microtubules

Liposome finding implies electrical effect on cell development

... through optical and scanning electron microscopy, microtubules were observed to immediately form and extend from the phospholipid balloon, like a seed putting forth a stalk or root. Hayes believes that the phenomena may have significant implications for both cellular biology and for nanotechnology. "This findin...

Key mechanism in genetic inheritance during cell division identified

...hat the kinetochore proteins form rings around the microtubules and this ring formation promotes microtubule assem...chromosome to each daughter cell. After which, the microtubules again disassemble and reform back into skeletal systems for the two new daughter cells. It has been ...

The making and breaking of microtubules

...th and shrinkage is key to the diverse workings of microtubules in the cell. For the first time, researchers have...onal structures of tubulin (the protein from which microtubules are formed) during the assembly and disassembly of microtubules. Details of these peculiar structure...

Gene controls whether fear is a factor

...the brain needs to quickly disassemble and rebuild microtubules to form connections where they are needed," Shumya... in the amygdala, leading to the overproduction of microtubules in certain areas. In essence, the cells lose their flexibility." Indeed, the researchers found impa...

Marathon of nano-sprinters

... of the cell. Kinesin and dynein motors move along microtubules and myosins move along actin filaments. The step s...tips of our fingers and toes. Within such an axon, microtubules provide the tracks along which molecular motors transport their cargo, such as vesicles filled with ...

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microtubules at Biology Products

Mouse Anti-MAP1 Light Chain Monoclonal Antibody, Unconjugated, Clone E12 from GeneTex

...ns which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Immunogen...

microtubules at Biology Technology

Assessing Gene Function with siRNA Libraries

... correct, functional interactions between spindle microtubules and kinetochores in preparation for metaphase and subsequent anaphase onset. A second kinase siRNA that also generated cells in mitotic arrest induced the formation of aberrant s...

A Screen of shRNAs Targeting Tumor Suppressor Genes to Identify Factors Involved in Paclitaxel Sensitivity

...ol-Meyers Oncology) functions by stabilization of microtubules so they cannot depolymerize. It effectively shifts the equilibrium in cells towards microtubule assembly, disrupting the normal operation of the microtubule network and thereby arresting the mitotic process. Treatment with paclitaxel alon...

Glossary for The BioPharm Guide to Fermentation and Cell Culture

...o small to be seen by the naked eye. microtubules Cellular organelles common in microorganisms: thin tubes that make structures involved in cellular movement. mitochondria Animal-cell organelles that reproduce using their own DNA. They metabolize nutrients to provide the cell ...

microtubules at Biology Definition

Tubulin

Tubulin is the protein which makes up microtubules . Microtubules are assembled from dimers of &alp...lin binds GTP and assembles onto the (+) ends of microtubules in the GTP-bound state. Once assembled into microtubules, it hydrolyzes GTP into GDP. The GDP-boun...

Mitosis

...somes of the cell serve as organizing centers for microtubules . During prophase, the two centrosomes — whi... independently of mitosis — begin recruiting microtubules (which may be thought of as cellular ropes or poles) and forming mitotic spindles . By increasing t...

Quaternary structure

...ary structure. Examples include nucleosomes and microtubules . Changes in quaternary structure are called conformational changes . It is through such changes, which underlie cooperativity and allostery in "multimeric" enzymes, that many proteins undergo regulation and perform their physiological function....

Pseudopod

...s , are thin pseudopods contain complex arrays of microtubules and are enveloped by cytoplasm . Axopodia are responsible for phagocytosis, by rapidly retracting in response to physical contacts. Reticulopodia , also known as reticulose pseudopods , are complex formations where individual pseudopods are blen...

Prophase

...icate independently of mitosis - begin recruiting microtubules (which may be thought of as cellular ropes or poles) and forming a mitotic spindle between them. By increasing the length of the spindle (growing the microtubules), the centrioles push apart to opposite ends of the cell nucleus. See also prom...

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microtubules at Biology Dictionary

Vesicle

...l article >>> Vesicle s may follow microtubules to their destination. Proteins within the membrane of the vesicle recognize and attach to proteins in other membranes . Full article >>> vesicle s Membrane-bound particles pinched off by constriction of a membrane, as in the ...

Tubulin

Tubulin is the protein which makes up microtubules . Microtubules are assembled from dimer s of &a...2; tubulin s The protein subunits from which microtubules are assembled. tumor suppressor genes Genes that normally keep cell division under control, pre...

Trans

...cle >>> Cytoskeleton - network of microtubules that support and give structure to cell while aiding in intracellular trans port Cytosol - jelly-like material that contains the organelles between the nucleus and the plasma membrane ... Full article >>> Back trans lati...

Sporozoan

...embers of this group share an "apical complex" of microtubules at one end of the cell (hence the name that many prefer to the old name of sporozoan s). All the members of the phylum are parasites . Full article >>> Sporozoan s Members of this group cause malaria and toxoplasmosis. The life...

Spirilla

...s believe that cilia, flagella, centrioles , and microtubules may have come from a symbiosis between a spirilla -like bacterium and an early eukaryotic cell . Full article >>>...

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microtubules at Medicine News

Discovery of Agile Molecular Motors Could Aid in Treating Motor Neuron Diseases

...walking across it, but in the cell it’s different: microtubules are packed together, with proteins studded along them, and cellular organelles and mitochondria are crammed in. The motor needs to maneuver around those ‘obstructions.’” Goldman and Holzbaur suggest that the ability of the dynein-dynactin motor to mo...

Research in the Origin of Microtubules

...nizing center (MTOC). From the MTOC, the growing microtubules launch out in all directions to the cell's periphe...al distribution that causes cells to move. While microtubules in some specialized cells can originate from non-centrosomal structures, the centrosome has been con...

A new century of Alzheimer's disease research

... lot about tau, which helps stabilize the roadlike microtubules that run inside nerve cell bodies. In the world of...inside neurons changes; they begin to come off the microtubules they had once supported, and bind together into paired and twisted filaments. “The hypothesis is tha...

microtubules at Medicine Products

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Myriad Genetics Presents Azixa's Mode of Action at AACR

...iting the formation ofmicrotubules. Tumors rely on microtubules to maintain thecytoskeletal structure of their new vasculature, whereas maturevascular endothelium of healthy tissue uses actin filaments toprovide the needed structure. Therefore, tumor vasculature isselectively targeted, leaving healthy normal tiss...

EntreMed Presents Multi-Mechanism Antitumor Data for ENMD-1420 in Preclinical Models

...otility. Given their primaryrole in cell division, microtubules have been an important targetfor anticancer drugs -- often referred to as tubulin inhibitors ormicrotubule targeting agents. These compounds bind to tubulinprotein, either in the monomer form or polymerized in microtubules,and prevent cancer cell pro...

ZIOPHARM Presents Unique Mechanism Data for Indibulin at AACR

...specific tubulin and does not disrupt normalaxonal microtubules in vitro, likely accounting for the differencewith...nd vinca alkaloids, interferes withthe function of microtubules by binding to their building blocks,tubulin. However, the specific tubulin binding site for indibuli...

microtubules at Medicine Dictionary

Organ

...ing center in this cell , organ izing all of the microtubules of the mitotic and meiotic spindles, and is therefore the yeast equivalent of the centrosome found in vertebrate cells. Full article >>> Carcinoma A type of cancer that starts in the skin or the lining of organ s. Adenocarcin...