The making and breaking of microtubules
...icrotubule growth. When GTP binds to a particular locus on beta tubulin (the E-site or exchangeable site) polymerization occurs: tubulin dimers pile onto the protofilaments, and the microtubule grows. But through hydrolysis (the word means "water splitting"), GTP readily changes to a different nucleotide,...Improved statistical tools reveal many linked loci
...on: Storey JD, Akey JM, Kruglyak L (2005) Multiple locus linkage analysis of genomewide expression in yeast. PLoS Biol 3(8): e267. ...A new molecule discovered in the battle between plants and disease
...ubmitted). The peptide is encoded by a gene at the locus At5g64900 and is derived from the carboxyl terminus of a 92 amino acid precursor, proAtPep1, a scenario commonly found in both animal and plant peptide precursors. No physiological role was known for AtPep1, and a function was sought in Arabidopsis b...Studies on human genome variation provide insight into disease
...erage. In some cases, a particular variant at one locus is perfectly associated with a specific variant at another locus; in other words, the two markers are "genetically indistinguishable." Dr. Lon Cardon and his colleagues describe in this month's issue of Genome Research how these "genetically indis......erage. In some cases, a particular variant at one locus is perfectly associated with a specific variant at another locus; in other words, the two markers are "genetically indistinguishable." Dr. Lon Cardon and his colleagues describe in this month's issue of Genome Research how these "genetically indis...Genotyping Single Nucleotide Polymorphisms with Molecular Beacons
...h 20 affected relatives, a diabetes susceptibility locus (IDDM17) maps to10q25.1. 4 IDDM 17 and its flanking markers are localized to a 120-kbregion within a completely sequenced bacterial artificial chromosome (BAC) basedon association studies of a number of SNPs. We genotyped a group of people inthe fam...Map and Link Human Genetic Disorders with SSLP Analysis
...e haplotypesallow the transmission of a particular locus through a family to be analyzed;furthermore, they determine whether that locus is linked to a particularphenotype, as well as aid in identifying recombinational events, which defi......troduced that alter the function of the gene locus of interest, for example by inactivating or modify...d that are specific either for the wild-type locus or for the mutant locus. In Figure 1, one primer is located on the wild-type locus. Two revers...Fully automated DNA purification and efficient multiplex PCR for analysis of microsatellite loci
...l DNA samples, irrespective of whether the locus was homozygous (both alleles generate a fragment of the same size) or heterozygous (fragments of different size are generated from each allele). Satisfactory results were obtained using the same number of PCR cycles and...Microfluidic analysis of multiplex PCR products for the genotyping of Helicobacter pylori
...ceof the cag pathogenicity island,which is a 40 kb locus containing31 genes associated with theinduction of interleukin 8 secretionby gastric epithelial cells3.The allelic variants of the iceAgene are distinguished into iceA1or iceA2 and only one of whichbeing found in all H. pylori strains.The iceA gene s...Researchers Identify Sipa 1 Gene, Responsible For Cancer Metastasis
...d the presence of a putative metastasis efficiency locus on mouse chromosome 19. This chromosome region, which is orthologous to human 11q12-13, harbors a known metastasis suppressor gene Brms1. However, this gene has no obvious polymorphisms that influence metastasis. Authors used a multiple cross mappi...Genes Affect Drinking Behavior Of Smokers
...re affected by two loci on chromosome four and one locus on chromosome two, which precede alcoholism. As many as 200 genes are involved in chromosome four, some of which play a role in alcohol metabolism. It is as yet not known as to which genes play a deciding role in this behavioral pattern. Based on thi...WHO Rules Out Human Transmission Of Bird Flu In 4 Cases
...t Asia in December 2003. Indonesia is currently a locus of the disease with 49 cases, second only to Vietnam with 93 cases. (Source:PTI News)...Rural Poor are Better off Than Slum Dwellers: UN Report
...w UN-HABITAT report released Saturday //. As the locus of poverty shifts from rural areas to urban centres, UN-HABITAT's "State of the World's Cities" report provides concrete data to reveal that the world's one billion slum dwellers are more likely to die earlier, experience more hunger and disease, att......targeting exclusively excitatory networks, a major locus of plasticity lies within the inhibitory networks. Our data show that inhibitory networks within the cortex are highly plastic, and that some pathological states arise through inappropriate activation of inhibitory plasticity.” Sourc: EurekAlert....