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Mitosis in Medical News

Mitosis gets harder thanks to new gene discovery

... halves of the cell to slide apart. What makes mitosis so interesting is that it is one of the ... Natures most important processes, our interest in mitosis stems from the fact that if you want to kill ... drug target. During the different phases of mitosis the pairs of chromosomes within the cell condense ...

EntreMed Reports Second Quarter 2009 Financial Results

... shown to inhibit a distinct profile of angiogenic tyrosine kinase targets in addition to the Aurora A kinase. Aurora kinases are key regulators of mitosis (cell division), and are often over-expressed in human cancers. ENMD-2076 also targets the Flt-3 and FGFR3, kinases which have been shown to play ...

Molecule tracking reveals mechanism of chromosome separation in dividing cells

... on molecular machines and motors, Wordeman for work on chromosome movement, and Davis for studies of spindle poles. All are part of the Seattle mitosis Club led by Sue Biggins at the Fred Hutchinson Cancer Research Center. To understand how the kinetochore functions, the scientists sought to ...

EntreMed Focuses on Development of ENMD-2076

... profile of angiogenic tyrosine kinase targets in addition to Aurora A kinase and other oncogenic proteins. Aurora kinases are key regulators of mitosis (cell division), and are often over-expressed in human cancers. In addition, ENMD-2076 is relatively selective for the Aurora A isoform in comparison ...

Stem-cell sentry sounds the alarm to maintain balance between cancer and aging, U-M researchers find

... cell and one cell committed to develop into a specific tissue type such as a skin cell, a blood cell or, in this case, a sperm cell. That form of mitosis is called asymmetric division, and it's exactly what stem cells need to maintain a healthy balance between uncommitted and committed cells. Cell ...

Combination of 2 novel anti-cancer agents may help fight CML resistant to current therapy

... include MK-0457, a Bcr/Abl kinase inhibitor that also targets another protein called an aurora kinase. Aurora kinase plays an important role in mitosis and cell division. In preclinical studies, MK-0457 is active against the T315I Bcr/Abl mutation, a major cause of imatinib resistance, and has shown ...

Research shines spotlight on a key player in the dance of chromosomes

... the location and the timing of delivery. They are fueled by a small molecule, adenosine tri-phosphate (ATP). Some motor proteins are essential to mitosis the process by which cell division occurs in higher organisms. During cell division it is important for chromosomes to line up at the middle of the ...

Loss of Antenna Leads to Cancer in Insects

... has a role in controlling normal cell movement and tumor cell invasion. Golemis laboratory has also shown that Aurora A and HEF1 interact to initiate mitosis (chromosome separation) during cell division. Suggestively, many cancers produce too much of the Aurora A protein, including breast and ...

Sea Creature's Toxin Could Lead to Promising Cancer Treatment

... known drugs caused significant weight loss and loss of white blood cells while AB-5 caused neither side effect. “That the diazonamide toxin blocks mitosis selectively in cancer cells is almost too desirable an outcome to be true,” said Dr. Steven McKnight, chairman of biochemistry and senior author of ...
Mitosis in Medical Technology

Entremed Presents Results of ENMD-2076 Phase 1 Study in Advanced Cancer Patients

... shown to inhibit a distinct profile of angiogenic tyrosine kinase targets in addition to the Aurora A kinase. Aurora kinases are key regulators of mitosis (cell division), and are often over-expressed in human cancers. ENMD-2076 also targets the Flt-3 and FGFR3, kinases which have been shown to play ...

EntreMed Presents Initial Clinical Results for ENMD-2076

... profile of angiogenic tyrosine kinase targets in addition to Aurora A kinase and other oncogenic proteins. Aurora kinases are key regulators of mitosis (cell division), and are often over-expressed in human cancers. ENMD-2076 targets a defined set of kinases, including Flt-3 and FGFR3, which have ...

EntreMed Receives New Patent for 2-Methoxyestradiol Analogs

... fronts -- directly by disrupting microtubules, an intracellular matrix necessary for the rapid division of cancer cells, through inhibition of mitosis and induction of apoptosis, and by blocking blood vessels that feed tumors (angiogenesis inhibition). U.S. Patent No. 7,371,741 entitled "Estradiol ...

EntreMed Presents Data for Phase 2 Study of MKC-1 in Metastatic Breast Cancer

... of action, which involves inhibition of the Akt-mTOR pathway, binding importin-b and tubulin, cell cycle arrest, and apoptosis. MKC-1 arrests mitosis by inhibiting an intracellular target important in cellular trafficking that has been shown to be involved in cell division. MKC- 1 has been shown to ...

Cytokinetics Announces Non-clinical Data to be Presented at the 2007 AACR Annual Meeting

... these drugs target tubulin, a cytoskeletal protein involved not only in mitosis and cell proliferation, but also in other important cellular ... represent the next generation of anti-mitotic cancer drugs by arresting mitosis and cell proliferation without impacting unrelated, normal ...

EntreMed's Aurora Kinase Inhibitor Induces Tumor Regression in Preclinical Models

... been shown to inhibit a unique profile of angiogenic tyrosine kinase targets in addition to the Aurora kinases. Aurora kinases are key regulators of mitosis (cell division), and are often over-expressed in human cancers. ENMD-981693 is selective for the Aurora A isoform in comparison to Aurora B. ...

Cytokinetics Reports Additional Clinical Trials Data for Ispinesib

... that drugs that inhibit KSP and CENP-E and other mitotic kinesins may represent the next generation of anti-mitotic cancer drugs by arresting mitosis and cell proliferation without impacting unrelated, normal cellular functions, thereby avoiding many of the toxicities commonly experienced by ...
Mitosis in Biological News

Is this the beginning of the end of plant breeding?

... The first steps of both meiosis and mitosis are the replication of the dividing cell's DNA. ... condense into tightly bound structures, and in mitosis these form an X shape in which each half of the X ... centre of the X. Thus the differences between mitosis and meiosis are that meiosis has two rounds of ...

Death, division or cancer? Newly discovered checkpoint process holds the line in cell division

... 250 million cells in your body are undergoing mitosis in order to replenish cells that die as a result ... Technion, discovered the ability of MCF2 to block mitosis by shutting down an ubiquitin ligase enzyme known ... proteins themselves are faulty, however, mitosis results in aneuploidy, the loss or gain of ...

UCSB scientists show how certain vegetables combat cancer

... drugs taxol and vincristine inhibit cell division during mitosis. mitosis is the process in which the duplicated DNA in the form of chromosomes is ... powerful anticancer agents, interferes with microtubule functioning during mitosis in a similar manner to the more powerful anticancer drugs. However SFN is ...

DNA template could explain evolutionary shifts

... others that resulted from shuffling within an exon. Studies of one family two children and a mother demonstrated that the event occurred during mitosis or cell division, a significant finding that further confirms the significance of the event. The researchers noted that finding this mitotic ...

Scientists deconstruct cell division

... Baltimore, MDThe last step of the cell cycle is the brief but spectacularly dynamic and complicated mitosis phase, which leads to the duplication of one mother cell into two daughter cells. In mitosis, the chromosomes condense and the nucleus breaks down. ...

Mutant host cell protein sequesters critical HIV-1 element

... transcriptase, providing a better treatment outcome," explains Dr. He. The researchers found that a mutant form of Src-associated protein in mitosis of 68kDa (Sam68), a host cellular protein involved in HIV-1 pathogenesis, specifically interacts with nef mRNA and directly suppresses Nef ....

Proteins strangle cell during division

... squeezes the cell into two so that two new daughter cells are formed. At first it looks like mitosis, as discussed in many a biology lesson. However, mitosis is the process whereby the chromosomes are distributed between the two daughter cells. Cell division is the process whereby the two daughter cells ...

Cholesterol-lowering drugs and the effect on muscle repair and regeneration

... of the study was to determine SC viability during proliferation when treated with statins which may be indicative of the ability of SCs to undergo mitosis (i.e. divide to make new cells). The research team used primary cell lines isolated from quadriceps muscle biopsies. SC were mixed and grown for ...

How chemo kills tumors: research to reduce side effects

... race starts between two competing cellular signalling networks. One network is trying to kill the cell, the other is trying to cause the cell to exit mitosis and thus allow the cell to survive. The winner of the race decides the fate of the cell; death or survival. "The factors influencing the race not ...

How molecular muscles help cells divide

... and how all the pieces get to the right place to get the job done. Time-lapse imaging and computer modeling demonstrated that cells undergoing mitosis set up small clusters of proteins, or nodes, on the inside of the cell membrane around the equator of the cell. Proteins in these nodes begin to put ...
Mitosis in Biological Technology

EntreMed ENMD-2076 Phase 1 Data to Be Presented at ASCO Annual Meeting

... profile of angiogenic tyrosine kinase targets in addition to Aurora A kinase and other oncogenic proteins. Aurora kinases are key regulators of mitosis (cell division), and are often over-expressed in human cancers. ENMD-2076 targets a defined set of kinases, including Flt-3 and FGFR3, which have ...

EntreMed Initiates ENMD-2076 Clinical Trial in Multiple Myeloma

... profile of angiogenic tyrosine kinase targets in addition to Aurora A kinase and other oncogenic proteins. Aurora kinases are key regulators of mitosis (cell division), and are often over-expressed in human cancers. In addition, ENMD-2076 is relatively selective for the Aurora A isoform in comparison ...

Assessing Gene Function with siRNA Libraries

... to monitor the percent of cells undergoing mitosis at any given point in time, with and ... the fraction of time that cells spend in mitosis versus the rest of the cell cycle. ... with a control scrambled siRNA, undergoing mitosis (mitotic index range of 2.1 to 2.3). ...

Quantitative Analysis of the Cell Cycle in Imaging Applications

... commit to DNA synthesis (S phase) and replicate their chromosomal DNA. The G2 phase (second gap) follows when cells continue to grow and prepare for mitosis (M phase, division). The G2 gap allows time for the cell to complete its DNA replication before initiating mitosis. During mitosis, the ...

Identification of cells in S phase using the Cell Proliferation Fluorescence Kit and IN Cell Analyzer 1000

... by their pink nuclei.

Figure 2 depicts the effect of Mitomycin C (MMC), a cytostatic drug that inhibits mitosis causing cells to accumulate in G2 phase of the cell cycle. Cells were incubated with increasing concentrations of MMC (as indicated below each set of ...

Analysis of in vitro micronucleus assays using the IN Cell Analyzer 3000 Micronuclei Formation Analysis Module

... cells with micronuclei. As cells are exposed to higher doses of compounds, cell cycle inhibition and cytotoxicity results in cell arrest prior to mitosis preventing micronuclei formation, with a resulting drop in micronuclei frequency at higher compound doses. This is evident from examination of ...

siRNA screening of the cell cycle with two dynamic GFP sensors (from Discovery Matters Issue 1, July 2005)

... gene knockdown. For example, treatment of cells with cyclin A2 siRNA (CCNA2) resulted in a significant accumulation of cells in prophase and mitosis to a similar degree to that observed for cyclin B1 (CCNB1), corresponding with the requirement for cyclin A for G1/S and G2/M transitions. In ...

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Mitosis in Biological Products

PPase-2A from Promega

Description:... catalytic subunit, PPase-2A has broad substrate specificity and may play a regulatory role in DNA replication, transcription, protein synthesis, mitosis and glycogen metabolism. PPase-2A is stimulated in vitro by basic proteins such as protamine, histones and polylysine. The enzyme is inhibited by ...
Company:Promega
Mitosis in Biological Definition

Cell growth

... Eukaryotic cell reproduction either involves mitosis or a more complex process called meiosis . mitosis and meiosis are sometimes called the two " ... articles on DNA replication , binary fission , mitosis , meiosis , and cytokinesis . The rest of this ...

Meiosis

... hydras ). The mechanistic differences between mitosis , which produces somatic cells, and meiosis, is best understood by considering mitosis first. (All jargon used in this article is defined in the article on mitosis .) As described earlier, meiotic nuclear ...

Mitosis

... Overview of the major events in mitosis In biology , mitosis is the process of chromosome segregation and ... of the organism's genome. In most eukaryotes mitosis is accompanied with cell division or ...

Prophase

... Prophase is a stage of mitosis . In prophase the genetic material ( DNA ), which ... but are called chromosomes again. The task of mitosis is to assure that one copy of each sister ... The other important piece of hardware in mitosis is the centriole , which serves as a sort of ...

Mitosis

... Overview of the major events in mitosis In biology , mitosis is the process of chromosome segregation and ... of the organism's genome. In most eukaryotes mitosis is accompanied with cell division or ...

Cell division

... Eukaryotic cells usually undergo a process of nuclear division, called mitosis , followed by division of the cell, called cytokinesis . A diploid ... Cell cycle Cell growth External link How Cells Divide: mitosis vs. Meiosis ...

Anaphase

... Anaphase ( Greek : ανά = up and φάσις = stage) is the stage of meiosis or mitosis when chromosomes separate. Each chromatid moves to opposite poles of the cell (opposite ends of the nuclear spindle ). Anaphase is preceded by ...

Apoptosis

... to the proliferation and subsequent destruction of a mass of cells equal to an individual's body weight. Homeostasis is achieved when the rate of mitosis (cell proliferation) in the tissue is balanced by cell death. If this equilibrium is disturbed, either of two things happen: The cells are ...

Cancer

... suppressor genes. In general, mutations in both types of genes are necessary, as a mutation limited to an oncogene would be suppressed by normal mitosis control. Mutations can have various causes. Particular causes have been linked to specific types of cancer. Tobacco smoking is associated with ...

Cartilage

... of the cartilage model. Interstitial Interstitial growth results in an increase of cartilage mass and occurs from within. Chondrocytes undergo mitosis within their lacuna but remain imprisoned in the matrix, which results in clusters of cells called isogenous groups . Cartilage in fetal ...

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Mitosis in Biological Dictionary

Telophase

... (stage), is a stage in either meiosis or mitosis in an eukaryotic cell reversing the effects of ... column. ... telophase n. The final stage of mitosis or meiosis during which the chromosomes of ... Compendium (Redirected from Telophase ) ... mitosis is the process during which an eukaryotic cell ....

Prophase

... Prophase is a stage of mitosis in which the chromatin condenses into a highly ... 2009 prophase ent. ... The first stage of mitosis is known as the prophase , where the nuclear ... DNA strands slowly ... Genetics: stages of mitosis ... Prophase - Wikipedia, the free ...

Prometaphase

... Prometaphase is the phase of mitosis following prophase and preceding metaphase, in ... prometaphase , metaphase, anaphase and ... mitosis (Preprophase, Prophase, Prometaphase , ... cell division ( in cell (biology): mitosis and cytokinesis ...

Mitosis

... mitosis is the process in which a eukaryotic cell ... divides the ... (Click to enlarge) mitosis (Academy Artworks) mitosis n. Biology. , pl. -ses. ... During ...

Kinetochore

... apart. Prometaphase is the phase of mitosis following prophase and preceding metaphase, in ... assembles the kinetochore during meiosis and mitosis ... concluded that Cid directs kinetochore ... by ... Perhaps most recognizable phase of mitosis is termed metaphase where the chromosomes, ...

Karyokinesis

... (Redirected from Karyokinesis ) ... mitosis is the process in which a eukaryotic cell ... from Biology-Online.org dictionary. ... mitosis = karyokinesis + cytokinesis I think what ... division of the nucleus of a cell during mitosis or ... What is the difference between ...

Haploid gametophyte

... phases, known ... Haploid cells undergo mitosis to produce a gametophyte . ... A haploid ... gametes ... Haploid cells undergo mitosis to produce a gametophyte . ... A haploid ... by mitosis. ... Haploid cells undergo mitosis to produce a gametophyte . The gametophyte ...

Daughter Cell

... cycle. This type of cell division ... mitosis is the process in which a eukaryotic cell ... the number of daughter cells produced from mitosis and meiosis differ? ... Isogamy: algal ... another. ... Daughter cells produced by mitosis either maintain their ability ... Cytokinesis ...

Cytokinesis

... of cytokinesis . ... Cytokinesis . mitosis ... Cytokinesis ... Thus a special term, ... of a cell into two. ... In biology, mitosis is the process by which a cell separates its ... late anaphase or early telophase (before mitosis ends), as the ... Mitosis, process in which a ...

Cell nucleus

... the nucleus (pl. ... cell is going through mitosis and its nucleus has ... A drawing of a cell ... separates the cell's genetic material ... mitosis divides the chromosomes in a cell nucleus . ... to migrate into the center of the cell before mitosis can ... The cell nucleus and its content. ...

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