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Metastasis in Medical News

Ready for relapse: Molecule helps breast cancer cells to survive in the bone marrow

... cells and thereby extend the period during which metastasis may emerge after the diagnosis and removal of a ... signal that was abundantly expressed in bone metastasis tissue. These results demonstrate that Src ... cell survival provides mechanistic insights into metastasis latency, and suggests strategies to hasten the ...

Lab Study Finds Protein That May Inhibit Cancer Spread

... is no approved therapy for inhibiting or treating metastasis -- the migration of cancer cells from the original cancer site to other parts of the body. metastasis is one of the leading causes of cancer death. ... secrete a protein called prosaposin that inhibits metastasis by promoting production of factors that block the ...

Potent metastasis inhibitor identified

... Boston have isolated a potent inhibitor of tumor metastasis made by tumor cells, one that could potentially ... a protein called prosaposin -- which inhibits metastasis by causing production of factors that block the ... at Children's, encouraged him to focus on the metastasis inhibitor -- prosaposin. "You might have a drug ...

Joan Massagué wins BBVA Foundation Frontiers of Knowledge Award in Biomedicine

... research into the genetic and cellular bases of metastasis and remains an acknowledged leader in this field. ... Research into the genes involved in cerebral metastasis and their mode of action, "is still very much at ... stage", says Massagu. "These are the first brain metastasis genes to be identified, with clinical data". ...

Where tumor cells boldly go: Weill Cornell cancer biologists shed light on the metastatic niche

... far from the primary tumor, well before full metastasis takes hold. "In cancer, it is metastatic ... players that mediate changes at future sites of metastasis such as liver, lung, brain or bone, and thereby ... future when we'll be able to prevent metastasis through a new approach for early detection and ...

Tips from the American Journal of Pathology

... 174: 1921-1930 TIP30 Inhibits Lung Cancer metastasis Researchers in Shanghai, China suggest that ... of TIP30 expression promoted lung cancer metastasis and angiogenesis in mice, Tong et al conclude ... roles in suppressing the progression and metastasis of lung cancer." These findings highlight TIP30 ...

Instead of fighting breast cancer, immune cell promotes its spread

... as a promoting factor in breast cancer metastasis and provides a potentially good marker for breast ... pathway downstream of RANKL blocks primary metastasis and can potentially be developed as a treatment ... and immune response, we can also reduce tumor metastasis and are very likely to develop a therapy that is ...

M. D. Anderson launches graduate program in cancer metastasis

... Texas System. The Graduate Program in Cancer metastasis Research: Bench to Bedside, will concentrate on ... program is the first to treat the study of metastasis as a separate discipline," said program organizer ... faculty. UT System allocated $485,250 to the metastasis program over three years, one of only seven ...

Master molecular switch may prevent the spread of cancer cells to distant sites in the body

... one day lead to a drug that controls cancer cell metastasis and tissue fibrosis. This change in cell ... physiological consequences, leading to cancer metastasis as well as other disease processes such as tissue ... cells, then it might be possible to prevent metastasis or control fibrosis," notes corresponding author ...

New findings measure precise impact of fat on cancer spread

... implanted in the mice. However, the rate of metastasis rose a dramatic 300 percent in the mice fed a ... supported the other results showing increased metastasis in animals fed a high-fat diet. The researches ... work will focus on not only how obesity increases metastasis but also how it might play a direct role in ...

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Metastasis in Medical Technology

Mayo Clinic Study Shows Drug Could Effectively Treat, Prevent the Spread of Breast Cancer

... for controlling tumor growth, metastasis to bone and bone disorders," such as osteolysis ... as a therapeutic agent to target primary tumors, metastasis to bone and tumor-induced osteolysis. There are ... cancer. "Targeting metastatic tumors at sites of metastasis would be of great benefit for patients who have ...

YM BIOSCIENCES ANNOUNCES NIMOTUZUMAB PRESENTATIONS TO BE MADE AT THE 100TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH AND EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY

... nimotuzumab in combination with radiation. These two indications - brain metastasis from lung cancer and palliative therapy in non-small cell lung cancer ... of high unmet need. In the US, approximately 140,000 cases of brain metastasis are diagnosed annually and the frequency is increasing as more patients ...

Rosetta Genomics to Present Multiple Posters at the 44th Annual Meeting of the American Society of Clinical Oncology (ASCO)

... cancer of unknown primary (CUP). Accurately identifying the origin of a metastasis can be critical in guiding treatment decisions. Rosetta Genomics' ... 8:00AM - 12:00PM; Hall S102a; abstract # 11026. The distinction of liver metastasis from hepatocellular carcinoma (HCC) and determining its tissue origin is a ...

Genzyme Announces Second Pivotal Mozobil Trial Meets Primary Endpoint

... cardiovascular disease, HIV, renal ischemic disease, and prevention of metastasis in oncology. About Mozobil Mozobil, a novel small molecule CXCR4 ... arterial disease, HIV, renal ischemic disease, and prevention of metastasis in oncology. These statements are subject to risks and uncertainties that ...

Amgen Announces Positive Top-Line Results for Denosumab in Trial for Delay of Skeletal Related Events in Bone Metastases Patients Compared to Zometa(R)

... Capanna R, Coia LR, Coleman R. et al. eds. Textbook of Bone Metastases. Hoboken, NJ: Edition: John Wiley and Sons; 2005:105. (2) Mundy GR. metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer . 2002 Aug;2(8):584-93. (3) Schulman K and Kohles J. Cancer. ...

Denosumab Demonstrates Superiority Over Zometa(R) in Pivotal Phase 3 Head-to-Head Trial in Breast Cancer Patients With Bone Metastases

... Capanna R, Coia LR, Coleman R. et al. eds. Textbook of Bone Metastases. Hoboken, NJ: Edition: John Wiley and Sons; 2005:105. (2) Mundy GR. metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer . 2002 Aug;2(8):584-93. (3) Schulman K and Kohles J. Cancer. ...

New Small and Medium Sized Enterprises Join TI Pharma by Signing Two New Projects

... needed more than ever," says Roel Schaapveld, Chief Executive Officer, InteRNA. There is a large body of evidence indicating that tumor growth and metastasis formation are dependent on the formation of new blood vessels. Furthermore, angiogenesis is an early event in the development of tumors, being ...

/C O R R E C T I O N -- Agendia B.V./

... addressing the panel's recommendations. The FDA-cleared assay is always clinically useful and indicates whether a patient is at low or high risk for metastasis and the resulting clarity is vital in helping physicians personalize treatment options. "St. Gallen's guideline inclusion is a key step in ...

Agendia's Breast Cancer Recurrence Test MammaPrint Included in International St. Gallen Expert Consensus Recommendations

... addressing the panel's recommendations. The FDA-cleared assay is always clinically useful and indicates whether a patient is at low or high risk for metastasis and the resulting clarity is vital in helping physicians personalize treatment options. "St. Gallen's guideline inclusion is a key step in ...

Paclitaxel Poliglumex (OPAXIO(TM)) Added to Cisplatin and Radiation Produces 45% Pathologic Complete Remissions in Patients With Esophageal Cancer

... confirmed, locally advanced adenocarcinoma or squamous cell carcinoma of the esophagus or gastro-esophageal junction with no evidence of distant metastasis received weekly paclitaxel poliglumex (50mg/m2) and cisplatin 25mg/m2 for six weeks with concurrent 50.5Gy of radiation. Twenty-three eligible ...

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Metastasis in Medical Products

MammaPrint Breast Cancer Diagnostic Test

Description:... MammaPrint is a gene expression profiling test that predicts the risk of metastasis in breast cancer patients. It is based on groundbreaking research performed at the Netherlands Cancer Institute and the Antoni Van Leeuwenhoek ...
Company:Agendia Corporate

Feridex I.V.®

Description:... natural function, the agent is taken up by macrophages found only in healthy liver cells but not in most tumors. The liver is a principal site for metastasis of primary cancer originating in other parts of the body, particularly colon cancer, which is a common cancer in the United States. The ability to ...
Company:Advanced Magnetics, Inc.
Metastasis in Medical Definition

Ocular oncology

... MD. 1.Choroidal Hemangioma [2] 2.Choroidal Melanoma [3] 3.Choroidal metastasis [4] 4.Choroidal Nevus [5] 5.Choroidal Osteoma [6] 6.Ciliary Body ... progression Dysplasia - Carcinoma in situ - Invasive cancer - metastasis Topography Anus - Bladder - Bile duct - Bone - Brain - ...

Pathology

... - Cyst - Pseudocyst - Hamartoma - Benign neoplasm Malignant progression Dysplasia - Carcinoma in situ - Invasive cancer - metastasis Topography Anus - Bladder - Bile duct - Bone - Brain - Breast - Cervix - Colon/rectum - Duodenum - Endometrium - ...
Metastasis in Medical Dictionary

Metastasis

... metastasis Definition: metastasis is the movement or spreading of cancer cells ... via the blood stream or the lymph system . metastasis Powered by: This information is provided by an ...

Cytology

... cells. Liver function tests may show involvement of the liver from metastasis , or may be abnormal without metastasis . An ultrasound of the abdomen and kidney may show the tumor . ...

Ecchymosis

... are common in these high-risk patients and arise from retrobulbar metastasis . Extensive bone marrow metastasis may result in pancytopenia. Grade II ' A greater number of muscle ...

Lumbar

... Lumbar puncture should be avoided as central nervous system (CNS) metastasis at diagnosis is rare,[2] and lumbar puncture may be associated with an increased incidence of subsequent development of CNS metastasis .[3] ... The lumbar vertebrae are the five largest and strongest of ...

Spleen

... and recycling them. It also plays a handful of minor roles. Spleen metastasis - CT scan Definition: metastasis is the movement or spreading of cancer cells from one organ or ...

Adenocarcinoma

... of anal cancer s are adenocarcinoma s, which affect glands in the anal area. Vitamin D inhibition of prostate adenocarcinoma growth and metastasis in the Dunning rat prostate model system. Urology . 1997 Dec;50(6):999-1006. Guyton KZ, Kensler TW, Posner GH. Vitamin D and vitamin D ...

Benign

... a benign tumor may grow very large. Cancer ous tumor s may shed cancer cells that spread to other parts of the body. This is called a metastasis . 9. Although rare, a pituitary tumor (a usually benign tumor ) can cause an overproduction of prolactin which can interfere with the ...

Cancer

... of the pear-shaped organ that lies on the undersurface of the liver . Description ... Cancer spreading to other organ s or tissue s ( metastasis ) Recurrence of carcinoma within the colon Development of a second primary colorectal cancer Calling your health care provider: ... ...

Cardiac

... problems, there may rarely be medical complications, including respiratory or cardiac malfunction, and blood clots in the legs and lungs . metastasis Dehydration Cardiac arrest from electrolyte imbalances Call Health Care Provider: If you have watery diarrhea for more than 2-3 days, you ...

Cardiac arrest

... from a blunt, nonpenetrating blow to the chest. The situation is just the opposite when cardiac arrest occurs outside a hospital setting. metastasis Dehydration Cardiac arrest from electrolyte imbalances Call Health Care Provider: If you have watery diarrhea for more than 2-3 days, you ...

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Metastasis in Biological News

Advances in lung cancer research announced at conference

... In non-small cell lung cancer (NSCLC), brain metastasis is a devastating complication that occurs in as ... to identify those at risk for developing brain metastasis may guide new therapies. A team led by Dr. ... to predict, treat and ultimately prevent brain metastasis in patients with non-small cell lung cancer," Dr. ...

Team finds breast cancer gene linked to disease spread

... 8 and appears to be crucial to cancer's spread or metastasis because it helps tumor cells stick tightly to ... identifying the genetic mechanism at play in the metastasis of breast cancer, the scientists may have ... Johnson Medical School. "Not only has a new metastasis gene been identified, but this also is one of a ...

Newly identified gene powerful predictor of colon cancer metastasis

... 20 percent of the patients have already developed metastasis by the time their colon cancer is diagnosed. In ... are at high risk of developing life-threatening metastasis in the liver and the lungs. As a result, more ... cellular tissue, and eventually settle down as metastasis at various sights throughout the body far from ...

Einstein researchers develop a new way to study how breast cancer spreads

... how cancer cells move during the early stages of metastasis may help scientists develop more effective cancer ... itself. We can now look at the early steps of metastasis in high resolution and specific regions of the ... provides a powerful tool for studying cancer metastasis and is part of a growing body of Einstein cancer ...

It is important to demonstrate the influence of the microenvironment in the process of metastasis

... in these cancer cells during their growth as metastasis in the liver of patients. This in vitro culture ... work in which colon cancer -generated hepatic metastasis is analysed, a disease which may be propitiated ... entitled Study of the genes involved in hepatic metastasis of colon cancer and which are regulated by ...

Colorectal cancer

... BAMBI is associated with two import signaling pathways and thus promotes metastasis formation," Dr. Fritzmann said. "These signaling pathways (Wnt and ... genes more closely, in order to better understand the individual steps of metastasis formation. Aim To predict at an early stage whether the tumor will ...

NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis

... Hernando, who notes that the average survival for patients after melanoma metastasis occurs is only nine months. "Normal cells are unable to travel and survive ... studies in mice to block the growth of the primary melanoma tumor or the metastasis by using anti-miRNA. All these steps will determine if this approach ...

Massague honored with inaugural AACR Distinguished Leadership Award in Breast Cancer Research

... the role of transforming growth hormone factor-Beta (TGF-Beta) in the metastasis of breast cancer cells to the lung, has been selected to receive the ... These investigations demonstrated that a genetic predisposition for metastasis can sometimes be identified in primary malignancies before the cancer has ...

Dense tissue promotes aggressive cancers

... been tied to matrix degradation, which is thought to be important for metastasis and spread of cells through the body." Because metastasis is often what makes cancers deadly, new leads on how to block it are ...

TG2 identified as potential therapeutic target in chemo-resistant ovarian cancer

... melanoma, breast cancer and pancreatic cancer. "Drug resistance and metastasis are major impediments to the successful treatment of ovarian cancer and ... that silencing TG2 with the siRNA liposome reduced tumor size, slowed metastasis and enhanced the effect of gemcitabine chemotherapy. "This aberrant ...

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Metastasis in Biological Technology

Agendia Publishes Direct Evidence That MammaPrint Predicts Benefit of Chemotherapy in Breast Cancer

... since MammaPrint is highly prognostic for early metastasis risk. Only early metastasis risk can be reduced by chemotherapy as shown by ... MammaPrint identifies patients with early metastasis risk - those patients who are likely to develop ...

Accurate Identification of Tumor Origin Using MicroRNAs is Published by Rosetta Genomics' Scientists and Collaborators in Nature Biotechnology

... in the US in 2008.. "Accurately identifying the origin of a metastasis in CUP patients can be critical for determining appropriate treatment, and ... identify the origin of the cancer. Accurately identifying the origin of a metastasis can be critical in guiding treatment decisions. The study results ...

VisEn Launches New Cat-K FAST(TM) Fluorescence Molecular Imaging Agent

... in vivo . Cathepsin K expression is well known as a key biomarker and therapeutic target in a range of bone-related diseases, including cancer metastasis to bone, as well as in atherosclerosis. The new Cat-K FAST (TM) agent is expected to significantly expand research and enhance drug development ...

Agendia to Present Multiple Predictive and Prognostic Studies on Breast and Colorectal Cancers at ASCO Annual Meeting

... to develop metastases within five years following surgery. Several authoritative studies have shown that chemotherapy particularly reduces early metastasis risk. In planning treatment, the MammaPrint test results provide doctors with a clear rationale to assess the benefit of chemotherapy in addition to ...

OncoGenex Pharmaceuticals Announces Release of Two ASCO Abstracts: Impact of OGX-011 on Survival in Randomized Phase 2 Trial and Phase 1 Safety Data for OGX-427

... predictive of overall survival. The analysis defined only three variables predictive of overall survival: performance status, presence of visceral metastasis and assignment to the OGX-011 treatment arm. Based on the multivariate analysis, patients treated with OGX-011 had a rate of death 46% lower than ...

Micromet, Inc. To Regain Rights to Blinatumomab in North America; Reports Financial Results for the Fourth Quarter and Full Year ended December 31, 2008

... to initiate a randomized, controlled, multicenter phase 2 clinical trial for relapsed colorectal cancer patients after complete resection of liver metastasis with adecatumumab, an EpCAM-targeting human monoclonal antibody that we develop in collaboration with Merck Serono; Before the end of 2009, ...

UK's Institute of Cancer Research and Silicon Graphics Establish Long-Term Alliance to Design and Outfit World-Class Network Biology Lab

... within the larger biological network, The Institute's researchers hope to achieve breakthroughs that lead to new drugs or treatments that prevent metastasis - the stage when cancer can turn deadly. "Studying the dynamics of cellular networks will put unprecedented demands on our technology ...

Agendia's Breast Cancer Test MammaPrint(R) Standard of Care at Netherlands Cancer Institute - AVL

... analytical validation and reporting systems to ensure patient safety issues are addressed. Highly accurate, MammaPrint identifies patients with early metastasis - those patients who are likely to develop metastases within five years following surgery. Several authoritative studies have shown that chemotherapy ...

Rosetta Genomics Announces Exclusive Distribution Agreement With Teva Pharmaceutical Industries Ltd.

... of the metastases' primary origin can be critical for determining appropriate treatment.Current diagnostic methods to identify the origin of a metastasis include a wide range of costly, time consuming, and at times inefficient tests. miRview(TM) mets offers physicians with a fast, accurate, and easy to ...

Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting

... on Colon and Rectal Cancers that included the recommendation that a determination of the KRAS gene status of either the primary tumor or a site of metastasis should be part of the pre-treatment work-up for patients diagnosed with metastatic colorectal cancer. Further, the guidelines recommended that EGFr ...
Metastasis in Biological Definition

Cancer

... body where the cells are not normally located ( metastasis ). Cancer is caused by damage to DNA (genetic ... ulceration or jaundice . Symptoms of metastasis (spreading) : enlarged lymph nodes , cough ... extent of the disease and whether there has been metastasis to regional lymph nodes . Staging determines ...

Muscle

... uterus ), leiomyosarcoma (malignant, very rare) Striated muscle: rhabdomyoma (benign) and rhabdomyosarcoma (malignant) - both very rare metastasis from elsewhere (e.g. lung cancer ) Smooth muscle has been implicated to play a role in a large number of diseases affecting blood vessels , ...
Metastasis in Biological Dictionary

Mouth

... Oral cancer is any cancerous tissue growth located in the mouth . It may arise as a primary lesion originating in any of the oral tissues, by metastasis from a distant site of origin, or by extension from a neighboring anatomic structure, such as the nasal cavity or ... Our mouth and teeth ...

Epigenetics

... Medline/PubMed and ... epigenetics ... Epigenetics : Principles of Eukaryotic Genome Control (2008), by ... DNA Methylation, Epigenetics and metastasis (2005), by Manel Esteller (Ed. ... How life experiences — from toxin exposure to receiving affection — can alter genome expression. ... ...

Cancer

... Cancer is a class of diseases in which a group of cells display uncontrolled growth, invasion, and sometimes metastasis . These three malignant properties of cancers differentiate them from benign tumors, which ... Dedicated to helping everyone who faces cancer ...
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(Date:8/20/2014)... Research UK scientists have discovered that acral melanomas the ... Marley,s death are genetically distinct from other more common ... external) published in the journal Pigment Cell & Melanoma ... of the hands, soles of the feet, nail-beds and other ... of melanoma, it,s not caused by UV damage from the ...
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