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Macrophage in Medical News

Stunning finding: Compounds protect against cerebral palsy

... oxide-producing enzymes found in endothelial and macrophage cells. Endothelial cells regulate blood pressure, and macrophage cells play an important role in the immune ... good selectivity of the brain enzyme over the macrophage enzyme but with no selectivity over the ...

Prostaglandin receptor key to atherosclerosis development

... EP4 receptor. They also observed an increase in macrophage programmed cell death (apoptosis) in the ... that two pathways known to be involved in macrophage cell survival (PI3K/Akt and NF-kappaB pathways) ... mice, suggesting a mechanism for the increase in macrophage cell death. "Our studies clearly show that ...

TB treatment for the elderly likely requires a boost to immune response

... therapy in the lung that would activate the macrophage better, either way they should be able to control ... also called an antigen-presenting cell. The macrophage activates specific molecules that make pieces of ... called interferon gamma, which activates the macrophage to help it kill the bacteria. If the immune ...

Weill Cornell receives $2.4 million in grants from Gates Foundation to fight tuberculosis

... of macrophages, helped identify the first macrophage activating factor (interferon-g) and its ... demonstrated the role of the respiratory burst in macrophage biology, and pioneered numerous advances in ... research efforts, including those directed at macrophage interactions with Mycobacterium tuberculosis. ...

NIH awards $10.8M to Columbia to study connection between diabetes and heart disease

... these diseases. Expansion of Earlier Work on macrophage Deaths Link to Atherosclerosis The molecular ... pile up to form what Dr. Tabas calls a macrophage graveyard or necrotic core causing plaque ... raising the possibility that amplified plaque macrophage death is an important factor in the higher rate ...

Stripping leukemia-initiating cells of their 'invisibility cloak'

... on the surface of those cells that sends a "don't eat me" signal to the macrophage immune cells that serve as a first line of defense, according to the ... stem cells co-opt this ability and take it to an extreme in order to evade macrophage killing. With their colleagues Ravindra Majeti and Mark Chao at ...

Lung cancer cells activate inflammation to induce metastasis

... (LLC) showed particularly potent activation of macrophages. Furthermore, macrophage activation was mediated by a secreted protein. Biochemical purification ... of an extracellular matrix protein called versican as the major macrophage activator and metastasis enhancing factor. Versican is also found in very ...

Anti-parasite drug may provide new way to attack HIV

... created by HIV ensures the long-term production of HIV within long-lived macrophage reservoirs. The current study was conducted jointly by the Medical ... seeking to show that Akt inhibition ends the survival of HIV-infected macrophage reservoirs under real-life conditions. ...

Rogue bacteria involved in both heart disease and infertility

... its infected with C. pneumoniae, the microbe traffics cholesterol from the macrophage cell membrane to its own, causing a change in the macrophage that makes it rigid and unable to move. The bacterium also disturbs the ...

Long-Life Gene Might Help Lower Cholesterol

... receptor (LXR). This protein is responsible for moving cholesterol out of macrophage cells. When they're full of cholesterol, macrophage cells can generate the plaques that clog arteries. SIRT1 increases LXR ...

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Macrophage in Medical Technology

Doctors Urge Precaution to Shield Against Swine Flu

... activity in people with low NK cell function, improving the coordination of many aspects of immune response, including the interaction of dendritic macrophage cells, T-cells and B-cells, resulting in improved health. The benefit of AHCC's NK Cell supporting effect, and its role in defense against ...

BioMarin Initiates Phase 1/2 Clinical Trial for GALNS for Morquio A Syndrome

... a systemic skeletal dysplasia, short stature, and joint abnormalities, which limit mobility and endurance. Malformation of the thorax as well as macrophage dysfunction in the lung likely impairs respiratory function and contributes to sinopulmonary infections. Odontoid dysplasia and ligamentous laxity ...

Studies Presented at AACR Annual Meeting Highlight Multiple Immunomodulatory Mechanisms of Peregrine's PS-Targeting Antibodies

... the tumor microenvironment, showing that the anti-PS antibody induced a sequential release of cytokines and beta-chemokines and stimulated enhanced macrophage recruitment to tumors. Furthermore, the researchers showed that in vitro , PGN635 induced antibody-dependent death of endothelial cells, the same ...

Novel Valortim(R) Mechanism of Action Data Presented at the Keystone Symposia on Molecular and Cellular Biology

... shown that in addition to inhibiting anthrax toxin, Valortim(R) augments the immune system's ability to kill anthrax bacilli. In an in vitro mouse macrophage model, Valortim(R) enhanced the killing of B. anthracis (anthrax) by macrophages in a time and dose-dependent manner. The new data presented ...

VIA Pharmaceuticals Announces Positive Results of Phase 2 Studies of VIA-2291 in Patients With Serious Cardiovascular Disease

... at all doses tested (p<0.001). The second trial, the carotid endarterectomy (CEA) trial, missed its primary endpoint of percentage reduction in macrophage inflammatory cells in plaque tissue, but met key secondary endpoints including reduction of high sensitivity C-reactive protein (hs-CRP) (p<0.01). ...

Cytokine Demonstrates Oral Efficacy of Small-Molecule MIF Inhibitors

... efficacy in animal models. Based on these results, the Company announced that it is advancing one of these compounds into preclinical development. macrophage Migration Inhibitory Factor, or MIF, is linked to many conditions, including arthritis, asthma, cancer, sepsis, inflammatory bowel disease and ...

Data Presented at AACR Meeting Shows Peregrine's Selective Anti-VEGF Antibodies are as Effective as Avastin(R) in Preclinical Cancer Models

... with the finding that the VEGFR2 receptor dominates VEGF-induced macrophage recruitment into tumors. The researchers also tested an equivalent fully ... 2128: Blockade of tumor-derived VEGF activation of VEGF receptor 2 reduces macrophage infiltration into tumors and decreases metastasis in a pre-clinical ...

Positive Results Using Affitech-Identified Human Antibody That Blocks VEGF Binding to VEGF Receptor 2 in Preclinical Cancer Model Reported by Peregrine

... library screening method, when tested by Peregrine on a pancreatic cancer model, showed significant reduction of the growth, vascularization and macrophage infiltration of pancreatic tumors in mice. This is the first antibody from Affitech's library that has been tested in a preclinical development ....

Xanthus Presents Novel Approach for Autoimmune Disease Reversal with Symadex

... ability to reverse chronic autoimmune disease in this animal model is notable. The study results suggest this activity may result from inhibiting macrophage function rather than inhibiting T cell function. This mechanism is novel in my experience," said Dr. Karlik. "We now have a significant body of ...
Macrophage in Medical Products

Uretex® Self-Anchoring Urethral Support System

Features:... separate symmetrical passage. Omnidirectional stability: Retains memory and shape. Controlled elongation. Macroporous: Encourages ingrowth. Allows macrophage access. High tear resistance: Strength on warp and weft. ...
Company:C. R. Bard, Inc.
Macrophage in Medical Dictionary

Granulocyte

... in the stool . H ... GM-CSF ( granulocyte - macrophage colon y stimulating factor) An immune ... y-stimulating factor (G-CSF) and granulocyte - macrophage colon y-stimulating factor (GM-CSF), have been ... ) (Leukine) Sargramostim ( Granulocyte - macrophage colon y stimulating factor (GM-CSF); Leukine) ...

Macrophage

... macrophage : A type of white blood that ingests (takes in) foreign material. macrophage s are key players in the immune response to ... invaders such as infectious microorganism s. macrophage s ...

Monocyte

... monocyte enters tissue s, it develops into a macrophage . Monocyte A large white blood cell that ... the body and there differentiate (evolve) into macrophage s. A machine generated percentage of the ... bacteria . Activated monocyte s turn into macrophage s that can engulf and destroy microorganism s ...

Collagen

... cell migration from capillaries. Disruption of collagen in dermis. macrophage infiltration. Lymphocyte s and macrophage s express HLA-DR. But aloe does more than just offer comfort: ...

Lymphocyte

... A white blood cell of the mononuclear leukocyte subgroup (like macrophage / monocyte s ). Lymphocyte s are white blood cells that are part ... or proportion of certain types of lymphocyte s in the patient's blood . macrophage ... lymphocyte (LIM-fo-site) A type of white blood cell . ...

Phagocyte

... and destroying a virus or other foreign matter by phagocyte s. See macrophage ; Monocyte . phagocyte An immune system cell that can surround and kill microorganism s and remove dead cells. Phagocyte s include macrophage s. phantom limb pain ... Acute Lupus Hemo phagocyte Syndrome ....

Reservoir

... HIV and that is not easily penetrated by drugs. Examples include macrophage s, lymphocyte s, the brain, and testes . Ommaya reservoir (o-MY-a ... immune system are also liable to HIV attack. Called monocyte s and macrophage s, these cells may serve to transport the virus to the brain. They may ...

Strains

... used internally, because of its irritant effect on the stomach . macrophage TROPIC VIRUS : HIV strains that preferentially infect macrophage s in cell culture experiments. A flu shot only protects against a ...

Alpha

... both TNF forms are found in the MHC . Both forms of TNF bind to the same receptors and therefore have the same activities. TNF alpha is produced by macrophage s and some other cells. Fetal alpha globulin; AFP How Performed: Adult or child: Blood is drawn from a vein ( venipuncture ), usually ...

Antigen

... substances that for some reason are acting as antigen s; ... Lymph node s are concentrations of lymph atic tissue with T cells, B cells and macrophage s which recognize antigen s and mount a response. When a lymph node responds, it undergoes a hyperplasia with an increase in the numbers of ...

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Macrophage in Biological News

Proteomics study yields clues as to how tuberculosis might be thwarting the immune system

... to demonstrate the endogenous level of LC3-II in macrophage phagosomes through the combination of sensitive ... tuberculosis are phagocytosed into the macrophage cell, they are able to subvert various host ... certain mycobacterial products can modulate macrophage autophagy activity. They are also looking for ...

Policing cells demand ID to tell friend from foe, say University of Pennsylvania cell engineers

... to eat their own kind. Like a police dog, a macrophage responds to a signal that means let go, Dennis ... as well as plastic particles. In all cases, the macrophage binds to a target, often identified by a cloak of ... surface that is specifically recognized by the macrophage to switch off the headlock, thus stopping ...

TB bacterium uses its sugar coat to sweeten its chances of living in lungs

... cell. As part of what is called the innate immune response, the macrophage activates specific molecules that make pieces of the bacteria visible to ... and that allows it to avoid an inflammatory response by slipping into the macrophage through this scavenger receptor," Schlesinger said. During his ...

Dominant cholesterol-metabolism ideas challenged by new research

... ABCA1 might be part of the molecular machinery involved in apoptosis and macrophage activity. The Penn State-Amherst team performed a complex series of ... They also examined the role of ABCA1 enzyme in apoptosis and macrophage activity. A key part of the study was using cells from sufferers of a ...

Older men more likely than women to die after pneumonia

... in The FASEB Journal, GenIMS researchers led by Drs. Yende and Angus found that people with certain gene variations associated with higher levels of macrophage migration inhibitory factor, an innate immune response regulator, were less likely to die following CAP. "Macrophage migration inhibitory factor ...

New study overturns orthodoxy on how macrophages kill bacteria

... or in mice lacking the ability to make superoxide. This suggests that the superoxide and other reactive oxygen species are not making it from the macrophage into the bacterial cytoplasm, Slauch said. "We conclude from all this data that the most sensitive target of ROS in the macrophages lies outside ...

New mediator of smoking recruits

... lung disease. The article from Prasse et al "suggest[s] that chronic nicotine stimulation induced by cigarette smoking promotes macrophage and Langerhans cell accumulation in the lung via an increase in [osteopontin production]." Osteopontin and cellular receptors for nicotine may ...

Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies

... the tumor microenvironment, showing that the anti-PS antibody induced a sequential release of cytokines and beta-chemokines and stimulated enhanced macrophage recruitment to tumors. Furthermore, the researchers showed that in vitro, PGN635 induced antibody-dependent death of endothelial cells, the same ...

UC Davis researchers exploring gene therapy to fight AIDS

... the investigation. "The virus targets cells that are descendants of hemopoeitic stem cells." During the first stages of infection, HIV targets macrophage cells, gaining entrance into the cell by binding to a receptor called CCR5 on the cell's surface. Later in the infection it targets CD4+ T cells, ...

2 genes are important key to regulating immune response

... -- is a boon to medical research," Dr. Ma explains. Prior studies had already shown that CD36 -- a protein receptor lying on the surface of the macrophage -- was important for the recognition of apoptotic cells by macrophages. In this work, the researchers observed that CD36 also helped to trigger IL-10 ...

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Macrophage in Biological Technology

Preclinical Data From Amgen's Oncology Pipeline to be Presented at AACR

... murine CSF-1R monoclonal antibodies (mAb), M279 and AFS98 were evaluated for their effect on mouse corneal angiogenesis and corneal macrophage recruitment in vivo Lead author: Liu H. Abstract No. 1106 (Sunday, April 19, 2009, 1:00 pm - 5:00 pm) -- Complementary and ...

BioMarin's Clinical Trial Application for GALNS for Morquio A Syndrome Accepted by the MHRA

... a systemic skeletal dysplasia, short stature, and joint abnormalities, which limit mobility and endurance. Malformation of the thorax as well as macrophage dysfunction in the lung likely impairs respiratory function and contributes to sinopulmonary infections. Odontoid dysplasia and ligamentous laxity ...

Morria Biopharmaceuticals Plc Announces Results From its Pre-Clinical Screening of Novel Anti-Inflammatory Compounds

... assess the anti-inflammatory properties of Morria's proprietary multi-functional anti-inflammatory compounds. The Immunoprofiler(TM) Screen uses rat macrophage cells which are stimulated using endotoxin (LPS), a potent inflammation-inducing agent. The assay measures key inflammatory mediators, which are ...

A single VSOP can do a 'proton' magic!

... Sensor Only Protein/ Hv1, can carry protons even without making a multimeric complex. Since VSOP is known to be expressed in phagocytes such as macrophage and neutrophil that remove infected pathogens, this finding may help to design new medications for enhancing the activities of innate immunity. They ...

LifeQuest World Launches Immune System Boosting Supplement to the North American Market

... "Our research has shown that this extract is the most powerful, natural immune-stimulatory dietary supplement discovered to date with respect to macrophage activation," says Dr. David Pasco, Assistant Director at NCNPR. The results of this research were published in Planta Medica (Pugh et al, 2001 67(8): ...

PharmAthene Reports Year-End 2007 Financial Results

... the Department of Defense. -- Presenting new mechanistic data for Valortim(TM) showing that Valortim(TM) may possess the ability to enhance macrophage killing of Bacillus anthracis (anthrax) spores within macrophages, potentially blocking the ability of the spores to develop into bacteria ...

Derma Sciences Announces Clinical Poster on Use of MEDIHONEY(TM) Wound & Burn Dressings Wins First Place Award at APWCA

... Regulski said, "Because of its capability as a debrider, anti-inflammatory, free-radical absorber, odor fighter, and properties for fibroblast and macrophage enhancement, this dressing is incredibly versatile and cost-effective. It takes the place of two or three dressings which saves money, and it is very ...

Amarin Signs Agreement to Acquire Ester Neurosciences

... indirect inhibitory effect on key pro-inflammatory cytokines via modulation of AChE-R, as well as a direct anti-inflammatory effect via modulation of macrophage activity mediated by interaction with the toll-like receptor or TLR signalling pathway. Ester Integration Preparations for the integration of ...

Ranbaxy to Consolidate Position in Biopharmaceuticals and Speciality Injectables Including Oncology

... Zenotech has received three Indian approvals for Oncology Biopharmaceuticals i.e. GCSF (Granulocyte Colony Stimulating Factor), GM-CSF (Granulocyte macrophage Colony Stimulating Factor) and IL-2 (Interleukin-2). For the latter two, Zenotech is the first to receive approvals in India, and has a pipeline of ...

Taming the anthrax threat

... as it activates inside the defender macrophages, Bergmans team used DNA microarrays, a technology emerging in the last decade, to examine mouse macrophage cells infected with the attenuated version of the microbe. It is modified so that it cannot infect laboratory workers but remains infectious in mice ...

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Macrophage in Biological Products

RAW 309 Cr.1 Cell Lysate from Santa Cruz Biotechnology, Inc.

Description:... 500 g protein in 200 l SDS-PAGE Western blotting buffer mouse whole cell lysate; Abelson transformed macrophage cells whole cell lysate provided as Western blotting positive control should be stored at -20C and repeated freezing and thawing should be ...
Company:Santa Cruz Biotechnology, Inc.

Mouse Anti-Macrophage L1 protein Calprotectin Monoclonal Antibody, Unconjugated, Clone B314.1 (MAC 387) from Abcam

Description:... Mouse monoclonal [B314.1 (MAC 387)] to macrophage L1 protein Calprotectin (rating: ****) ( Abpromise for all tested ....
Company:Abcam

Osteoclasts Culture Kit from B-Bridge International

Description:... of around 4.5. The bone mineral is then solubilized and the collagen degraded. Osteoclast differentiation and function is controlled primarily by macrophage Colony-Stimulating Factor (M-CSF) and Receptor for Activation of Nuclear Factor Kappa B Ligand (RANKL). The absence of NF-Kappa B leads to the bone ...
Company:B-Bridge International

Human Granulocyte Macrophage Colony Stimulating Factor, Unconjugated from PeproTech

Description: ...
Company:PeproTech
Macrophage in Biological Definition

Antibody

... because this enables that in different situations only certain immune mechanisms respond to antigens. The humoral immune response When a macrophage ingests a pathogen , it attaches parts of its proteins to a class II MHC protein. This complex is moved to the outside of the cell membrane , ...

Immune system

... perforin / apoptosis /clonal selection immunosuppression immunosuppressive drug immunotherapy lymphatic system / lymphocyte macrophage major histocompatibility complex / class I MHC /class II MHC monoclonal antibody / polyclonal antibody ...
Macrophage in Biological Dictionary

Lipid

... up to 34% and triglycerides by up to 76% while also improving circulatory health. Just $29.95 Nature - the world's best science and medicine ... macrophage lipid droplets: Inert? ... Lipid structure database. Gene/protein database. MS analysis tools ... This is a targeted update of the February ...
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(Date:7/10/2014)... An international team ... step of photosynthesis in action for the first time. The ... used the world,s most powerful X-ray flashlight at the US ... molecular complex called photosystem II as it splits water into ... earth,s atmosphere. The researchers report their results in the scientific ...
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