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Lipase in Medical News

Solvay Pharmaceuticals, Inc. Announces Commercial Availability of CREON(R) (Pancrelipase) Delayed-Release Capsules

... in three prescription strengths dosed by lipase units. As of today, the new FDA-approved dosage strengths are CREON (R) 6,000 lipase units, CREON (R) 12,000 lipase units, and CREON(R) ...

Prescription Copay Assistance for Patients taking Gleevec or Tasigna for Philadelphia chromosome-positive Chronic Myelogenous Leukemia (Ph+ CML)

... to their occurrence. Elevated serum lipase Caution is recommended in patients with history of pancreatitis. Check serum lipase periodically. Liver function abnormality ... (28%), neutropenia (28%), elevated lipase (15%), and hyperglycemia (11%). In accelerated ...

Video: CREON(R) (Pancrelipase) Delayed-Release Capsules First and Only Pancreatic Enzyme Product to Receive FDA Approval Under New Guidelines

... patients. Caution should be exercised when doses of CREON(R) exceed 2,500 lipase units/kg of body weight per meal (or greater than 10,000 lipase units/kg of body weight per day). Care should be taken to ensure that ...

Video and Photo: Tasigna(R) Receives US Approval Providing New Hope to Chronic Myeloid Leukemia Patients With Resistance or Intolerance to Existing Therapies

... is recommended in patients with history of pancreatitis. Check serum lipase periodically. Liver function abnormality: Tasigna may result in ... febrile neutropenia, leukopenia, intracranial hemorrhage, elevated lipase and pyrexia. Tasigna may need to be withheld and/or dose reduced for QT ...

How to manage Chinese obese children with non-alcoholic fatty liver disease?

... the hepatic aspect of the metabolic syndrome. Multiple therapeutic agents such as vitamin E, -carotene, metformin, PPAR-gamma agonists, and the lipase inhibitor orlistat have been demonstrated to be useful in NAFLD in a small series of cases. Lifestyle intervention (dietary restriction and exercise) ...

Amsterdam Molecular Therapeutics Initiates Program for Late Stage Liver Cirrhosis and Reports Strong Progress in AMT-011 With Trial Fully Recruited and European and US Submission On Track for First Half of 2008

... address unmet medical needs." Clinical Program AMT-011 The clinical development of AMT's lead product AMT-011 for the treatment of Lipoprotein lipase Deficiency is proceeding according to plan. All patients have been recruited in the Canadian study. A total of 6 patients have been injected with ...

JCI table of contents: Nov. 21, 2007

... in which blood clots form inappropriately inside blood vessels, such as occurs in individuals with pancreatic cancer. TITLE: Bile saltdependent lipase interacts with platelet CXCR4 and modulates thrombus formation in mice and humans AUTHOR CONTACT: Laurence Panicot-Dubois Universit de la ...

Is it pancreatitis in acute abdominal pain in acute viral hepatitis?

... sequelae on mean follow-up of 12 (range 8-24) months. Patients with acute viral hepatitis with severe abdomen pain should undergo serum amylase, lipase and ultrasonography or contrast-enhanced computed tomography of the abdomen to prove acute pancreatitis as a cause of abdomen pain. Hepatitis E ...

Baby with white blood!

... in stool. On detection the baby, a boy child, was found to have lipemic blood. Doctors said that this condition could be either due to// ‘familial lipase deficiency syndrome’ or ‘familial apolypoprotein C-2’. However, clinical tests conducted have shown that the reason was more likely to be that of a ...
Lipase in Medical Technology

Glybera(TM) Shows Long-Term Health Benefits

... in acute pancreatitis in lipoprotein lipase deficient patients. Recurrent acute pancreatitis ... the most debilitating complication of lipoprotein lipase deficiency (LPLD) and is associated with ... patients with the genetic disorder lipoprotein lipase deficiency. LPLD is an orphan disease for ...

Video: Tasigna(R) Demonstrates Rapid Response as Initial Therapy in Life-Threatening Form of Leukemia

... to their occurrence. Elevated serum lipase Caution is recommended in patients with history of pancreatitis. Check serum lipase periodically. Liver function ... (28%), neutropenia (28%), elevated lipase (15%), and hyperglycemia (11%). In accelerated ...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

... to their occurrence. Elevated serum lipase Caution is recommended in patients with history of pancreatitis. Check serum lipase periodically. Liver function ... (28%), neutropenia (28%), elevated lipase (15%) and hyperglycemia (11%). In accelerated ...

Strength and Innovation of Novartis Oncology Products and Pipeline With Potential to Improve Patient Treatment Demonstrated by More Than 170 Abstracts at ASCO Annual Meeting

... with history of pancreatitis. Check serum lipase periodically. Liver function abnormality Serum ... neutropenia (28%), elevated lipase (15%), and hyperglycemia (11%). In accelerated ... (37%), anemia (23%), and elevated lipase (17%). Other serious adverse reactions included ...

AMT: Glybera(R) Lowers Pancreatitis Incidence Significantly

... of acute pancreatitis in Lipoprotein Lipase Deficient patients. Recurrent acute pancreatitis is the most debilitating complication of Lipoprotein lipase Deficiency (LPLD) and is associated with significant morbidity and mortality. To date only one patient from the two clinical trials had an ...

Exelixis Reports Encouraging Phase 1 Data for XL184 at ASCO

... vomiting, hair hypopigmentation, and palmar-plantar erythema. Dose-limiting toxicities included palmar-plantar erythema, elevation of liver enzymes, lipase elevation, and mucositis. Pharmacokinetic analyses indicate that the half-life of XL184 was approximately 100 hours (range 59-136 hours), with ...

Exelixis Initiates Phase 1/2 Trial of XL184 in Patients With Non-Small Cell Lung Cancer

... (DLTs) have been reported, including Grade 3 palmar/plantar erythema (hand-foot syndrome), Grade 3 AST elevation, Grade 3 ALT elevation, and Grade 3 lipase elevation in patients dosed at 11.52 mg/kg (intermittent dosing schedule), as well as a DLT of Grade 2 mucositis in a patient dosed at 265 mg (daily ...

Updated Phase 1 Data for Exelixis' XL184 Demonstrate Pharmacodynamic and Clinical Anti-Tumor Activity

... toxicities (DLTs) have been reported, including Grade 3 palmar/plantar erythema, Grade 3 AST elevation, Grade 3 ALT elevation, and Grade 3 lipase elevation in patients dosed at 11.52 mg/kg, as well as a DLT of Grade 2 mucositis in a patient dosed at 265 mg. Serious adverse events (AEs) ...

Amsterdam Molecular Therapeutics BV to present preclinical proof-of-concept data on its gene therapy AMT-020 to treat acute intermittent porphyria

... a unique, stable and scalable GMP production platform. Its lead product, AMT-011, is in phase II for the first indication: treatment of lipoprotein lipase deficiency type I. The company's Management, Supervisory and Scientific Advisory Board bring together an extensive know-how from both gene ...
Lipase in Medical Products

Lipase (Liquid)

Description:... For the quantitative in vitro determination of lipase in human serum and ....
Company:Randox Laboratories Ltd.
Lipase in Medical Dictionary

Amylase

... Elevated serum amylase Elevated urine amylase Elevated serum lipase Test that show inflammation of the pancreas : ... - Amylase Urine ... citrate. Elevated levels of the pancreatic enzyme s, amylase and lipase Elevated white blood cell count Elevated liver enzyme s and ...

Chronic pancreatitis

... the fast because the acute phase is over, eat a low calorie , low fat diet . In chronic pancreatitis , that organ often no longer produces lipase normally. Without it, fats cannot be properly handled by the body. Inflammation of the pancreas . Chronic pancreatitis may cause diabetes ...

Digestive Disorders

... a device used to measure how well your child's asthma is under control. Digestive disorders affect the production and release of the enzyme lipase from the pancreas , or bile from the liver , which are substances that aid digestion of fats; absorptive disorders disturb the absorptive and ...

Dysautonomia

... Familial dysautonomia . Search All of MedicineNet For: search help Printer-Friendly Format ... Familial Chylomicronemia (Familial Lipoprotein lipase Deficiency ) Familial Combined Hyperlipidemia Familial Dysautonomia ( Riley-Day Syndrome ) Familial Dysbetalipoproteinemia Familial ...

Familial Dysautonomia

... Familial dysautonomia . Search All of MedicineNet For: search help Printer-Friendly Format ... Familial Chylomicronemia (Familial Lipoprotein lipase Deficiency ) Familial Combined Hyperlipidemia Familial Dysautonomia ( Riley-Day Syndrome ) Familial Dysbetalipoproteinemia Familial ...

Familial Hypercholesterolemia

... hypercholesterolemia familial hyperlipoproteinemia familial hypertriglyceridemia familial juvenile nephrophthisis familial lipoprotein lipase deficiency familial mediterranean fever familial non hemolytic non obstructive jaundice ... ...
Lipase in Biological News

Key to 'curing' obesity may lie in worms that destroy their own fat: McGill researchers

... within a few days. This is because they lack an enzyme that blocks the activity of a very important triglyceride lipase. Without this regulation the lipase burns up all the fat it encounters and destroys the worm's energy reserves." This discovery was a near-accidental by-product of Roy's regular line ...

Scripps research team defines new painkilling chemical pathway

... have remained largely unknown. Teasing out 2-AG's specific impacts have proven challenging. Comparable to FAAH, an enzyme called monoacylglycerol lipase (MAGL) breaks down 2-AG. But, despite numerous attempts, no group had been able to develop a chemical that inhibits MAGL specifically. "The ...

New bacteria discovered in raw milk

... so they are unlikely to cause disease. Some bacteria produce extracellular enzymes that are remarkably heat tolerant and can resist pasteurisation. lipase enzymes cause flavour defects and proteases can lead to bitterness and reduced yields of soft cheese. Raw milk is consumed in rural areas of ...

Gene linked to rare disease activates fat breakdown

... the activity of so-called adipose triglyceride lipase (ATGL) up to 20-fold. "We knew that the enzyme ... the first fatty acid from triglyceride. A third lipase finishes the job, Zechner said. The ... study will examine how CGI-58 activation of the lipase affects energy metabolism in various tissues. As ...

Baby's genes affect mom's cholesterol levels

... involved in lipid metabolism, lipoprotein lipase and apolipoprotein E. "Apolipoprotein E and lipoprotein lipase play important roles in the degradation of ... (also known as polymorphisms) of lipoprotein lipase and apolipoprotein E that are known to influence ...

Link found between immune system and high plasma lipid levels

... into the blood where it plays a key role in lipid metabolism. The livers of mice with T cells expressing LIGHT made and secreted much less hepatic lipase ?and consequently, had higher plasma lipid levels. The authors write: "Our data may help to explain the long time dogma that chronic ...
Lipase in Biological Technology

Video: Higher Initial Dose of Gleevec Achieved Better Early Responses than Standard Dose for Patients with Chronic Myeloid Leukemia

... with history of pancreatitis. Check serum lipase periodically. Liver function abnormality ... neutropenia (28%), elevated lipase (15%), and hyperglycemia (11%). In accelerated ... (37%), anemia (23%), and elevated lipase (17%). Other serious adverse reactions included ...

AMT Starts Preregistration Trial for Glybera(TM)

... today the treatment of the first patient in a preregistration clinical trial with Glybera(TM). This gene therapy product targets lipoprotein lipase deficiency (LPLD), a seriously debilitating and potentially lethal disease. The randomized controlled trial has been designed to gather ...

AMT's Lead Product Poised to Address Major Liver Disease

... AMT-011, NAFLD, NASH and the metabolic syndrome AMT-011 is currently in its last phase of clinical development for the treatment of lipoprotein lipase (LPL) deficiency that is associated with very high circulating triglyceride (fat) levels. The product consists of an AAV-based vector that delivers ...

Preparation of PCR Quality Template DNA from a Wide Range of Tissues Using InstaGene Matrix

... to amplify a 120 base pair fragment of the Canine Pancreatic lipase Gene (Mickel et al., 1989). Amplification was carried out using ... K. S. and Scheele, G. A., Structure of the Canine Pancreatic lipase Gene, J.Biol.Chem., 264 , 12895-12901 (1989). ...
Lipase in Biological Definition

Lipase

... A lipase is a water - soluble enzyme that catalyzes ... A2 or A3). In the example of human pancreatic lipase (HPL), which is the main enzyme responsible for ... down fats in the human digestive system , a lipase acts convert triglyceride substrates found in ...
Lipase in Biological Dictionary

Lipase

... A lipase is a water-soluble enzyme that catalyzes the ... thus comprise a subclass of the esterases. lipase is an enzyme necessary for the absorption ... people produce sufficient amounts of pancreatic lipase . ... ... the ...

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