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Metabolite in Medical News

Advanced blood analysis may speed diagnosis of heart attacks

... heath status. But the technology to assess metabolite levels is in the early stages, as is the ... of their significance. For instance, how much metabolite levels normally vary between healthy individuals ... heart cells to reduced oxygen and found that one metabolite increased cell death, while two others decreased ...

DDT Compound Speeds Breast Cancer Growth

... Insecticide metabolite disrupts hormone-sensitive cells, study finds ... Breast Cancer Research , suggests that DDT's main metabolite blocks a pathway of a hormone that would ... de sant publique in Quebec found that the metabolite blocked the androgen receptors (AR) found on ...

GlaxoSmithKline Obtains Exclusive U.S. OTC Marketing Rights to MEVACOR(R) (lovastatin) from Merck & Co., Inc.

... beta-hydroxyacid form. This is a principal metabolite and an inhibitor of 3-hydroxy-3-methylglutaryl- ... Both lovastatin and its beta-hydroxyacid metabolite are highly bound (>95%) to human plasma proteins. ... of lovastatin and its beta-hydroxyacid metabolite (as measured by the area under the ...

Hyperion Therapeutics Announces Results of Phase I Study in Patients With Liver Cirrhosis

... was given fasting on day 1 or with a meal on day 8. Excretion of the main metabolite PAGN was similar between healthy adults and cirrhotic subjects. Urinary ... dysfunction, decreased appetite, body odor (probably caused by its metabolite phenylacetate) and bad taste or taste aversion. Patients with urea cycle ...

Urine test may determine if a smoker is at risk for lung cancer

... question." Yuan and colleagues hypothesized that the presence of the metabolite NNAL in a patient's urine might predict risk of lung cancer. This metabolite has been shown to induce lung cancer in laboratory animals, but the effect ...

Study sheds new light on link between obesity and infertility

... 2006 to April 2007. Dr. Robker and her colleagues measured hormone and metabolite levels in follicular fluid obtained from the subjects' ovaries during ... an altered ovarian follicular environment, particularly increased metabolite and androgen activity levels, which may be associated with poorer ...

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Metabolite in Medical Technology

NKTR-102 (PEG-Irinotecan) Demonstrates Significant Tumor Growth Inhibition In Multiple Preclinical Tumor Models

... Exposure of Tumor Tissue to the Active metabolite of Irinotecan SAN FRANCISCO, Oct. 25 ... the effective half-life of irinotecan's active metabolite in tumor tissues. In a colorectal cancer model, ... NKTR-102 administration, exposure to the active metabolite of irinotecan in colorectal and lung tumor tissue ...

Cardax Pharmaceuticals Nominates Clinical Candidate Heptax for Liver Disease; Heptax Ameliorates Inflammation and Oxidative Stress Related to Liver Disease and Metabolic Syndrome

... Preclinical animal studies with the Company's compounds or its active metabolite have demonstrated reductions in blood pressure, triglycerides, cholesterol ... required for clinical study and it is converted to the natural active metabolite in the gastrointestinal tract. It effectively combines the properties of ...

Covance Announces Integrated Radiolabeled Clinical Pharmacology Studies

... radiochemical and chemical analysis services to obtain definitive metabolite disposition data in humans. Covance offers 24-hour turnaround of ... parent compound; total radioactivity; pharmacokinetic interpretation; and metabolite profiling and identification. Covance's clinical development ...

Ardea Biosciences Identifies Lead Development Candidate for Gout, RDEA594

... elevated levels of uric acid in the blood stream. RDEA594 is a major metabolite in both humans and animals of RDEA806, the Company's lead ... has potential for treating gout patients with hyperuricemia. RDEA594 is a metabolite of RDEA806, a non-nucleoside reverse transcriptase inhibitor (NNRTI) in ...

Additive Anti-Tumor Activity of NKTR-102 in Combination With Bevacizumab Highlighted in Positive Preclinical Data Presented at AACR Meeting

... and a 4-fold lower peak plasma concentration (Cmax) of SN38, the active metabolite of irinotecan, as compared to the equivalent dosing of irinotecan. The ... in a markedly improved time-concentration profile for SN38, the active metabolite of irinotecan, as compared to treatment with irinotecan. Nektar ...

Tumor Growth Inhibition and Pharmacokinetic Profile of NKTR-102 (PEG-Irinotecan) in Multiple Solid Tumors To Be Presented at Upcoming AACR-NCI-EORTC International Conference

... in a significantly improved pharmacokinetic profile for the active metabolite of irinotecan as compared to treatment with irinotecan. "The studies for ... data focused on the pharmacokinetics and pharmacodynamics of the active metabolite of irinotecan following administration of NKTR-102 in mouse xenograft ...

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Metabolite in Medical Products

CVC 123 Calibration Verification Controls

Description:... CVC 123 is an assayed quality control material used for confirming the calibration and linearity of blood gas, electrolyte, and metabolite ....
Company:RNA Medical

Androstanediol Glucuronide RIA Test

Description:... Androstanediol glucuronide (3alpha-diol G) is the glucuronide conjugate of 3alpha-androstanediol, a major metabolite of dihydrotestosterone (DHT) [1,2]. 3alpha-diol G has strong androgenic activity estimated at 75% of the bioactivity of testosterone [2]. Serum ...
Company:Diagnostic Systems Laboratories, Inc.

Androstanediol Glucuronide EIA Test

Description:... Androstanediol glucuronide (3alpha-diol G) is the glucuronide conjugate of 3alpha-androstanediol, a major metabolite of dihydrotestosterone (DHT) [1,2]. 3alpha-diol G has strong androgenic activity estimated at 75% of the bioactivity of testosterone [2]. Serum ...
Company:Diagnostic Systems Laboratories, Inc.

Opiates - Rapid Test

Description:... The RapidOPI test is an immunochromatography based one step in vitro test. It is designed for qualitative determination of Opiates and its metabolite in human urine specimens. The presence of morphine in human urine above a cut-off level of 300 ng/mL can be detected. This assay has not been ...
Company:Bio-Quant, Inc.

Opiates II - Rapid Test

Description:... Opiate II Rapid Opiates is an immunochromatography based one step in vitro test. It is designed for qualitative determination of Opiates and its metabolite in human urine specimens. The presence of morphine in human urine above a cut-off level of 2,000ng/mL can be detected. This assay has not been ...
Company:Bio-Quant, Inc.

Cocaine - Rapid Test

Description:... This device is a qualitative immunoassay intended to be used to inspect the overdose usage of cocaine by detecting the benzoylecgonine, a metabolite of cocaine, in human urine at a cutoff level of 300 ng/mL. It is for health care professional use ....
Company:Bio-Quant, Inc.

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Metabolite in Medical Dictionary

Metabolite

... metabolite Definition: A metabolite is any substance produced or used during ... end product that remains after metabolism . metabolite : Any substance produced by metabolism or by a ...

Serotonin

... 5-HIAA - This is a test which measures the amount of 5-HIAA, a metabolite of serotonin , in the urine . A 24 hour urine collection is required ... serotonin , ... Serology for Tularemia Serosanguineous Serotonin metabolite (5-HIAA) Serous Labyrinthitis ( Labyrinthitis ) Serous Otitis Media ( ...

Abuse

... smoking , and other drug use can be both causes and consequences of depression . OraSure-based tests for a group of drugs and their metabolite s, referred to as NIDA-5 ( cocaine , meth amphetamine , cannabinoids [ marijuana ], opiates, and phencyclidine [PCP]), will eventually be marketed as ...

Aflatoxins

... Aflatoxins Related Category: Pathology (f´ltk´´snz), a group of secondary metabolite s that are cancer -causing byproducts of a mold that grows on nuts and grains, particularly peanuts. Aflatoxins are toxins produced by a ...

Aflatoxin

... Aflatoxin s Related Category: Pathology (f´ltk´´snz), a group of secondary metabolite s that are cancer -causing byproducts of a mold that grows on nuts and grains, particularly peanuts. Aflatoxin Definition: Aflatoxin s are ...

Catecholamines

... electron microscopy, or by finding elevated levels of serum catecholamines (e.g., dopamine and norepinephrine ) or urine catecholamine metabolite s, ... In Japan a program was initiated to screen infants for neuroblastoma by testing for substances called catecholamines (made by the ...

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Metabolite in Biological News

The 21st century tomato

... Expression of certain genes may regulate metabolite activity, but metabolites may also have a ... and followed the transmission of information from metabolite to gene. In continuing research, Carrari and ... and nutrition, as well as to improve yield. metabolite analysis also has possible applications in drug ...

First finding of a metabolite in 1 sex only

... development, the existence of a sex-specific metabolite is a previously unrecognized and potentially ... that the presence or absence of a sex-specific metabolite might affect an animal's development, anatomy and ... Now that the existence of a sex-specific metabolite has been proved for one animal, Kleps says ...

Birth control has long-term effect on hormone exposure

... postmenopausal phase of the study and frozen for subsequent analysis of metabolite concentrations. Lab results showed that the premenopausal use of oral ... isoflavones induced fewer significant effects on postmenopausal estrogen metabolite concentrations. "The magnitude and persistence of oral contraceptive ...

Healthy or diseased?

... concentrations." By a subsequent clustering of the test statistics of such metabolite pairs, it is possible to identify groups of metabolites which discriminate ... of the metabolome. "With this recent quantum leap in the area of metabolite analysis, the challenge to bioinformatics is to develop customized, ...

Chemicals in common consumer products may play a role in pre-term births

... samples collected during the third trimester and compared them to the control group who carried to term. They found significantly higher phthalate metabolite levels in the women who delivered prematurely. Premature birth is a significant risk factor for many health problems in childhood that can ...

Embryology study offers clues to birth defects

... that control the growth and differentiation of progenitor cells by regulating specific genes. One of these signaling molecules is retinoic acid, a metabolite produced from vitamin A (retinol), which plays a key role in the development of limbs and other organs. Dr. Duester's lab was instrumental in ...

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Metabolite in Biological Technology

Idenix Pharmaceuticals Reports Data From Three Hepatitis C Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver

... exposure to IDX184 and the resulting nucleoside metabolite (NM). IDX184 is fully active against HCV ... (PK/PD) relationship between nucleoside metabolite concentrations in serum and viral load reductions in this study. Trough serum nucleoside metabolite levels were low, ranging from 2-8 ng/mL, and ...

XenoTech LLC Offers Drug Industry New Metabolite Profiling Services Following Acquisition of Waters Synapt HDMS System

... that XenoTech (Lenexa, KS) has begun offering new metabolite profiling services made possible in part by its ... The Synapt HDMS System is the centerpiece of its metabolite profiling efforts and allows XenoTech to offer ... for XenoTech. Its unique system of in vitro metabolite profiling can alleviate the need for expensive ...

Significant Anti-Tumor Activity and Extended Half-Life of NKTR-102 (PEG-irinotecan) Highlighted in Phase 1 Data Presented at EORTC-NCI-AACR Symposium

... Active metabolite concentrations of NKTR-102 significantly more ... The observed plasma half life of the active metabolite (SN38) of NKTR-102 was 50 days; this is ... dosing.(1) Increased SN38 levels, the active metabolite of irinotecan responsible for its ...

Ausio Pharmaceuticals to Present at Bio(R) 2009

... Ausio has developed AUS-131, a pharmaceutical formulation of the soy metabolite S-equol. AUS-131 is expected to provide soy health benefits by ... About AUS-131 AUS-131 is pure, synthetic S-equol, a potent metabolite of the soy isoflavone, daidzein, which is produced in only a subset of ...

Tethys Bioscience Announces Acquisition of Lipomics Technologies

... Addition of metabolite technology uniquely positions company as it expands its ... terms were not disclosed. The acquisition brings together Lipomics' metabolite profiling technology with Tethys' proven expertise in the use of protein ...

ESA Receives 2008 Frost & Sullivan North American Technology Innovation Award for Development of Integrated Metabolomics Systems

... Electrochemical detection in line with mass spectrometry streamlines the metabolite analysis, synthesis, and evaluation process. In order to determine the ... are identified, scale-up can be done for clinical trials to evaluate metabolite toxicity in humans." Dr. Acworth continued, "We are honored to be ...

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Metabolite in Biological Products

8-iso-13,14-dihydro-15-keto Prostaglandin F2alpha from Cayman Chemical

Description:... Prostaglandin F2α (8-iso-13,14-dihydro-15-keto PGF2α) is a metabolite of the isoprostane, 8-isoprostane (8-iso PGF2α), in rabbits, ... PGF2α was a significant component of the metabolite profile, which was comprised mostly of dinor 8-isoprostane metabolites. ...
Company:Cayman Chemical

Prostaglandin E1-d4 from Cayman Chemical

Description:... It is intended for use as an internal standard for the quantification of PGE1 by GC- or LC-mass spectrometry. PGE1 is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid (DGLA), but it is virtually undetectable in the plasma of normal humans or other animals. Its pharmacology includes ...
Company:Cayman Chemical

20-HETE-d6, Deuterium Conjugated/Tagged from Cayman Chemical

Description:... 20-HETE is a cytochrome P450 (CYP450) metabolite postulated to play an autacoid role in the renal and cerebral vasculature. In rat cerebral microvessels, 20-HETE is a vasoconstrictor that mediates ...
Company:Cayman Chemical

20-HETE-d6, Deuterium Conjugated/Tagged from Cayman Chemical

Description:... 20-HETE is a cytochrome P450 (CYP450) metabolite postulated to play an autacoid role in the renal and cerebral vasculature. In rat cerebral microvessels, 20-HETE is a vasoconstrictor that mediates ...
Company:Cayman Chemical

LTQ XL Linear Ion Trap from Thermo Scientific

Description:... with new software packages, the LTQ XL delivers complete solutions for your structural elucidation questions MetWorksTM - Automated metabolite Identification Mass FrontierTM 5 - Structure Elucidation BioWorksTM 3.3 - Protein Identification SIEVETM - Automated Label-Free ...
Company:Thermo Scientific

Cocaine Metabolite ELISA Kit, Single from Bio-Quant Inc.

Description: Request ...
Company:Bio-Quant Inc.
Metabolite in Biological Dictionary

Secondary metabolite

... ... Aspects of the topic secondary - metabolite are discussed in the following places at ... however, ... Fermentation and secondary metabolite screening. ... The epithet " secondary " connotes an ecological function for a metabolite . ... However, many other secondary ...

Coenzymes

... to as cosubstrates. ... The term coenzymes is sometimes defined in such a way as to include prosthetic ... Coenzymes fall into two groups: metabolite ... Of the metabolic coenzymes , the most widely used is adenosine triphosphate, ATP, ... which is itself a coenzyme . ... Get information, ...
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(Date:3/11/2015)... March 11, 2015   The Sync Project™ ... to scientifically measure and harness music to improve ... biometrics and objective measurements of physiology, enabling the ... scale in large populations. It is designed for ... clinicians perform rigorous studies and accelerate the discovery ...
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