Scripps research scientists engineer new type of vaccination that provides instant immunity
... area. In addition, the most common vaccination strategies use whole proteins, viruses, or other complex immunogens not just the specific part of the macromolecule that is recognized by the immune system to elicit an immune response, which makes for wasted immune activity. Then there is the body's own kinetics ...New understanding of how big molecules bind will lead to better drugs, synthetic organic materials
... depend on geometrical features. It is the geometrical arrangement of the component parts, as much as their chemical identity, that determines how a macromolecule will behave and interact with other molecules both large and small. Some molecules will only react or bind with certain others, often temporarily, on ...An All Important Breakthrough Reached In Understanding T cell response For Parasitic Diseases
... is that the T cell response in T. cruzi is highly focused on a relatively small set of cellular features called 'epitopes,' which are part of a macromolecule that is recognized by the immune system. The specific epitopes involved are ones encoded by the trans-sialidase (or 'ts') family of genes. 'The ...Discovery of Agile Molecular Motors Could Aid in Treating Motor Neuron Diseases
... (ALS, commonly known as Lou Gehrig’s disease). Using a specially-constructed microscope that allows researchers to observe the action of one macromolecule at a time, the team found that a protein motor is able to move back and forth along a microtubule – a molecular track – rather than in one direction, ...Artificial cells, simple model for complex structure
... one with a higher percentage of PEG and one with a higher percentage of dextran. "The materials do not separate completely with one type of macromolecule in one section and the other completely apart," says Keating. "But the two aqueous phases are different enough that additional molecules, such as ...Proteins may behave differently in natural environments
... expansion was directly related to the function of the assembly. From a more global perspective, this is strong evidence that we need to study how any macromolecule behaves in a solution environment." ...Discovery of agile molecular motors could aid in treating motor neuron diseases
... (ALS, commonly known as Lou Gehrig's disease). Using a specially-constructed microscope that allows researchers to observe the action of one macromolecule at a time, the team found that a protein motor is able to move back and forth along a microtubule ?a molecular track ?rather than in one direction, ...Researchers add crucial information on how the body's T cells react to parasitic diseases
... is that the T cell response in T. cruzi is highly focused on a relatively small set of cellular features called "epitopes," which are part of a macromolecule that is recognized by the immune system. The specific epitopes involved are ones encoded by the trans-sialidase (or "ts") family of genes. "The ...Polymer Degradation Mechanisms Encountered in Pyrolysis-GC/MS
... elevated temperatures. The utility of the technique is based on the application of thermal energy to produce volatile fragments and products from a macromolecule compounds capable of being analyzed using GC/MS. The production of these analytes must, of course, be reproducible and follow chemical principles ...