Navigation Links
Lysosome in Medical News

Pathway to cell death redefined in landmark study

... garbage disposal. Powerful enzymes within the lysosome digest old, worn out proteins, carbohydrates, ... even invading bacteria and viruses. But if the lysosome becomes damaged and leaky, these enzymes can turn ... that SRP-6 staves off necrosis by protecting the lysosome membrane from damage caused by the calpain family ...

Pathway to cell death redefined in landmark study

... garbage disposal. Powerful enzymes within the lysosome digest old, worn out proteins, carbohydrates, ... even invading bacteria and viruses. But if the lysosome becomes damaged and leaky, these enzymes can turn ... that SRP-6 staves off necrosis by protecting the lysosome membrane from damage caused by the calpain family ...

St. Jude finds link between cellular defense processes, showing how cancer cells survive

... a sac that fuses with a bag of digestive enzymes called the lysosome. The lysosome then releases the digestive enzymes into the sac and the enzymes degrade ... machinery to enable the phagosome to fully develop and fuse with the lysosome even if autophagy itself doesnt occur simultaneously, Green said. We ...

Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells

... apparently unstable because they cannot fold properly into their correct three-dimensional structure. The corrupted, mutant enzymes fail to reach the lysosome and to break down fatty glucosylceramides, which then accumulate there. The current approaches to treating Gaucher disease (and many other ...
Lysosome in Medical Technology

BioMarin Initiates Phase 1/2 Clinical Trial for GALNS for Morquio A Syndrome

... and importantly, the growth plate. Our experiments have also shown that GALNS is taken up into human Morquio chondrocytes in vitro and reaches the lysosome to clear keratan sulfate." Chris Hendriksz, M.D., Consultant in Metabolic Disorders, Birmingham Children's Hospital, added, "This is a very ...

Protein Found to Shield Pancreatic Cancer Cells from Self-Destruction

... When autophagy occurs, a double membrane forms around a cell organ, or organelle. This autophagosome then merges with a digestive organelle called a lysosome and everything inside is consumed, leaving the vacuole and a residue of digested material. If enough of this happens, the cell dies. Gabriel ...
Lysosome in Biological News

Iron-moving malfunction may underlie neurodegenerative diseases, aging

... With their modification, which they call the lysosome patch clamp, Xu's group was able to record TRPML1 ... of the lysosome," Xu said. "And we know the lysosome is important for all kinds of cell biology, ... conditions. "If we can somehow manipulate the lysosome iron level, we probably can provide a treatment ...

Biologists at UC San Diego identify key protein in cell's 'self-eating' function

... components through this self-eating process. A part of the cell called the lysosome engulfs and degrades subcellular detritus. The ability of cells to recycle ... and working to understand how and why they are selected by the lysosome for degradation. What the biologists found, he said, is that this new ...

In scientific first, Einstein researchers correct decline in organ function associated with old age

... filled with enzymes. When the chaperone and its cargo "dock" on a receptor molecule on the lysosome's surface, the damaged protein is drawn into the lysosome and rapidly digested by its enzymes. In previous work, Dr. Cuervo found that the chaperone surveillance system, in particular, becomes less ...

Cellular self-eating promotes pancreatitis

... destroying the pancreas by prematurely activating a digestive enzyme. In autophagy, a vesicle swallows a portion of cytoplasm and ferries it to the lysosome for digestion. The process is often beneficial, allowing hungry cells to recycle molecules, for example. However, the researchers previously ...

Nixing immaturity in red blood cells

... an envelope or vesicle around components of the cell that need to be degraded and removed. The vesicle then fuses with a cellular component called a lysosome that degrades its contents. The inclusion of components in the cell by autophagy vesicles was generally considered to be nonspecific. This is ...

Going live with click chemistry

... said Bertozzi. In addition to their cell surface roles, glycans can regulate many intracellular processes, including trafficking of proteins to the lysosome and transcription and translation. There is great scientific interest in monitoring the dynamics of glycans as they move about within cells and on ...

Penn researchers link cell's protein recycling systems

... of neurodegeneration. “We found that whenever we knocked the lysosome system down, neurodegeneration always got worse,” says Taylor. “Then when ... was prevented.” The accumulated misfolded proteins were cleared out by the lysosome system. “Then we knew that this system can compensate for the impaired ...

Protein found to shield pancreatic cancer cells from self-destruction

... When autophagy occurs, a double membrane forms around a cell organ, or organelle. This autophagosome then merges with a digestive organelle called a lysosome and everything inside is consumed, leaving the vacuole and a residue of digested material. If enough of this happens, the cell dies. Gabriel ...
Lysosome in Biological Technology

YM BIOSCIENCES ANNOUNCES PRESENTATIONS FOR TWO OF ITS ANTI-CANCER DRUGS AT AACR ANNUAL MEETING

... in drug-resistant tumour cells. Genomic studies have shown that two tesmilifene-dependent genes in MCF-7(DOX-2) cells were found to be related to lysosome function. "This is an important finding suggesting that tesmilifene can target cells that are normally resistant to chemotherapy and may have ...

ZyStor to exhibit cell disorder treatments

... very rare genetic disorders known as lysosomal storage disorders. A lysosome is a cell compartment containing enzymes that digest particles and that ... surfaces on clinically significant tissues - so that it can get into the lysosome of the cell, where it can then reduce the storage material that builds up ...

ZyStor seeks to raise $15M for clinical trials

... the enzyme's carbohydrates. The tag is embedded within the therapeutic enzyme to promote internalization into the cell, targeting the enzyme to the lysosome and prolonging the life of enzymes in the bloodstream. In addition to the experiment in Florida, more animal studies are underway, including a ...

Transfection Reagent Selector Kit Handbook

... receptors (e.g. sialylated glycoproteins) on the surface of eukaryotic cells. Once inside the cell, SuperFect Reagent buffers the lysosome after it has fused with the endosome, leading to pH inhibition of lysosomal nucleases. This ensures stability of SuperFectDNA ...
Lysosome in Biological Products

Mouse Anti-LAMP2 Monoclonal Antibody, Phycoerythrin Conjugated, Clone H4B4 from Abcam

Description:... Mouse monoclonal [H4B4] to LAMP2 - lysosome Marker (Phycoerythrin) ( Abpromise for all tested applications). entrezGeneID: 3920 SwissProtID: ...
Company:Abcam
Lysosome in Biological Definition

Amino acid

... many proteins as a regulatory mechanism, changing the conformation and behavior of the polypeptide in acidic regions such as the late endosome or lysosome . I Ile Isoleucine hydrophobic 131.17 6.05 2.32 9.76 K Lys Lysine basic 146.19 9.60 ...

Lipase

... the interior spaces of living cells to degrade lipids. In the example of lysosomal lipase, the enzyme is confined within an organelle called the lysosome . Other lipase enzymes, such as pancreatic lipases, are found in the spaces outside of cells and have roles in the metabolism, absorption and ...

Organelle

... bacteria : chloroplast mitochondrion Other organelles include: centriole endoplasmic reticulum golgi apparatus lysosome myofibril plastids nucleus peroxisome ribosome vacuole vesicle melanosome Other related structures: ...

Vesicle

... endocytic vesicle. This is the basic way for a cell to feed (except for photosynthesis in plants, which don't have lysosomes). The membrane of the lysosome is impermeable for lysozyme , the enzyme that does the actual digestion, to protect the cell interior from being digested by its own enzyme. ...
Lysosome in Biological Dictionary

Lysosome

... organelles, food particles, and ... lysosome ( ) n. A membrane-bound organelle in the ... enzymes that function in intracellular lysosome an organelle found in the cytoplasm of most ... in leukocytes and liver and kidney ... the lysosome does not digest the wall of ...

Lysosomes

... lysosomes in nearly every animal ... lysosome ( ) n. A membrane-bound organelle in the ... pathways (phagocytosis, endocytosis, ... The lysosome is a membranous bag which contains hydrolytic enzymes that are used ... The lysosome contains over 40 enzymes, some of which are the ...

Vacuole

... and word games. Encyclopedia article about Vacuole . Information about Vacuole in the Columbia ... In animals, a lytic vacuole known as the lysosome typically functions to process ... ... information on Vacuole ... They also use contractile vacuole s to pump out excess water so ... This ...

More>>

Other Contents
(Date:1/22/2015)... Oceanside,CA (PRWEB) January 22, 2015 For over 20 ... the Oceanside and Vista area has treated just about ... other personal injury circumstances. And for those same twenty-plus years, ... victims of all those injuries with the best possible doctor. ...
(Date:1/22/2015)... La Jolla, Calif. (PRWEB) January 22, 2015 ... and Assemblymembers Susan Bonilla (D-Concord) and Kristin Olsen ... (CHI) for their leadership in advancing biotechnology, biomedical ... Mitchell, Bonilla and Olsen each received the “2014 ...
(Date:1/22/2015)... WASHINGTON, DC (PRWEB) January 22, 2015 ... conditions in vulnerable communities and cause financial distress to ... report by analysts at Howard University’s Center on Race ... of dollars in economic activity, payday loans at the ...
(Date:1/22/2015)... Compare-autoinsurance.org has released a new blog post presenting a list of ... . , Some types of vehicles cannot be covered under ... blog post to see if their vehicle qualifies for auto insurance ... of the cars that cannot be covered by a plan. Clients ...
(Date:12/26/2014)... December 26, 2014 The US represents the ... report. In 2013, GlobalData’s forecast estimates that sales of branded ... market due to the high incidence of the disease, high ... 5EU, Japan, and China. Increased sales of CRC therapies over ...
Breaking Medicine News(10 mins):Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 3Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 4
(Date:1/22/2015)... (NASDAQ: NXTD and NXTDW) a biometric authentication company focused ... the Wocket™ smart wallet at CES 2015 in Las Vegas ... of the "11 Hot Products at CES" in a review published in ... by Newseveryday.com and "The top 10 gadgets from CES 2015" by ...
(Date:1/22/2015)... , Jan. 22, 2015   EyeLock, Inc. , a ... has appointed Steve Gerber to the new role ... be responsible for leading development of mobile platforms and wearable ... of success and innovation in the semiconductor industry to his ...
(Date:12/22/2014)... , Dec. 22, 2014  The 2014 Holiday Season may ... Acuity Market Intelligence reports that the long anticipated floodgates ... that intensifying demand for smart phones, tablets, and wearable ... market of 2.5 billion users with nearly 4.8 billion ...
Breaking Biology News(10 mins):CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2
Other TagsOther Tags