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Micronucleus in Medical News

New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes

... ovary (CHO) chromosome aberration assay, an in vitro cytogenetics assay in CHO, an in vitro rat hepatocyte DNA alkaline elution assay, and an in vivo micronucleus assay. rat fertility studies with oral gavage doses of 125, 250, and 1000mg/kg, males were treated for 4 weeks prior to mating, during mating, ...

TetraQ recognized for toxicology services

... toxicology services include cytotoxicity assays, genotoxicity assays - bacterial mutation (Ames) tests; mouse lymphoma assay; mammalian erythrocyte micronucleus testing; dose range finding; safety pharmacology (cardiovascular, central nervous and respiratory systems); off-target screening; and hERG binding ...

DNA-damage Test Could Aid Drug Development

... toxicity in humans, not animals, and you could obtain human bone marrow thats left over from medical procedures.' 'If you could change the micronucleus assay to have a human cell readout, that would be pretty amazing,' says Samson. Down the road, she suggests, such a test might offer a new way to ...
Micronucleus in Medical Technology

Late Breaking Data Released at ADA Showed that the Investigational Use of Januvia and Metformin as Initial Combination Therapy Provided Significant Glucose Lowering Efficacy over 54 Weeks in Patients with Type 2 Diabetes

... (CHO) chromosome aberration assay, an in vitro cytogenetics assay in CHO, an in vitro rat hepatocyte DNA alkaline elution assay, and an in vivo micronucleus assay. In rat fertility studies with oral gavage doses of 125, 250, and 1000 mg/kg, males were treated for 4 weeks prior to mating, ...

An Investigational Study Released at ADA Showed that Initial Combination Therapy with Januvia (sitagliptin) and Metformin Led to Improvement in Markers of Beta Cell Function in Patients with Type 2 Diabetes

... (CHO) chromosome aberration assay, an in vitro cytogenetics assay in CHO, an in vitro rat hepatocyte DNA alkaline elution assay, and an in vivo micronucleus assay. In rat fertility studies with oral gavage doses of 125, 250, and 1000 mg/kg, males were treated for 4 weeks prior to mating, ...
Micronucleus in Biological News

DNA-damage test could aid drug development

... toxicity in humans, not animals, and you could obtain human bone marrow that's left over from medical procedures." "If you could change the micronucleus assay to have a human cell readout, that would be pretty amazing," says Samson. Down the road, she suggests, such a test might offer a new way to ...
Micronucleus in Biological Technology

Analysis of in vitro micronucleus assays using the IN Cell Analyzer 3000 Micronuclei Formation Analysis Module

... Key words: micronucleus assays • toxicology • image analysis • IN Cell Analyzer micronucleus induction is a key characteristic of genotoxic ... of new drug candidates. Manual scoring of micronucleus assays is time consuming and subject to operator ...

Reliable Assessment of Micronuclei for Genotoxicity Testing in Mice or Rats

... Precise and cost-effective micronucleus analysis made easy with the icroFlow micronucleus Analysis Kit Dorothea K. Torous Carol R. ... Mark J. Dycaico Stratagene The icroFlow micronucleus Analysis Kit provides researchers with ...

The Genesis of Gendicine: The Story Behind the First Gene Therapy

... observed. Results from both a Chinese hamster lung (CHL) cell-chromosomeaberration test and mouse bone-marrow micronucleus assay were negative. Gendicine will not replicate in the infected cells and is incapable of multi-cycle infection and of spreading to ...
Micronucleus in Biological Dictionary

Micronucleus

... A micronucleus is the smaller nucleus in ciliate protozoans, ... cell-based assay platform that ... in vitro micronucleus assay is among ... GENOTOXICITY : THE micronucleus TEST. A ...

Macronucleus

... and replaced by a new one, ... Each cell contains a germ line micronucleus and a somatic macronucleus . ... All endogenous RPB3 genes in the ... ... Color the macronucleus red. ... 7. What do the macronucleus and micronucleus do? 8. Define conjugation. ... Macronucleus - Wikipedia, the free ...
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(Date:4/17/2014)... million older Americans suffer from depression, often brought on ... research a project that followed the lives of ... found that Internet use among the elderly can reduce ... , "That,s a very strong effect," said Shelia Cotten, ... and media who led the project. "And it all ...
(Date:4/17/2014)... about one in five infants in the United States ... first several months after birth. Research into probiotic use ... the April 1, 2014 issue of the British ... study, "Probiotics and Infant Colic," concluding that the use ... colic did not reduce crying or fussing in ...
(Date:4/17/2014)... (BUSM) have discovered that the anti-seizure drug ezogabine, ... findings, reported in the American Journal of ... more effective treatments for alcoholism. , Excessive consumption ... of illness and death in the U.S. and ... productivity of workers and necessitating huge health care ...
(Date:4/17/2014)... researchers at UC Davis has shown that the cyclin ... cell division, also boosts the mitochondrial activity to power ... has been shown to perform both jobs. This newfound ... control cellular energy production, potentially advancing cancer care and ... the journal Developmental Cell . , "These proteins ...
(Date:4/17/2014)... team led by Cesar A. Arias, M.D., Ph.D., at ... (UTHealth) has identified a new superbug that caused a ... in the April 17 issue of The New ... is part of a class of highly-resistant bacteria known ... is a major cause of hospital and community-associated infections. ...
Breaking Medicine News(10 mins):Health News:Internet use can help ward off depression among elderly 2Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2Health News:BUSM researchers find anti-seizure drug may reduce alcohol consumption 2Health News:Dual role: Key cell division proteins also power up mitochondria 2Health News:New MRSA superbug emerges in Brazil 2
(Date:4/17/2014)... Press journal Current Biology on April 17 ... lives. The Brazilian insects, which represent four distinct but ... the first example of an animal with sex-reversed genitalia. ... several different animals, Neotrogla is the only ... says Kazunori Yoshizawa from Hokkaido University in Japan. , ...
(Date:4/17/2014)... Pine forests are chock full of wild animals and ... populations of fungi are churning away in the soil, ... , Despite the vital role these fungi play in ... A Stanford-led team of scientists has generated a genetic ... North America. The work was published this week in ...
(Date:4/17/2014)... domestication derive from Charles Darwin, whose ideas in ... during the 19th century, a period when landowners ... is from Darwin that we inherit the ideas ... wild species and total human control over breeding ... this industrial setting has been applied too broadly ...
Breaking Biology News(10 mins):In sex-reversed cave insects, females have the penises 2Stanford biologists help solve fungal mysteries 2Stanford biologists help solve fungal mysteries 3The story of animal domestication retold 2The story of animal domestication retold 3The story of animal domestication retold 4
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