Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats
... activated by harmful fats, PGC-1beta alters liver metabolism through a cascade of biochemical signals. The result is an upsurge in the liver's production of very low-density lipoprotein (VLDL) cholesterol, the precursor of low-density lipoprotein (LDL) cholesterol (known as the "bad" form of cholesterol) and t...W.M. Keck Foundation funds study of friendly microbes
...ims to directly identify the products of bacterial metabolism in the intestine. The goal is to characterize previously unknown chemical compounds that play important roles in regulating the properties of the microbial community and human physiology. To do so, the researchers will use a new type of mass spectrom...Gene variations explain drug dose required to control seizures
...nking variation in genes involved in the action or metabolism of the anti-epileptic drugs, carbamazepine and phe... because of the drug's variable affects on patient metabolism and its potential neurologic side effects. The team identified genes considered to be obvious candi...Plant hemoglobins: Oxygen handlers critical for nitrogen fixation
...bins are important for oxygen transport and energy metabolism in plant root nodules. Furthermore, these proteins help to maintain free-oxygen concentrations in nodules at levels low enough to avoid damage of oxygen-sensitive nitrogenase, the bacterial enzyme complex responsible for symbiotic nitrogen fixation. ......t three years developing the ability to measurethe metabolism of small groups of cells and studying how they respondto drugs, toxins and pollutants. To do so, the interdisciplinary teamhas developed two basic technologies: special electrodes that canmeasure the concentrations of the chemicals that cells consume...LTQ XL Linear Ion Trap from Thermo Scientific
... information for the most demanding proteomics and metabolism applications. Multiple dissociation techniques (PQD, ETD, CID) Extensive coverage for predicted and unpredicted metabolites Fast polarity switching for high-sensitivity analysis of unknowns Intelligent Data DependentTM acquisition Platform for ...Rabbit Anti-Mint3 Polyclonal Antibody, Unconjugated from ABR-Affinity BioReagents
...nsport, endocytosis, and metabolism. Abnormal APP metabolism has been shown to be the cause of an early-onset type of Alzheimers disease....Osteoclasts Culture Kit from B-Bridge International
...ing osteoporosis, bone reabsorbtion, or other bone metabolism disorders....NanoMate ™ 100 with ESI Chip Technology from Advion Biosciences, Inc.
...ions, or long acquisition times for proteomics and metabolism applications where greater sample information is needed.<P.The NanoMate 100 with the ESI Chip is the worlds first and only fully-automated chip-based nanoelectrospray system suitable for most API mass spectrometers. The system provides life-scien......s Metabolic Profiler is an integrated platform for metabolism studies, and analysis of complex mixtures. It features an HPLC-microTOF ESI-TOF system, an optional Avance NMR spectrometer and integrated software for data acquisition, evaluation and statistical analysis for applications like:Assessment of the meta...Human Primary Preadipocytes and Differentiated Adipocytes
...ferentiated Adipocytes A new paradigm for energy metabolism research Yuan-Di C. Halvorsen Zen-Bio, Inc. Peter Pingerelli Matt C. Petre Stratagene Regis Saladin Ligand Pharmaceuticals Michael R. Briggs SmithKline Beecham Pharmaceuticals Stratagene introduces new tools to facilitate the study of human ...Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon Allelic Discrimination Kits
...) A key enzyme in homocysteine metabolism C to T substitution at nucleotide position 677 that results in an Ala to Val change 13 Caucasians (38%) 13 Individuals of mutant homozygote have an elevated plasma h...hNT BlueNeurons Express b-Galactosidase at High Levels
...to express glutamate receptor channels, change the metabolism of amyloid precursor proteins and become permissive for infection by the human immunodeficiency virus (HIV). An increasing number of reports describe transplantation of hNT neurons intorodent brains.15 hNT neurons successfully integr...Tissue Specificity for Mutation Parallels Tissue Specificity for Cancer
... respectively) but not in the liver tissue.Benzene metabolism takes place partially in the liver, while final oxidationsteps can take place in the bone marrow. Conclusions The Big Blue transgenic rodent assay system accurately predicts mutations inspecific tissues. In a number of cases, mutations are recovere......oplasmal contamination include inhibition of metabolism and growth, as well as interference with nucleic acid synthesis and cell antigenicity. Acute infection causes total deterioration of the cell culture, sometimes with a few apparently resistant colonies that may, in fact, also be chr...Stress can make you overweight
... the University of Maryland, says that the slowing metabolism of people over 45 makes them more vulnerable to stress, which releases hormones that stimulate both appetite and the storage of fat. The approach of menopause puts women even more at risk due to waning sex hormones. Therefore people who near 40's...Drug abuse leads to long standing changes in the brain
...er colleagues used PET scanning to measure glucose metabolism in the brains of the same group of methamphetamine abusers and in control subjects. Glucose metabolism is a measure of brain cell activity, and reduced glucose metabolism can be a very sensitive indicato......and ADHD, after taking into account differences in metabolism between mice and humans. The researchers found Ritalin increased the activity of a gene called c-fos in the striatum, a part of the brain involved in movement and motivation. "These data do suggest that there are effects of Ritalin on cell function ......iversity Medical School and the kidney and mineral metabolism center at Children's Memorial Hospital, Chicago, agreed the new research might pave the way for development of "designer drugs that really target this mutation." But Langman cautioned it is premature to suggest this new finding will quickly lead to ...Myoglobin Assay for the VITROS ECi Immunodiagnostic System
...ac, reproductive, endocrinology, oncology and bone metabolism testing are currently available, with infectious disease assays under development. The VITROS ECi can simultaneously process 60 accessible samples for a throughput of 90 patient reportable results per hour.......ac, reproductive, endocrinology, oncology and bone metabolism testing are currently available, with infectious disease assays under development. The VITROS ECi can simultaneously process 60 accessible samples for a throughput of 90 patient reportable results per hour....... Most of the residual DHT undergoes intracellular metabolism to 3a -androstanediol and 3a -androstanediol glucuronide. Only a small proportion of DHT escapes into the peripheral circulation, where it is present primarily complexed to sex-hormone binding globulin [3]. In fetal life, testosterone causes virili......ion, vascular tone, substrate utilization and bone metabolism [1,2,3]. Cortisol is excreted in urine in an unbound (free) form. Cortisol levels follow a ACTH-dependent circadian rhythm with peak levels in the early morning and a nadir at night. Increased amounts of ACTH and cortisol are also secreted independen...Gene Chips to Detect CYP Variations: A New Step Toward Customized Medical Therapy.
... 2C19, 2D6, 2E1, 3A4) account for over 90% of drug metabolism (but do not appear to account for the selectivity of BiDil). Since a patient can take several concurrent medications metabolized by the same CYP enzyme, it should come as no surprise that CYP-related drug interactions are common. Clinicians are gen......d clinical practice of paediatricendocrinology and metabolism throughout the world. Founded in 1962,ESPE has increased in both size and scope, becoming one of thelargest and most leading international scientific communities ofpaediatric endocrinologists. About Generex Generex is engaged in the research and de...Major New Review Supports the Broader Potential of CeNeS COMT Inhibitor Discovery Programme
...alabsorption, short plasma half-life and extensive metabolism issues.The goal of breaking away from this nitrocatechol series has beenachieved by CeNeS scientists, and a number of discrete chemicalseries without the nitrocatechol group have been identified. TheCOMT inhibitor programme was carefully chosen by Ce......sitagliptin is excreted unchanged in theurine with metabolism being a minor pathway of elimination. Following...that the primary enzyme responsible for thelimited metabolism of sitagliptin was CYP3A4, with contribution fromCYP2C8. Excretion Following administration of......ment activities leverage the company'sexpertise in metabolism to develop potential therapies to treatdiabetes and obesity. Amylin is located in San Diego, Californiawith over 1,600 employees nationwide. For more information aboutAmylin and the company's diabetes products, visit <a target="_blank" href="http...