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Lymphocytes in Medical News

Cell division find prompts overhaul of immune response modeling

... the proliferation and survival of T and B lymphocytes white blood cells that are crucial to the body's ability to generate immunity. When lymphocytes are exposed to pathogens they are stimulated to ... of cell divisions, which increases the number of lymphocytes many hundredfold. After a period the cells stop ...

Ludwig Institute of Cancer Research Ltd., Brussels Branch, Issues Statement Concerning Prospect Therapeutics Inc's. GCS-100 Molecule

... that human tumors contain a large number of T lymphocytes which are directed against specific antigens of the tumor cells, but that these lymphocytes are in a state of paralysis. An important ... on the cell surface. The function of these T lymphocytes could readily be restored in vitro by addition ...

Instead of fighting breast cancer, immune cell promotes its spread

... 2009 in Denver. According to Tan, the role of lymphocytes in breast cancer progression has been ... cells, but paradoxically, the infiltration of lymphocytes such as B cells and T cells into breast cancer is ... mice that developed breast tumors. One group had lymphocytes in the tumors and expressed RANKL while the other ...

Protein helps immune cells to divide and conquer

... that is required for immune cells called B lymphocytes to divide and replicate themselves. The rapid ... describes why CD98hc is essential in order for B lymphocytes to transition into antibody-secreting cells. It ... lymphocytes," said Cantor. "But when B or T lymphocytes were stimulated by antigens for instance, to ...

Suspected cause of type 1 diabetes caught 'red-handed' for the first time

... protein from around the body and present them to lymphocytes to initiate an immune system reaction. The lymphocytes lead immune attacks against foreign invaders like ... cells, Calderon exposed the dendritic cells to lymphocytes taken from diabetic mice. ...

Immunotherapy: enlisting the immune system to fight cancer

... 2539 Blocking CTLA-4, a cellular molecule on lymphocytes that inhibits immune response, produced ... The researchers found that activation of lymphocytes occurred primarily in the higher doses. They also could detect lymphocytes targeting proteins expressed by prostate cancer ...

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Lymphocytes in Medical Technology

Markers in Blood and Spinal Fluid, and a New Imaging Agent, Show Promise for Early Detection of Alzheimer's

... directly cause their death. The equivalent cell cycle defect is found in lymphocytes of people with Alzheimer's. lymphocytes are white blood cells in the immune system that can easily be collected ...

Trubion Announces Initiation of Phase I/II Clinical Trial of TRU-015 for the Treatment of B-Cell Non-Hodgkin's Lymphoma

... immunity. In the United States, 85 percent of all cases of NHL come from B lymphocytes (B cells) and 15 percent from T lymphocytes (T cells). About 63,190 new cases of NHL will occur this year in the ...

MacroGenics and Lilly Achieve Targeted Patient Enrollment in PROTEGE, a Global Phase 2/3 Clinical Trial of Teplizumab in Type 1 Diabetes

... for the treatment of individuals with recent-onset type 1 diabetes, is a humanized monoclonal antibody engineered to alter the function of the T lymphocytes that mediate the destruction of the insulin-producing beta cells of the islets of the pancreas. Teplizumab binds to an epitope of the CD3-epsilon ...

Trubion Announces Positive Data From a Phase 1 / 2 Study of TRU-016 for the Treatment of Chronic Lymphocytic Leukemia (CLL)

... course of four to 12 weeks. Beginning with the 0.1 mg/kg dose, evidence of biologic activity was observed. The median reduction in peripheral lymphocytes was 67% and was as high as 98%. Two patients with leukemia cutis had complete or partial clearance of skin lesions. One patient had a 36% reduction ...

Agennix Receives Fast Track Designation From FDA for Talactoferrin in Combination With Sunitinib for Renal Cell Carcinoma

... Following maturation, these dendritic cells activate Natural Killer (NK) and Natural Killer T-cells (NK-T) of the innate immune pathway and CD8+ lymphocytes of the adaptive immune pathway. Initiating the immune response in the GALT, and away from the tumor, reduces the effect of anti-immune factors ...

Study Demonstrates that AHCC(R) Enhances Immune System by Increasing the Production of Key Dendritic Cells

... DC2). Other parameters measured included mixed-leukocyte reaction (MLR), natural killer (NK) cell activity, the proliferative response of T lymphocytes toward mitogen (phytohemagglutinin [PHA]) and cytokine production of interleukin (IL)-2, IL-4, IL-6, IL-10, interferon gamma-gamma, and (alpha)-tumor ...

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Lymphocytes in Medical Products

Mitogen Proliferation, Lymphocytes

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' ...
Company:ARUP Laboratories

Antigen & Mitogen Proliferation Panel, Lymphocytes

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' ...
Company:ARUP Laboratories

Antigen Proliferation, Lymphocytes

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' ...
Company:ARUP Laboratories
Lymphocytes in Medical Definition

Central tolerance

... self antigens of the host). In mammals the process occurs in the thymus (T cells) [2] [3] and bone marrow (B cells), when maturing lymphocytes are exposed to self antigens. Self antigens are present in both organs due to endogenous expression within the organ and importation of antigen due ...
Lymphocytes in Biological News

Seemingly suicidal stunt is normal rite of passage for immune cells

... breaks in the DNA of immune cells known as lymphocytes activate genes that cause the cells to travel ... have known for two decades or more that lymphocytes can break their own DNA in this fashion, creating ... ability to repair DNA damage slowed down, the lymphocytes can't activate the genes that get them to where ...

Researchers identify a cell type that limits stroke damage

... is caused by the body's immune response. Cells such as microglia and lymphocytes provoke harmful effects similar to those observed during nervous system ... by blocking the production of neurotoxins and modulating the action of lymphocytes and microglia in the brain. ...

Immunotherapy in high-risk pediatric sarcomas shows promising response

... provided a remission. Patients underwent aphaeresis to harvest blood lymphocytes that were then frozen. From this, dendritic cells were later extracted. ... immunotherapy received a common flu vaccine, as well as their own lymphocytes and their own dendritic cells, which had been infused with tumor antigens. ...

Stop and smell the flowers -- the scent really can soothe stress

... exposed lab rats to stressful conditions while inhaling and not inhaling linalool. Linalool returned stress-elevated levels of neutrophils and lymphocytes key parts of the immune system to near-normal levels. Inhaling linalool also reduced the activity of more than 100 genes that go into overdrive in ...

'First aid' for brain cells comes from blood

... University Hospital have shown that certain immune cells in the blood inhibit inflammation after a stroke. These cells are known as regulatory T lymphocytes (Treg). The regulator cytokine Interleukin 10 plays an important role in this protection, perhaps offering a new approach to stroke therapy. The ...

Researchers explore new driver of transplant rejection: Platelets

... the general that initiates acute rejection, it would put the troops in disarray," says Rabb. "Traditional therapies therefore inhibit or deplete T lymphocytes and other white blood cell components of the immune system. The newest kid on the block is the platelet and it represents an opportunity to target ...

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Lymphocytes in Biological Technology

JCI table of contents: Dec. 3, 2007

... and rheumatoid arthritis (RA) are caused when immune cells known as lymphocytes attack our own body tissues. Depletion of the B cell subset of lymphocytes using an antibody specific for the protein CD20 has been shown to be ...

R-Tech Ueno Notifies R&D Items

... type present in the vascular endothelium and the free type present in the serum. The former serves as a molecule adherent to white blood cells and lymphocytes and is involved in inflammation while the latter detoxifies amine in the living body by its amine oxidase activity. In other words, VAP-1 is a ...

Carbon Design Innovations, Inc. Introduces Carbon Nanotube Probe Technology for Atomic Force Microscopy, CNT-Probes Deliver New Level of AFM Imaging Performance

... "The carbon nanotube AFM probes from C|D|I reveal the most accurate surface morphology, especially for cellular samples such as rat basophilic lymphocytes cells," states Dr. G. Y. Liu, University of California, Davis. "All observations reflect upon the superior geometry of these CCHAR probes, ...

Micromet Presents Update at ASCO 2009 on a Phase 1b Combination Study of Adecatumumab and Docetaxel

... nausea, vomiting, stomatitis, constipation, fatigue, fever and chills. Laboratory abnormalities included reduction in various blood cells such as lymphocytes and neutrophils comparable to what is typically observed with docetaxel monotherapy. The overall response rate according to RECIST [version ...

OncoGenex Pharmaceuticals Announces OGX-011 Treatment Provides Survival Benefit in Randomized Phase 2 Trial in Advanced Metastatic Prostate Cancer

... of mild fever, chills and creatinine levels (a laboratory measure for reduced kidney function) and a moderate to significant decrease in circulating lymphocytes in the blood (another laboratory measure) without any increase in infection rate compared to the docetaxel arm. The investigators concluded that the ...

Novavax Announces Enrollment in the Second Phase II Study of its Seasonal Influenza VLP Vaccine Candidate

... influenza virus and prevent spread throughout the cells of the respiratory tract -- and the matrix 1 or "M1" virus that stimulates cytotoxic T lymphocytes to kill cells that may already be infected. This three-pronged approach may offer an advantage over existing vaccines which contain mostly HA with ...

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Lymphocytes in Biological Products

Rat Anti-Gamma delta T Lymphocytes Monoclonal Antibody, Unconjugated, Clone MAC320 from BD Biosciences Pharmingen

Description:... Gamma delta T lymphocytes Purified Anti-Porcine clone MAC320, Isotype Rat IgG 2a , kappa, 0.1 mg Consult technical datasheet for ....
Company:BD Biosciences Pharmingen

Human Genetic Cell Bank Service from European Collection of Cell Cultures (ECACC)

Description:... Genetic Cell Bank Service The Human Genetic Cell Bank Serviceat ECACC is based on Epstein-Barr Virus (EBV) immortalisation of human peripheral blood lymphocytes (PBLs) resulting in the production of lymphoblastoid cell lines (LCLs). These cell lines are subsequently banked, providing a renewable and ...
Company:European Collection of Cell Cultures (ECACC)

Mouse Anti-Rabbit T LYMPHOCYTES Monoclonal Antibody, Unconjugated, Clone KEN-5 from AbD Serotec

Description: MOUSE ANTI RABBIT T LYMPHOCTYES Immunogen: Rabbit ...
Company:AbD Serotec
Lymphocytes in Biological Definition

Antibody

... showed in 1976, portions of the genome in B lymphocytes can recombine to form all the variation seen in ... or antigen affinity chromatography. If the lymphocytes that produce the antibodies can be isolated and ... links Lymphomation: Immunoglobulins How lymphocytes Produce Antibody PLOS primer: V(D)J ...

Antigen

... they start to secrete cytokines . The cytokines then activate cytotoxic lymphocytes T (CTL), antibodies secreting lymphocytes B , macrophages and other cells. Endogenous antigens ...

Immune system

... unique to every individual. T cells, a group that encompasses cytotoxic T lymphocytes ( CTLs ), the cells that kill virally-infected cells, contain ... cells. The functions of CMI are performed by T cells , also called T lymphocytes (T means they develop in the thymus ). There are two major types of T ...

Major histocompatibility complex

... It interacts exclusively with CD8+ T cells (also known as cytotoxic T cell lymphocytes or CTLs). The fate of a virus-infected cell is almost always apoptosis , ... interact exclusively with CD4+ T cells (also known as helper T cell lymphocytes or HTLs). The helper T cells then help to trigger an appropriate immune ...

Semen

... in response to the sperm. These antibodies mistakenly recognized native T lymphocytes as foreign antigens , and consequently the T lymphyocytes would fall under attack by the body's B lymphocytes . Other semen components shown to spur an immunosuppressive effect are ...

T cell

... T cells are a subset of lymphocytes that play a large role in the immune response . The abbreviation "T" ... links T cell development Throughout life, a source of all lymphocytes remains bone marrow. Progeny of multipotential lymphoid stem cells (CFU-L) ...

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Lymphocytes in Biological Dictionary

White blood cells

... ... The nongranuloctye white blood cells , lymphocytes and monocytes, do not have ... White blood ... Red Blood Cells . White Blood Cells . lymphocytes and ... five kinds of white blood cells ... and other diseases. Granulocytes, monocytes, and lymphocytes are white blood cells . Also called ...

Venules

... cells found in regular venules . HEVs enable lymphocytes circulating in the blood to directly enter a ... pia venules in the cerebral cortex. ... ... lymphocytes at specialized high endothelial venules within lymph nodes and other ... of Rolling T lymphocytes in Peripheral Lymph Node High Endothelial ...

T lymphocytes

... to a group of white blood cells known as lymphocytes , and play a central role in cell-mediated ... receptor on their ... The small lymphocytes are the T cells and B cells. ... The lymphocytes involved in adaptive immunity (i.e. B and T ...

Monocytes

... are formed from monoblasts. Collectively, lymphocytes and monocytes ... Monocytes deposit ... Electron Microscopy of PHA Localization in Human lymphocytes and Monocytes . ... The grains are localized ... cells, instead, distinguish themselves in lymphocytes and monocytes . ... The iron was released ...

Lymphocytes

... Functionally distinct subsets of lymphocytes correlate with their appearance. Most, but not all large granular lymphocytes are more commonly known as the ... B cells are lymphocytes that play a large role in the humoral immune ...

Cytotoxic T cell

... cytotoxic T cell belongs to a sub-group of T lymphocytes that are capable of inducing the death of ... understood CD8+ T cells are cytotoxic T lymphocytes (CTLs) ... Movie showing how cytotoxic T lymphocytes can kill tumor and other diseased cells . ... ...

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