dose ...

Acorda Therapeutics Presents Data from its Phase 3 Study of Fampridine-SR in Multiple Sclerosis at the American Academy of Neurology Meeting

... but the smallest axons have a special covering of a fatty substance called myelin that acts as insulation to preserve and speed these nerve signals, much ... cord helps preserve the transmission of electricity. In MS, the myelin becomes damaged and the axon cannot effectively transmit electrical ...

Acorda Therapeutics Presents Fampridine-SR Data at ACTRIMS Meeting

... but the smallest axons have a special covering of a fatty substance called myelin that acts as insulation to preserve and speed these nerve signals, much ... cord helps preserve the transmission of electricity. In MS, the myelin becomes damaged and the axon cannot effectively transmit electrical ...

Data to be presented at AAN Meeting -Study results of drug candidate for MS

... - cells that help form myelin in the CNS. Stimulation of S1P receptors on oligodendrocytes may help limit demyelination and/or promote myelin repair. (Barske et al) In the third study, conducted in an established animal model of MS [experimental autoimmune encephalomyelitis (EAE) in ...

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Myelin in Medical Dictionary

Chronic

... Chronic , spontaneous loss or destruction of myelin . myelin is a soft, white, somewhat fatty material that forms a thick sheath around the core of myelin ated nerve fiber . chronic idiopathic ...

Multiple Sclerosis

... reasons, immune cells attack and destroy the myelin sheath that insulates neuron s in the brain and ... body's immune system attacks the protective myelin sheaths that surround the nerve cells of the ... towards specific tissue components (e.g., myelin ) and may be limited to the central nervous ...

Myelin

... myelin Definition: myelin is an insulating layer that forms around nerve ... and fatty substances. The purpose of the myelin sheath is to allow rapid and efficient ...

Nerve

... demyelination (destruction of parts of the myelin sheath covering the nerve ) and axon ... at Home Medical Treatment ... Nerve and myelin sheath Charcot-Marie- Tooth (CMT) disease ... sheath made of a fatty substance called myelin that helps to transmit nerve impulses. ...

Syndrome

... causes the destruction, removal, or loss of the myelin sheath of a nerve . myelin is the substance of the cell membrane that coils to form the myelin sheath. The ...

Bovine

... is insulin obtained from cattle. bowel ... Myloral ( bovine [cow] myelin ) An investigational oral preparation for the treatment of multiple ... Tuberculotic Tuberculous ... Myloral, an oral preparation of bovine myelin , has recently been tested in clinical trials for its effectiveness in ...

Fiber

... , mould , fiber s from clothing and other fabrics and detergents . myelin is a soft, white, somewhat fatty material that forms a thick sheath around the core of myelin ated nerve fiber . Patients show progressive, usually symmetric ...

Guillain

... called Guillain -Barr' Syndrome , an illness that attacks the myelin (a fatty sheathlike covering) around nerve s, causing paralysis . ... response may be directed towards specific tissue components (e.g., myelin ) and may be limited to the central nervous system (e.g., MULTIPLE ...

Guillain-barre Syndrome

... an immunization (specifically Swine flu ), the disease affects the myelin sheath, which coats nerve cells. Landry- Guillain-Barre Syndrome ( ... response may be directed towards specific tissue components (e.g., myelin ) and may be limited to the central nervous system (e.g., MULTIPLE ...

Multi

... system . For unknown reasons, immune cells attack and destroy the myelin sheath that insulates neuron s in the brain and spinal cord. Multi ... has one axon, which is wrapped in multi ple layers of a substance called myelin . COMPUTERIZED TOMOGRAPHY (CT) SCAN - A specialized x-ray procedure ...

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Myelin in Biological News

MS study offers theory for why repair of brain's wiring fails

... attack oligodendrocytes, ultimately damaging the myelin sheath to the point that the electrical signals ... recruit fresh, immature oligodendrocytes to the myelin sheath to repair the damage, for a time. This ... see if they could determine what was slowing down myelin repair. They lesioned a small region of white ...

One size does not fit all

... demonstrates that statin therapy in mice inhibits myelin repair or remyelination in the central nervous ... nervous system-accessible immune therapies on the myelin repair processes in patients with MS and other ... system (CNS), in which immune cells attack the myelin sheath (the protective insulation of nerve ...

Human ES cells progress slowly in myelin's direction

... which are responsible for making myelin in the central nervous system. myelin forms an insulating sheath that surrounds nerve ... precursor cells that may be used to repair lost myelin sheaths. These findings also raise awareness of ...

Claudin 11 stops the leaks in neuronal myelin sheaths

... protein called claudin 11 makes the neuronal myelin sheath a snug fit. The study will be published in ... Like the rubber coating on a copper wire, the myelin sheatha membrane extension of glial cells that ... junctions between successive spiral layers of the myelin sheath, but it was unknown whether it was ...

In the war against diseases, nerve cells need their armor

... Up until now, very little was known about myelin maintenance. This new information provides vital ... other progressive demyelinating diseases in which myelin is destroyed, causing irreversible damage and ... such a vital role in maintaining the structure of myelin in the adult nervous system," says Dr. Tim ...

Multiple sclerosis research charges ahead with new mouse model of disease

... (MS) is one of several diseases in which myelin the insulator for electrical signaling in the ... like the rubber insulation on an electrical cord, myelin surrounds long projections from the body of a ... the molecular factors and changes that lead to myelin breakdown. In a new study published in Disease ...

Resuscitation technique after brain injury may do more harm than good

... quickly and efficiently. Infants have much less myelin than adults; as myelin develops in children they become more coordinated. Areas of the brain with dense areas of myelin appear white, hence the term "white matter." ...

Turning back the clock for Schwann cells

... that might help researchers understand why myelin production falters in some diseases. Wrapped ... whether c-Jun is involved in illnesses where myelin dwindles, such as Charcot-Marie Tooth disease and ... sclerosis, in which immune attacks destroy myelin in the central nervous system. Unlike Schwann ...

Rutgers scientist's research reveals critical knowledge about the nervous system

... the nerves electrical signals. A fatty substance, myelin covers those axons both to protect them and to ... signals within the nervous system. Once that myelin is lost,the electrical signal breaks down and ... cells and tell them, You are going to become myelin cells and you are going to myelinate me, explains ...

Researchers design first model motor nerve system that's insulated and organized like the human body

... explained: "The nodes of Ranvier act like power station relays along the myelin sheath. They chemically boost signals, allowing them to get across breaks ... system to explore the origins of diabetic neuropathy. Once the causes of myelin degradation are identified, targets for new drug therapies can be tested ...

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Myelin in Biological Technology

UCF team's advanced nerve cell system could help cure diabetic neuropathy, related diseases

... and other conditions caused by a loss of myelin insulation around nerves can be debilitating and ... travel long distances because of breaks in their myelin insulation called nodes of Ranvier, each of which ... travel their normal path from node to node due to myelin breakdown. Within the brain and spinal cord, ...

BioMS Medical reports results of exploratory phase II trial of dirucotide in relapsing remitting multiple sclerosis

... ---------------- Dirucotide is a synthetic peptide that consists of 17 amino acids having a sequence identical to that of a portion of human myelin basic protein (MBP). Dirucotide is being investigated for the potential treatment of multiple sclerosis (MS), an autoimmune disease caused by immune ...

New label-free method tracks molecules and drugs in live cells

... of saturated and unsaturated fats in our diets." SRS microscopy could also prove useful in neuroimaging, since neurons are coated with fatty myelin sheaths. The researchers' use of SRS microscopy to analyze skin tissue could also open new frontiers in drug development. Xie and colleagues used ...

MS Drug Development Agreement Based on WEHI's Medicinal Chemistry

... could block a potassium channel called Kv1.3. This potassium channel selectively inhibits autoreactive T cells, such as those that attack the myelin sheath in people with MS. Dr Baell says, "Our research in this area had a rocky start, but when our first patents were published in 2003, Start-Up ...

Lilly and BioMS Medical Announce Global Licensing and Development Agreement

... ---------- About MBP8298 MBP8298 is a synthetic peptide that consists of 17 amino acids having a sequence identical to that of a portion of human myelin basic protein (MBP). MBP8298 is being developed for the potential treatment of multiple sclerosis (MS), an autoimmune disease caused by immune attack ...

BioMS Medical achieves enrollment milestone in U.S. phase III multiple sclerosis trial

... The proposed mechanism of action of MBP8298 is, by design, to re-introduce such a state of "tolerance" to a critical portion of the nerve's myelin Basic Protein that is an immunological site of attack in many MS patients. This is accomplished by the I.V. injection of MBP8298 every six months. ...

LiquiChip Kits for bead-based cytokine and kinase assays

... Kinase assay without radioactivity The LiquiChip Ser/Thr Kinase Kit is based on the phosphorylation of myelin basic protein (MBP) immobilized on LiquiChip beads. After incubation with a sample, phosphorylation of serine and threonine ...
Myelin in Biological Products

Mouse Anti-Human MBP aa67-74 Monoclonal Antibody, Unconjugated from AbD Serotec

Description:... MOUSE ANTI HUMAN MBP (67-74) Immunogen: Human myelin basic ...
Company:AbD Serotec
Myelin in Biological Definition

Neuron

... rapidly, generally speaking. Many neurons have insulating sheaths of myelin around their axons, which enable their action potentials to travel ... nervous system and Schwann cells in the peripheral nervous system. The myelin sheath in peripheral nerves normally runs along the axon in sections about ...

Axon

... each foot. These single-cell fibers may extend a metre or even longer. In vertebrates generally, the axons of many neurons are sheathed in myelin , which is formed by either of two types of glial cells : Schwann cells ensheathing peripheral neurons and oligodendrocytes insulating those ...

Brain

... on the surface of cerebral cortex, as well as in clusters called nuclei deep within the brain. White matter refers to axons and their surrounding myelin insulation, which gives this tissue its white color. White matter is found in bundles of fibers known as tracts which connect the different parts of ...

Cell growth

... rapid action potential propagation. Mammals also use this trick for increasing the speed of signals in the nervous system, but they can also use myelin to accomplish this, so most human neurons are releatively small. h Other experimental systems for the study of cell size regulation One ...

Magnetic resonance imaging

... tissues however the diffusion is very often anisotropic . For example a molecule inside the axon of a neuron has a low probability to cross a myelin membrane. Therefore the molecule will move principally along the axis of the neural fiber. Conversely if we know that molecules locally diffuse ...

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Myelin in Biological Dictionary

Schwann cells

... In myelinated axons, Schwann cells form the myelin sheath (see below). The sheath is not ... In myelinated axons, Schwann cells form the myelin sheath (see below) ... Theodor Schwann ... ... Other Schwann cells do not produce myelin but continue to ensheath one or more ... ...

Peripheral protein

... toxin-3. Phosducin family ... Peripheral myelin protein 22 is produced primarily by ... ... The buildup of unprocessed peripheral myelin protein 22 probably also disrupts ... ... nervous system that connects the brain ... myelin peripheral protein . ...

Myelin sheath

... myelin is a dielectric material that forms a layer, the myelin sheath , usually around only the axon of a ... the proper functioning of the nervous system. myelin is an outgrowth glial cell: ... ...

Myelin

... myelin is a dielectric material that forms a layer, the myelin sheath, usually around only the axon of a ... the proper functioning of the nervous system. myelin is an outgrowth glial cell: ... ...

Nodes of Ranvier

... Nodes of Ranvier are the gaps formed between the myelin sheaths generated by different cells. A myelin sheath is a many-layered coating, largely composed of a fatty substance ...

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