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Knockout in Medical News

Persistent bacterial infection exploits killing machinery of immune cells

... the arginase gene in their macrophages (arginase knockout mice). After infecting the arginase knockout mice with the TB bacteria, they observed that the ... lungs. The researchers then infected arginase knockout mice with an intracellular parasite that causes ...

St. Jude finds 'dancing' hair cells are key to humans' acute hearing

... a malfunction of somatic motility. While the knockout experiments were strong evidence for the role of ... same kinds of hearing deficiency as the previous knockout mice, Zuo said. Therefore, we believe that these ... criticism of our earlier experiments with the knockout mice. The new experiments, Zuo said, thus firmly ...

Cocaine's effects on brain metabolism may contribute to abuse

... to chronically high levels of dopamine in the DAT knockout mice. It also suggests that dopamine levels may ... and motor function. Interestingly, DAT knockout mice have been suggested as an animal model for ... in metabolism in the thalamus region in the DAT knockout mice. This effect may likely be due to the effect ...

Possible safer target for anti-clotting drugs found

... platelet aggregation was restored. When calpain-1 knockout mice and mice lacking PTP1B were crossed to ... finding, the fact that the calpain-1 knockout mice have elevated PTP1B levels may prove ... in diabetes and obesity. "Our calpain-1 knockout mice with their elevated PTP1B levels offer a ...

Mouse model for mesothelioma reproduces human disease

... imaging, closely resembled human MM. Interestingly, Nf2;Ink4a/Arf knockout mice had a more invasive cancer when compared with Nf2;p53 knockout mice. The researchers went on to show that the loss of Ink4a makes a ...

Fragile X Syndrome Corrected in Mice

... paper that demonstrates a remarkable rescue of fragile X features when the knockout mouse is crossed with a mGluR5-deficient mouse," said Dr. Randi Hagerman, ... good evidence for this treatment in the trial of mGluR5 antagonists in the knockout mouse [lacking FMRP] and other animal models of fragile X, this genetic ...

Lexicon Initiates Phase 2 Clinical Trial of LX2931 in Patients With Rheumatoid Arthritis

... glaucoma and irritable bowel syndrome, all of which were discovered by the company's research team. The company has used its proprietary gene knockout technology to identify more than 100 promising drug targets. Lexicon has focused drug discovery efforts on these biologically-validated targets to ...

Lexicon Pharmaceuticals Provides Clinical Pipeline Update and Reports 2009 Second Quarter Financial Results

... diabetes, glaucoma and irritable bowel syndrome, all of which were discovered by Lexicon's research team. Lexicon has used its proprietary gene knockout technology to identify more than 100 promising drug targets. Lexicon has focused drug discovery efforts on these biologically-validated targets to ...

Gene's novel role may provide key to treating liver and neurodegenerative diseases

... human immune system responsible for fighting viruses and other pathogens that invade the body, the two scientists began developing the first in vivo knockout mouse model to closely examine FAIM's role in preventing programmed cell death. BTI Executive Director Miranda Yap, Ph.D., said, "The Immunology ...

AGA Institute presents cutting-edge research during DDW

... at the Epithelial Cell Interface. D. Polk (8:39 a.m.) Changes in Mucosal Homeostasis Leading to Hypersensitivity to Mucosal Injury in NHE3 knockout Mice. D. Laubitz et al. (9:04 a.m.) Colitis-associated variant of TLR2 causes impaired mucosal repair due to TFF3 deficiency. A. Eyking et al. (9:21 ...

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Knockout in Medical Technology

Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

... embryos and rapidly generate heritable, knockout mutations in a whole organism. Rats are ... using serial sampling. Generating rats with knockout mutations has been a major challenge, but the new ... his colleagues, Dr. Jacob's team hopes to use knockout rats to gain a better understanding of disease ...

Lexicon Initiates Phase 2a Trial of LX6171 Drug Candidate for Cognitive Disorders

... was identified through Lexicon's large-scale gene knockout program, the Genome5000(TM). knockout mice lacking this protein showed improved ... company has used its proprietary gene knockout technology to discover more than 100 promising ...

St. Jude Finds 'Dancing' Hair Cells Are Key to Humans' Acute Hearing

... mice showed exactly the same kinds of hearing deficiency as the previous knockout mice," Zuo said. "Therefore, we believe that these experiments eliminate criticism of our earlier experiments with the knockout mice." The new experiments, Zuo said, thus firmly establish that the ...

Sangamo BioSciences and Sigma-Aldrich Announce Publication of Study Demonstrating Zinc Finger Technology for Rapid Generation of 'Knock-Out' Cell Lines

... need for selection markers and other complicated strategies to identify knockout cells -- a dramatic improvement over existing methodologies." The work, ... that selection markers were not required to identify multiple independent knockout cell lines with minimal screening effort. "This publication represents ...

Lexicon Files Investigational New Drug Application for LX2931 as a Potential Treatment for Rheumatoid Arthritis

... programs, the LX2931 target enzyme was identified through Lexicon's gene knockout program, Genome5000(TM). Knockout mice lacking this enzyme had a ... and autoimmune diseases. The company has used its proprietary gene knockout technology to discover more than 100 promising drug targets and create an ...

Lexicon's Drug Candidate LX1032 for Carcinoid Syndrome Receives Orphan Drug Designation From EMEA

... glaucoma and irritable bowel syndrome, all of which were discovered by the company's research team. The company has used its proprietary gene knockout technology to identify more than 100 promising drug targets. Lexicon has focused drug discovery efforts on these biologically-validated targets to ...

Sangamo BioSciences Announces Achievement of Key Milestone in Cell Engineering Agreement With Genentech

... purposes using Sangamo's proprietary zinc finger DNA-binding protein nuclease (ZFN) technology. Genentech scientists demonstrated the successful knockout of two preselected genes in a Chinese hamster ovary (CHO) cell line. The milestone achievement triggered a payment from Genentech to Sangamo. ...

Isis and Collaborators Present New Research at the ATVB Annual Conference

... new research titled "Antisense inhibition of apolipoproteinC-III mitigated features of metabolic syndrome and reduced atherosclerosis in LDL receptor knockout mice" showing the ability of antisense drugs in a late-stage research program targeting apoC-III to selectively reduce triglycerides in both liver ...

Lexicon Pharmaceuticals Provides Clinical Pipeline Update and Reports 2009 First Quarter Results

... diabetes, glaucoma and irritable bowel syndrome, all of which were discovered by Lexicon's research team. Lexicon has used its proprietary gene knockout technology to identify more than 100 promising drug targets. Lexicon has focused drug discovery efforts on these biologically-validated targets to ...

Lexicon Presents Clinical Data on LX1032 for Carcinoid Syndrome at European Neuroendocrine Tumor Society Meeting

... glaucoma and irritable bowel syndrome, all of which were discovered by the company's research team. The company has used its proprietary gene knockout technology to identify more than 100 promising drug targets. Lexicon has focused drug discovery efforts on these biologically-validated targets to ...
Knockout in Medical Products

Knockout

Description:... With a large white surface and a black X in the center, knockout really makes you look the ....
Company:CIBA Vision
Knockout in Medical Definition

Autoimmune regulator

... candidiasis. [1] AIRE is expressed primarily in the thymus. A gene knockout of the murine homolog Aire has created a transgenic mouse model to study the mechanism of disease in human patients. [2] Research on the knockout mouse has demonstrated that Aire functions through initiating the ...
Knockout in Biological News

Genetically engineered mice yield clues to 'knocking out' cancer

... mice without the neil1 gene (known as neil1 knockout mice). During their first 6-10 months of life, ... Jaruga and Gldal Kirkali found that both types of knockout mice exhibited significant accumulation of two ... and hepatocellular (liver cell) tumors. Double knockout mice had a higher incidence of tumors than the ...

Body weight influenced by thousands of genes

... Database for information on body weights of knockout mouse strains. knockout mice have had a specific gene inactivated, or "knocked out. By studying how the knockout mice differ from normal mice, researchers obtain ...

Ultraconserved elements in the genome: Are they indispensable?

... in the September, 2007 issue of PLoS Biology, the knockout mice in this study showed almost no ill effects ... what happens when they are missing. Instead, our knockout mice were not only viable and fertile but showed ... the researchers prepared four lines of knockout mice, each type lacking one of the chosen ...

Time (and PPAR-beta/delta) heals all wounds

... between layers of the skinthe epidermal hyperproliferation seen in the knockout mice could be due to faulty signals from the dermal cells. But this ... keep stimulating keratinocyte division. Similarly, PPARβ/δ knockout mice expressed less sIL-1ra after wounding and produced more growth ...

RING finger protein 5 may guide treatment for muscle disease in older adults

... Following this discovery, the team developed three mouse models: one knockout model in which the RNF5 gene was missing, and two in which cells could be ... within muscle and a variety of other organs. A comparison of normal and knockout mice exposed to muscle-damaging toxin showed slower healing in the ...

How does the opioid system control pain, reward and addictive behavior?

... an unexpected alteration of emotional reactivity in the delta-receptor knockout mice (Filliol et al 2000). The mutant mice demonstrated increased levels ... and nicotine, natural reinforcers) are abolished in the mu-receptor knockout mice. Blocking the mu-receptor may build a valuable approach for the ...

Gene-targeting pioneer Mario Capecchi shares 2007 Nobel Prize in Medicine

... Sweden. The prize recognizes Capecchis pioneering development of knockout mice technology, a gene-targeting technique that has revolutionized the ... freedom to manipulate the DNA sequences in the genome of living mice. knockout technology makes possible detailed evaluation of the function of every ...

C. difficile spores spread superbug

... of the mouse. Although the majority of mice exhibited no visible symptoms of C. difficile , the team found that one particular group of knockout mice with mutations associated with impaired immune defence began to lose weight and became moribund. The similarity with the human manifestation of ...

Mouse model provides clues to human language development

... supported and confirmed the findings. In a second step to further substantiate this hypothesis, the Helmholtz scientists analyzed the heterozygous knockout mouse model in which one of the normally two copies of the Foxp2 gene is missing. This loss leads to serious changes: The ability of the mice to hear ...

New findings in taste and smell

... in human tears β1,3-N-Acetylglucosaminyltransferase 1 (β3GnT1) regulates signaling in olfactory neurons CNGA2 heterozygous mice with a knockout TRPM5 show fewer glomeruli targeted by OSNs with nonfunctional CNGA2 Copy-number variation map obtained by high-resolution genomics reflects human ...

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Knockout in Biological Technology

Transposagen Creates a Rat Model of the Human Immune System

... worldwide licensing rights to create TKO(TM) knockout Rat Models using a variety of mobile DNA technologies. knockout rats are pharmaceutical research models with ... Transposagen's goal is to produce 30,000 unique knockout rat lines to represent each gene in the rat ...

OMT announces a breakthrough in the development of a novel human antibody platform

... announced the creation of the first targeted knockout rats as detailed in "Knockout Rats Produced via ... monoclonal antibody platform. "Creating a knockout rat was the biggest challenge OMT faced", said ... ZFNs developed by Sangamo BioSciences, Inc. to knockout a gene encoding rat immunoglobulin. The mutations ...

Sigma-Aldrich Launches Breakthrough Genome-Editing Tools

... platform technology include creation of knockout and knock-in cell lines, cell lines that yield ... of ZFNs in the creation of whole animal knockout models in mice and other species, including rats ... By facilitating the creation of complete gene knockout and knock-in somatic, embryonic and primary cell ...

Sangamo BioSciences Reports Second Quarter 2009 Financial Results

... of the Roche Group. Genentech scientists demonstrated the successful knockout of two pre-selected genes in a Chinese hamster ovary (CHO) cell line using ... or knocked out. The technology opens the door for the production of knockout animals in species other than mouse and broadens the possibilities for new ...

USC researchers derive first embryonic stem cells from rats

... Researchers at USC are currently working on generating the first gene knockout rat through ES cell-based technologies. "If our work is feasible it is likely that many labs will follow up to generate different types of gene knockout rat models," he says. "This will have a major impact on the future of ...

Nuevolution Announces Drug Discovery Alliance With Lexicon Pharmaceuticals

... for nearly 5,000 human genes by studying the corresponding mouse genes in knockout animals. This endeavor led to the identification of more than 100 highly ... alliance is designed to accelerate Lexicon's ability to move from novel knockout validated targets to drug candidates as we continue to build our pipeline ...

Lexicon Presents Class of Compounds Modulating TPH1, the Target for its LX1031 Investigational Drug for Irritable Bowel Syndrome

... with no detectable levels in the periphery. Importantly, the TPH1 knockout mice were healthy and exhibited no significant adverse effects. Top-line ... and cognitive disorders. The company has used its proprietary gene knockout technology to discover more than 100 promising drug targets and create an ...

Lexicon to Provide Clinical Pipeline Update and Report Second Quarter 2009 Financial Results on July 28, 2009

... diabetes, glaucoma and irritable bowel syndrome, all of which were discovered by Lexicon's research team. Lexicon has used its proprietary gene knockout technology to identify more than 100 promising drug targets. Lexicon has focused drug discovery efforts on these biologically-validated targets to ...

AEterna Zentaris: New Data Published on its Ghrelin Antagonist Compound, AEZS-123 (JMV2959), Supports its Use in Alcohol Addiction

... produced by the stomach and acting in the brain. Compelling evidence obtained with the administration of AEZS-123, and a ghrelin receptor mouse knockout model, highlights the role of ghrelin to regulate the rewarding value of alcohol in a mouse model of alcohol dependence. When ghrelin's actions are ...

Lexicon Initiates Phase 2 Clinical Trial of LX1032 in Patients With Carcinoid Syndrome

... glaucoma and irritable bowel syndrome, all of which were discovered by the company's research team. The company has used its proprietary gene knockout technology to identify more than 100 promising drug targets. Lexicon has focused drug discovery efforts on these biologically-validated targets to ...
Knockout in Biological Products

TargeTron Gene Knockout System from Sigma-Aldrich

Description:... The TargeTron(TM) Gene knockout System provides optimized reagents and protocols ... genomics approaches. Compared to existing knockout methodologies, the TargeTron system is quite ... and screening for the desired knockout. Gene knockout using the TargeTron system has been validated in ...
Company:Sigma-Aldrich

* Quick & Easy E. coli Gene Deletion Kit from Gene Bridges GmbH

Description:... This kit is designed to knockout or alter genes on the E.coli chromosome in less than one week. Red/ET recombination allows the exchange of genetic information in a base pair ...
Company:Gene Bridges GmbH
Knockout in Biological Definition

Molecular genetics

... is possible to induce the deletion of a particular gene, creating a gene knockout . Alternatives include the random induction of DNA deletions and ... forward and reverse genetics screens RNA interference gene knockout transgenics and overexpression mapping, cloning, and sequencing ...

Reverse genetics

... site-directed mutagenesis , for example, by deletion of a gene by gene knockout (as can be done in some organisms, such as yeast and mice ) -- and only ... is the application of RNA interference . RNAi creates a specific knockout effect without actually mutating the DNA of interest. In C. elegans , ...

Long-term potentiation

... PMID 2869411 McHugh TJ, Blum KI, Tsien JZ, Tonegawa S, Wilson MA. "Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice." Cell . 1996 Dec 27;87(7):1147-8. PMID 8980239 Tang YP, Wang H, Feng R, Kyin M, Tsien JZ. "Differential effects of enrichment on ...
Knockout in Biological Dictionary

Transgenic mouse

... transgenic . ... CWRU Transgenic Mice and knockout Mice : Transgenic Core Facility ... ... pay for the maintenance of foster mothers ... knockout & Transgenic Research Portal - articles, ... of transgenic organism used in research is the knockout ... The mouse core facility at Boston ...

Gene targeting

...sue,... Specializes in providing mouse gene knockout and DNA sequencing services to academic and ... ... iTL uses gene targeting technologies to knockout or knockin genes ... What is gene targeting ... Sciences: The creation of standard or conditional knockout mice, or knockin mice, utilizes some proprietary ...

Gene knockout

... A gene knockout is a genetic technique in which an organism is ... is done for research purposes. Also known as knockout organisms or simply knockouts, they are used in ... known function. Researchers ... A knockout mouse is a genetically engineered mouse in ...

Knock-Out

... A knockout is a winning criterion in several full-contact combat sports, such as ... Thai, mixed martial arts, Karate and others sports involving striking. A knockout is usually awarded when ... ... out rondje ... Er is een nieuwe ...

Transgenic

... laboratory models to study ... The technology for creating transgenic animals is constantly improving and will ... CWRU Transgenic Mice and knockout Mice: Transgenic Core Facility ... The Roth lab developed transgenic mice in which activity of specific neuronal ... [ANDi, the first ...

Recombination

... the variation ... More technically put, genetic recombination is the transmission-genetic process ... Homologous Recombination Method (and knockout Mouse) ... To perform homolgous recombination , you must know the DNA sequence of the gene ... A creation science resource megasite where you ...

Gene expression

... and integrates the gene expression information in MGI. ... Gene Expression Notebook (GEN) Mouse Phenome Database (MPD) Deltagen and Lexicon knockout Mice ... long oligonucleotide arrays for gene expression analysis including tiling expression , mutiplex expression for a broad range of ...

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(Date:8/29/2014)... 29, 2014 Thirteen Novant Health ... Great 100 Nurses in North Carolina list ... excellence and provides scholarships to nursing students at all ... Novant Health Presbyterian Medical Center are: Rea ... Nora King, Lissa Ready, Amber Segerlin, Carmen Smith, Melissa ...
(Date:8/29/2014)... By Steven Reinberg ... (HealthDay News) -- The vast majority of American babies ... from serious illnesses, federal health officials said Thursday. ... vaccines that prevent measles, mumps, and rubella (MMR); polio; ... Centers for Disease Control and Prevention. "Nationally, vaccination ...
(Date:8/29/2014)... study from the research group of Dr. John Lewis at ... Research Institute (London, ON) has confirmed that "invadopodia" play a ... in Cell Reports , shows preventing these tentacle-like structures ... , Roughly 2 in 5 Canadians will develop cancer in ... of the disease. In 2014, it,s estimated that nine Canadians ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 Floors of ... especially when wearing socks. Also, many patients are relegated ... poor balance, surgery recovery, Alzheimer’s, etc. Two inventors from ... to optimize patient safety. , This special pair of ... It also keeps patients who are relegated to beds ...
(Date:8/29/2014)... University School of Medicine have identified one way the ... insight that could lead to new therapies, in ... Host & Microbe . , In work performed at ... the researchers developed a detailed map of how a ... that takes signaling molecules in and out of the ...
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(Date:8/28/2014)... The support of peer groups and clinicians ... programs, according to recent University of Georgia research. ... the Athens-Clarke County area determined that role models ... of mothers of infants. , "Mothers who received ... at breastfeeding," said study co-author Alex Anderson, an ...
(Date:8/28/2014)... Aug. 28, 2014  Privacy Advocate and Senior Staff ... Lynch , joins the lineup of biometric and mobile ... Biometrics UnPlugged Executive Summit in Tampa, Florida ... Previously announced speakers include Steven Rahman, Director, Technology and Strategy ... at Experian. The theme of this year,s event is ...
(Date:8/28/2014)... (Maximizing Access to Research Careers) Program has announced ... of Sports Medicine,s Conference on Integrative Physiology of ... These awards are meant to promote the ... underrepresented groups into the mainstream of the basic ... young scientists at the American College of Sports ...
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