DURECT Corporation Announces Second Quarter 2009 Financial
... specific drug delivery challenges for both small molecule
and biologic agents. Shortly after the end of ... SABER and DURIN technologies to both small
and biologic agents of interest to our ... compliance, efficacy and safety for small molecule
and biologic drugs. For more information, please ...
Molecule plays early role in nonsmoking lung cancer
... at the National Cancer Institute has identified a molecule
believed to play an early and important role in ... who had never smoked and found high levels of a molecule
called miR-21. The levels were even higher in ... levels of that molecule.
Furthermore, the molecule
was equally high in early stage tumors and late ...
Leukemia cells evade immune system by mimicking normal cells, Stanford studies show
... cancer stem cells express higher levels of the molecule
have a poorer prognosis than those whose cells ... injected into mice. The results indicate that the molecule
may serve both as a prognostic factor and a ... diseased or dying cells by binding to a molecule
on the macrophage's surface. The interaction ...
Molecule Helps Leukemia Cells Hide From Immune System
... had cancer stem cells with higher levels of this molecule
have a poorer prognosis than those whose cells ... Stanford.
The study findings show that the molecule
could be a prognostic factor and a valuable ... stem cells from macrophages by binding to a molecule
on the macrophage's surface. The macrophages are ...
Post-transplant combo can replace toxic immune-suppressing drugs in monkeys
... neither costimulation blockers (in this case, a molecule
called CTLA4-Ig) or alefacept could prevent ... or self-reactive antibodies.
CTLA4-Ig mimics a molecule
found on T cells (CTLA4) and acts as a decoy. ... drugs.
Alefacept targets memory T cells via a molecule
on their surfaces called CD2, the authors found. ...
Fate Therapeutics to Present Data on Stimulation of Osteogenic Activity Using Small Molecule Modulators of Wnt Pathway
... presentation of data from its research on small molecule
modulators of the Wnt pathway for ... study highlights the potential for using small molecule
Wnt activators as osteogenic agents. Because ...
The Company's poster entitled, "A small molecule
activator of the canonical Wnt pathway stimulates ...
Molecule in Medical Technology
Cognition Therapeutics Closes Series A Financing to Advance Drug Candidates for Alzheimer's Disease
... drug discovery company developing small molecule
disease-modifying treatments for Alzheimer's, has ... Ph.D., J.D. "Our combination of novel, small molecule
drug candidates and biologically-relevant ... leader in the discovery and development of small molecule
therapeutics targeting the toxic proteins that ...
USC Keck School of Medicine's Dr. Alan Epstein Receives Prestigious National Cancer Institute RAID Award for Breakthrough IL-2 Molecule Therapeutic
... program is to show proof of principle that a new molecule
is a viable candidate for expanded clinical ... to help propel the manufacturing of this novel molecule
toward Phase 1 clinical trials."
"We are in ... toxicity therapies for cancer, has licensed the molecule
from USC . The technology is covered under U.S. ...
Vantia Therapeutics' Lead Candidate VA106483 Demonstrates Positive Anti-diuretic Effect in Phase IIa Trial in Nocturia
... pharmaceutical company developing novel, small molecule
targeting large, underserved medical ... US$500 million.
VA106483 is a novel small molecule
drug candidate that exerts its effect
directly in ... has been developed by Vantia based on its small molecule
development expertise and is the first of ...
FDA Advisory Panel Makes Favorable Recommendation for GlaxoSmithKline and Genmab's ARZERRA(TM) (ofatumumab)
... cell surface), small loop epitope (a portion of a molecule
to which an antibody binds) on the CD20 molecule
on B-cells. Ofatumumab also binds to the large loop of the CD20 molecule. The CD20 molecule
is a key target in CLL therapy because it is ...
Fate Therapeutics Announces First Patient Treated in Phase 1b Clinical Trial of FT1050 for Hematopoietic Stem Cell Support
... Small molecule
Stem Cell Modulator Administered in Dual Cord ... in a Phase 1b clinical trial of FT1050, a small molecule
Stem Cell Modulator (SCM) designed to increase ... the initial step in our approach - using a small molecule
to treat cells ex vivo but creating an in vivo ...
TRACON Pharmaceuticals' Small Molecule TRC102 and Antibody TRC105 to be Presented at ASCO 2009
... on cancer stem cells.
TRC102 is a small molecule
inhibitor of base excision repair that reverses ... and alkylating agent chemotherapies. The molecule
is currently being studied as an oral agent in ... cancer patients in January, 2008. TRC102, a small molecule
that reverses resistance to chemotherapeutics, ...
Molecule in Medical Products
Molecule in Medical Definition
Cryostasis (clathrate hydrates)
... These "cages" are unstable when empty, collapsing into conventional ice crystal structure, but they are stabilised by the inclusion of the gas molecule
within them. Most low molecular weight gases (including O 2 , N 2 , CO 2 , CH 4 , H 2 S, Ar, Kr, and Xe) will form a hydrate under some ...
Molecule in Medical Dictionary
... protein found in every red blood cell . Hemoglobin , a protein molecule
present in all red blood cells, is responsible for transporting oxygen ... of hemoglobin in a volume of blood . Hemoglobin is the protein molecule
within red blood cells that carries oxygen and gives blood its red ...
... Names: Arginine vasopressin; Antidiuretic hormone ; AVP; Vasopressin How the test is performed: ... ADH (antidiuretic hormone ): A peptide molecule
that is released by the pituitary gland at the base of the brain after being made nearby (in the hypothalamus ). ADH D medications: Are they ...
... a rigid deformity. Surgery is necessary in these cases. Baer MR, Stewart CC, Lawrence D, et al.: Expression of the neural cell adhesion molecule
CD56 is associated with short remission duration and survival in acute myeloid leukemia with t(8;21)(q22;q22). Blood 90 (4): 1643-8, 1997. ...
... search help Printer-Friendly Format ... Amino Acids Peptides Peptides Protein s Glycoproteins Amino Acid (a.a.) Monoamine Small organic molecule
containing both a carboxyl group and an amino group bonded to the same carbon atom. Amino acids are molecules that (in technical terms) contain ...
... ear infections are described as: ... An anti cancer drug that belongs to the family of drugs called antineoplastic antibiotics . receptor A molecule
inside or on the surface of a cell that binds to a specific substance and causes a specific physiologic effect in the cell . Complications that ...
... identifying them for attack by the immune system . ANTIEMETIC: A drug used to treat nausea or vomiting . antibody (AN-tee-BOD-ee): A molecule
that protects the body against disease by attacking foreign tissue s or organ isms. Antibodies are also called immunoglobulin s. - Antibody ...
Molecule in Biological News
Nanophysics: Serving up Buckyballs on a silver platter
... and chemists alike. Like a soccer ball, the molecule
consists of 20 carbon hexagons and 12 carbon ...
To do this, researchers need to know how the molecule
forms bonds with a metal substrate, such as ... way namely, by forming a 'hole' beneath each C60 molecule
- that reinforces the bonding between the carbon ...
Protein can help cells or cause cancer, Purdue researcher finds
... overabundance of the polo-like kinase 1, or Plk1, molecule
during cell growth, as well as a shortage of the ... Studies in Liu's laboratory showed that the Plk1 molecule
indirectly attacks p53 in a process called ... affected.
Liu said it is unknown why the Plk1 molecule
chooses to initiate ubiquitination over ...
GUMC discovery highlights new direction for drug discovery
... discovering and successfully testing a small molecule
that keeps the fusion protein from sticking to ... shape constantly.
"Most targeted small molecule
cancer drugs inhibit the intrinsic activity of a ... stuck to another protein, RNA helicase A (RHA), a molecule
that forms protein complexes in order to control ...
Rampant helper syndrome
... cofactor known as F0 or F420 which is the tiny molecule
deazaflavin. It has previously been found only in ... and has accordingly been considered the signature molecule
for those species. A research group working with ...
Enzymatic methane production involves the tiny molecule
deazaflavin, known as cofactor F0 or cofactor ...
New trigger for chronic inflammation in rheumatoid arthritis discovered
... A signal molecule
made by the human body that triggers the immune ... from disease. Today's findings show that a signal molecule
called tenascin-C can trigger the same molecular ... injected the active part of the tenascin-C molecule
into mice joints. They found it caused the joints ...
Toxic molecule may help birds 'see' north and south
... at the University of Illinois report that a toxic molecule
known to damage cells and cause disease may also ... the reaction partner is not the benign oxygen molecule
that we all breathe, but its close cousin, ... said. But this gives an advantage, since the molecule
must be present at low concentrations but not ...
Molecule in Biological Technology
New clues about a hydrogen fuel catalyst
... out of a tank, but getting hydrogen out of a molecule
requires a catalyst. Now, researchers reveal new ... catalyst chemically reacts with ammonia borane, a molecule
that stores hydrogen densely, to release the ... hydrogen as part of a larger molecule. The molecule
that contains hydrogen atoms, in this case ...
EnVivo Pharmaceuticals Announces Reversal of Cognitive Deficits in Alzheimer's Disease Transgenic Mouse Model With Gamma-Secretase Modulator
EVP-0962 is a proprietary small molecule
that belongs to a new generation of potential ... and confirms that EVP-0962 is an ideal molecule
to test the AB-hypothesis in our upcoming human ... dedicated to discovering and developing small molecule
therapeutics for disorders of the central nervous ...
Global Small Molecule Kinase Inhibitors Market to Reach $16.2 Billion by 2015, According to a New Report by Global Industry Analysts, Inc.
... release of a comprehensive global report on Small molecule
Kinase Inhibitors market. World market for small molecule
kinase inhibitor drugs is projected to reach ... among others.
The report titled "Small molecule
Kinase Inhibitors: A Global Strategic Business ...
ChemoCentryx's Traficet-EN(TM) Phase II/III Induction Phase Data in Crohn's Disease to be Featured in Oral Presentation at 2009 Digestive Disease Week
... Traficet-EN is an orally-available small molecule
drug that controls the inappropriate immune ...
Traficet-EN is an orally-available small molecule
drug which is administered in capsule form and ... chemoattractant receptors with different small molecule
compounds. ChemoCentryx's lead compound, ...
DNA gripped in nanopores
... of the DNA. The researchers drove a single DNA molecule
through a nanopore in order to analyze the forces ... DNA was linked. In this way they pulled the DNA molecule
through a nanopore. The various dimensions of the ... basis for highly promising developments in single molecule
techniques based on nanopores. For example, such ...
ChemoCentryx Identifies Novel Small Molecule C5aR Antagonist
... it has identified an orally bioavailable small molecule
antagonist of the C5a receptor, CCX168, as a ... for clinical development. The acceptance of the molecule
as a development candidate triggered a $5.0 ... a highly potent and specific C5a receptor small molecule
antagonist, and unlike other compounds that have ...
Molecule in Biological Products
Mouse Anti-Human Procollagen Type I C-Peptide (PIP) Monoclonal Antibody, Unconjugated, Clone PC5-5 from QED Bioscience Inc.
Description:... Adhesion molecule
Company:QED Bioscience Inc.
Rabbit Anti-Warfarin Polyclonal Antibody, Unconjugated from Abcam
Description:... Rabbit polyclonal to Warfarin ( Abpromise for all tested applications). Antigen: Chemical / Small molecule
conjugated to ...
Mouse Anti-Zeralenone Monoclonal Antibody, Unconjugated, Clone 11C9 from Abcam
Description:... Mouse monoclonal [11C9] to Zeralenone ( Abpromise for all tested applications). Antigen: Chemical / Small molecule
conjugated to BSA: ...
Mouse Anti-L1 Cell Adhesion Molecule Monoclonal Antibody, Unconjugated, Clone UJ127 from GeneTex
Description:... Mouse Monoclonal to L1 Cell Adhesion molecule
The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); ...
Mouse Anti-PRKAR2 Monoclonal Antibody, Unconjugated, Clone RS17 from GeneTex
Description:... Mouse monoclonal [RS17 ] to PRKAR2 cAMP is a signaling molecule
important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the ...
Sheep Anti-Decorin Polyclonal Antibody, Unconjugated from Abcam
Description:... Antigen: Synthetic peptide: IGPEVPDDRDFEPS conjugated to KLH, corresponding to amino acids 6-19 of Human Decorin (fragment 36-49 of the precursor molecule
bone proteoglycan II). Entrez GeneID: 1634 Swiss Protein ID: ...
Molecule in Biological Definition
... is usually used to:
Purify and concentrate a molecule
from a mixture into a buffering solution.
Reduce the amount of a molecule
in a mixture.
Contents ... a cell lysate, growth medium or blood serum. The molecule
of interest will have a well known and defined ...
... An antigen is any molecule
that is recognized by antibodies . Usually, an ... cell to its environment via a histocompatibility molecule
. Depending on the antigen presented and the histocompatibility molecule
used, several types of immune cells can leap ...
... of solute molecules are transported for each ATP molecule
that is hydrolyzed; for example, 3 Na + ions ... for adding an inorganic phosphate group to a molecule
of adenosine diphosphate (ADP) to form a molecule
of adenosine triphosphate (ATP). This enzyme ...
... not require oxygen . The process converts one molecule
of glucose into two molecules of pyruvate , ... into pyruvate are (in brief):
A glucose molecule
from the hydrolysation of starch or glycogen is phosphorylated using one ATP molecule
to give glucose-6-phosphate.
... into chromatin both to constrain the size of the molecule
and to allow the cell to control expression of ... during prophase . (Two copies of the DNA molecule
are now present) (5) Chromosome during metaphase ... into chromatin both to constrain the size of the molecule
and to allow the cell to control expression of ...
Citric acid cycle
... metabolic pathways that are involved in fuel molecule
catabolism and ATP production.
The citric ... within the cytoplasm in prokaryotes .
catabolism (including glycolysis ) produces ... energy gained from the complete breakdown of one molecule
of glucose by glycolysis, the citric acid cycle ...
Molecule in Biological Dictionary
... acid (RNA) is a biologically important type of molecule
that consists of a long chain of nucleotide ...to... Messenger ribonucleic acid (mRNA) is a molecule
of RNA encoding a chemical "blueprint" ... ... Ribonucleic acid (RNA): A nucleic acid molecule
similar to DNA but containing ... rna: ...
Recombinant DNA molecule
... is incorporated into a single recombinant molecule
. ... links the two into a molecule
of recombinant DNA . ... molecules of ... ... How do we get the recombinant molecule
into a bacterial cell? ... A single-stranded ...
... A plasmid is an extra-chromosomal DNA molecule
separate from the chromosomal DNA which is ... ... Plasmid , small, usually ring-shaped molecule
of deoxyribonucleic acid DNA, which ... ... more. ... A plasmid is an extrachromosomal DNA molecule
... Acaryochloris marina MBIC11017 plasmid ...
... enter the binding groove of an empty MHC molecule
and ... The floor of the peptide - binding ... values ... ... structure of MHC class II molecule
has revealed open peptide binding groove . ...... The peptide - binding groove of an HLA molecule
consists of two parts, a floor and ... In the ...
... properties of muscle ... Each myosin molecule
is composed of two ... actin n. A protein ... ... As you already learned, each myosin molecule
in skeletal muscle has two globular ... (You ... ... An ideal myosin would never use an ATP molecule
in the absence of actin, since ... ...
... Messenger ribonucleic acid ( mRNA ) is a molecule
of RNA encoding a chemical "blueprint" ......  mRNA processing . The pre- mRNA molecule
undergoes three main modifications. ... The pre- mRNA processing at the 3' end of the RNA molecule
involves cleavage of ... Importantly, not ...