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Mitochondrial in Medical News

Cell Protein Could Help Spur Malignancy

... results open the possibility that inhibiting the mitochondrial function of STAT3 could be a promising cancer ... university's medical school. "By knowing this mitochondrial function is critical, it may be possible to ... Levy and his team made the discovery about the mitochondrial role of STAT3 by analyzing tumors caused by the ...

Research points to a new way to protect kidneys threatened by insufficient blood or toxins

... renal failure may be possible by blocking the mitochondrial fragmentation that occurs when kidneys don't get ... and leads to acute renal failure. "When mitochondrial fragmentation is blocked, it can save the cells ... in the cell, work together to make pores in the mitochondrial outer membrane. Cytochrome c, a protein that ...

Key protein in cellular respiration discovered

... codes for a protein (TFB1M) that is essential to mitochondrial protein synthesis. If TFB1M is missing, ... from progressive heart failure and increase mitochondrial mass, which is similar to what we find in patients with mitochondrial diseases." The scientists believe that the ...

JCI online early table of contents: April 6, 2009

... Augusta, have now provided new insight into the mitochondrial changes that occur in acute rodent kidney injury, ... protein Drp1, which is known to be involved in mitochondrial fission, and blocking its function substantially reduced mitochondrial fragmentation and apoptotic cell death. ...

Naturally fluorescent molecules may serve as cancer biomarker

... living cells, we should be able to monitor the mitochondrial activity and thus the integrity of any given ... a known inhibitor of some of these critical mitochondrial enzymes. The researchers found that the NADH ... Other neurodegenerative diseases related to mitochondrial anomalies can also be detected with our method," ...

Seahorse XF96 Extracellular Flux Analyzer Wins Best New Product Award for DRUG DISCOVERY at 2009 Molecular Medicine Conference

... analytical instrument for the kinetic measure of mitochondrial oxygen consumption and cytoplasmic glycolysis in ... Compound Safety Prediction Group, who spoke about mitochondrial toxicity at the conference and one of the first ... diabetes, ageing and cancer, and to screen for mitochondrial toxicity. The XF96 Analyzer offers the ...

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Mitochondrial in Medical Technology

Seahorse Bioscience Announces the XF96 Extracellular Flux Analyzer for Cellular Bioenergetics

... instrument for the kinetic measurement of mitochondrial oxygen consumption and cytoplasmic glycolysis in ... us to quantify subtle changes in ATP turnover, mitochondrial uncoupling or respiratory chain inhibition that ... pathways." Martin Brand, a leading mitochondrial researcher from the Buck Institute, Novato, CA ...

New Research Shows One in 200 People Born with DNA Mutation That Can Lead to Devastating, Often Fatal Disease

... Mutation Causing mitochondrial Disease More Common Than Previously Believed ... disease in them or their offspring. mitochondrial disease is a devastating and often fatal disease, and mitochondrial disorders are at the core of many well known ...

Medivation Presents Positive New Data on Dimebon's Long-Term Efficacy and Novel Mechanism of Action at the International Conference on Alzheimer's Disease

... Medivation presented new data on Dimebon's novel mitochondrial mechanism of action. Mitochondria generate energy ... roles in mediating cell function and survival. mitochondrial dysfunction has been linked in the ... data presented showed that Dimebon improves mitochondrial function in the setting of cellular stress with ...

Edison Pharma Hits Milestone as A0001 Enters Phase 1 Clinical Development

... Targeting inherited mitochondrial diseases as an archetype for diseases of ... energy metabolism. Children with inherited mitochondrial defects clinically present with many conditions ... with aging. Edison believes that inherited mitochondrial diseases may be genetic roadmaps to deciphering ...

Transgenomic Establishes Collaboration With the National Cancer Institute to Investigate Mitochondrial Genome and Associated Nuclear Genes in Cancer Cell Lines

... mutational analysis and sequencing of the mitochondrial genes in the NCI 60 cancer cell line panel. mitochondrial damage is increasingly recognized as an early ... This is the first comprehensive evaluation of the mitochondrial genome in the NCI 60 panel. The data from this ...

Michael J. Fox Foundation Awards Up to $3 Million to Industry Teams to Jumpstart Promising PD Drug Development

... factories' of body cells. It is believed that mitochondrial function is decreased in people with Parkinson's disease and that mitochondrial toxins induce parkinsonian symptoms in ... are developing unique compounds that improve mitochondrial function and that are currently being evaluated ...

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Mitochondrial in Medical Dictionary

Fatigue

... Prolonged exposure can lead to brain damage and even death . 1 2 ... mitochondrial TOXIC ITY: Damage to the mitochondria, often characterized by muscular ... conditions, such as lactic acidosis . Nucleoside analogs may cause mitochondrial toxic ity. Deficient activity of the pituitary gland causing slowed ...

Lead

... cells but not in melanocytes (pigment-producing cells of the skin ). mitochondrial TOXIC ITY: Damage to the mitochondria, often characterized by muscular ... conditions, such as lactic acidosis . Nucleoside analogs may cause mitochondrial toxic ity. These are the facts and the reasons that lead us to ...

Carcinoma

... : A malignant tumor . CARDIOMYOPATHY : A disease of the heart muscle s. CARNITINE: A compound involved in transferring fatty acids across mitochondrial membrane s. carcinoma in situ (KAR-si-NO-ma in SYE-too) Cancer that involves only the cells in which it began and that has not spread to ...

Cardiomyopathy

... include: ... CARDIOMYOPATHY : A disease of the heart muscle s. CARNITINE: A compound involved in transferring fatty acids across mitochondrial membrane s. CARDIOMYOPATHY (Keshan Disease , Muscular Dystrophy of the Heart ) CAUSES AND TREATMENT "The word means " heart muscle ...

Enzyme

... seeds, bread, fish and meat (especially pork) Chromium ... UbiQGel (co enzyme Q10) Orphan drug status granted by the FDA for the treatment of mitochondrial cytopathies. Mfg: Tishcon Corporation. Source: PR Newswire - 07/25/00. Amylase is an enzyme that is filtered out of the blood by the kidney ...

Lactic acidosis

... , glucagon , fructose , or sorbitol. Antifreeze poisoning can also cause lactic acidosis . Effect of co enzyme Q10 in patients with mitochondrial myopathy , encephalopathy, lactic acidosis , and stroke -like episodes (MELAS): evaluation by noninvasive tissue oximetry. J Neurol.Sci. ...

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Mitochondrial in Biological News

Stress signals link pre-existing sickness with susceptibility to bacterial infection

... mitochondrial diseases disrupt the power generating machinery ... of a signaling protein that is associated with mitochondrial disease. Patients with mitochondrial disease exhibit a wide range of symptoms ...

Scientists discover gene mutation responsible for hereditary neuroendocrine tumor

... yeast Saccharomyces cerevisiae, in order to study mitochondrial functions before going back to humans and ... Following this strategy, we first characterized a mitochondrial protein called Sdh5 in yeast and then moved on to ... potential role in human disease." Sdh5 is a mitochondrial protein that is highly conserved, meaning that it ...

Bad mitochondria may actually be good for you

... Mice with a defective mitochondrial protein called MCLK1 produce elevated amounts of ... slower rate and live longer than normal mice. mitochondrial oxidative stress is a popular theory explaining ... as they age a finding that seems to indicate the mitochondrial stress theory may not be correct. ...

How mitochondria get their membranes bent

... of great relevance to a better understanding of mitochondrial function in general. Recently, in cooperation ... Reichert, who has been appointed as professor for mitochondrial Biology to the Goethe University within the ... as we have for the first time found out how mitochondrial ultrastructure is regulated and which components ...

HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection

... dismutase (Cu/Zn SOD) and glutathione, whereas mitochondrial SOD levels remained unaffected in pancreatic ... (INS-1 cells) exposed to nelfinavir. However, the mitochondrial uncoupling protein (UCP2) levels were ... component) it is likely that it may act as a mitochondrial antioxidant. Indeed pretreatment of pancreatic ...

UMMS researchers publish DNA identification of czar's children

... he and his colleagues completed basic studies of mitochondrial DNA inherited through the maternal lines and ... Yuri Moliaka, were able to determine the complete mitochondrial genome sequences from the remains. After doing ... Rogaev and colleagues reconstructed the complete mitochondrial genome sequences from the remains and, analyzing ...

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Mitochondrial in Biological Technology

MEDomics Announces MitoDx(TM), the First NextGen Mitochondrial Genome Diagnostic Test

... Genetic Test Provides Early Diagnosis of mitochondrial Diseases LOS ANGELES, June 9 /PRNewswire/ -- ... an innovative test for early diagnosis of mitochondrial diseases, a group of disorders that can result in ... blindness, deafness, and diabetes. The MEDomics mitochondrial genome test, MitoDx(TM), uses the revolutionary ...

New Cellular Bioenergetics Workshops Series Inaugurated by Seahorse Bioscience with Two of the World's Leading Bioenergetics Researchers

... Bioscience, Inc. to organize an advanced XF mitochondrial workshop and will share their years of experience ... learning experience with the world's leaders in mitochondrial physiology." "The workshop will help ... Buck Institute for Age Research specializing in mitochondrial dysfunction. He is also a visiting Professor in ...

Transgenomic Completes Licensing Option With Dana-Farber Cancer Institute on Cold-PCR for Enrichment of DNA Mutations

... products for mutation detection in cancer and mitochondrial diseases," said Eric Kaldjian, CSO at ... It could also have application in analysis of mitochondrial DNA heteroplasmies." "We are delighted to ... resistance and relapse as well as expanding our mitochondrial DNA toolbox." Technical Information ...

Medivation Reports Fourth Quarter and Year-End 2008 Financial Results and Provides Corporate Update

... that Dimebon potentially stabilizes and improves mitochondrial function in a way that prevents neuron death and ... , which quantified the impact of Dimebon on mitochondrial function. Responses were seen on mitochondrial function at low concentrations of Dimebon across ...

'Museomics' yields new insights into extinct Tasmanian tiger

... an international team of scientists has sequenced mitochondrial and nuclear DNA from the hair of the male ... 70 years later. In addition to using the mitochondrial genome sequence to study the phylogeny of the ... about even bigger projects. "The large amount of mitochondrial and nuclear DNA gained in our study demonstrates ...

Medivation Presents New Data on Dimebon's Novel Mechanism of Action

... it promoted neurite outgrowth and it preserved mitochondrial function after brain cells were challenged with ... beta amyloid, Dimebon was shown to stabilize mitochondrial function, a vital element of neuron function and ... progression of Alzheimer's disease by preserving mitochondrial function. This potential novel mechanism may help ...

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Mitochondrial in Biological Products

MitoPT Detection of Mitochondrial Permeability from B-Bridge International

Description:... If the cell is not undergoing apoptosis, the mitochondrial DY will be intact, and the MitoPT reagent will ... and fluoresce red. If the cell is apoptotic, the mitochondrial DY will be breaking down, thereby causing the ... are referred to as J-aggregates (8). When the mitochondrial DY collapses in apoptotic cells, the MitoPT ...
Company:B-Bridge International

MitoLight Mitochondrial Apoptosis Detection Kit from CHEMICON

Description:... Disruption of the mitochondrial transmembrane potential is one of the earliest ... a lipophilic cation, termed as MitoLight, as a mitochondrial activity marker. MitoLight is a mitochondrial dye that stains mitochondria in living cells in a ...
Company:CHEMICON

APO LOGIX - JC-1 Mitochondrial Membrane Potential Detection Kit from BACHEM

Description:... In situ detection of apoptosis and mitochondrial membrane potential. The mitochondrial permeability transition event provides an early ... in the electrochemical gradient across the mitochondrial membrane, as measured by the change in the ...
Company:BACHEM

Isolated Mitochondria Staining Kit from Sigma-Aldrich

Description:... intactness and detects events that dissipate the mitochondrial membrane potential. Features and Benefits: ... reagents required for the detection of changes in mitochondrial inner-membrane electrochemical potential ... the antibiotic Valinomycin that permeabilizes the mitochondrial membrane, and thus, dissipates ...
Company:Sigma-Aldrich

Mito Casp from BACHEM

Description:... A simultaneous dual parameter assay for mitochondrial membrane potential detection and poly caspase activity. Active caspases ... covalently to the active caspases within the cells. At the same time the mitochondrial membrane potential is visualized by a cell-permeable cationic red ...
Company:BACHEM

MitoLightApoptosis Detection Kit from CHEMICON

Description:... Disruption of the mitochondrial transmembrane potential is one of the earliest intracellular events that ... Detection Kit utilizes a lipophilic cation, termed as MitoLight, as a mitochondrial activity marker. MitoLight partitions differently in healthy cells than in ...
Company:CHEMICON

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Mitochondrial in Biological Definition

Apoptosis

... or its mouse homolog, called DIABLO), a mitochondrial protein, is released into the cytosol . SMAC ... understood. But it has been found that a mitochondrial outer-membrane protein, VDAC2, interacts with BAK ... VDAC2: BAK and BAX are activated, and the mitochondrial outer-membrane becomes permeable, aparently these ...

ATP synthase

... particles of 9 nm diameter that pepper the inner mitochondrial membrane. They were originally called elementary ... , were ATP synthase is located in the inner mitochondrial membrane (so that F 1 -part sticks into mitochondrial matrix, were ATP synthesis takes place). ...

Electron transfer chain

... humans, an ETC is found spanning the inner mitochondrial membrane and accepts electrons from electron ... , shuttles these electrons from within the mitochondrial matrix across the inner mitochondrial membrane into the intermembrane space, where the ...

Human

... During the 1990s , variations in human mitochondrial DNA were recognized as a valuable source for ... Since the human embryo normally takes its mitochondrial DNA from its mother's egg and not from the sperm , variations in human mitochondrial DNA provide a means of identifying those ...

Mitochondrion

... 1 Mitochondrion structure 1.1 The mitochondrial membranes 1.2 The mitochondrial matrix 2 mitochondrial functions 2.1 Energy conversion ...

Mitochondrion

... 1 Mitochondrion structure 1.1 The mitochondrial membranes 1.2 The mitochondrial matrix 2 mitochondrial functions 2.1 Energy conversion ...

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Mitochondrial in Biological Dictionary

Nuclear genome

... ") but can ... from their chloroplast and mitochondrial genomes to their nuclear chromosomes. ... ... in a haploid ... from their chloroplast and mitochondrial genomes to their nuclear chromosomes. ... ... sequence ... Pattern of Organization of Human mitochondrial Pseudogenes in the Nuclear Genome ... ...

MtDNA

... mitochondrial DNA ( mtDNA ) is the DNA located in organelles ... organisms is found in the cell nucleus. mitochondrial DNA was discovered by Margit M. K. Nass and ... mitochondrial Eve (mt-mrca) is the name given by researchers to ...

Mitochondrial membrane

... as "cellular ... The outer mitochondrial membrane , which encloses the entire organelle, ... channel (about 2-3 ... exact: inner mitochondrial membrane . Definition ... 0031966 : mitochondrial membrane [1599 gene products] GO:0005743 : ...

Mitochondrial DNA

... mitochondrial DNA (mtDNA) is the DNA located in organelles ... organisms is found in the cell nucleus. mitochondrial DNA was discovered by Margit M. K. Nass and ... Human mitochondrial genetics is the study of the genetics of the ...

Maternal inheritance

... termed maternal (mitochondrial) inheritance . mitochondrial ... Maternal , inheritance ,biologica ... ... This maternal inheritance of mitochondrial DNA ... Maternal inheritance . Synonym(s) ... evolution confirm maternal inheritance of mitochondrial DNA. Maternal inheritance looks very much ...

Intermembrane space

... to that of the content of the cytoplasm. mitochondrial intermembrane space . Term information. Term lineage. External references ... GO:0005758 : mitochondrial intermembrane space [161 gene products] ... ... European Bioinformatics Institute ... GO:0005758 mitochondrial intermembrane space ... ...

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