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Mitotic in Medical News

Lack of CHFR gene expression sets stage for breast cancer

... then line up in the middle of a structure, the mitotic spindle, which forms to aid cell division. The ... because some cancer drugs interact with the mitotic spindle as a way to curb cell division. ... alpha tubulin, a protein important in forming mitotic spindles, and with a ...

Key factor in brain development revealed, offers insight into disorder

... by helping regulate the orientation of the cells mitotic spindles -- the microtubules that draw the two ... Specifically, Lis 1 makes sure that the mitotic spindle is oriented perpendicular to the top and ... and weakened microtubules and an inability of the mitotic spindle to rotate the microtubules properly in ...

Experimental cancer pharmaceuticals under trial

... A potent and selective inhibitor of the mitotic kinesin CENP-E (GSK923295A) demonstrates a novel ... The experimental drug, GSK923295A, inhibits the mitotic kinesin centromere-associated protein E (CENP-E), ... two, identical, daughter cells. The resulting mitotic arrest can lead to apoptosis, or cell death. A ...

A breakthrough in gastric carcinogenesis

... Checkpoint with forkhead and ring finger (CHFR) is a mitotic stress checkpoint gene whose promoter is frequently methylated in various ... MIN of gastric cancer patients. Both MIN and CHFR hypermethylation induce mitotic check point disruption and confer a survival advantage to the cells, ...

Cell division studies hint at future cancer therapy

... the American Cancer Society to pursue his studies. He focuses on the mitotic spindle, a sort of demarcation line that helps a dividing cell divvy up ... details may eventually lead to better cancer treatment, such as disrupting mitotic spindle organization so cancer cells cannot divide, Dr. Du says. The ...

Journal of Clinical Oncology Publishes TREANDA Study Demonstrating Significant Improvement in Overall Response and Progression-Free Survival in Chronic Lymphocytic Leukemia

... by a process known as apoptosis (programmed cell death) as well as by an alternate cell death pathway which disrupts normal cell division known as mitotic catastrophe (a non-apoptotic pathway). Cephalon holds exclusive rights to market and develop TREANDA in the United States. TREANDA is licensed ...

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Mitotic in Medical Technology

Oncolytics Biotech(R) Inc. Announces Publication of Research on Synergistic Activity of Reovirus and Chemotherapy in NSCLC

... agents, and that the reovirus-taxane combination most effectively achieves synergy through accelerated apoptosis triggered by prolonged mitotic arrest. About Oncolytics Biotech Inc. Oncolytics is a Calgary-based biotechnology company focused on the development of oncolytic viruses ...

Journal of Clinical Oncology Publishes Study of Cephalon Medication TREANDA Plus Rituximab in Relapsed Non-Hodgkin's Lymphoma

... to cell death by a process known as apoptosis (programmed cell death) and potentially by an alternate cell death (non-apoptotic) pathway known as mitotic catastrophe (a disruption of normal cell division). The exact mechanism of action of TREANDA remains unknown. Cephalon holds exclusive rights to ...

Kosan Initiates Phase 2 Trial of Epothilone KOS-1584 in Non-Small Cell Lung Cancer

... its value for potential pharmaceutical collaborators." KOS-1584 is a member of a class of cytotoxic macrolides (epothilones) capable of causing mitotic arrest by polymerization of cellular microtubules. Since microtubules are essential for mitosis, motility, secretion and proliferation, the observed ...

Sunesis Pharmaceuticals to Present Non-Clinical Data at the Annual Meeting of the American Association for Cancer Research

... of Aurora kinases, has preclinical anti-activity and induces apoptosis Session: Heat Shock Protein Inhibitors, Aurora Kinase and other mitotic Inhibitors Abstract #5648 8:00 a.m. - 12:00 p.m. Exhibit Hall B-F, San Diego Convention Center About Sunesis Pharmaceuticals Sunesis ...

EntreMed Commences Continuous Dosing Clinical Trial For MKC-1

... To date, MKC-1 has been evaluated in over 400 patients in multiple Phase 1 and 2 clinical trials. MKC-1 has been shown to induce apoptosis, inhibit mitotic spindle formation, and prevent chromosome segregation in the M-phase (mitosis) of the cell cycle. Furthermore, MKC-1 inhibits the PI3K-Akt-mTOR ...

EntreMed Commences Phase 2 Study With MKC-1 in Ovarian/Endometrial Cancers

... tumor growth inhibition or regression in multiple preclinical models, including paclitaxel-resistant models. MKC-1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase (mitosis) of the cell cycle, and induce apoptosis. Furthermore, MKC-1 inhibits the ...
Mitotic in Medical Products

Fluorescent HEp-2 ANA

Features:... Abundant easy-to-read mitotic cells Clear pattern identification Ready-to-use pattern controls and conjugates Substrate slides Positive pattern controls for: homogeneous, ...
Company:Immuno Concepts N.A. Ltd.

Fluorescent HEp-2000 ANA

Features:... Assurance for the Indirect Immunofluorescence Test for Autoantibodies to Nuclear Antigen (IF-ANA). Approved Guideline lA. Abundant easy-to-read mitotic cells Clear pattern identification Ready-to-use pattern controls and conjugates Positive pattern controls for: - homogeneous - centromere - ...
Company:Immuno Concepts N.A. Ltd.
Mitotic in Medical Dictionary

ACTH

... physician s alike. An anti cancer drug used in treating adrenocortical cancer and ACTH -producing pituitary tumor s (Cushing's disease ). mitotic activity ... The amino acids are coupled by a peptide bond, a special linkage in which the nitrogen atom of one amino acid binds to the ...

Behavior

... behavior s of dividing mammalian cells- Using a dominant-negative chimeric tropomyosin, we have studied roles of actin filaments in cytokinesis, mitotic spindle orientation, and blebbing of dividing cells. Studies of behavior therapy for OCD have found it to be a successful treatment for the ...

Genes

... dimyarian; dimyary; dingo; dinmont; diodon; diodont; dio genes ; ... We have recently cloned two novel genes , Pini and Pin2, involved in mitotic regulation. Research Interest: The main focus of my research is quorum sensing regulation of virulence genes in entero hemorrhagic Escherichia ...

Hemorrhage

... organ s and essential structures. While low-grade tumor s are usually curable by surgery alone, higher-grade sarcoma s (as determined by the mitotic index and by the presence of hemorrhage and necrosis ) are associated with higher local treatment failure rates and increased metastatic ... ...

Lymph system

... cells of the lymph system (called T lymphocyte s) become cancer ous. T138067 An anti cancer drug that belongs to the family of drugs called mitotic inhibitors. It inhibits the growth of cancer cells by preventing cell di vision . It usually affects the lungs , but it can affect other ...

Nausea

... and vomiting . It belongs to the family of drugs called antiemetics. dolastatin 10 An anti cancer drug that belongs to the family of drugs called mitotic inhibitors. MORNING SICKNESS - Also known as hyperemesis gravidarum . Recurrent nausea and vomiting often seen in the first 12 weeks of ...

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Mitotic in Biological News

Death, division or cancer? Newly discovered checkpoint process holds the line in cell division

... have discovered a novel activity, called the mitotic checkpoint factor 2 (MCF2). This appears to be ... J. Yen, Ph.D., senior member at Fox Chase. "The mitotic checkpoint is a complex series of quality control ... cells tend to bypass quality control, such as the mitotic checkpoint, so as to allow them to shuffle their ...

Is this the beginning of the end of plant breeding?

... are normally meiotic which make pollen and egg cells and are replaced by mitotic divisions. The work, by a team of researchers in France and Austria, is ... pairs of chromosomes while the second meiotic division is just like the mitotic di vision: the chromosomes line up at the middle of the new cell and the ...

Slicing chromosomes leads to new insights into cell division

... between the resulting daughter cells. Forces in a structure called the mitotic spindle guide the replicated chromosomes to opposing sides as one cell ... long, thin tubes that form a central component of the cytoskeleton and the mitotic spindle. They serve as intracellular structural supports and as railways ...

Double success for Instituto Gulbenkian de Ciencia scientists working on chromosome segregation

... same genetic information as their mother, with reduced risk of cancer. When segregating, chromosomes attach and move along proteins tracks (the mitotic spindle), from the centre of the cell to the poles. The centromere is the area of the chromosome that directs this attachment by controlling the ...

DNA template could explain evolutionary shifts

... mitosis or cell division, a significant finding that further confirms the significance of the event. The researchers noted that finding this mitotic rearrangement of the gene in the mother, who did not have the disorder, of two children with a neuropathy suggests that the mechanism might be ...

The downside of microtubule stability

... the researchers found that dynamin 2 was essential for the capture step, not for transportation. Dynamin 2 also clings to microtubules of the mitotic spindle, and the team next wants to determine whether the protein regulates microtuble dynamics during the cell cycle. ...
Mitotic in Biological Technology

JCI online early table of contents: March 6, 2008

... the SBDS protein was found to be located at the mitotic spindle, a structure that forms when a cell is ... of a cell. Consistent with a role for SBDS in mitotic spindle stability, BMSCs from individuals with ... the treatment of individuals with SDS. TITLE: mitotic spindle destabilization and genomic instability ...

Nerviano Medical Sciences Receives Approval From the FDA to Enter Phase I Clinical Trials for Their Polo Like Kinase (PLK) Inhibitor

... Nerviano Medical Sciences to begin a phase I clinical study with its selective PLK-1 small molecule inhibitor for the treatment of cancer. PLK-1 is a mitotic kinase required for the proliferation of cancer cells. This new compound is orally bioavailable, highly efficient and well tolerated in preclinical ...

Neuralstem Receives Final Notice of Allowance for New Stem Cell Immortalization Technology Patent

... this patent allows us to grow practically unlimited quantities of neural stem cells from all regions of the brain without regard to the natural mitotic (growth) limits of cells from a particular region. Equally important, this technology is a next-generation immortalization process that avoids the ...

RNAi Helps Illuminate the Inner Workings of the Cell Cycle: Synthetic RNAissance™ Genes Created by DNA2.0 Enable Key Research

... group was able to show that ubiquitination of Cdc20 is required to prevent a cell from dividing before all of its chromosomes are lined up on the mitotic spindle. This cell cycle checkpoint is essential to prevent serious genetic damage in animals from yeast to humans. "We were delighted to ...

EntreMed's MKC-1 Meets Primary Efficacy Endpoint in Non-Small Cell Lung Cancer Clinical Trial

... tumor growth inhibition or regression in multiple preclinical models, including paclitaxel-resistant models. MKC-1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase (mitosis) of the cell cycle, and induce apoptosis. Furthermore, MKC-1 inhibits the ...

Cephalon Receives FDA Approval for TREANDA, a Novel Chemotherapy for Chronic Lymphocytic Leukemia

... leads to cell death by a process known as apoptosis (programmed cell death) as well as by an alternate cell death (non-apoptotic) pathway known as mitotic catastrophe (a disruption of normal cell division). The exact mechanism of action of TREANDA remains unknown. In December 2007, Cephalon submitted ...

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Mitotic in Biological Products

Anti-MPM-2, phospho-Ser / Thr-Pro (Mitotic protein monoclonal #2) Antibody, Agarose Conjugated from Upstate

Description:... MPM-2, agarose conjugate Formulation: PBS with 0.05% sodium azide Quality Assurance: routinely evaluated by immunoprecipitating mitotic MPM2 antigens from colcemid treated human HeLa cells as shown by subsequent immunoblot using the monoclonal anti-phospho-Ser/Thr-Pro, MPM2 ...
Company:Upstate

Mouse Anti-Human XPMC2H Polyclonal Antibody, Unconjugated from Novus Biologicals

Description:... Mouse polyclonal antibody to REXO4 - XPMC2 prevents mitotic catastrophe 2 homolog (Xenopus ...
Company:Novus Biologicals
Mitotic in Biological Definition

Mitosis

... and nucleus of a cell in the process of mitotic division. (Schfer.) I to III, prophase; IV, ... of as cellular ropes or poles) and forming mitotic spindles . By increasing the length of the ... control this process by generating a signal - the mitotic spindle checkpoint - that tells the cell to ...

Mitosis

... and nucleus of a cell in the process of mitotic division. (Schfer.) I to III, prophase; IV, ... of as cellular ropes or poles) and forming mitotic spindles . By increasing the length of the ... control this process by generating a signal - the mitotic spindle checkpoint - that tells the cell to ...

Centromere

... centromere is a region of a eukaryotic chromosome where the kinetochore is assembled. Thus, it is the site where spindle fibers of the mitotic spindle attach to the chromosome during mitosis . It is also the site of the primary constriction visible in microscopy images of chromosomes. ...

Chromatid

... of mitosis or meiosis . Each chromosome consists of two exactly identical (" sister ") chromatids. After they have been pulled apart by the mitotic spindle , chromatids are called "chromosomes". Sister chromatids are joined at a point called the centromere . In non-gametic, non-dividing human ...

Cytoskeleton

... with dyneins and kinesins they transport organelles like mitochondria or vesicles .) the axoneme of cilia and flagella the mitotic spindle synthesis of the cell wall in plants. The prokaryotic cytoskeleton The cytoskeleton was previously considered to be a feature only ...

Meiosis

... earlier, meiotic nuclear division consists of two stages, called meiosis I and meiosis II . It starts with a cell in the same state as does a mitotic division. However, the alignment of chromosomes for prophase is different. Homologous chromosomes join into tetrads (so called because each tetrad ...

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Mitotic in Biological Dictionary

Prometaphase

... be divided into five phases. In prophase the mitotic spindle forms and the chromosomes condense. In ... and Nigg, 1996; Rapley et ... causes a delay in mitotic entry with subsequent arrest at prometaphase , ... cell enters prometaphase , during which the mitotic spindle ... Prometaphase I embryos ...

Mitotic spindle

... by cytokinesis, which divides the ... mitotic spindle n. The fusiform figure characteristic ... Bub3 is a conserved component of the mitotic spindle assembly complex. ... attachment of chromosomes to the mitotic spindle via the kinetochore is vital ... ...

Spindle Fibers

... Welcome Teachers and ... But microtubular spindle fibers and a mitotic process comparable to that of ... Titin in insect spermatocyte spindle ... plane (the metaphase plate) halfway between the spindle poles. ... The mitotic spindle contains the fibers (microtubules) responsible for ... ...

Sister Chromatids

... on paired sister chromatids and dissociates from them, as ... In mitotic cells, sister chromatids are held ... phenomenon, called sister - ... enables cells to ... of sister chromatids to opposite ... mitotic metaphase chromosomes show sister chromatids ... of sister - ...

S phase

... a chromatid. The enzyme ... S phase n. The phase of the mitotic cycle during which DNA synthesis occurs. ... During S phase , the ... . Pronunciation of S phase . ... S phase . noun. The phase of the mitotic cycle during which DNA ... S phase . ( 2009) ... Cell cycle articles ...

Prophase

... center ... The distinguishing feature of prophase is the setup of the mitotic spindle, ... ProPhase is a therapeutically focused training ... the free encyclopedia ... Mitosis: Prophase ... In prophase the mitotic spindle forms and the chromosomes condense. ... Aspects of the topic ...

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