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Lysosomes in Medical News

St. Jude Study Reveals a New Function for an Old Enzyme in Fatal Childhood Disease

... white cell lysosomes are more prone than normal lysosomes to dock and eventually fuse with the cell ... to discover that an old, ubiquitous enzyme in lysosomes better known for digesting cellular ... that the way NEU1 regulates the pool of lysosomes destined for lysosomal exocytosis is by cutting ...

Pathway to cell death redefined in landmark study

... study, Drs. Silverman, Luke and colleagues labeled enzymes within the lysosomes of SRP-6-deficient animals with a fluorescent biomarker to observe how these enzymes reacted after an injury to the critical structure. The lysosomes popped, released their contents into the cell and these digestive enzymes ...

Pathway to cell death redefined in landmark study

... study, Drs. Silverman, Luke and colleagues labeled enzymes within the lysosomes of SRP-6-deficient animals with a fluorescent biomarker to observe how these enzymes reacted after an injury to the critical structure. The lysosomes popped, released their contents into the cell and these digestive enzymes ...

Immune reaction to metal debris leads to early failure of joint implants

... According to Hallab, when specialized cells of the immune system, called macrophages, encounter this metallic debris, they "engulf it in sacs called lysosomes and try to get rid of the debris by digesting it with enzymes." But the particles damage the lysosomes, Hallab said, "and the cells start screaming ...

Toxicity mechanism identified for Parkinson's disease

... selected proteins are funneled into lysosomes, compartments of the cell devoted to chewing up discarded proteins. Mao and colleagues found that lysosomes isolated from cells will absorb MEF2D protein, and interfering with CMA chemically causes MEF2D levels to rise. MEF2D is a transcription factor, ...

New Alzheimer's predictors advance earlier detection

... at digesting and expelling the toxic, misfolded protein, the researchers report. The study shows that the failure to degrade amyloid beta in lysosomes containing the digestive enzymes is an important factor in Alzheimer's disease. Amyloid beta and another protein called tau are associated with the ...

Drugs Activating PXR May Help In Treating Niemann-Pick type C disease

... and recycling units within cells known as lysosomes become jammed, preventing proper degradation of ... In NPC, the molecule that builds up in the lysosomes is cholesterol. Cells use compounds made from ... own internal cholesterol level. The jam in the lysosomes disrupts creation of these byproducts, impairing ...

Progressive Genetic Diseases Can Be Detected By A Simple Blood Test

... newborn testing. Lysosomes are small compartments within cells that help to recycle waste cellular material within the body. Enzymes within the lysosomes do this job by breaking up waste materials into smaller pieces. If one of these enzymes is not functioning, usually because of a problem in the ...

Dark skin protects

... contained inside vesicles called melanosomes. Larger, more numerous melanosomes make for darker skin. Mackintosh suggests melanosomes might act like lysosomes in the immune system, which engulf invading microorganisms and use enzymes to kill them. "Melanin is a sticky molecule. The bacteria and fungi ...
Lysosomes in Medical Technology

Amicus Therapeutics Presents Preclinical Data from Studies of Plicera for Gaucher Disease

... a summary of the preclinical Plicera data being presented at ACMG. - In vitro exposure to Plicera increased transport of GCase to the lysosomes in cells derived from a patient with the N370S mutation. Once in the lysosome, the enzyme was stable and active for more than 3 days ...
Lysosomes in Biological News

New data on the breakdown of the KRas protein

... known activity takes place, to the lysosomes. The lysosomes are organelles responsible for breaking down ... whether the signals emitted on the way to the lysosomes have a different meaning for the cell than those ... cancer and diseases in which the formation of lysosomes is abnormal, such as Niemann-Pick disease. KRas ...

The Prestige oil spill caused changes in the cell structure of mussels

... changes at cell level in the mussels. Up to 2004 it could be seen that the lysosomes organs responsible for cellular digestion suffered drastic changes in ... From 2004 on the situation showed signs of recovery and the size of the lysosomes had returned to their reference values, although in 2006, the stability of ...

In scientific first, Einstein researchers correct decline in organ function associated with old age

... molecules known as chaperones to seek out damaged proteins. After finding such a protein, the chaperone ferries it towards one of the cell's many lysosomes membrane-bound sacs filled with enzymes. When the chaperone and its cargo "dock" on a receptor molecule on the lysosome's surface, the damaged ...

NYU Langone Medical Center's tip sheet to the International Conference on Alzheimer's Disease 2008

... at digesting and expelling the toxic, misfolded protein, the researchers report. The study shows that the failure to degrade amyloid beta in lysosomes containing the digestive enzymes is an important factor in Alzheimer's disease. Amyloid beta and another protein called tau are associated with the ...

Biologists at UC San Diego identify key protein in cell's 'self-eating' function

... and dispose of harmful peroxides that are by-products of oxidative chemical reactions. Different organelles within the cell are degraded by lysosomes when the organelles are damaged or not necessary, said Jean-Claude Farr, the biologist who identified Atg30. The team is investigating peroxisomes, ...

Mechanism for the in-vivo transport of siRNA

... the siRNAs were able to enter the cell via the normal absorption route like HDL, because this route leads into the cells own digestive system with lysosomes that would degrade the siRNAs. So how would the siRNAs be able to avoid this degradation" Stoffel concluded that they simply use a different doorway ...

A key antibody, IgG, links cells' capture and disposal of germs

... that corral invading pathogens and the potent lysosomes that eventually kill off the germs. The ... plays a key role in this merger of phagosomes and lysosomes into the so-called phagolysosomes that finally do ... Specifically, the antibody prompts phagosomes and lysosomes to dock and bind to each other with actin ...

The biggest bug in gut discomfort

... and was briefly cloaked in the early endosomal marker EEA-1, and then the late endosomal marker Lamp-1. Was C. jejuni trafficking to conventional lysosomes after all" To check, the researchers fed traceable dyes to infected cells. Taken up into the endocytic pathway, the fluorescent dyes co-localized ...

A molecule impedes the destruction of the 'Brucella' bacteria

... bacteria, such as those of tuberculosis or legionelosis. Brucella penetrates the macrophages within membranous vesicles that are not fused with lysosomes (structures containing cellular products necessary to destroy bacteria) as occurs in other micro-organisms. On the contrary, they reach certain ...
Lysosomes in Biological Technology

Mechanism for the in-vivo transport of siRNA

... the siRNAs were able to enter the cell via the normal absorption route like HDL, because this route leads into the cells own digestive system with lysosomes that would degrade the siRNAs. So how would the siRNAs be able to avoid this degradation" Stoffel concluded that they simply use a different doorway ...

Milwaukee area biotech ZyStor seeks more funding

... Lysosomal Storage Diseases. LSDs are a class of more than 40 genetic diseases, each caused by the lack of a specific lysosomal enzyme in human cells. lysosomes act as a cellular recycling center where macromolecules are broken down into their component parts, and the absence of any lysosomal enzyme causes a ...
Lysosomes in Biological Definition

Golgi apparatus

... function is to process proteins targeted to the plasma membrane, lysosomes or endosomes and those that will be secreted from the cell, and sort them ... is involved in the transport of lipids around the cell as well creating lysosomes -- organelles involved in digestion . ...

Vesicle

... reticulum , or are made from parts of the plasma membrane . lysosomes (membrane-bound digestive vesicles) can digest macromolecules (break them ... to protect the cell interior from being digested by its own enzyme. lysosomes are made in the Golgi apparatus. Neurons store neurotransmitters in ...

Cytoplasm

... and the cell's interior is liquid. The insoluble constituents of the cytoplasm are organelles (such as the mitochondria , the chloroplast , lysosomes , peroxysomes , ribosomes ), several vacuoles , cytoskeletons as well as complex membrane structures (e.g. endoplasmic reticulums or the ...

Endomembrane system

... endoplasmic reticulum is an extension of the nuclear envelope]. The Golgi apparatus acts as the packaging and delivery system for molecules. lysosomes are the "digestive" units of the cell. They utilize enzymes to break down macromolecules and also act as a waste disposal system. Vacuoles act ...

Eukaryote

... modified in stacks of flattened vesicles, called Golgi bodies or dictyosomes. Vesicles may be specialized for various purposes. For instance, lysosomes contain enzymes that break down the contents of food vacuoles, and peroxisomes are used to break down peroxide which is toxic otherwise. Many ...

Major histocompatibility complex

... cytosolic as in class I). Loading of class II molecules must still occur inside the cell; extracellular proteins are endocytosed , digested in lysosomes , and bound by the class II MHC molecule prior to the molecule's migration to the plasma membrane. The peptides are longer, generally between 15-24 ...

Peroxisome

... that separates them from the cytosol (the internal fluid of the cell). Peroxisomes were discovered by Christian de Duve in 1965 . Unlike lysosomes , which are formed in the Golgi apparatus , peroxisomes usually self-replicate by enlarging and then dividing, although there is some indication new ...

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Lysosomes in Biological Dictionary

Lysosome

... lysosomes are organelles containing digestive enzymes . ... - Wikipedia, the free encyclopedia ... lysosomes are the cells' garbage disposal system. ... The ... & Encyclopedia Articles Quickly. ... lysosomes are about 1 μm in diameter, are surrounded by a ...

Lysosomes

... lysosomes are organelles containing digestive enzymes ... organelles, food particles, and ... lysosomes break down cellular waste products and debris from outside the cell ... In this regard, the lysosomes recycle the cell's organic material in a process ...

Pinocytosis

... is a form of endocytosis in which small particles are brought into the cell suspended within small vesicles which subsequently fuse with lysosomes to hydrolyze, or to break down, the particles. This process requires energy in the form ... a process by which liquid droplets are ingested by ...

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(Date:4/17/2014)... 17, 2014) Two recent papers by a ... colleagues may help scientists develop treatments or vaccines ... Japanese encephalitis and other disease-causing flaviviruses. , Jeffrey ... molecular genetics at the School of Medicine and ... Medical Institute, and colleagues recently published articles in ...
(Date:4/17/2014)... April 17, 2014U.S. military personnel who served in ... concussive traumatic brain injury (TBI) were compared to ... other medical reasons. Differences in measures of overall ... months after injury are reported in an article ... journal from Mary Ann Liebert, Inc., publishers. The ...
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(Date:4/17/2014)... Calif.) An international team led by researchers at ... complex, which plays a key role in cell division, ... This is the first time the complex has been ... make cyclin B1/Cdk1 an excellent target to control cellular ... The research was published online today in the journal ...
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(Date:4/17/2014)... chili peppers. Information about archaeological remains of ancient chili ... appearance of words for chili peppers in ancient dialects ... highlight the value of multi-proxy data analysis. Their results ... papers presented in a special feature issue of the ... on plant and animal domestication edited by Dolores Piperno, ...
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