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Lysis in Medical News

Targets on the horizon: Emerging therapies and novel targets

... therapies, BiTE antibodies can recruit killer T cells for redirected lysis of tumor cells, said Roman Kischel, M.D., director of immunotherapy at ... expressing the antigen are attacked by T cells, and we can see target cell lysis at very low picomolar concentrations of BiTE antibodies. When ...

Journal of Clinical Oncology Publishes TREANDA Study Demonstrating Significant Improvement in Overall Response and Progression-Free Survival in Chronic Lymphocytic Leukemia

... adverse reactions have been associated with TREANDA in clinical trials: myelosuppression, infections, infusion reactions and anaphylaxis, tumor lysis syndrome, skin reactions, and other malignancies. TREANDA has a unique chemical structure that is synthesized to combine an alkylating group ...

MO BIO Laboratories, Inc. Launches PowerFood(TM) Microbial DNA Isolation Kit

... Further, it is the only complete kit on the market, eliminating the need to purchase additional reagents for post-purification clean up and lysis enzymes. The PowerFood Microbial DNA Isolation Kit incorporates patented Inhibitor Removal Technology(R) (IRT) to remove PCR-inhibiting compounds ...

Pharmacomechanical Thrombectomy Procedure Adoption to Accelerate Due to More Aggressive Treatment of Deep Vein Thrombosis, According to Millennium Research Group

... is slated to begin recruitment in July 2009. "Firms are hoping that results of this trial will clarify the association between rapid clot lysis and the prevention of post-thrombotic syndrome in patients with proximal DVT, as well as demonstrate how PMT may have lower bleeding risks compared ...

NeuroTherm Completes Acquisition of the Micron Epidural Catheter

... for us to provide an epidural catheter as part of our product mix," continues Davis. The Micron Catheter is used in a procedure called Epidural lysis of Adhesions; a common interventional pain procedure used to remove scar tissue. The scar tissue which typically result from back surgery, inflame ...

Early treatment of systemic onset JIA with anakinra restores the IL-18 response

... the six month study, numbers of NK cells slightly increased initially but remained stable throughout treatment with anakinra, although specific lysis (the death of a cell by breaking of the cellular membrane) was restored to normal within just three days. Interestingly, the NK cell response after ...
Lysis in Medical Technology

Phase III Trial Results Show Elitek(R) (rasburicase) Significantly Reduced Plasma Uric Acid Levels versus Allopurinol in Adults with Hematologic Cancers at Risk for Tumor Lysis Syndrome

... malignancies at high or potential risk for tumor lysis syndrome (TLS) demonstrated that Elitek(R) ... allopurinol alone (p=0.06). Tumor lysis syndrome is a potentially life-threatening ... (p=0.06). Among patients at high risk for tumor lysis syndrome, the PUA response rate was 89% with ...

Micromet Demonstrates That the Antibodies in Commercial Products Herceptin, Erbitux, Vectibix and Xolair Can Be Converted Into Highly Potent, T Cell- Engaging BiTE Antibodies

... IgE target antigens, all showed high potency as demonstrated by redirected lysis of respective target cells at half maximal concentrations below 1 ng/ml ... how to recruit T cells for a very selective and highly effective lysis of target cells. Proof of concept has been established for the BiTE ...

Micromet Presents Preclinical Data Showing Activity of Erbitux and Vectibix Based BiTE Antibodies against KRAS- and BRAF-mutated Human Colorectal Cancer Cells

... for the treatment of patients with KRAS- and BRAF-mutated colorectal cancer is now possible." (1)Lutterbuese, R. et al. Highly efficient lysis of KRAS- and BRAF-mutated human colon cancer cells by T cell-engaging BiTE antibodies derived from anti-EGFR antibodies cetuximab and panitumumab ...

Jennerex Treats First Patients in Phase 2 JX-594 Trial for Liver Cancer

... high levels in cancer cells. To enhance product efficacy, JX-594 is also engineered to express the GM-CSF protein. GM-CSF complements the cancer cell lysis work of the product candidate, leading to a cascade of events resulting in tumor necrosis, tumor vasculature shutdown and an anti-tumoral immune ...

Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma

... and pulmonary disorders, reversible posterior leukoencephalopathy syndrome, gastrointestinal adverse events, thrombocytopenia, neutropenia, tumor lysis syndrome and hepatic events. Women of childbearing potential should avoid becoming pregnant while being treated with VELCADE. Nursing mothers are ...

New Study Shows PCR and FCR Have Significant Activity in B-cell Chronic Lymphocytic Leukemia

... Superiority of Rasuburicase vs. Allopurinol on serum uric acid control in adult patients with hematologic malignancies at risk of developing Tumor lysis Syndrome Multiple Myeloma Jeffrey Matous, M.D., Rocky Mountain Cancer Centers-Midtown: Phase II study ...

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Lysis in Medical Products

Wampole ISOSTAT/ISOLATOR Microbial System

Description:... of its susceptibility to antimicrobial agents are essential. The Wampole ISOSTAT/ ISOLATOR Microbial System is a blood culture method based on lysis centrifugation. This technology is used to concentrate microorganisms in the sample resulting in faster isolation and increased recovery of organisms ...
Company:Inverness Medical Innovations

Centra-GP8F

Description:... research and patient specimen processing are typical uses. A special capability is extremely accurate low speed control to 50 xg to prevent lysis of delicate cells. Rotor variety accepts popular large capacity bottles up to 750 ml, 28x50/48x15 ml Falcon/Corning conical tubes ...
Company:ThermoFisher Scientific

Vortex adapter, for Labnet vortex, holds 2 each 50 ml tubes

Description:... Use the Mo Bio Vortex adapter to process multiple samples at the same time. The adapter holds tubes horizontally to increase cell lysis and mixing efficiency. Ideal for bead beating ....
Company:Mo Bio Laboratories, Inc.

Vortex adapter, for Labnet vortex, holds 12 each 1.5 - 2.0 ml tubes

Description:... Use the Mo Bio Vortex adapter to process multiple samples at the same time. The adapter holds tubes horizontally to increase cell lysis and mixing efficiency. Ideal for bead beating ....
Company:Mo Bio Laboratories, Inc.

Vortex adapter, for Labnet vortex, holds 4 each 15 ml tubes

Description:... Use the Mo Bio Vortex adapter to process multiple samples at the same time. The adapter holds tubes horizontally to increase cell lysis and mixing efficiency. Ideal for bead beating ....
Company:Mo Bio Laboratories, Inc.

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Lysis in Medical Definition

Ultrasound-enhanced systemic thrombolysis

... CLOTBUST: Design of a Randomized Trial of Ultrasound-Enhanced Thrombolysis for Acute Ischemic Stroke sagepub.com Combined lysis of Thrombus in Brain Ischemia with Transcranial Ultrasound and Systemic TPA Internet Stroke Center See also Ultrasound ...
Lysis in Medical Dictionary

BAER

... Ethylene Glycol Test Euglobulin Clot lysis ( Euglobulin lysis Time ) Euglobulin lysis Time Evoked Auditory Potentials ( BAER - ...

Euglobulin lysis time

... Euglobulin lysis time Definition: This is a test that measures the euglobulin lysis time in blood . The euglobulin lysis time is a measure of the activity of the fibrin ...

Chronic Pelvic Pain

... / sterility , pelvic mass, ectopic pregnancy , endometriosis , polycystic ovaries , pelvic inflammatory disease (PID), congenital anomalies, lysis of adhesion s, cytology sampling, ... If untreated, cervicitis may lead to pelvic inflammatory disease , infertility , ectopic pregnancy ...

Concomitant

... Concomitant with this action, the Surgeon General again became responsible for management of the Commissioned Corps personnel system. Hemolysis lysis (opening) of red blood cells, with concomitant leakage of cell contents from the cells. Hemolytic anemia Anemia due to hemolysis . Jaundice ...

Ectopic Pregnancy

... / sterility , pelvic mass, ectopic pregnancy , endometriosis , polycystic ovaries , pelvic inflammatory disease (PID), congenital anomalies, lysis of adhesion s, cytology sampling, ... one that is growing outside of the uterus . An ectopic pregnancy usually occurs in the tube that ...

Fibrin

... that is the essence of the clot . Search All of MedicineNet For: search help Printer-Friendly Format ... Increased fibrin olysis (shortened lysis time) may indicate: Cirrhosis Extensive vascular ( blood vessel) trauma or surgery Hereditary deficiency of fibrin ogen Leukemia ... ...

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Lysis in Biological News

From foe to friend: Researchers use salmonella as a way to administer vaccines in the body

... Outlined in the paper, "Regulated programmed lysis of recombinant Salmonella in host tissues to ... system that would display regulated delayed lysis in vivo after invasion into and colonizing ... that the system we have devised results in cell lysis in the absence of arabinose and clearance of the ...

American Society for Microbiology honors George Liu

... He worked on dissecting the function of Group B streptococcus (GBS) hemolysin. He showed that this toxin has an unusual dose effect that causes lysis of phagocytes at a higher dose, apoptosis at an intermediate dose, and downregulation of inflammation at a low dose. The golden color imparted by ...

Study reveals how viruses collectively decide the fate of a bacterial cell

... change, which can result in a switch to the lytic pathway. The decision of the genetic circuit that controls whether a virus initially chooses lysis or lysogeny is not random. Instead, cell fate is controlled by the number of infecting viruses in a coordinated fashion, according to the new study, ...

After the yeast is gone bacteria continue to develop flavor of sparkling wine

... wines. During aging, substantial chemical changes take place due to cell lysis which contributes to the sensory characteristics of Cava. The ... quality and consumer acceptability of the wine could be due to growth and lysis of bacteria," says Rius. ...

Gene that helps mosquitoes fight off malaria parasite identified

... the process of parasite lysis, whereby the mosquito rids itself of the parasite. "This study furthers our knowledge of the malaria-parasite lysis in mosquitoes. It may help provide better tools for controlling the disease in the future," said lead author Eappen G. Abraham, PhD, research ...
Lysis in Biological Technology

Micromet to Present Six Posters on Progress of BiTE Antibodies at the Annual Meeting of American Association for Cancer Research

... Lutterbuese, R. et al. (2009). Highly efficient lysis of KRAS- and BRAF-mutated human colon cancer ... a major contribution to redirected target cell lysis by T cell-engaging BiTE antibody MT110. AACR ... Aigner, M. et al. (2009). Effective in vitro lysis of human melanoma cell lines by T lymphocytes ...

InVitria Among Leading Innovators in Cell Culture Media According to Top Biotechnology Publication

... Also mentioned in the article is InVitria's Lysobac™, a cell lysis reagent used in microbial fermentation to improve recombinant protein ... well-defined and regulatory compliant cell culture media and bacterial lysis components. They can also contribute to operational efficiency and reduced ...

InVitria Expands Sales Team

... versus bovine and human transferrin. And Lysobac is a bacterial cell lysis agent that is more efficient and consistent compared to chicken lysozyme. ... for mammalian cell culture media. -- Lysobac -- A bacterial cell lysis agent that is more efficient and more consistent compared to chicken ...

Micromet is Presenting Four Posters on BiTE(R) Antibodies at the International AACR-NCI-EORTC Conference

... against melanoma cells by recruiting T cells for efficient tumor cell lysis in vitro (abstract A61). This poster has been selected for inclusion in ... that is expressed on healthy epithelial cells. The mode of tumor cell lysis of MT110 was found to be largely dependent on the pore-forming protein ...

Proteolix Announces Positive Data From Two Ongoing Phase 2 Clinical Trials of Carfilzomib in Multiple Myeloma at the 50th Annual Meeting of the American Society of Hematology

... among relapsed patients and toxicities were manageable. The most common adverse events were fatigue, anemia and neutropenia. Two cases of tumor lysis syndrome were observed among bortezomib-naive patients, and with additional monitoring and management guidelines no further events have been ....

InVitria Touts Product Advantages at Cambridge's Cell Culture Conference

... that also delivers iron similar to transferrin in cell culture media. (see http://www.Lacromin.com ) -- Lysobac - Lysobac is a bacterial cell lysis agent that is more efficient and more consistent compared to chicken lysozyme and provides higher recombinant protein yield compared with mechanical ...

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Lysis in Biological Products

PCR Diagnosis-Bacteria Identification Kit from BioChain

Description:... This kit consists of universal lysis buffer, PCR mix, DNA polymerase and universal control primers for 100 25 l ... Aureus, Streptococcus Agalactiae, and etc. With the powerful Universal lysis buffer, the sensitivity of this system is so high that bacteria DNA can be ...
Company:BioChain

M-PER from Pierce Biotechnology, Inc.

Description:... M-PER Mammalian Protein Extraction Reagent is a liquid, ready-to-use cell lysis solution that means no scraping, no freeze-thaw cycles and no sonication! With M-PER Reagent, rapid lysis occurs in just five minutes at room temperature, yielding 25% more protein ...
Company:Pierce Biotechnology, Inc.

96 well plate shaker, 220 V from Mo Bio Laboratories, Inc.

Description:... Disrupts biological cells for DNA isolation. Designed to hold two 96 well plates (includes 96 well plate adapters from Mo Bio). Provides consistent lysis across the entire plate length (max capacity is 192 individual wells). Can be used for soil, microorganisms, animal tissue, plants, seeds, bones, ...
Company:Mo Bio Laboratories, Inc.

Insect Cell Lysis Buffer from BD Biosciences Pharmingen

Description:... Insect Cell lysis Buffer 50 ...
Company:BD Biosciences Pharmingen

LIGHT DIAGNOSTICS™ CMV pp65 Dextran Leukocyte Separation Kit, included in kit #3247 from CHEMICON

Description:... for the qualitative identification of lower matrix protein pp65 of CMV in isolated peripheral blood leukocytes. Kit Components: Erythrocyte lysis Buffer - (Catalog No. 5122) One bottle containing 220 mL of buffered ammonium chloride. (NH4CL) Fixation Solution (5X) - (Catalog No. 5113) One ...
Company:CHEMICON

LIGHT DIAGNOSTICS™ CMV pp65 NH4Cl Leukocyte Separation Kit, alternate to #3246 from CHEMICON

Description:... all the materials necessary for the isolation and preparation of Leukocytes for use in CMV antigen studies analysis. Kit Components: Erythrocyte lysis Buffer - (Catalog No. 5122) One bottle containing 220 mL of buffered ammonium chloride. (NH 4 Cl) Fixation Solution (5X) - (Catalog No. 5113) One ...
Company:CHEMICON

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Lysis in Biological Definition

Lysis

... lysis ( Greek lusis from luein = to separate) is ... more specifically as cytolysis osmotic lysis chemical lysis ...

Lytic cycle

... 1 Description 1.1 Infection 1.2 Growth 1.3 Replication and lysis Description The lytic cycle is a three-stage process. ... into DNA, which is then transcribed again into mRNA. Replication and lysis After many virus copies are made, they are assembled into complete ...

Alexander Fleming

... Fleming inspected the Petri dish further and found that the bacterial colonies around the fungus were transparent because their cells were lysing . lysis is the breakdown of cells, and in this case, potentially harmful bacteria. The importance was immediately recognized, however the discovery was ...

Antibody

... to various cell receptors and complement proteins. In this way it mediates different physiological effects of antibodies ( opsonization , cell lysis , mast cell, basophil and eosinophil degranulation and other processes). The variable regions of the heavy and light chains can be fused together ...

Antigen

... with class I histocompatibility molecules . If cytotoxic CD8 + T cells recognize them, they begin to secrete different toxins that cause the lysis or apoptosis of the infected cell. In order to keep the cytotoxic cells from killing cells just for presenting normal proteins, they run through a ...

Glycolysis

... in the formation of ATP. These two reactions pull the glycolytic pathway to completion. Etymology From Greek glyk meaning sweet and lysis meaning dissolving. See also Gluconeogenesis Krebs cycle Anaerobic respiration External links The Glycolytic enzymes in ...

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Lysis in Biological Dictionary

Lysis

... lysis refers to the death of a cell by breaking of ... the contents ... Cytolysis, or osmotic lysis , occurs when a cell bursts due to an osmotic ... and causes ... MySpace Music profile for lysis (writing new shit!!). Download ...

Minicircles

... ... to probe for the existence of kinks in 94-bp-long minicircles . ... Preparation of mitochondrial telomeric minicircles by alkaline lysis ... To relax supertwisted minicircles , 4 µl of DNA was incubated for 60 min at 15°C ... Minicircles are released from the network into the ...

Lytic cycle

... can have either lytic or lysogenic cycle , depending on the environment. In the lytic cycle , l phages replicate rapidly and eventually cause lysis of the ... Definition of lytic at Dictionary.com with free online dictionary, pronunciation, ... lysogenic life cycle . list of lytic ...

Gel shift assay

... gel - shift assay . ... RNA-protein gel mobility shift assay . Munro's binding buffer. 10mM Hepes, pH 7.6. 3 mM MgCl2 ... RNase free H20. lysis buffer. Munro's buffer + 0.2% NP-40 in ... A gel shift assay , also referred to as an EMSA is an electrophoretic mobility assay . ... Gel ...

DNase

... fluctuations will ... Thermo Scientific Deoxyribonuclease I ( DNase I) is a single, glycosylated ... DNase I is commonly added to cell lysis reagents to remove the viscosity caused ... ( RQ1 RNase-Free DNase may be used in applications where ... This DNase is suited for ...

CAT assay

... ... A direct assay for chloramphenicol acetyl transferase ( CAT ) has been presented ... Promega, " CAT Enzyme Assay System with Reporter lysis Buffer", on line ... CAT assay . CAT assay . Chloramphenicol Acetyl Transferase ( CAT ) is a bacterial enzyme which inactivates ... GFP ...

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